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La dépression chez les adolescents est une préoccupation majeure en raison de son impact sur la santé mentale et sur le risque de suicide qui constitue la quatrième cause de décès chez les 15- 29 ans. Malgré l’existence d’alternatives thérapeutiques, la gestion des troubles dépressifs demeure complexe en raison de la résistance aux traitements. Comprendre les facteurs influençant la réponse aux thérapies est donc crucial. L'intervention préventive cognitive- comportementale PreVenture, conçue pour cibler des traits de personnalité spécifiques comme le désespoir, un facteur de risque pour le développement de la dépression, offre une alternative de traitement prometteuse pour les adolescents. Des résultats préliminaires ont démontré le potentiel de PreVenture à réduire les symptômes dépressifs et les pensées suicidaires chez des adolescents canadiens. Ce projet vise à étudier les modérateurs cognitifs impliqués dans la réponse à cette intervention, en évaluant leur influence sur les symptômes dépressifs et les idées suicidaires chez des adolescents de 12 à 13 ans. Un modèle de croissance latent a été utilisé pour étudier la croissance des symptômes dépressifs et des pensées suicidaires. L’analyse de modération a permis d’étudier l’interaction entre PreVenture et la cognition. Les résultats indiquent que les adolescents rencontrant des difficultés de mémoire avant l'intervention montrent une réduction significative de leurs idées suicidaires dans les années suivantes. Cependant, aucun des modérateurs cognitifs n'a été identifié pour les symptômes dépressifs. En incluant les profils cognitifs d’adolescents à risque, ce projet met en avant la contribution des caractéristiques individuelles dans la prévention du suicide chez les adolescents. / Depression among adolescents is a major concern due to its impact on mental health and the risk of suicide, which ranks as the fourth leading cause of death among 15- to 29-year-olds. Despite the existence of therapeutic alternatives, managing depressive disorders remains complex due to treatment resistance. Understanding the factors influencing treatment response is therefore crucial. The cognitive-behavioral preventive intervention PreVenture, designed to target specific personality traits such as hopelessness, a risk factor for depression development, offers a promising treatment alternative for adolescents. Preliminary results have demonstrated PreVenture's potential to reduce depressive symptoms and suicidal thoughts among Canadian adolescents. This project aims to study the cognitive moderators involved in the response to this intervention by assessing their influence on depressive symptoms and suicidal ideation in adolescents aged 12 to 13. A latent growth model was used to examine the growth of depressive symptoms and suicidal thoughts. Moderation analysis allowed the investigation of the interaction between PreVenture and cognition. The results indicate that adolescents with memory difficulties prior to the intervention show a significant reduction in suicidal ideation in the following years. However, none of the cognitive moderators were identified for depressive symptoms. By including cognitive profiles of at-risk adolescents, this project highlights the contribution of individual characteristics to adolescent suicide prevention.

Yes / A growing literature shows that exposure to civil conflict could have long-term effects on psychological well-being in adulthood. This paper examines the long-term effects of exposure to the Nigerian civil war on the psychological well-being of heads of household using a difference-in-differences approach. We find that exposure to the civil war is associated with an increase in depressive score or symptoms in later life. We also find gender and locational differences in the effects of the civil war on depressive symptoms. The findings of this paper reveal that illness, household income, ownership of formal accounts, access to electricity, and unemployment, are some of the potential mechanisms through which exposure to conflict could affect depressive symptoms in later life. The findings of this paper support the hypothesis that exposure to shocks such as conflict could have deleterious consequences on well-being in later life.

