The last two decades have seen new insights, data and analytical methods to establish the behaviour of structures in fire. These methods have slowly migrated into practice and now form the basis for modern quantitative structural fire engineering. This study presents a novel methodology for determining the imposed heat fluxes on structural members. To properly characterise the temperature rise of the structural elements, a post-processing model for computational fluid dynamics tools was developed to establish the heat fluxes imposed on all surfaces by a fire. This model acts as a tool for any computational fluid dynamics model and works on the basis of well resolved local gas conditions. Analysis of the smoke layer and products of combustion allow for heat fluxes to be defined based on smoke absorption coefficients and temperatures. These heat fluxes are defined at all points on the structure by considering full spatial and temporal distributions. Furthermore, heat fluxes are defined by considering directionality and both characteristic length and time scales in fires. Length scales are evaluated for different structural member geometries, while time scales are evaluated for different structural materials including applied fire protection. It is the output given by this model that provides the input for the thermal analysis of the structural members that is a necessary step prior to the structural analysis to be undertaken. The model is validated against the experimental results of the previously mentioned large scale fire tests, showing good agreement. In addition, comparisons are made to current methods to highlight their potential inadequacies.

The understanding of the subjective experience of a visually stable world despite the occurrence of an observer's eye movements has been the focus of extensive research for over 20 years. These studies have revealed fundamental mechanisms such as anticipatory receptive field (RF) shifts and the saccadic suppression of stimulus displacements, yet there currently exists no single explanatory framework for these observations. We show that a previously presented neuro-computational model of peri-saccadic mislocalization accounts for the phenomenon of predictive remapping and for the observation of saccadic suppression of displacement (SSD). This converging evidence allows us to identify the potential ingredients of perceptual stability that generalize beyond different data sets in a formal physiology-based model. In particular we propose that predictive remapping stabilizes the visual world across saccades by introducing a feedback loop and, as an emergent result, small displacements of stimuli are not noticed by the visual system. The model provides a link from neural dynamics, to neural mechanism and finally to behavior, and thus offers a testable comprehensive framework of visual stability.

Neurônios do córtex visual primário (V1) são seletivos à orientação, direção e freqüência espacial de estímulos apresentados em seus campos receptivos. Os últimos 40 anos acumularam uma quantidade considerável de teorias e dados sobre o processamento cortical de seletividade. Apesar disso, um consenso sobre os mecanismos que geram preferência a orientação, uma das características mais marcantes do processamento visual inicial, ainda está longe de ser atingido. Este cenário torna-se ainda mais interessante quando se considera evidências recentes de plasticidade operando em diferentes escalas temporais em estágios iniciais como V1, que resultam em uma organização dinâmica da seletividade à orientação que se pensava rígida e inflexível no córtex adulto até então. Neste trabalho, descreve-se a construção de um modelo neuronal do córtex visual de primatas composto de 6 camadas corticais representando o canal M de processamento visual. As características fisiológicas e neuroanatômicas do modelo foram derivadas a partir de dados experimentais do sistema visual de primatas. Na primeira parte deste trabalho, o perfil de seletividade à orientação do modelo é apresentado e comparado com resultados experimentais. Os neurônios modelados apresentaram diversidade em seus padrões de seletividade a orientação consistente com dados experimentais (medidos com ISO, VC, MBA). Esta diversidade reflete a heterogeneidade de classes eletrofisiológicas presente no modelo e os diferentes padrões de circuitaria laminar. Na segunda parte examina-se o papel de plasticidade de curto termo na circuitaria intracortical na alteração dinâmica dos perfis de seletividade orientação. Depressão e deslocamento da resposta na vizinhança da orientação preferida foram observados mas não aumento em pontos distantes. Os neurônios simulados apresentaram alguma diversidade nos perfis de plasticidade de curto prazo restrita a camadas com com alta densidade de células com disparo em rajada. / V1 neurons are selective for the orientation, direction and spatial frequency of stimuli presented at their receptive fields. The last 40 years have witnessed the accumulation of a considerable amount of theory and data about the cortical processing of feature selectivity. Yet the mechanisms that underly orientation preference, one of the most conspicuous features of early visual cortical processing, remain far from reaching a consensus. This landscape gets even richer with the recent recognition of different time scales of plasticity operating as early as V1 resulting in a dynamic organization of orientation selectivity previously thought to be rigid and unmodifiable in the adult cortex. In this work we present a spiking neuron model of the primate primary visual cortex composed of 6 cortical layers, representing the M channel of visual processing. The physiological and architectural properties of the model were derived from experimental data for the primate visual pathway. In the first part we present the orientation selectivity profile of the model and discuss its relationship to experimental reports. Neurons have shown a diversity of orientation selectivity dependent responses consistent with data (measured with OSI, CV, HWB). This diversity is thought to reflect the electrophysiological heterogeneity of model cortical cells and the different patterns of laminar circuitry. In the second part of this study we examine the role of shortterm plasticity of the intracortical circuitry in the dynamic modification of orientation selectivity profiles. Depression and shift around preferred orientation but not enhancement at the far flank of the tuning curves are observed. Simulated neurons have also shown some diversity in short-term plasticity restricted to layers with high density of bursting cells.

