Thesis advisor: Larry H. Ludlow / Item Response Theory (IRT) is a contemporary measurement technique which has been used widely to model testing data and survey data. To apply IRT models, several assumptions have to be satisfied. Local item independence is a key assumption directly related to the estimation process. Many studies have been conducted to examine the impact of local item dependence (LID) on test statistics and parameter estimates in large-scale assessments. However, in the heath care field where IRT is experiencing greater popularity, few studies have been conducted to study LID specifically. LID in the health care field bears some unique characteristics which deserve separate analysis. In health care surveys, it is common to see several items that are phrased in a similar structure or items that have a hierarchical order of difficulties. Therefore, a Guttman scaling pattern, or a deterministic response pattern, is observed among those items. The purposes of this study are to detect whether the Guttman scaling pattern among a subset of items exhibit local dependence, whether such dependence has any impact on test statistics, and whether these effects differ when different IRT models are employed. The score-based approach - forming locally dependent dichotomous items into a polytomous testlet - is used to accommodate LID. Results from this dissertation suggest that the Guttman scaling pattern among a subset of items does exhibit moderate- to high-degree of LID. However, the impact of this special LID is minimal on internal reliability estimates and on the unidimensional data structure. Regardless of which models are employed, the dichotomously-scored person ability estimates are highly correlated with the polytomously-scored person ability estimates. However, the impact of this special LID on test information differs between Rasch models and non-Rasch models. Specifically, when only Rasch models are involved, test information derived from the LID-laden data is underestimated for non-extreme scores; whereas, when non-Rasch models are used, the opposite finding is reached –that is, LID tends to overestimate test information. / Thesis (PhD) — Boston College, 2008. / Submitted to: Boston College. Lynch School of Education. / Discipline: Educational Research, Measurement, and Evaluation.

Human immunodeficiency virus (HIV) and substance abuse (drug and/or alcohol) independently impair the immune system; importantly, the combination of HIV infection and substance abuse might produce more than an additive effect on this system. Tumor necrosis factor-alpha (TNF-?) and Interferon gamma (IFN?) are pro-inflammatory cytokines involved in differentiation of Th0 cells into Th1 cells. Interleukin 4 (IL-4) and Interleukin 10 (IL-10) are anti-inflammatory cytokine involved in differentiation of Th0 cells to Th2 cells. Unbalanced Th1 and Th2 cells can lead to immune suppression. Thus, changes in these cytokines could have important implications for people infected with HIV (HIV+). Resistance training can counteract muscle wasting, improve strength, and improve muscle mass. The purpose of this study was to examine the effect of resistance training on resting concentrations of circulating TNF-?, IFN-?, IL-4, and IL-10. Sixteen men (42 ± 11 years, 180.4 ± 9.1 cm, 89.2 ± 20.7 kg) infected with HIV and enrolled in an intensive 60-day in-patient substance addiction/abuse treatment program were recruited shortly after admission to the treatment facility. Participants were assigned to one of two groups using randomization: supervised resistance exercise 3 times per week using a progressive and non-linear periodized program (Exercise) or no exercise training (Non-Exercise) for six weeks. Before (Pre) and after (Post) the 6-week period, resting and fasted blood samples were obtained and analyzed for serum TNF-?, IFN-?, IL-4, and IL-10 concentrations using a high-sensitivity ELISA. TNF-? did not change following the 6-week period for Exercise (Pre: 4.8 ± 2.7 pg·ml-1; Post: 4.6 ± 2.4 pg·ml-1) or Non-Exercise (Pre: 3.0 ± 1.3 pg·ml-1; Post: 2.7 ± 0.8 pg·ml-1). IFN-?, IL-4, and IL-10 concentrations were below detectable limits. No adverse effects of the intervention were reported. A six-week resistance training program does not elicit changes in circulating TNF-? concentrations in men infected with HIV and undergoing an intensive in-patient substance addiction/abuse treatment program. Concentrations of IFN-?, IL-4, IL-10 were below detectable levels. Six weeks of resistance training was not sufficient to affect circulating TNF-?, nor enough to increase concentrations of IFN-?, IL-4, IL-10 to detectable levels. The lack of adverse effects shows that adding resistance training to the current in-patient treatment regimen for substance abuse among men infected with HIV is safe.