With the onset of the coronavirus pandemic in 2020 in Germany, the population faced a mentally challenging time. Governmental measures like social distancing measures, lockdowns and quarantines were implemented to reduce the spread of the coronavirus and save as many lives as possible. People of old age were soon identified as high risk group for a lethal course of disease and as in particular need of protection. Mental health professionals feared an aggravation of mental distress and mental pathology. Against this background, this dissertation aimed to investigate mental coping and the progression of mental health outcomes in old and oldest-old risk groups over the course of the COVID-19 pandemic, as well as associated sociodemographic and psychosocial factors associated with it. In our first study, we investigated the perceived stress coping competence (self-efficient coping vs. helplessness-associated coping) as well as perceived worries about and perceived threat by the COVID-10 pandemic and associated sociodemographic and psychosocial factors in the oldest-old population in Germany in the early phase of the pandemic. Linear multivariate regression models revealed that in our sample of n=197 people aged 78 to 100 years old higher levels of resilience were linked to higher perceived self-efficient coping. Male gender compared to the female gender, and a medium educational level in reference to a low educational level, was associated with less helplessness-associated coping. Loneliness showed associations with both, self-efficient and helplessness-associated coping. Higher levels of anxiety and depressive symptoms were linked to higher scores of helplessness-associated coping. Regarding perceived worries about the pandemic, binary logistic regression models showed that male gender and higher perceived social support were linked to more worries about the pandemic. Despite the higher risk for a severe course of disease for people of old age, older age was associated with less perceived personal threat by the coronavirus. Furthermore, more reported depressive symptoms were linked to less perceived threat, and higher reported somatization symptoms were associated with higher personal threat by the virus. Therefore, mental health factors seem to shape the way oldest-old individuals perceive the COVID-19 pandemic in partly unexpected ways, and resilience may illustrate an important factor when targeting more functional ways of coping with stress. Moreover, people of oldest-old age experiencing greater loneliness, high depressive and anxiety symptoms could be supported by adapting their coping skill repertoire to foster the feeling of self-efficiency when coping with stress. In our second and third study, we analyzed the development and progression of mental health factors like depressive, anxiety and somatization symptoms. First, in study 2 with n=156 people of oldest-old age (range= 78 to 97 years) Wilcoxon t-tests showed an increase of anxiety, depressive and somatization symptoms from 2021 to 2021 with generalized regression models revealing that higher levels of symptomatology in 2020 were associated with higher symptom burden in 2021. Higher perceived social support in 2020 was linked to less depressive symptoms in 2021. Building on this findings, we then conducted multilevel mixed-effects generalized linear models to analyzed data over three points of measurement from 2020, 2021 and end of 2021/beginning of 2022 with n=135 participants (age range= 78 to 97 years). Results showed that after a first increase of depressive and anxiety symptoms from 2020 to 2021, symptomatology levels stayed relatively stable from 2021 to 2021/2022. Moreover, older age and higher reported worries were associated with higher levels of anxiety symptoms. Greater perceived social support was linked to less anxiety and depressive symptoms over time. Resilience was associated with less depressive symptoms. Since pre-existing heart conditions illustrated an additional risk factor, next to an older age (60+ years), for a serious and lethal course of coronavirus disease, the fourth study additionally focused on an old age sample with cardiovascular risk profiles. The aim was a comparison of this cardiovascular risk group with the general old age population in terms of symptomatology levels and psychosocial factors associated with it. We analyzed data of n=1236 participants with n=618 showing a cardiovascular risk profile, drawn from the AgeWell.de study, and n=618 from a representative survey of the old age general population with an age range of 64 to 81 years in the beginning of the COVID-19 pandemic. Results showed that the cardiovascular risk group showed higher depressive symptom levels compared to the general population. Multivariate regression models revealed that in the cardiovascular risk group higher perceived social support was linked to less depressive and