Neurônios do córtex visual primário (V1) são seletivos à orientação, direção e freqüência espacial de estímulos apresentados em seus campos receptivos. Os últimos 40 anos acumularam uma quantidade considerável de teorias e dados sobre o processamento cortical de seletividade. Apesar disso, um consenso sobre os mecanismos que geram preferência a orientação, uma das características mais marcantes do processamento visual inicial, ainda está longe de ser atingido. Este cenário torna-se ainda mais interessante quando se considera evidências recentes de plasticidade operando em diferentes escalas temporais em estágios iniciais como V1, que resultam em uma organização dinâmica da seletividade à orientação que se pensava rígida e inflexível no córtex adulto até então. Neste trabalho, descreve-se a construção de um modelo neuronal do córtex visual de primatas composto de 6 camadas corticais representando o canal M de processamento visual. As características fisiológicas e neuroanatômicas do modelo foram derivadas a partir de dados experimentais do sistema visual de primatas. Na primeira parte deste trabalho, o perfil de seletividade à orientação do modelo é apresentado e comparado com resultados experimentais. Os neurônios modelados apresentaram diversidade em seus padrões de seletividade a orientação consistente com dados experimentais (medidos com ISO, VC, MBA). Esta diversidade reflete a heterogeneidade de classes eletrofisiológicas presente no modelo e os diferentes padrões de circuitaria laminar. Na segunda parte examina-se o papel de plasticidade de curto termo na circuitaria intracortical na alteração dinâmica dos perfis de seletividade orientação. Depressão e deslocamento da resposta na vizinhança da orientação preferida foram observados mas não aumento em pontos distantes. Os neurônios simulados apresentaram alguma diversidade nos perfis de plasticidade de curto prazo restrita a camadas com com alta densidade de células com disparo em rajada. / V1 neurons are selective for the orientation, direction and spatial frequency of stimuli presented at their receptive fields. The last 40 years have witnessed the accumulation of a considerable amount of theory and data about the cortical processing of feature selectivity. Yet the mechanisms that underly orientation preference, one of the most conspicuous features of early visual cortical processing, remain far from reaching a consensus. This landscape gets even richer with the recent recognition of different time scales of plasticity operating as early as V1 resulting in a dynamic organization of orientation selectivity previously thought to be rigid and unmodifiable in the adult cortex. In this work we present a spiking neuron model of the primate primary visual cortex composed of 6 cortical layers, representing the M channel of visual processing. The physiological and architectural properties of the model were derived from experimental data for the primate visual pathway. In the first part we present the orientation selectivity profile of the model and discuss its relationship to experimental reports. Neurons have shown a diversity of orientation selectivity dependent responses consistent with data (measured with OSI, CV, HWB). This diversity is thought to reflect the electrophysiological heterogeneity of model cortical cells and the different patterns of laminar circuitry. In the second part of this study we examine the role of shortterm plasticity of the intracortical circuitry in the dynamic modification of orientation selectivity profiles. Depression and shift around preferred orientation but not enhancement at the far flank of the tuning curves are observed. Simulated neurons have also shown some diversity in short-term plasticity restricted to layers with high density of bursting cells.

