Thesis (Ph. D.)--University of North Texas, Dec., 2007. / Title from title page display. Includes bibliographical references.

Univ., Diss.--Frankfurt am Main, 2002.

Thesis (Ph. D.)--Hong Kong University of Science and Technology, 2004. / Includes bibliographical references (leaves 120-131). Also available in electronic version. Access restricted to campus users.

Thesis (Ph.D.)--Hong Kong University of Science and Technology, 2005. / Includes bibliographical references (leaves 107-111). Also available in electronic version.

Thesis (M.S.) -- Worcester Polytechnic Institute. / Keywords: Finite Difference; Pricing; C++. Includes bibliographical references (leaf 21).

Thesis (Ph. D.)--University of Washington, 2000. / Vita. Includes bibliographical references (leaves 265-302).

This thesis is regarded with the biomimetic total synthesis of phenolic natural products and describes two different projects. Chapter 1 introduces phenolic natural products, the most important biosynthetic pathways for their formation and some examples of relevant biomimetic syntheses. A short introduction to dimeric and pseudo-dimeric natural products can also be found in this chapter. Specific introductions can be found at the start of Chapters 2 and 3. Chapter 2 describes the total synthesis of a dimeric thymol derivative isolated from Arnica sachalinensis (which we have named “thymarnicol”). Inspired by the biosynthesis proposed by Passreiter and co-workers, we tested and confirmed the feasibility of a key hetero-Diels–Alder dimerisation step. During our investigations, we gained significant new insights into the origin and reactivity of thymarnicol. The final oxidative cyclisation has been found to occur spontaneously upon exposure to visible light in air. Chapter 3 discusses our efforts to develop a divergent biomimetic synthetic strategy towards a family of prenylated phenylpropanoid natural products isolated from Illicium genus plants. Our first biomimetic approach revealed the chemical instability of our proposed key intermediates. Therefore, a revised approach was trialled, allowing the total synthesis of a small set of natural products and related structures. We envisage that this strategy could be exploited by accessing a large number of members of this family of compounds.

Made available in DSpace on 2014-06-11T19:22:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2005-12-23Bitstream added on 2014-06-13T19:08:15Z : No. of bitstreams: 1 faria_fa_me_ilha.pdf: 449416 bytes, checksum: 5b125946a1b6572f4afaf42155ca56f0 (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Este trabalho aborda técnicas de controle em sistemas lineares realimentados com a derivada dos estados. Apresenta-se uma nova técnica de alocação de pólos, de forma que a resposta do sistema em malha fechada atenda alguns índices de desempenho. O projeto para o controlador é desenvolvido na forma de LMIs. Esse tipo de projeto é mais flexível no tratamento de robustez. Porém, é bem complicado inserir restriçõesi clássicas de índice de desempenho em LMIs. Para resolver essa situação usa-se o conceito de estabilidade regional (ou D-estabilidade) de sistemas. São apresentadas condições necessárias e suficientes para a D-estabilidade de sistemas lineares, realimentados com a derivada dos estados. Também são encontradas condições de suficiência para a D-estabilidade em sistemas com incertezas politópicas nos parâmetros. Apresenta-se a analogia que existe entre LMIs para sistemas com incertezas politópicas e LMIs para sistemas variantes no tempo. A eficiência da metodologia apresentada é avaliada através da solução de exemplos numéricos. / This work focuses control techniques in linear systems using only state-derivative feed- back. It presents new techniques for pole-placement, where the transient response of a linear system is specified by design constraints. The design of the controller is described in LMI framework. This framework is more exible on the design of robust systems. However, it is more difficulty to incorporate classical design constraints in LMIs. The problem is solved using D-stability concept. We proposed necessary and sufficient condi- tions for D-stability of linear system using state derivative feedback. Are also proposed sufficient conditions to uncertain linear system and time-varying systems with bounded parameters. The validity and applicability of this approach are illustrated by examples.

Submitted by ANDERSON RAFAEL ALVES null (andersonalves02@yahoo.com.br) on 2018-03-01T22:07:19Z No. of bitstreams: 1 Dissertação de Mestrado_Limites e Derivadas Uma abordagem para o Ensino Médio_Anderson Rafael Alves.pdf: 3324802 bytes, checksum: 0140974ce85a7cb7cb712209d9717277 (MD5) / Rejected by Maria Marlene Zaniboni null (zaniboni@bauru.unesp.br), reason: Solicitamos que realize correções na submissão seguindo as orientações abaixo: 1) FALTA ATA DA DEFESA - Inserir a Ata da Defesa após a ficha catalográfica. Agradecemos a compreensão. on 2018-03-02T17:57:29Z (GMT) / Submitted by ANDERSON RAFAEL ALVES null (andersonalves02@yahoo.com.br) on 2018-03-02T22:12:20Z No. of bitstreams: 1 Dissertação de Mestrado_Anderson Rafael Alves.pdf: 3183005 bytes, checksum: dd3a546bd4060a939884307089ec4870 (MD5) / Approved for entry into archive by Maria Marlene Zaniboni null (zaniboni@bauru.unesp.br) on 2018-03-05T16:11:12Z (GMT) No. of bitstreams: 1 alves_ar_me_bauru.pdf: 3183005 bytes, checksum: dd3a546bd4060a939884307089ec4870 (MD5) / Made available in DSpace on 2018-03-05T16:11:12Z (GMT). No. of bitstreams: 1 alves_ar_me_bauru.pdf: 3183005 bytes, checksum: dd3a546bd4060a939884307089ec4870 (MD5) Previous issue date: 2018-02-19 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Nesta dissertação abordamos os conceitos básicos de algumas funções elementares, limites, continuidade, além do conceito de derivada e sua aplicabilidade. Esse material apresenta uma formação sólida no que diz respeito aos pré-requistos necessários para um aluno do ensino médio ingressar num curso superior, em que o mesmo trabalhará, eventualmente, com aspectos relacionados ao Cálculo. Como uma proposta didática introduziremos os conceitos de limite e derivada utilizando ferramentas computacionais, neste, caso o software GeoGebra e apresentação em Beamer. / In this dissertation we will study the basic concepts of some elementary functions, limits, continuity, beyond the concept of derivative and it applicability. This material will present a solid training regarding the prerequisites required for a high school student to enter an upper course where he will eventually work with aspects related to Calculus. As a didactic proposal we will introduce the concepts of limits and derivative using computational tools, in this case GeoGebra software and Beamer presentation. / Não consta