anxiety symptoms. In the general old age population perceived social support was associated with depressive symptoms, social support and anxiety symptoms showed no such association. Higher perceived worries were associated with higher reported anxiety symptoms in the general population only. Perceived resilience was linked to less depressive and anxiety symptoms in both groups. In conclusion, the oldest-old individuals showed an overall good mental health in the long term despite a first increase in anxiety and depressive symptomatology within the first year. Fostering perceived social support and perceived resilience may play an important role in preventing and reducing depressive symptomatology in times of crises like the pandemic.:Table of Contents I 1. Introduction 1.1. The Severe Acute Respiratory Syndrome Coronavirus 2: the Disease and the Pandemic 1.2. Mental Health during the Pandemic in the General Adult Population 1.3. Mental Health in Old Age – with a Focus on Depression and Anxiety 1.3.1. Epidemiology 1.3.2. Etiology 1.4. Social Support as a Protective Factor? The Role of Social Goals over the Lifespan 1.5. Aims of the Dissertation 2. Empirical Investigations in the Old Age Population during the COVID-19 Pandemic 2.1. The Perception of Coping with Stress in the Oldest-old Population 2.2. The Development of Mental Health Factors and the Role of Social Support in the Oldest-old Population 2.3. The Development of Depressive and Anxiety Symptoms during the COVID-19 Pandemic and the Role of Psychosocial Factors in the Oldest-old Population 2.4. Depressive and Anxiety Symptoms in an Old Age Cardiovascular Risk Group Compared to the Old Age General Population 3. General Discussion 3.1. Implications for Prospective Research and Impulses for Public Mental Health Strategies 4. Conclusion Summary References Appendix List of Tables and Figures II

Motivation - Depression is a mental disorder that has been associated with cardiovascular morbidity and mortality in the Western world. Cardiometablic mechanisms have been implicated as possible intermediating factors in the relationship between depressive symptoms and cardiovascular disease; however this has not yet been determined in black Africans (hereafter referred to as Africans). Aim - The overarching aim of this study was to investigate the relationship between depressive symptoms and cardiometabolic risk. We therefore aimed to assess cardiometabolic function, neuroendocrine responses, inflammatory and haemostatic markers in Africans with depressive symptoms compared to those without symptoms of depression. Methodology - Manuscripts presented in Chapter 2, 3 and 4 utilised data from the cross-sectional, target population multi-disciplinary “Sympathetic activity and Ambulatory Blood Pressure in Africans” (SABPA) study. The participants comprised of 200 African teachers from the Dr Kenneth Kaunda District in North-West province, South Africa. As cardiovascular disease is compromised by a positive HIV status, 19 participants were excluded from further statistical analysis. Stratification was based on the Patient Health Questionnaire 9-item (PHQ-9), which has been validated in a sub-Saharan African setting. PHQ-9 scores > 10 were used to classify participants as having signs of depressive symptoms. Subjects were further stratified by gender (Manuscript 1 and 3) and cortisol responses (Manuscript 2). Cardiometabolic health measures included 24-hour blood pressure, metabolic syndrome markers, neuroendocrine markers [cortisol and 3-methoxy-4-hydroxy-phenylglycol (MHPG)], left ventricular hypertrophy (LVH),inflammatory and haemostatic markers (fibrinogen, C-reactive protein, plasminogen activator inhibitor-1 and D-dimer). Resting 12-lead ECG Cornell Product-Left ventricular hypertrophy (CP-LVH) was measured as a marker of target end-organ damage and cardiovascular dysfunction (Manuscript 1 and 2). Means and prevalence were computed through t-test and Chi-square analysis respectively. Significant differences of mean cardiometabolic measures between depressive symptom status groups were also determined by analysis of covariance (adjusted for traditional cardiovascular risk factors and additional factors as specific per manuscript). Multivariate analysis was used to demonstrate associations between left ventricular hypertrophy (LVH) and cardiometabolic markers in Africans with depressive symptoms (Manuscript 1 and 2) and a logistic regression analysis were performed to examine the association between depressive symptoms and inflammatory/haemostatic factors (Manuscript 3). All subjects who participated gave informed consent, the study was approved by the Ethics Committee of North-West University (NWU-0003607S6), in accordance with the principles outlined by the World Medical Association Declaration of Helsinki of 1975 (revised 2008). Results and conclusions of the individual manuscripts - The aim of the