Há evidências convincentes de que o início da doença de Alzheimer é precedido por uma redução de estímulos sensoriais, como ocorre durante a aposentadoria, catarata, surdez e degeneração macular, em um cérebro idoso que apresenta deficiência de receptores tipo GABAA. Neste trabalho foi utilizado um modelo computacional fenomenológico do koniocortex, que é a primeira camada cortical que recebe estímulos sensoriais, adaptado para simular as fases iniciais da doença de Alzheimer. A arquitetura e as propriedades dos neurônios do modelo computacional do koniocortex se assemelham as do cérebro, sendo também capaz de aprender, permitindo com isso que a memória de curto prazo seja testada em qualquer momento. Usando o modelo computacional é possível também analisar as fases iniciais da doença de Alzheimer simulando o \"envelhecimento\" do koniocortex artificial através de um conjunto de parâmetros referentes à plasticidade intrínseca, à acetilcolina, aos estímulos sensoriais, ao pruning sináptico, entre outros. O modelo computacional revela que, quando o envelhecimento afeta os neurônios que expressam receptores GABA-A ocorrendo na sequência uma redução dos estímulos sensoriais, o resultado dessa cascata de eventos leva ao hipermetabolismo e ao início da fase de deposição excessiva das placas -amiloide / There is compelling evidence that Alzheimers disease onset is preceded by a reduction of sensory stimuli like during job retirement, cataract, deafness or even macular degeneration, over an aged brain with impaired GABA-A receptor inhibitions. In this paper, was adapted a phenomenological computational model of the koniocortex which is the first cortical layer that receives sensory stimuli to simulate the initial phases of Alzheimers disease. The architecture and neurons properties of the modeled koniocortex resemble those of the brain, so that the model is also able to learn, thereby allowing the assessment of short-term memory at any moment. By using the computational model, it is possible to analyze the initial phases of Alzheimers disease by aging the artificial koniocortex through a set of parameters related to intrinsic plasticity, acetylcholine, sensory stimuli, synaptic pruning, among others. The computational model shows that when aging occurs in such way that GABA-A receptor expressing neurons are affected, and, in the sequence, a reduction of sensory stimuli takes place, the result of this cascade of events leads to hypermetabolism and to the initial phase excessive deposition of beta-amyloid plaques

Submitted by Silvana Teresinha Dornelles Studzinski (sstudzinski) on 2016-06-13T13:42:00Z No. of bitstreams: 1 Elionai de Souza Magalhães_.pdf: 2039789 bytes, checksum: 5d3f44b9164f4c68bcb09e63c3a2dda0 (MD5) / Made available in DSpace on 2016-06-13T13:42:00Z (GMT). No. of bitstreams: 1 Elionai de Souza Magalhães_.pdf: 2039789 bytes, checksum: 5d3f44b9164f4c68bcb09e63c3a2dda0 (MD5) Previous issue date: 2016-03-04 / IFAM - Instituto Federal de Educação, Ciência e Tecnologia do Amazonas / A responsabilidade de tomar decisões em si não é fácil, e quando está relacionada à gestão de recursos na área pública é uma tarefa ainda mais difícil, pois está ligada a um alto nível de complexidade. Neste trabalho, é apresentado um modelo computacional baseado em análise de decisão multicritério para a priorização da alocação de recursos financeiros para as comunidades ribeirinhas da região de Coari, Amazonas. Com o surgimento da Pesquisa Operacional, foi possível o desenvolvimento de métodos que auxiliam os tomadores de decisão no que se refere à avaliação e escolha em ambientes que envolvem multicritérios. É o caso da gestão pública, cuja decisão sobre a alocação de recursos passa pela análise de diversos critérios. As técnicas de decisão multicritério, aliadas às novas tecnologias de informação e comunicação, possibilitam novas formas de conhecimento e maior qualidade em diversos serviços. O emprego destas tecnologias no desenvolvimento de ferramentas de auxílio à decisão para a alocação de recursos é de grande utilidade, tendo em vista a automação no processo de análise e rapidez na obtenção dos resultados, possibilitando agilidade na tomada de decisão. Neste trabalho, é desenvolvido um modelo computacional baseado na técnica de Auxílio à Decisão Multicritério para ajudar na alocação de recursos públicos em comunidades ribeirinhas do Amazonas. O modelo emprega a técnica TOPSIS de análise multicritério com o intuito de obter um ranking das comunidades, para assim indicar aquela com maior grau de prioridade para receber a alocação de recursos públicos. Os experimentos foram realizados assumindo um conjunto de seis critérios empregados na ordenação de oito regiões de comunidades ribeirinhas. No estudo realizado, a lista de priorização indicou a região de comunidades do Baixo Solimões como a prioritária para a alocação de recursos