Individuals under 20 years old have the highest risk of developing type 1 diabetes because their beta cells are destroyed at a faster rate than any other age group. Previous studies have looked at delaying and slowing down the rate of beta cell destruction through the use of anti-CD3 antibody treatments. Specifically, Teplizumab and Otelixizumab drug therapies have been used to treat individuals within 12 weeks of diagnosis. Previous studies done with Teplizumab and Otelixizumab have focused on individuals between 12 and 40 years old; however, there is little research done the effects of these treatments on individuals under 12 years old. Since type 1 diabetes is primarily diagnosed in children the purpose of this proposal is to further the knowledge of the preservation of beta cells in children with the use of Teplizumab and Otelixizumab drugs over 2 years. This study will also focus on the delay of onset type 1 diabetes with the use of Teplizumab in high-risk individuals under 20 years of age. The high-risk individuals will be determined by using genetic screening on individuals with an affected immediate family member. Individuals will also be tested to see if they carry insulin autoantibodies (IAA), protein tyrosine phosphate-related IA-2 molecule (IA-2A), islet cell antibodies (ICA), and glutamic acid decarboxylase (GADA). Individuals that test positive for carrying the DR3/DR4 alleles in the genetic screening and that have two or more autoantibodies present in their immune systems will be selected to participate. The purpose of this proposal is to further understand the impact of anti-CD3 antibody treatment on young individuals diagnosed with type 1 diabetes and to further understand if treatment in young individuals with anti-CD3 antibodies can delay or prevent the onset of type 1 diabetes.

The creative destruction of existing industries as a consequence of discontinuous technological change is a central theme in the literature on industrial innovation and technological development. Established competence-based and market-based explanations of this phenomenon argue that incumbents are seriously challenged only by ‘competence-destroying’ or ‘disruptive’ innovations, which make their existing knowledge base or business models obsolete and leave them vulnerable to attacks from new entrants. This paper challenges these arguments. With detailed empirical analyses of the automotive and gas turbine industries, we demonstrate that these explanations overestimate the ability of new entrants to destroy and disrupt established industries and underestimate the capacity of incumbents to perceive the potential of new technologies and integrate them with existing capabilities. Moreover, we show how intense competition in the wake of technological discontinuities, driven entirely by incumbents, may instead result in late industry shakeouts. We develop and extend the notion of ‘creative accumulation’ as a way of conceptualizing the innovating capacity of the incumbents that appear to master such turbulence. Specifically, we argue that creative accumulation requires firms to handle a triple challenge of simultaneously (a) fine-tuning and evolving existing technologies at a rapid pace, (b) acquiring and developing new technologies and resources and (c) integrating novel and existing knowledge into superior products and solutions. / Knowledge Integration and Innovation in Transnational Enterprise

Anno 2013 Europe resides in a severe economic crisis that has been lasting for five years. Companies are struggling to deal with the influences of this crisis and require strategic insights to maintain performance. According to theory entrepreneurship and innovation are central mechanisms in the creation of wealth in the capitalist system and an entrepreneurial strategy could provide relatively much benefit in a crisis period. This study focuses on the central question:  How does an entrepreneurial orientation affect the performance of companies in the economic crisis? To answer this question a variety of theories on entrepreneurship, innovation and the creation of wealth in capitalism were examined. On many occasions quantitative research has been performed to measure the relationship between an entrepreneurial orientation and performance. This study provides an extra dimension by using archival financial data of companies during and before the crisis to draw comparisons and examine developments in performance in relation to an entrepreneurial orientation. Data on the entrepreneurial orientation was collected with an online survey which was sent to companies. The results of the survey indicated the degree of entrepreneurial orientation of the companies in separate categories; innovativeness, proactiveness and risk taking. The results were linked to their financial performance which was obtained from a database. Comparisons between the performance before and during the crisis in relation to the scores on entrepreneurship were made, and the development of their financial performance since the crisis was examined. The results of this study indicate that an entrepreneurial orientation has a relatively more positive influence on performance during the crisis. However the relationship between an entrepreneurial orientation and performance is highly dependent on the company and type of industry so no unilateral positive correlations with performance were found. For a set of industrial, manufacturing, chemical and service companies the development of the financial performance since the crisis is highly positively correlated with innovativeness and proactiveness. For a set of other company types including foundations, (public) utility companies, (public) real estate companies, construction companies, trade and investment firms no correlations were found. The findings in this study indicate that depending on the type of company and industry, an entrepreneurial orientation can have a strong positive effect on the development of financial performance in the crisis.