study was to investigate the associations between depressive symptoms and cardiometabolic function including cardiovascular dysfunction. Markers of cardiometabolic function assessed were 24 hour blood pressure measurements, metabolic syndrome markers, neuroendocrine markers [cortisol and 3-methoxy-4-hydroxy-phenylglycol (MHPG)], inflammatory and haemostatic variables (fibrinogen, C-reactive protein, plasminogen activator inhibitor-1 and D-dimer). Manuscript 1, focused on LVH as a marker of cardiovascular dysfunction and metabolic syndrome components as markers of cardiometabolic function. The aim of the study was to assess the associations between LVH and metabolic syndrome (MetS) risk markers in participants with and without depressive symptoms. Results revealed that in African men with depressive symptoms the most significant determinants of LVH were systolic blood pressure (SBP) and the percentage glycosylated haemoglobin (HbA1c). While in African women (with depressive symptoms), this association was determined by low high-density lipoprotein (HDL-cholesterol). The study concluded that in black African men, independent of depressive symptoms, cardiometabolic factors (namely SBP and HbA1c) may be the driving significant factors in the development of cardiovascular diseases. Furthermore, the data showed that depressive symptoms in African women were associated with a measure of target end organ damage, and that this association was driven by a metabolic factor. Manuscript 2, the aim of this manuscript was to examine the relationship between depressive symptoms, neuroendocrine responses [with cortisol and 3-methoxy-phenylglycol (MHPG) as markers] and cardiovascular risk, i.e. LVH. The results revealed that Africans with depressive symptoms demonstrated blunted cortisol and MHPG levels in response to acute mental stress, in comparison to those without symptoms of depression. Additionally, these low cortisol and blunted MHPG responses were associated with LVH in this ethnic group. The conclusion for this manuscript was that, blunted neuroendocrine responses linked depressive symptoms and ECG left ventricular hypertrophy in Africans. When coupled to their hypertensive status, these vasoconstrictive responses (cortisol and MHPG) may underpin the increased long-term depression and vascular disease risk in urban Africans. Manuscript 3, the aim of this manuscript was to investigate the relationship between depressive symptoms and inflammatory/haemostatic markers in a cohort of urban-dwelling black African men and women. Our data demonstrated hypercoagulation vulnerability in African men with depressive symptoms. The African men with signs of depression displayed higher plasminogen activator inhibitor (PAI-1) levels and marginally elevated D-dimer levels. It was concluded that hypercoagulation may partially be the mediating factor between depressive symptoms and cardiovascular risk in African men; a situation that may be exacerbated by hyperkinetic blood pressure. In conclusion, through the assessement of cardiometabolic function and neuroendocrine responses, it seems that Africans withdepressive symptoms are at great risk for cardiovascular related morbidity and mortality, this was particulary evident in the African men (Manuscript 1 and 3). Additionally, it appears that blunted neuroendocrine responses and hypercoagulation could be seen as possible cardiovascular risk markers in Africans with depressive symptoms. / PhD (Physiology), North-West University, Potchefstroom Campus, 2014

Motivation - Depression is a mental disorder that has been associated with cardiovascular morbidity and mortality in the Western world. Cardiometablic mechanisms have been implicated as possible intermediating factors in the relationship between depressive symptoms and cardiovascular disease; however this has not yet been determined in black Africans (hereafter referred to as Africans). Aim - The overarching aim of this study was to investigate the relationship between depressive symptoms and cardiometabolic risk. We therefore aimed to assess cardiometabolic function, neuroendocrine responses, inflammatory and haemostatic markers in Africans with depressive symptoms compared to those without symptoms of depression. Methodology - Manuscripts presented in Chapter 2, 3 and 4 utilised data from the cross-sectional, target population multi-disciplinary “Sympathetic activity and Ambulatory Blood Pressure in Africans” (SABPA) study. The participants comprised of 200 African teachers from the Dr Kenneth Kaunda District in North-West province, South Africa. As cardiovascular disease is compromised by a positive HIV status, 19 participants were excluded from further statistical analysis. Stratification was based on the Patient Health Questionnaire 9-item (PHQ-9), which has been validated in a sub-Saharan African setting. PHQ-9 scores > 10 were used to classify participants as having