O objetivo do presente estudo foi avaliar o efeito da desnutrição proteica em humanos e em modelo animal por meio de medidas comportamentais e bioquímicas. Participaram desse estudo 60 crianças com idade de 7 a 10 anos, sendo 20 eutróficas (grupo controle, GC), 20 com desnutrição atual (grupo experimental atual, GEa) e 20 com desnutrição pregressa (grupo experimental pregresso, GEp). Esses três grupos foram replicados em modelo animal, sendo cada grupo composto por 6 ratos wistar. A acuidade visual (AV) e a sensibilidade ao contraste (SC) foram medidas por meio do método psicofísico em humanos (experimento I) e em ratos (experimento II). Para a medida comportamental com animais foi desenvolvido o Labirinto de Imagens. As análises bioquímicas foram realizadas por meio da técnica de imunohistoquímica e de morfometria da retina de 5 animais de cada grupo (experimento III). Os resultados dos testes comportamentais em humanos e em animais mostraram prejuízos no desempenho dos grupos desnutridos, principalmente no GEp, mesmo com recuperação nutricional. O Labirinto de Imagens se mostrou uma ferramenta útil para medida de parâmetros visuais em roedores. Entretanto, as análises histológicas não apresentaram diferenças significantes entre os grupos, o que provavelmente se deve ao nível de análise não ser capaz de medir componentes sinápticos, arborização dendrítica ou do sistema de neurotransmissão / Not informed by the author

Image sizes have increased exponentially in recent years. The resulting high-resolution images are often viewed via remote image browsing. Zooming and panning are desirable features in this context, which result in disparate spatial regions of an image being displayed at a variety of ( spatial) resolutions. When an image is displayed at a reduced resolution, the quantization step sizes needed for visually lossless quality generally increase. This paper investigates the quantization step sizes needed for visually lossless display as a function of resolution, and proposes a method that effectively incorporates the resulting ( multiple) quantization step sizes into a single JPEG 2000 codestream. This codestream is JPEG 2000 Part 1 compliant and allows for visually lossless decoding at all resolutions natively supported by the wavelet transform as well as arbitrary intermediate resolutions, using only a fraction of the full-resolution codestream. When images are browsed remotely using the JPEG 2000 Interactive Protocol ( JPIP), the required bandwidth is significantly reduced, as demonstrated by extensive experimental results.

ABSTRACT Global summation of radial frequency patterns and the effect of sudden onset glare on shape discrimination The purpose of this study was to provide evidence of global pooling around the circumference of the Radial frequency (RF) pattern, and to study the effect of sudden onset glare on shape discrimination. The RF stimuli were generated by the amplitude modulation of the radius of a circle which deforms them from circularity, while the cross sectional luminance profile was the fourth derivative of Gaussians (D4). The amplitude of the stimuli determines how distinct the pattern is and thus measures the degree of sensitivity while the radial frequency determines the number of lobes the pattern has. In the first part of the study, whole RF patterns (RF3 to RF16) and open component fractions (0.125, 0.25, 0.5, 0.75), which are incomplete sectors of the whole, were tested against their respective reference unmodulated patterns. Subjects were tasked with discriminating minute deviations from their reference patterns. In the second part of the study, high contrast (20 X detection threshold) RF3 and RF4 contours and equivalent low contrast (5 X detection threshold) RF3 and RF4 contours were used as stimuli. Shape discrimination threshold for the high contrast target was determined with and without sudden onset glare. The result of the first part of the study showed that threshold decreased significantly as larger component RF patterns were tested (p < 0.05). The decrease could not be accounted for by the probabilistic sampling of local filters (probability summation). The result of the second part of the study showed that shape discrimination threshold increased with sudden onset glare. The increase was even more pronounced with lower mean luminance and when smaller fractions of the contours were tested. Shape discrimination threshold was significantly higher with high contrast contours in the presence of glare than equivalent low contrast contours, indicating that the veiling luminance model alone could not account for a decrease in visual performance in this shape discrimination task.