Made available in DSpace on 2014-06-11T19:29:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-03-20Bitstream added on 2014-06-13T19:58:59Z : No. of bitstreams: 1 ribeiro_apd_me_arafo.pdf: 10016445 bytes, checksum: 54f364c1faa5066e22a82916fe0e1ac2 (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / Para considerar a Terapia Fotodinâmica (PDT) como tratamento clínico da estomatite protética, é necessário conhecer tanto o potencial antifúngico, como efeito citotóxico desta terapia sobre células normais do indivíduo. Assim, o objetivo desse estudo in vitro foi avaliar a citotoxicidade da PDT antifúngica com o fotossensibilizador Photogem® associado ao LED azul e ao LED vermelho em cultura de fibroblastos L929 e células odontoblastóides MDPC-23. As células foram cultivadas (30.000 células/cm2) em placas de 24 compartimentos por 48 horas e ambos os tipos celulares foram incubados com Photogem® (0, 10, 25, 50, 100 ou 150 mg/L) e irradiados ou não pelo LED azul (460 ± 3 nm; 25,5 ou 37,5 J/cm2; 22 mW/cm2) ou LED vermelho (630 ± 3 nm; 70 ou 100 J/cm2; 25 mW/cm2) . O metabolismo celular foi determinado 0, 12 e 24 horas após a PDT utilizando o teste do metiltetrazolium (MTT), e a morfologia celular avaliada pela microscopia eletrônica de varredura (MEV). A técnica de citometria de fluxo foi utilizada para avaliar o tipo de morte celular (necrose ou apoptose) assim como estimar os níveis intracelulares das espécies reativas de oxigênio (EROs). Observou-se redução do metabolismo celular estatisticamente significante para todas as concentrações do Photogem® quando irradiadas em qualquer dose de luz, sendo essa redução de 90 a 97% tanto para as células L929 quanto MDPC-23 (ANOVA and Dunnet’s post hoc tests; p<0.05). Essa redução da atividade mitocondrial não foi dependente da concentração do fotossensibilizador e nem da dose de luz empregada. Também, foi demonstrado que a atividade mitocondrial das células submetidas a PDT não foi recuperada após 12 ou 24 horas, caracterizando um dano irreversível. A presença do Photogem® e da luz isoladamente não alterou estatisticamente a atividade mitocondrial de ambas as linhagens. As células submetidas... / In order to consider the photodynamic therapy (PDT) as a clinical treatment for candidosis, it is necessary to know its antifungal potential and its cytotoxicity effect on normal cells. Therefore, the purpose of this in vitro study was to evaluate the cytotoxicity of PDT with Photogem® associated to blue and red LED on L929 and MDPC-23 cell cultures. The cells (30.000 cells/cm2) were seeded in 24-well plates for 48 hours, incubated with Photogem® (10, 25, 50, 100 or 150 mg/L) and were irradiated or not with a blue LED source (460 ± 3 nm; 25.5 or 37.5 J/cm2; 22 mW/cm2) or with a red LED source (630 ± 3 nm; 75 or 100 J/cm2; 22 mW/cm2). Cell metabolism was evaluated by the MTT assay (ANOVA and Dunnet’s post hoc tests; p<0.05) and cell morphology was examined by scanning electron microscopy. Flow cytometry was employed to analyze the type of PDT-induced cell death (necrosis or apoptosis) as well as to estimate intracellular production of reactive oxygen species (ROS). There was a statistically significant decrease of mitochondrial activity for all Photogem® concentrations associated to blue or red LED regardless irradiation time; this reduction ranged from 90 to 97% for both cell lines. This reduction, however, was not dependent on the photosensitizer concentration. It was also demonstrated that the mitochondrial activity of the cells submitted to PDT was not recovered after 12 or 24 hours, characterizing irreversible cell damage. PDT-treated cells presented an altered morphology with ill-defined limits. In both cell lines, there was a predominance of necrotic cell death when in contact with the photosensitizer. The presence of Photogem® and exposure to blue and red LED increased the intracellular levels of ROS in both L929 and MDPC- 23 cells in a dose-dependent manner. The association of Photogem® and blue LED caused severe toxic effects on normal cell culture... (Complete abstract click electronic access below)