signs of depressive symptoms. Subjects were further stratified by gender (Manuscript 1 and 3) and cortisol responses (Manuscript 2). Cardiometabolic health measures included 24-hour blood pressure, metabolic syndrome markers, neuroendocrine markers [cortisol and 3-methoxy-4-hydroxy-phenylglycol (MHPG)], left ventricular hypertrophy (LVH),inflammatory and haemostatic markers (fibrinogen, C-reactive protein, plasminogen activator inhibitor-1 and D-dimer). Resting 12-lead ECG Cornell Product-Left ventricular hypertrophy (CP-LVH) was measured as a marker of target end-organ damage and cardiovascular dysfunction (Manuscript 1 and 2). Means and prevalence were computed through t-test and Chi-square analysis respectively. Significant differences of mean cardiometabolic measures between depressive symptom status groups were also determined by analysis of covariance (adjusted for traditional cardiovascular risk factors and additional factors as specific per manuscript). Multivariate analysis was used to demonstrate associations between left ventricular hypertrophy (LVH) and cardiometabolic markers in Africans with depressive symptoms (Manuscript 1 and 2) and a logistic regression analysis were performed to examine the association between depressive symptoms and inflammatory/haemostatic factors (Manuscript 3). All subjects who participated gave informed consent, the study was approved by the Ethics Committee of North-West University (NWU-0003607S6), in accordance with the principles outlined by the World Medical Association Declaration of Helsinki of 1975 (revised 2008). Results and conclusions of the individual manuscripts - The aim of the study was to investigate the associations between depressive symptoms and cardiometabolic function including cardiovascular dysfunction. Markers of cardiometabolic function assessed were 24 hour blood pressure measurements, metabolic syndrome markers, neuroendocrine markers [cortisol and 3-methoxy-4-hydroxy-phenylglycol (MHPG)], inflammatory and haemostatic variables (fibrinogen, C-reactive protein, plasminogen activator inhibitor-1 and D-dimer). Manuscript 1, focused on LVH as a marker of cardiovascular dysfunction and metabolic syndrome components as markers of cardiometabolic function. The aim of the study was to assess the associations between LVH and metabolic syndrome (MetS) risk markers in participants with and without depressive symptoms. Results revealed that in African men with depressive symptoms the most significant determinants of LVH were systolic blood pressure (SBP) and the percentage glycosylated haemoglobin (HbA1c). While in African women (with depressive symptoms), this association was determined by low high-density lipoprotein (HDL-cholesterol). The study concluded that in black African men, independent of depressive symptoms, cardiometabolic factors (namely SBP and HbA1c) may be the driving significant factors in the development of cardiovascular diseases. Furthermore, the data showed that depressive symptoms in African women were associated with a measure of target end organ damage, and that this association was driven by a metabolic factor. Manuscript 2, the aim of this manuscript was to examine the relationship between depressive symptoms, neuroendocrine responses [with cortisol and 3-methoxy-phenylglycol (MHPG) as markers] and cardiovascular risk, i.e. LVH. The results revealed that Africans with depressive symptoms demonstrated blunted cortisol and MHPG levels in response to acute mental stress, in comparison to those without symptoms of depression. Additionally, these low cortisol and blunted MHPG responses were associated with LVH in this ethnic group. The conclusion for this manuscript was that, blunted neuroendocrine responses linked depressive symptoms and ECG left ventricular hypertrophy in Africans. When coupled to their hypertensive status, these vasoconstrictive responses (cortisol and MHPG) may underpin the increased long-term depression and vascular disease risk in urban Africans. Manuscript 3, the aim of this manuscript was to investigate the relationship between depressive symptoms and inflammatory/haemostatic markers in a cohort of urban-dwelling black African men and women. Our data demonstrated hypercoagulation vulnerability in African men with depressive symptoms. The African men with signs of depression displayed higher plasminogen activator inhibitor (PAI-1) levels and marginally elevated D-dimer levels. It was concluded that hypercoagulation may partially be the mediating factor between depressive symptoms and cardiovascular risk in African men; a situation that may be exacerbated by hyperkinetic blood pressure. In conclusion, through the assessement of cardiometabolic function and neuroendocrine responses, it seems that Africans withdepressive symptoms are at great risk for cardiovascular related morbidity and mortality, this was particulary evident in the African men (Manuscript 1 and 3). Additionally, it appears that blunted neuroendocrine responses and hypercoagulation could be seen as possible cardiovascular risk markers in Africans with depressive symptoms. / PhD (Physiology), North-West University, Potchefstroom Campus, 2014