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The concept of "visual fatigue" has been studied for 70 years or more. In that time, no single metric of measuring visual fatigue nor one agreed-upon set of tasks to induce visual fatigue has been settled upon. Not even a robust definition of visual fatigue has been established. This research worked to solve some of those problems. This research first set out to develop an index of visual fatigue that could be used effectively in quantifying the subjective experience of visual fatigue. Then it sought to create a set of measurable tasks, representative of office work, that would induce visual fatigue. Taking these two developments, an experiment using human participants was conducted to validate these developments and work toward solving two issues in the visual fatigue field: how visual display technology and ambient illumination affect the onset of visual fatigue. A 4x4 within-subjects design was developed and executed to study how these two independent variables affected ratings of visual fatigue, performance on the task battery, subjective image quality judgments, and contrast sensitivity shifts. Two cathode ray tube (CRT) and two active-matrix LCD (AMLCD) monitors were used in this study. While many instances of the monitors as a whole caused significant differences in reports of visual fatigue, performance, subjective image quality, and contrast sensitivity loss, only a slight effect of display technology was found. Four of eleven visual fatigue and two of eight subjective image quality dimensions showed that the LCD monitors induced more visual fatigue and were rated poorer than the CRT monitors. Ambient illumination levels of 0, 300, 600, and 1200 lux affected all four groups of dependent variables. On the whole, lighting caused visual fatigue, with "watery eyes" and "glare from lights" being adversely affected by brighter lighting. The 0 and 1200 lux were associated with the worst performance, while 300 lux was associated with the best performance. Subjective image quality was affected by lighting, with increasing lighting causing bothersome screen reflections and more temporal (e.g., flicker and jitter) distortions; 600 lux induced more reports of image sizing anomalies. Finally, it caused significantly worse shifts at the 6.0 c/deg spatial frequency on the contrast sensitivity test. The data show that lighting of 300 lux is the best of these four illumination levels. The results of this study not only contribute to the body of research in the areas of display technology and ambient illumination, but several developments of this research are offered to the research community: a complete survey metric of visual fatigue, a standardized battery of tasks for studying visual fatigue and image quality, and a comprehensive subjective image quality survey. / Ph. D.

The purpose of this study was to examine the use of colored overlays as an aid to individuals with reading problems; and, in particular, to assess the role visual contrast sensitivity may play in this treatment and in reading problems in general. Arguments both supporting and refuting the validity of the Irlen technique of using colored overlays and lenses as a treatment for reading problems are reviewed. While much of the criticism regarding the Irlen technique appears warranted, it seems that, for many reading disabled individuals, overlays and lenses do provide relief from symptoms and help to raise scores on reading tests. Tinted overlays may work by improving the contrast ratio of print for those with poorer contrast sensitivity. It was hypothesized that reading scores of many poor readers would improve with the addition of tinted overlays, that those who were helped would show poorer contrast sensitivity than those who were not, that contrast sensitivity would also improve with the addition of a tinted overlay, and that subjects would be equally helped bv a neutral density gray overlay. One-hundred-seventy-four undergraduate volunteers were screened for reading ability with the Nelson Denny Reading Comprehension Test. The top 46 and bottom 46 were divided into three groups who were tested again using either a) one of four overlays deemed "optimal" for that subject by performance on the Tinker Speed of Reading test b) a gray overlay of the same density or c) no overlay. Contrast sensitivity was also tested under both conditions. The Irlen effect was not seen with this group of subjects. Results showed no significant effect of group or overlay color on reading performance. Scores in general increased significantly on the second trial, with low readers improving more than high readers. Contrast sensitivity showed no relationship to reading indices. / Master of Science

The increased reliance on night operations by the military over the last few decades has led to the development of various night imaging devices. Night vision goggles (NVGs) are one device which have gained widespread use in nighttime helicopter operations. However, rotorcraft accident data have indicated an increased occurrence of "pilot error" type accidents when NVGs are in use. NVG related accidents often can be linked to extremely poor ambient lighting and contrast conditions during nighttime operations as well as the imaging limitations of the NVGs. Research has shown that NVGs reduce visual acuity and depth perception when compared to unaided daylight viewing conditions. In this study the effects of illumination and contrast on stereoscopic vision with and without AN/AVS-6 goggles were investigated. Stereoacuity was measured using a modified Howard-Dolman apparatus with four levels of illumination and three levels of contrast. Testing was performed with NVGs for nighttime illuminations and unaided for daytime levels of illumination. Image measurements were performed on the NVGs to determine the impact of illumination on resolution and signal-to-noise ratio. Stereoscopic vision with NVGs was found to be significantly worse than under daylight conditions. Low levels of contrast also were found to reduce stereoacuity significantly. It was found that the worst stereoacuity in this study occurred under half moon or higher illumination levels. This research revealed that further NVG development should focus on the limitations of the NVGs under high light levels, and special considerations should be made for using NVGs in low contrast, high luminance situations. / Master of Science