This study assesses the relationship between planning and creative destruction in the village of Creemore, Ontario. The study has four objectives. The first is to describe the evolution of tourism in Creemore by tracking change in three variables: investment, visitor numbers and resident attitudes. Second, is to describe past and present tourism planning in the village. Third, is to assess Creemore’s position in the model of creative destruction, based on information presented in objectives one and two. The final objective is to provide recommendations for Creemore’s future based on information gained from the other objectives. To investigate the first objective, entrepreneurial investment was provided by secondary sources, including the Creemore Business Improvement Association (BIA). Visitor numbers were obtained from content analyses of copies of the local newspaper and from information provided by the Creemore Springs Brewery. Resident attitudes were gleaned from a survey completed by 126 residents of Creemore. To meet the second objective, a content analysis was completed on historic issues of the local newspaper and six key informant interviews were conducted. Based on the information provided from the first two objectives, it is concluded that Creemore is in the second stage of Mitchell’s (1998) model of creative destruction, Advanced Commodification. This conclusion is drawn since visitor numbers and investment levels are still low and resident attitudes are generally positive towards tourism. It is also concluded that tourism planning plays a large role in creative destruction, as it can speed up, or slow down, the process, depending on the types of planning that are implemented. Based on the findings of this study, it is recommended that a tourism plan be developed to help mitigate possible future negative impacts of tourism, and to ensure the village does not evolve any further along the path of creative destruction.

The intent of this study is to determine if the process of creative destruction is underway in a rural community located in Newfoundland and Labrador and to identify why this development sequence has or has not occurred. Three objectives underlie this study. The first is to determine at what stage Ferryland is situated in the Model of Creative Destruction. The second is to explain the community’s current stage in the model. The third objective is to provide recommendations for this community on its future development potential. These objectives were fulfilled through data collection that included: participant observation, content analysis of newspapers, and a review of relevant documents, key informant interviews, and resident and visitor surveys. This mixed method study concluded that the community of Ferryland is in the stage of advanced commodification in Mitchell’s (2009) Model of Creative Destruction. Three reasons are identified for its current state. First, the community lacks a tourism champion. Secondly, human capital shortage in Ferryland has created a lack of workers. Lastly, the actions of local stakeholders are not driven solely by the motivations outlined by Mitchell (2009). They are also underlain by the desire for pleasure; a motivation that does not appear to have encouraged fast-paced development. Furthermore, Ferryland is a community on a much smaller scale, which may have lessened perceived impacts and scale of development. Based on these conclusions, it is recommended that the Ferryland Tourism Committee creates a long-term plan for tourism that incorporates opinions of local residents.

This study assesses the relationship between planning and creative destruction in the village of Creemore, Ontario. The study has four objectives. The first is to describe the evolution of tourism in Creemore by tracking change in three variables: investment, visitor numbers and resident attitudes. Second, is to describe past and present tourism planning in the village. Third, is to assess Creemore’s position in the model of creative destruction, based on information presented in objectives one and two. The final objective is to provide recommendations for Creemore’s future based on information gained from the other objectives. To investigate the first objective, entrepreneurial investment was provided by secondary sources, including the Creemore Business Improvement Association (BIA). Visitor numbers were obtained from content analyses of copies of the local newspaper and from information provided by the Creemore Springs Brewery. Resident attitudes were gleaned from a survey completed by 126 residents of Creemore. To meet the second objective, a content analysis was completed on historic issues of the local newspaper and six key informant interviews were conducted. Based on the information provided from the first two objectives, it is concluded that Creemore is in the second stage of Mitchell’s (1998) model of creative destruction, Advanced Commodification. This conclusion is drawn since visitor numbers and investment levels are still low and resident attitudes are generally positive towards tourism. It is also concluded that tourism planning plays a large role in creative destruction, as it can speed up, or slow down, the process, depending on the types of planning that are implemented. Based on the findings of this study, it is recommended that a tourism plan be developed to help mitigate possible future negative impacts of tourism, and to ensure the village does not evolve any further along the path of creative destruction.