Objectif: La dépression est un problème fréquent chez les personnes atteintes de dégénérescence maculaire liée à l’âge (DMLA) et de rétinopathie diabétique (RD). Les antidépresseurs et les thérapies psychologiques sont souvent sous utilisés. Notre objectif était de déterminer si les outils d’auto-soins associés au support téléphonique limité pouvaient réduire les symptômes dépressifs. Méthodes: Un essai clinique randomisé à simple insu a été mené à l’Hôpital Maisonneuve Rosemont, Canada. Tous les patients éligibles étaient invités à participer à l’essai. Pour être éligibles, les participants devaient 1) avoir un diagnostic de DMLA avancée ou de RD, 2) au moins des symptômes dépressifs moyens et 3) une acuité visuelle meilleure que 20/200 dans leur meilleur oeil. Une moitié des participants était randomisée au bras d’intervention et l’autre moitié à l’intervention retardée/traitement usuel. L’intervention était composée d’outils audio et écrits en gros caractères, incluant des principes cognitifs comportementaux plus trois appels téléphoniques d’un coach d’une durée de 10 minutes chacun. Les données de suivi étaient collectées huit semaines plus tard, par téléphone. L’issu primaire était le changement de symptômes dépressifs à huit semaines, mesuré par le questionnaire sur la santé du patient, PHQ-9. Résultats: Quatre-vingts participants, âgés de 50 ans et plus ont été recrutés, dont 70 ayant des données complètes et 10 perdus de vue (12.5%). Le score moyen du iv PHQ-9 à l’inclusion était de 9.5 (SD=3.9) indiquant des symptômes dépressifs modérés. La réduction moyenne du score de PHQ-9 au terme du suivi était de 4.9 (SD=4.2) dans le groupe d’intervention et de 3.2 (SD=4.6) dans le groupe de traitement usuel, soit une différence intergroupe de 1.7 point (p=0.104). Après avoir contrôlé pour les disparités observées à l’inclusion notamment pour l’acuité visuel, l’utilisation des antidépresseurs et la participation à la psychothérapie, cette différence est passée de 1.7 à 2.3 et est devenue statistiquement significative (p=0.037). Soixante pourcent des participants du groupe d’intervention ont rapporté avoir utilisé les outils d’auto-soins au terme de l’étude ou de l’exploitation des données Conclusion: Les outils d’auto-soins accompagnés de support téléphonique conduisent à une petite amélioration des symptômes dépressifs chez les patients atteints de pathologies oculaires liées à l’âge. Des recherches additionnelles ciblant les meilleures stratégies pour soutenir les patients déprimés atteints de maladies oculaires liées à l’âge sont nécessaires. / Purpose: Depression is a common problem in people with age-related macular degeneration (AMD) and diabetic retinopathy (DR). Antidepressants and psychotherapy are often underutilized. Our goal was to determine if self-care tools plus limited telephone support could reduce depressive symptoms. Methods: A single-blind randomized controlled clinical trial was conducted at Maisonneuve-Rosemont Hospital in Montreal, Canada. All eligible patients were invited to participate in the trial. To be eligible, participants must have had either late stage AMD or DR, at least mild depressive symptoms, and visual acuity better than 20/200 in their better eye. Half were randomized to the intervention arm and half to delayed intervention/usual care. The intervention consisted of large print written and audio tools incorporating cognitive-behavioral principles plus three 10-minute telephone calls from a coach. Eight-week follow-up data were collected by telephone. The primary outcome was the 8-week change in depressive symptoms as measured by the Patient Health Questionnaire (PHQ-9). Results: Eighty participants, aged 50 years and older, were recruited while 10 were lost to follow-up (12.5%) giving 70 with complete data, 35 in each group. The mean baseline PHQ-9 score was 9.5 out of 27 (SD=3.9) indicating moderate depressive symptoms. The average decrease in PHQ-9 scores over the 8 weeks was 4.9 (SD=4.2) in the intervention group and 3.2 (SD=4.6) in the usual care group, a 1.7 point difference (P=0.104). After adjusting for baseline imbalances in visual acuity, ii antidepressant use, and participation in psychotherapy, the difference increased from 1.7 to 2.3 and became statistically significant (p=0.037). Sixty percent of those in the intervention group reported having used the tools at the end of the study. Conclusions: Self-care tools plus telephone coaching led to a small improvement in depressive symptoms in patients with age-related eye disease. Additional research into the best way to support depressed patients with age-related eye disease is necessary.