públicos e a robustez da priorização obtida na aplicação efetuada foi avaliada através da realização de uma análise de sensibilidade. / The responsibility of making decisions itself is not easy, and when it is related to the management of resources in the public sector is an even more difficult task, because it is linked to a high level of complexity. In this paper, we present a computational model based on multi-criteria decision analysis to prioritize the allocation of financial resources to the coastal communities of Coari region of Amazonas. With the emergence of Operational Research, development methods was possible that assist decision makers with regard to the evaluation and choice in environments that involve advanced. This is the case of public administration, whose decision on the allocation of resources involves the analysis of various criteria. The techniques of multi-criteria decision, combined with the new technologies of information and communication, enable new forms of knowledge and higher quality in different services. The use of these technologies in the development of the decision support tools for the allocation of resources is useful in view of automation in the process of analysis and speed in obtaining results, enabling agility in decision making. In this work, we developed a computational model based on the technique of Aid to Decision Multicriteria to assist in the allocation of public resources in riverine communities of Amazonas. The model uses the TOPSIS technique of multi-criteria analysis in order to obtain a ranking of the communities, so as to indicate that more priority to receive the allocation of public resources. The experiments were performed assuming a set of six criteria used in the ordination of eight regions of riverside communities. In the study, the list of priority indicated the region of the Lower Solimões communities as a priority for the allocation of public resources and the robustness of the obtained priority in the application made was assessed by performing a sensitivity analysis.

abstract: Much evidence has shown that first language (L1) plays an important role in the formation of L2 phonological system during second language (L2) learning process. This combines with the fact that different L1s have distinct phonological patterns to indicate the diverse L2 speech learning outcomes for speakers from different L1 backgrounds. This dissertation hypothesizes that phonological distances between accented speech and speakers' L1 speech are also correlated with perceived accentedness, and the correlations are negative for some phonological properties. Moreover, contrastive phonological distinctions between L1s and L2 will manifest themselves in the accented speech produced by speaker from these L1s. To test the hypotheses, this study comes up with a computational model to analyze the accented speech properties in both segmental (short-term speech measurements on short-segment or phoneme level) and suprasegmental (long-term speech measurements on word, long-segment, or sentence level) feature space. The benefit of using a computational model is that it enables quantitative analysis of L1's effect on accent in terms of different phonological properties. The core parts of this computational model are feature extraction schemes to extract pronunciation and prosody representation of accented speech based on existing techniques in speech processing field. Correlation analysis on both segmental and suprasegmental feature space is conducted to look into the relationship between acoustic measurements related to L1s and perceived accentedness across several L1s. Multiple regression analysis is employed to investigate how the L1's effect impacts the perception of foreign accent, and how accented speech produced by speakers from different L1s behaves distinctly on segmental and suprasegmental feature spaces. Results unveil the potential application of the methodology in this study to provide quantitative analysis of accented speech, and extend current studies in L2 speech learning theory to large scale. Practically, this study further shows that the computational model proposed in this study can benefit automatic accentedness evaluation system by adding features related to speakers' L1s. / Dissertation/Thesis / Doctoral Dissertation Speech and Hearing Science 2018