The intent of this study is to determine if the process of creative destruction is underway in a rural community located in Newfoundland and Labrador and to identify why this development sequence has or has not occurred. Three objectives underlie this study. The first is to determine at what stage Ferryland is situated in the Model of Creative Destruction. The second is to explain the community’s current stage in the model. The third objective is to provide recommendations for this community on its future development potential. These objectives were fulfilled through data collection that included: participant observation, content analysis of newspapers, and a review of relevant documents, key informant interviews, and resident and visitor surveys. This mixed method study concluded that the community of Ferryland is in the stage of advanced commodification in Mitchell’s (2009) Model of Creative Destruction. Three reasons are identified for its current state. First, the community lacks a tourism champion. Secondly, human capital shortage in Ferryland has created a lack of workers. Lastly, the actions of local stakeholders are not driven solely by the motivations outlined by Mitchell (2009). They are also underlain by the desire for pleasure; a motivation that does not appear to have encouraged fast-paced development. Furthermore, Ferryland is a community on a much smaller scale, which may have lessened perceived impacts and scale of development. Based on these conclusions, it is recommended that the Ferryland Tourism Committee creates a long-term plan for tourism that incorporates opinions of local residents.

In this essay i argue that there are three different variables that may be able to control the outcome of certain foreign policy choices. These three variables are External Threats, government division and public opinion. The Essay also tries to identify former president Bush motives behind the 2003 Iraqi War. It is partly argued that the three variables had a certain amount of influence on Bush decision making process. But the main focus lies on the motives behind the attack. There are several official motives identifies through different types of statements from different members of the elite group, the main motives being the threat that the Bush administration felt the former Iraqi president Saddam Hussein was responsible for and of course weapons of mass destruction, as you will notice while you read this essay there are more but in some way smaller motives that doesn't take as much place as the threat and WMD aspects.

In an event of a radiological dispersion device (RDD) detonated by terrorists in a high population density area, the hospitals and other medical facilities will be overwhelmed by people who may or may not have been contaminated by radioactivity. Under such circumstances, it would be desirable to identify people who have inhaled radioactive particles and direct them immediately for further treatment. A portable 3 by 3 NaI detector, which is widely available at most universities, was studied as a tool to identify and calculate the activity of unknown radioisotopes for such an RDD event.

The presence of metaphorical language in Charles Darwin's On the Origin of Species has been the source of much debate, particularly in the interaction between Darwin's theory and the Christian faith. The metaphorical language used to describe "nature," "evolution," "natural theology," and "natural selection" is examined?within Christianity prior to Darwin, in Darwin's writing of the Origin, and in the responses of three Victorian Christian critics of science. "Natural selection" and "evolution" had metaphorical meanings prior to Darwin's use of these terms. "Nature" was a highly metaphysical concept, described by the metaphor of natural theology. "Evolution" was associated with epic understandings of human progress. The metaphor of natural theology was particularly important to the faith of Western Christians by the time of Darwin. In order to better understand the role of natural theology, the theories of metaphor developed by Kenneth Burke in "Four Master Tropes" and by George Lakoff and Mark Johnson in Metaphors We Live By are compared. This comparison results in the development of an expansion of Lakoff and Johnson's metaphor theory, a model termed experienced metaphor. This model is used to explain Victorian Christians' emotional adherence to natural theology. Many of the interpreters of Darwin's work, both secular and Christian, saw natural selection as a rival to natural theology. The works of three prominent Victorians who attempted to defend natural theology against the apparent onslaughts of science are evaluated for additional metaphorical language regarding nature and evolution. Philip Gosse, G. K. Chesterton, and Charles Spurgeon each produced counter-metaphors to defend natural theology?metaphors of awe/wonder and of sin/destruction. The rhetorical effects of these counter-metaphors promote the rejection of Darwin's theory of evolution. The counter-metaphors identified are still in circulation within the debate over Darwin and Christianity today. The presence of metaphor in this debate deserves greater attention, in order to understand how metaphor affects the thinking of both Christian and secular audiences regarding Darwinian evolution.