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Submitted by SBI Biblioteca Digital (sbi.bibliotecadigital@puc-campinas.edu.br) on 2017-04-28T13:57:07Z No. of bitstreams: 1 CARLA FABIANA CARLETTI PESSOTTI.pdf: 1686396 bytes, checksum: cae4805c98f9d020da8253219f182a5e (MD5) / Made available in DSpace on 2017-04-28T13:57:08Z (GMT). No. of bitstreams: 1 CARLA FABIANA CARLETTI PESSOTTI.pdf: 1686396 bytes, checksum: cae4805c98f9d020da8253219f182a5e (MD5) Previous issue date: 2017-02-07 / Introduction: The longevity of the population results in a natural increase in the prevalence of diseases associated with aging, such as dementias, according to the current classification of DSM 5 (2013); dementias are in the Major Cognitive Disorder category; Occur in several pathological conditions, has characteristic the multiple development of cognitive deficits with impairments in basic and instrumental activities of daily living (AIVD/AVD), and specific care is required. In Brazil, caring for family/caregivers is common. The objective of this study was to describe the quality of life and the burden of family/caregivers of patients with dementia; analyze and compare the relationships between quality of life and the caregiver's burden. Procedures: 50 family/caregivers (GFC) and 50 patients with dementia (GDM) corresponding to family/caregivers were studied. In the GFC were evaluated sociodemographic aspects, quality of life, burden, depressive symptoms, religiosity index and resilience through the Qvd-DA instruments; Burden Interviw, BDI, PDUREL and Resilience Scale. In the GDM, sociodemographic, cognitive, neuropsychiatric and AIVD/AVD aspects were evaluated through the MEEM, INP, Semantic Verbal Fluency Test, Clock Drawing Test and DAD. The data were analyzed, related and compared between GFC, GDM, GDA and GNDA. Statistical tests were used with significance level p <0.05. Results: GFC predominated in the female gender (88%), mainly daughters (54%) and wives (32%), most married, with a mean age between 50 and 60 years and 8 years of schooling, years and 19 hours per day on average. GDM had a homogeneous distribution between genders, with a predominance of AD (68%), married (44%) and widowers (52%), above 70 years of age (78%), 82% of the patients had some kind of income. The GFC presented moderate burden, without depressive symptoms, high intrinsic religiosity index with daily practices of individual religious rituals and regular attendance to religious institutions, high perception of quality of life and high resilience index. Regarding severity of cognitive and neuropsychiatric impairment, GDA patients presented better performance than GNDA patients. Conclusion: The task of caring for patients with dementia is costly; the findings suggest that family/caregivers adapt to the situation they have experienced; they have shown moderate burden; minimal depressive symptoms; engagement in religious practices; high perception of quality of life and high resilience response to different situations. Family/caregivers with depressive symptoms presented greater perception of burden, lower resilience response, greater perception of quality of life impairment and greater intrinsic religiosity. Those who had greater resilience responses had a lower occurrence of depressive symptoms, a lower perception of burden, and a higher