Orientador: Ercy Mara Cipulo Ramos / Banca: Dionei Doffinger Ramos / Banca: Mariangela Macchione / Resumo: Introdução: A exposição ao cigarro promove alterações que prejudicam a eficácia do transporte mucociliar. Contudo, a influência da intensidade de exposição, assim como os efeitos da abstinência ao tabagismo sobre essas alterações foram pouco elucidados. Objetivos: Avaliar a influência de diferentes intensidades de exposição ao cigarro sobre o transporte mucociliar e o efeito da cessação do tabagismo sobre o transporte mucociliar nasal em fumantes avaliados durante um período de 180 dias. Casuística e Métodos: Participantes de um programa de cessação ao tabagismo, foram avaliados quanto ao histórico tabagístico, ao nível de dependência à nicotina, à avaliação da função pulmonar (espirometria), a concentração de monóxido de carbono no ar exalado (COex), ao nível de carboxihemoglobina (COHb) e ao transporte mucociliar (tempo de trânsito de sacarina - TTS). Para comparação foi avaliado um grupo... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Introduction: Exposure to cigarette smoke promotes changes that harm the effectiveness of the mucociliary clearance. However, the influence of the intensity of exposure, as well as the effects of abstinence from smoking on these changes is poorly understood. Objectives: To assess the influence of different intensities of exposure to cigarette smoke on mucociliary clearance and the effect of cessation of smoking on nasal mucociliary clearance in smokers evaluated over a period of 180 days. Methods: Participants from a smoking cessation programme, were evaluated about smoking behavior, level of nicotine dependence, lung function (spirometry), the carbon monoxide in exhaled air (exhaled CO), the carboxyhemoglobin (COHb) and mucociliary clearance (saccharin transit time - STT). Was evaluated for comparison... (Complete abstract click electronic access below) / Mestre

Condition-dependent sexual selection has the potential to align natural and sexual selection and accelerate adaptation. When the expression of a sexually selected trait is constrained by the condition of the bearer, it offers a reliable signal of quality on which females can base mate choice decisions. Individuals with highly expressed sexually selected traits are therefore expected to possess advantageous genes given the prevailing environmental conditions. Such genes can then spread by their naturally selected benefits as well as their sexually selected advantages, thereby accelerating adaptation. I investigate the effect of condition-dependent traits on mating and signalling behaviour to explore the potential for alignment between natural and sexual selection in the wild. By studying a wild population of the field cricket, Gryllus campestris, I explore condition-dependent sexual selection in a natural context. This avoids some limitations of laboratory studies, which may overestimate effects in the absence of natural and environmental variation. I employ a direct experimental test of the effect of condition on sexually selected traits and mating success, finding that while male acoustic signals are condition-dependent, modest increases in calling effort do not result in increased mating success. I investigate the effect of body size on mating success and find mating success to be independent of body size. I explore the possibility of condition- and context-mediated flexibility in mate-searching tactics, finding that while population density influences tactic choice, individual condition is unlikely to predict which tactic a male will adopt. Finally, I consider the role of female condition in sexual selection and find that mating latency in females is not condition-dependent, but that mating history has an important effect on female choosiness.

