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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Estresse por natação forçada e supersensibilidade de atrios direitos de ratos ao isoproterenol : papel da corticosterona

Moura, Maria Jose Costa Sampaio 15 February 1994 (has links)
Orientador : Sergio de Moraes / Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia / Made available in DSpace on 2018-07-19T10:06:05Z (GMT). No. of bitstreams: 1 Moura_MariaJoseCostaSampaio_D.pdf: 2398257 bytes, checksum: 4bb6ca6b210769976711075842c30902 (MD5) Previous issue date: 1994 / Abstract: The effect of stress obtained by repeated forced swimming on the sensitivity of the isolated pacemaker of the rat to the chronotropic effect of isoprenaline (ISO) was studied. Forced swimming stress induces supersensitivity to isoprenaline and a large increase in the plasma leveI of corticosterone. Adrenalectomy or pretreatment of the rats with RU 38486 an antiglucocorticoid compound prevented the development of forced swimming stress-induced supersensitivity to ISO. Administration of the synthetic glucocorticoid compound RU 28362 to rats not submitted to forced swimming stress causes supersensitivity to ISO. Pretreatment of the rats with diazepam or imipramine wich blocked the forced swimminginduced increase ín the plasma leveI of corticosterone abolished the development of pacemaker supersensitivity to ISO. We conc1uded that corticosterone seems to play a critical role in the modulation of the sensitivity of pacemaker beta adrenoceptors to isoprenaline during adaptation to repeated stress / Doutorado / Doutor em Ciências Biológicas

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