perception of a better quality of life. This data indicates that caregivers with resilience responses have fewer depressive symptoms. / Introdu??o: A longevidade da popula??o traz como decorr?ncia natural o aumento na preval?ncia de doen?as associadas ao envelhecimento como as dem?ncias, de acordo com a classifica??o atual do DSM 5 (2013), as dem?ncias est?o na categoria Transtorno Cognitivo Maior, ? uma s?ndrome que pode ocorrer em diversas condi??es patol?gicas, tem como caracter?stica o desenvolvimento m?ltiplo de d?ficits cognitivos com preju?zos em atividades b?sicas e instrumentais da vida di?ria (AIVD/AVD), sendo necess?rios cuidados espec?ficos. No Brasil ? comum os cuidados por familiares/cuidadores. O objetivo deste estudo foi descrever qualidade de vida e sobrecarga de familiares/cuidadores de pacientes com dem?ncia; analisar e comparar as rela??es entre qualidade de vida e sobrecarga do cuidador. Casu?stica e procedimentos: Foram estudados 50 familiares/cuidadores (GFC) e 50 pacientes com dem?ncia (GDM) correspondentes aos familiares/cuidadores. No GFC foram avaliados aspectos sociodemogr?ficos, qualidade de vida, sobrecarga, sintomas depressivos, ?ndice de religiosidade e resili?ncia atrav?s dos instrumentos Qvd-DA; Burden Interviw, BDI, PDUREL e Escala de Resili?ncia. No GDM foram avaliados aspectos sociodemogr?ficos, cognitivos, neuropsiqui?tricos e AIVD/AVD atrav?s dos instrumentos MEEM, INP, Teste de Flu?ncia Verbal Sem?ntica, Teste do Desenho do Rel?gio e DAD. Os dados foram analisados, relacionados e comparados entre os GFC, GDM, GDA e GNDA. Foram utilizados testes estat?sticos com n?vel de signific?ncia p< 0,05. Resultados: GFC predominou o g?nero feminino (88%), principalmente filhas (54%) e esposas (32%), a maioria casada, com idade m?dia entre 50 e 60 anos e com 8 anos de escolaridade, tarefa de cuidar h? 4 anos e 19 horas di?rias em m?dia. GDM houve distribui??o homog?nea entre g?neros, acima dos 70 anos (78%) com predom?nio na DA (68%), casados (44%) e vi?vos (52%), 82% dos pacientes possu?am algum tipo de renda. GFC apresentou sobrecarga moderada, sem sintomas depressivos, elevado ?ndice de religiosidade intr?nseca com praticas di?rias de rituais religiosos individuais e frequ?ncia regular a institui??es religiosas, elevada percep??o de qualidade de vida e alto ?ndice de resili?ncia. Quanto ? gravidade do comprometimento cognitivo e neuropsiqui?trico, os pacientes do GDA apresentaram melhor desempenho do que pacientes do GNDA. Conclus?o: A tarefa de cuidados ? pacientes com dem?ncia ? onerosa, os achados sugerem adapta??o dos familiares/cuidadores ? situa??o vivenciada, demonstraram sobrecarga moderada; sintomas depressivos m?nimos; engajamento em pr?ticas religiosas; elevada percep??o de qualidade de vida e elevada resposta de resili?ncia frente ?s diversas situa??es. Familiares/cuidadores com sintomas depressivos apresentaram maior percep??o de sobrecarga, menor resposta de resili?ncia, maior percep??o de comprometimento da qualidade de vida e maior religiosidade intr?nseca. Aqueles que possu?am maiores respostas de resili?ncia, apresentaram menor ocorr?ncia de sintomas depressivos, menor percep??o de sobrecarga e conseq?ente maior percep??o de melhor qualidade de vida. Esse dado indica que cuidadores com respostas de resili?ncia apresentam menos sintomas depressivos.