This thesis defends an account of what it is to trust other people, and what gives matters of trust a characteristic interpersonal or normative importance to us. Trust is an attitude of the trust stance; a more general attitude we take toward others in matters of trust, that includes distrust. Matters of trust are situations we trust/distrust others in. I put forward an account of the trust stance, that explains why matters of trust have interpersonal importance to us. Chapter 1 introduces the key questions to be addressed by the account. I outline how trust can be tied to specific actions, but can also be a general attitude we have about a person, or people. I set out how trust is standardly conceived as an anticipatory/predictive attitude, that also involves interpersonal import. That import is glimpsed in the possibility of betrayal by those we trust, and I point toward existing accounts of betrayal. I present arguments against accounts of trust that take it to be purely predictive, i.e. those of the rational choice/game-theoretic tradition. Chapter 2 introduces the dominant philosophical view of trust, which holds that to trust is to rely on another, such that we can be betrayed by her. I call this the Reliance plus (REL+) view. I offer a critical overview of three prominent REL+ accounts, from Baier (1986), Holton (1994), and Hawley (2014). I illustrate how an account of distrust that Hawley endorses, of betrayable non-reliance on another, results from REL+. Chapter 3 presents an argument against REL+. I argue it cannot allow for the possibility of uncertainty about another, where uncertainty is a trust stance attitude between trust and distrust. Uncertainty is possible, so REL+ must be false. Chapter 4 presents another argument against REL+. The argument is that distrust cannot be a product of non-reliance, so REL+ must be false. I argue that REL+ fails because it ignores a distinction between two senses of 'trust': an activity of reliance, and a mental state of assurance. Distrust is only an attitude of wariness, opposed to assurance, rather than reliance. I defend the claim that reliance requires practical dependence on what is relied on. I build upon in this claim in the next chapter. Chapter 5 defends an account of reliance as an activity, in support of the active/stative trust distinction from chapter 4. I evaluate Smith's (2010) account of reliance, which endorses practical dependence. I argue that Smith's account faces a dilemma, showing the account is either incomplete, or that it renders reliance impossible. I defend a 'role placement in activity' account of reliance, that avoids the dilemma. Chapter 6 defends a distinction between reliance and dependence in general. Where reliance involves practical dependence, I argue that dependence is a matter of fundamentally needing something as a matter of functioning and wellbeing. My account of the concept comes into play in chapter 8. Chapter 7 sets out a more detailed account of the stative trust stance attitudes. I use the active/stative distinction to address a question over whether we can trust voluntarily, and the relation between specific and general trust. I set out the concept of a situational vulnerability, that the trust stance attitudes are about, and which can result from reliance on another. I defend an account of the trust stance as a rolling schema: an anticipatory framework that involves interpreting another's motives toward us, in respect of situations of vulnerability. Chapter 8 argues that the interpersonal import of trust is a product of our felt need for secure attachments to individuals, and to belong to a group. I explain the relationship between social dependence on others and betrayability.

Orientador: Carlos Roberto Padovani / Resumo: Sabe-se que a época de plantio de determinadas culturas é dependente da ocorrência de chuva e das condições de temperatura e, também, que estas épocas variam de região para região. Muitos estudos, utilizando procedimentos clássicos de estatística para analisar como a temperatura afeta o crescimento de plantas e a produção de grãos na agricultura, já foram realizados no Brasil. Este trabalho apresenta uma alternativa para analisar valores de temperatura média do ar envolvendo distribuição espacial dos dados. Assim, com o objetivo de construir o mapeamento climático do Estado do Paraná por meio de uma técnica eficiente, simples e acurada (Geoestatística), foram utilizados dados obtidos pelo Instituto Agronômico do Paraná - IAPAR, coletados diariamente em 33 estações agrometeorológicas. A Geoestatística considera as associações entre amostras vizinhas através de sua geometria, ou seja, da localização das amostras no campo e detecta se existe influência de uma amostra sobre a outra, de acordo com a distância entre elas. As técnicas geoestatísticas de interpolação que se baseiam nessas associações entre amostras vizinhas, podem estimar com eficiência valores em locais não amostrados. A existência de dependência espacial é detectada pelo variograma (ou pelo covariograma). As análises permitiram concluir pela existência de dependência espacial na temperatura média do ar para os meses de janeiro e julho e o modelo esférico foi o que melhor expressou esta dependência espacial. As estimativas de temperatura em pontos não amostrados (um quadriculado com 50 colunas e 35 linhas, totalizando 1750 pontos sobre o Estado) foram obtidas através da técnica de interpolação Krigagem Universal e os mapas, comparados com os existentes no IAPAR, apresentaram-se eficientes, mesmo não considerando a variável altitude como variável auxiliar. / Abstract: It is well known that sowing periods for some crops depend on rain and temperature conditions, and that the harvesting period may vary from region to region. Several studies on the effect of temperature on plants and grain production have been carried out in Brazil, using classic statistical procedures. This study offers an alternative for the analysis of mean air temperature values involving spatial data distribution. Data from 33 agrometeorological stations, collected daily by IAPAR (Agronomical Institute of Paraná, Brazil), were used to generate climatic maps for the state, adopting an efficient, simple and accurate technique (Geostatistics). Geostatistics takes into consideration the associations among neighboring samples through its geometry, i.e., the location of samples in the field, and detects the influence of one sample over the other according to the distance between them. Interpolation geostatistical techniques based on these associations among neighboring samples allows to estimating values for non-sampled locations efficiently. The existence of spatial dependence is detected by the variogram or covariance function. Data from the geostatistical analysis showed spatial dependence in the atmospheric mean temperature for the months of January and July which was best expressed by the spherical model. Temperature estimates from non-sampled points (a square with 50 columns and 35 lines, totaling 1750 points around the state) were obtained by the Universal Kriging interpolation technique, and the mappings were more efficient compared to those from Caviglione et al. (2000), even when altitude was considered an auxiliary variable. / Doutor