Angiogenesis is a complex process coordinating cell migration, proliferation, and lumen formation. Changes to the microenvironment regulate angiogenesis through mechanotransduction and cytokine signals. In pulmonary hypertension, something in the process becomes abnormal, resulting in changes to the microenvironment and the formation of a glomerulus of dysfunctional capillaries, called a plexiform lesion. Endothelial cells, expressing CD117 (CD117+ EC clones) increase in the plexiform lesions of pulmonary hypertension, independent of pro-angiogenic VEGF signaling. We hypothesize that the mechanical environment and the macromolecular composition of the extracellular matrix, both, contribute to the aberrant angiogenesis. When we changed the mechanical environment, we changed the angiogenic potential and cellular phenotype of CD117+ Endothelial cell clones. Turbulent flow, pathologic substrate stiffness, and pathologic stretch increased Endothelial-to-mesenchymal markers, such as acta2, cnn1, snail, and slug in CD117+ EC clones while CD117- ECs showed minimal change. We perturbed the mechanical environment of CD117+ EC clones and identified changes in Bone Morphogenic Protein-2, an often overlooked pro-angiogenic cytokine. We coupled changes in the mechanical environment to Rho GTPase intracellular signaling, to predict how changes to the mechanotransduction would affect angiogenesis through a computational model. In our model of angiogenesis, we found vessel synchronicity to depend on both which cell undergoes mitosis, and also at which phase of GTPase cycling the cell undergoes mitosis. We believe changes to the GTPase cycling may be the mechanism linking mechanotransduction to the abnormal vessels found in pulmonary hypertension. We are the first group to look at the role of the ECM composition, independent of stiffness. Our results show diseased ECM composition alone leads to phenotypic changes indicative of PH progression. In conclusion, these results provide a possible cytokine implicated in the mechanotransduction of PH, established a computational model of angiogenesis which provides a mechanotransduction mechanism of disease progression, and established that the ECM composition alone is capable of phenotypic changes leading to disease progression.

People generally want to engage in a healthy lifestyle, to live in harmony with the environment, to contribute to social causes, and to avoid behaviours that are harmful for themselves and others. However, people often find it difficult to motivate themselves to engage in these beneficial behaviours. Even adopting a healthy lifestyle, such as healthy eating, physical activity, or smoking cessation, is hard despite being aware of the benefits. The increasing adoption and integration of technologies into our daily lives present unique opportunities to assist individuals to adopt healthy behaviours using technology. As a result, research on how to use technology to motivate health behaviour change has attracted the attention of both researchers and health practitioners. Technology designed for the purpose of bringing about desirable behaviour and attitude changes is referred to as Persuasive Technology (PT). Over the past decade, several PTs have been developed to motivate healthy behaviour, including helping people with addictive behaviour such as substance abuse, assisting individuals to achieve personal wellness, helping people manage diseases, and engaging people in preventive behaviours. Most of these PTs take a one-size-fits-all design approach. However, people differ in their motivation and beliefs about health and what constitutes a healthy life. A technology that motivates one type of person to change her behaviour may actually deter behaviour change for another type of person. As a result, existing PTs that are based on the one-size-fits-all approach may not be effective for promoting healthy behaviour change for most people. Because of the motivational pull that games offer, many PTs deliver their intervention in the form of games. This type of game-based PTs are referred to as persuasive games. Considering the increasing interest in delivering PT as a game, this dissertation uses persuasive games as a case study to illustrate the danger of applying the one-size-fits-all approach, the value and importance of tailoring PT, and to propose an approach for tailoring PTs to increase their efficacy. To address the problem that most existing PTs employ the one-size-fits-all design approach, I developed the Model-driven Persuasive Technology (MPT) design approach for tailoring PTs to various user types. The MPT is based on studying and modelling user’s behaviour with respect to their motivations. I developed the MPT approach in two preliminary studies (N = 221, N = 554) that model the determinants of healthy eating for people from different cultures, of different ages, and of both genders. I then applied the MPT approach in two large-scale studies to develop models for tailoring persuasive games to various gamer types. In the first study (N = 642), I examine eating behaviours and associated determinants, using the Health Belief Model. Using data from the study, I modelled the determinants of healthy eating behaviour for various gamer types. In the second study (N = 1108), I examined the persuasiveness of PT design strategies and developed models for tailoring the strategies to various