Alcoholism is a devastating chronic relapsing disorder with significant costs to individuals and society. The mesolimbic dopamine (DA) system plays an important role in regulating reward and addiction. GABA neurons located in the ventral tegmental area (VTA) regulate VTA DA neuron activity, and are a relevant target for alcohol in the brain. VTA GABA neurons exhibit marked hyperexcitability during withdrawal from ethanol. Past research has demonstrated that the motivational effects of opiates cause a change in VTA GABA(A) receptors in opiate-dependent animals, which switch from a GABA-induced hyperpolarization of GABA neurons to a GABA-induced depolarization. The focus of this study was to characterize excitatory and inhibitory synaptic activity in VTA GABA neurons during withdrawal from acute and chronic alcohol, and to evaluate the function of the GABA(A) receptor in the pathway to dependence. Animals were either given injections of ethanol or saline, or were kept in ethanol vapor or air chambers for three weeks. We used standard whole-cell, perforated patch, and cell-attached mode electrophysiological techniques and pharmacology to obtain recordings of cellular activity. Results for excitatory and inhibitory synaptic events were somewhat mixed and inconclusive. There is evidence for a shift in function of the GABA(A) receptor after exposure to ethanol. We found that after a single injection of ethanol (4.0 g/kg) or a chronic intermittent ethanol vapor exposure, VTA GABA neuron firing rate is less sensitive to muscimol's inhibitory effects. The neural substrates of addiction studied here are important steps in the road to alcohol dependence, and a better understanding of them may lead to novel therapies.

Un changement de pH peut induire une modification des propriétés chimiques et physiques des molécules, par exemple leur interaction avec la lumière. La modélisation de tels phénomènes est complexe en raison de l’ensemble statistique des états de protonation microscopiques et de la nature quantique de la propriété étudiée. Dans cette thèse, nous présentons un protocole de calcul qui associe une méthode capable d'échantillonner à la fois ces micro-états et les changements structuraux à un pH donné, et un cadre traitant la partie pertinente de la macromolécule avec des traitements avancés de mécanique quantique et le reste du système avec la mécanique moléculaire classique. Nous rapportons également la validation de ce protocole sur le relativement petit peptide M et son application à la rhodopsine sensorielle d'Anabaena, une protéine microbienne. Nous avons pu révéler quels sont les acides aminés titrables responsables du spectre d'absorption dépendant du pH de cette biomolécule / A change in the pH can modify the chemical and physical properties of molecules such as the way they interact with light. Modeling such phenomena is complex, because of the statistical ensemble of microscopic protonation states and of the very quantum nature of the property of interest. In this thesis, we present a computational protocol which merges a method capable of sampling at the same time these microstates and the structural changes at a given pH, and a framework treating the relevant portion of the macromolecule with advanced quantum mechanics treatments and the rest of the system with classical molecular mechanics. We also report the validation of this protocol on the relatively small peptide M and its application to the anabaena sensory rhodopsin, a microbial protein. We have revealed which are the titratable amino-acids responsible for the pH-dependent absorption spectrum of this biomolecule

I argue that, if God exists, moral facts ontologically depend on him. After distinguishing a variety of ways in which moral facts might ontologically depend on God, I focus my attention on the most prominent and most well-developed account of the relationship between God and morality viz., the account developed by Robert Adams in his Finite and Infinite Goods. Adams’ account consists of two parts—an account of deontic moral properties and an account of axiological moral properties. Adams’ account of deontic moral properties is a version of divine command theory according to which the property of being morally right (obligatory) and the property of being morally wrong are identical to the property of being commanded by God and the property of being forbidden by God, respectively. I argue that although Adams’ divine command theory is not vulnerable to many prominent objections that afflict other versions of divine command theory, his view is, nevertheless, both unmotivated and implausible. Next, I explain Adams’ account of axiological properties, which is a particular version of what I call “theistic valuational particularism.” According to Adams’ theistic valuational particularism, the property of being intrinsically good or excellent is identical to the property of faithfully and holistically resembling God. I argue that because Adams’ conception of excellence is so broad, there are some things that have the property of being excellent but fail to resemble God. I argue that the same problem afflicts other, modified versions of theistic valuational particularism, including one that is defended by Scott Hill and another that is championed by Mark Murphy. Nevertheless, I argue that this problem does not afflict what I call “theistic moral valuational particularism,” the view that moral goodness is identical to the property of resembling God in certain, specified ways. Furthermore, I argue that, if God exists, theistic moral valuational particularism is not only well motivated theologically, but it can withstand the two most prominent objections that have been lodged against it, viz., the arbitrariness objection and the divine ascription problem.

There is growing research evidence and public concern over the burgeoning of disorders which share common features with substance addictions. In order to investigate the presence and role of addiction features in disorders outside of substance addictions, symptoms of addiction were explored within three addiction groups: alcohol dependence (AD), an established addiction (n = 24); pathological gambling (PG) a disorder with growing empirical support as an addiction (n = 20); and compulsive shopping (CS), a proposed 'novel' addiction(n = 20). Participants were recruited from either the general population, or from the Auckland Salvation Army Bridge residential alcohol and drug treatment programme; Salvation Army Oasis Gambling Service; Pacific Peoples Addiction Service Incorporated; or Te Kahui Hauora O Ngati Koata Trust. Participants completed a battery of self-report measures comprising a demographics questionnaire; Addictive Disorder Questionnaire (ADQ); anxiety and depression subscales of the Symptom Checklist 90 Revised (SCL-90R); Barratt Impulsivity Scale II-r; and substance specific adaptations of the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Three general categories of addiction symptoms: physiological, salience and dyscontrol, were identified as broad aspects of addiction, common across all three groups. Measurable aspects of addiction, including impulsivity, obsessions, anxiety and depression were found to be endorsed similarly across the three addictions, irrespective of the severity of their addiction. Compulsions were found to be higher in the AD group. Higher anxiety was found to be correlated with higher addiction in the behavioural addictions (CS and PG), whereas depression and anxiety were associated with higher addiction severity in the AD group. The results provide support for broadening addiction diagnostic definitions, to be more encompassing of the psychological and physiological experiences of each symptom; and developing different diagnostic categories for non-substance addictions that reflect the severity of the addiction. Results also provide evidence for developmental phases of addiction, from an early 'hedonistic' impulsive phase, to a compulsive phase, in which increased dyscontrol, mood and anxiety, marks the severity of the addiction.