gamer types. Behavioural determinants and PT design strategies are the two fundamental building blocks that drive PT interventions. The models revealed that some strategies were more effective for particular gamer types, thus, providing guidelines for tailoring persuasive games to various gamer types. To show the feasibility of the MPT design approach, I applied the model to design and develop two versions of a Model-driven Persuasive Game (MPG) targeting two distinct gamer types. To demonstrate the importance of tailoring persuasive games using the MPG approach, I conducted a large-scale evaluation (N = 802) of the two versions of the game and compared the efficacy of the tailored, contra-tailored, and the one-size-fits-all persuasive games condition with respect to their ability to promote positive changes in attitude, self-efficacy, and intention. To also demonstrate that the tailored MPG games inspire better play experience than the one-size-fits-all and the contra-tailored persuasive games, I measure the gamers’ perceived enjoyment and competence under the different game conditions. The results of the evaluation showed that while PTs can be effective for promoting healthy behaviour in terms of attitude, self-efficacy, and intention, the effectiveness of persuasion depends on using the right choice of persuasive strategy for each gamer type. The results showed that one size does not fit all and answered my overarching research question of whether there is a value in tailoring PT to an individual or group. The answer is that persuasive health interventions are more effective if they are tailored to the user types under consideration and that not tailoring PTs could be detrimental to behaviour change.

Processing of visual stimuli in the vertebrate retina is complex and diverse. The retinal output to the higher centres of the nervous system, mediated by ganglion cells, consists of several different channels. Neurons in these channels can have very distinct response properties, which originate in different retinal pathways. In this work, the retinal origins and possible functional implications of the segregation of visual pathways will be investigated with a detailed, biologically realistic computational model of the retina. This investigation will focus on the two main retino-cortical pathways in the mammalian retina, the parvocellular and magnocellular systems, which are crucial for conscious visual perception. These pathways differ in two important aspects. The parvocellular system has a high spatial, but low temporal resolution. Conversely, the magnocellular system has a high temporal fidelity, spatial sampling however is less dense than for parvocellular cells. Additionally, the responses of magnocellular ganglion cells can show pronounced nonlinearities, while the parvocellular system is essentially linear. The origin of magnocellular nonlinearities is unknown and will be investigated in the first part of this work. As their main source, the results suggest specific properties of the photoreceptor response and a specialised amacrine cell circuit in the inner retina. The results further show that their effect combines in a multiplicative way. The model is then used to examine the influence of nonlinearities on the responses of ganglion cells in the presence of involuntary fixational eye movements. Two different stimulus conditions will be considered: visual hyperacuity and motion induced illusions. In both cases, it is possible to directly compare properties of the ganglion cell population response with psychophysical data, which allows for an analysis of the influence of different components of the retinal circuitry. The simulation results suggest an important role for nonlinearities in the magnocellular stream for visual perception in both cases. First, it will be shown how nonlinearities, triggered by fixational eye movements, can strongly enhance the spatial precision of magnocellular ganglion cells. As a result, their performance in a hyperacuity task can be equal to or even surpass that of the parvocellular system. Second, the simulations imply that the origin of some of the illusory percepts elicited by fixational eye movements could be traced back to the nonlinear properties of magnocellular ganglion cells. As these activity patterns strongly differ from those in the parvocellular system, it appears that the magnocellular system can strongly dominate visual perception in certain conditions. Taken together, the results of this theoretical study suggest that retinal nonlinearities may be important for and strongly influence visual perception. The model makes several experimentally verifiable predictions to further test and quantify these findings. Furthermore, models investigating higher visual processing stages may benefit from this work, which could provide the basis to produce realistic afferent input.