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The primary goal of this dissertation is to determine the relationship between the effects of tourism and stakeholders' quality of life. Specifically, the research investigates stakeholders' perception of the impact of tourism on their life domains, their satisfaction with life domains, and their overall life satisfaction. The relationships among these three components are examined. Depending on the types of stakeholders, their perceptions of and attitudes toward the impact of tourism and quality of life might be different. Therefore, the moderating effect of stakeholders' perceptions of the impact of tourism in life domains and satisfaction with life domains is investigated. Accordingly, the study proposes three research questions: (1) Does the perception of tourism impact in life domains affect satisfaction with different life domains? (2) Does satisfaction with life domains affect overall QOL? (3) Does the perspective of different stakeholders have a moderating effect on the relationship between the perception of tourism impacts in life domains and satisfaction with life domains? The sample population of stakeholders residing in Hawaii, Virginia, Orlando (FL), Las Vegas (NV), and New York City (NY) was surveyed. Four hundred seven usable questionnaires were subjected to data analysis. Structural equation modeling (SEM) and hierarchical multiple regression (HMR) were performed to test the hypotheses.     The results revealed that the stakeholders' perception of the impact of tourism in the material life domain did affect their material life domain satisfaction. This study also indicated that their satisfaction with the material and non-material life domains significantly influenced their overall quality of life. The hypothesized moderating effects of the perspective of different stakeholders on the relationship between the perception of the impact of tourism in material/non-material life domain and the material/non-material life satisfaction were supported. / Ph. D.

Retiring from work is a major personal and professional transition and has a major influence on one's life. It is imperative that these retired individuals endeavor to adjust to this life and change and learn to effectively manage their time. Tourism and gerontology researchers have been aware of the importance of seniors tourism and leisure activities to enhance their well-being. However, limited attention has been recently devoted to senior consumers, who are still often not included in a range of marketing practices in tourism studies. Therefore, this dissertation focuses on senior tourists who are over the age of 65 and retired, and mainly focuses on a senior's travel motivation, and examines the antecedents of travel motivation; personal values and travel constraints and their consequences; satisfaction with salient life domains of QoL, and overall QoL. The sample population of seniors residing in Jeju, South Korea was surveyed. A final sample of 328 were subjected to data analysis. Structural equation modeling (SEM), Chi-square difference test, independent t-tests, and multi-group analysis were performed to test the hypotheses. The findings of this dissertation revealed that a positive relationship between personal values and travel motivation of seniors. This means that if the senior tourists with strong personal values, then they are more motivated to go travel. On the other hand, travel constraints did have negative significant influence on travel motivation. Another finding of the study showed that travel motivation affect their satisfaction with different life domains; if they are highly motivated, they are more satisfied with their life domains including family, social, emotional, leisure and health life, which in turn contribute to their overall quality of life. Findings also indicated that statistical significance of the moderating effect in the model, thus suggesting that there were some meaningful moderating effects of the type of leisure activity patterns on the relationship between satisfaction with life domains and overall quality of life. The study also provided managerial implications for tourism marketers and destination managers. / Ph. D.

Dans le contexte du « Tout Electrique », les fabricants de l’aéronautique cherchent à augmenter la puissance embarquée tout en limitant la masse de ces dispositifs électriques. Une des solutions envisagées est d’augmenter la densité de flux magnétique des matériaux magnétiques de ces appareils. L’inconvénient de l’emploi de ces matériaux réside dans leurs déformations sous l’effet du champ magnétique. Dans le cas des noyaux magnétiques de transformateurs, ceux-ci sont composés d’un empilement d’une centaine de tôles magnétiques d’épaisseur variant entre 0,2 et 0,5mm. La déformation successive des tôles du transformateur est à l’origine d’un bruit acoustique indésirable. La source principale de ces déformations est la magnétostriction qui provient du réarrangement sous champ magnétique de la structure en domaines du matériau. Dans le cadre de ces travaux de thèse, nous nous intéressons à l’alliage Fe-27%Co produit par la société APERAM Alloys Imphy, commercialement appelé AFK1. Le choix de cet alliage provient du fait qu’il présente une aimantation à saturation la plus élevée de tous les matériaux ferromagnétiques (2,4T). Son emploi permettrait alors un gain certain de densité de puissance. Selon une gamme métallurgique particulière, l’AFK1 présente une basse magnétostriction isotrope, qui s’illustre par une déformation nulle jusqu’à 1,5T puis par une déformation à saturation de l’ordre de 10ppm. L’objectif principal de ces travaux de thèse consiste à déterminer l’origine d’un tel comportement et les mécanismes associés. Les résultats expérimentaux montrent que les conditions de traitements thermiques semblent avoir un effet sur le comportement magnétostrictif. On montre par ailleurs que la magnétostriction est indépendante de l’orientation cristallographique de l’AFK1. Des essais de magnétostriction sous contrainte mécanique ont permis de supposer que l’AFK1 disposait d’une structure en domaines principalement composée de parois à 180°. La mise en place de cette structure a pu être confirmée par microscopie magnéto-optique (effet Kerr). Afin de mieux comprendre l’origine de l’orientation des domaines dans le matériau, l’influence de la géométrie d’échantillon sur le comportement magnétostrictif a également été étudiée au cours de ces travaux de thèse. Une modélisation du comportement faiblement magnétostrictif a finalement été proposée par le biais d’une approche multi-échelle. Le modèle met en évidence la nécessité de considérer une proportion non négligeable de domaines séparés par des parois à 180° pour restituer la basse magnétostriction de l’AFK1. / The main challenge in the aeronautical field concerns the increase of higher power density electrical devices onboard aircrafts. One of the solutions proposed is to increase the magnetic flux density of magnetic materials which compose these devices. The main drawback of this solution leads in the high deformation the materials concerned exhibit under magnetic field. For example, the core of onboard transformers is composed of a stack of about hundred of magnetic steel sheets, with a thickness range between 0.2 and 0.5mm. The deformation of the entire structure leads to an unwanted acoustic noise that originates from the high magnetostriction deformation of the material deriving from the change of magnetic domains configuration under magnetic field. In this thesis work, the magnetostrictive behaviour of the Fe-27$%$Co alloy is studied. This magnetic alloy is produced and marketed by APERAM Alloys Imphy as AFK1. This material leads to a low and isotropic magnetostrictive behaviour after an appropriate metallurgical process. The deformation is null up to 1.5T and the magnetic saturation is reached with a deformation lower than 10ppm. The main goal of this thesis is to understand the origin of the low magnetostrictive behaviour and to model it. The experimental results show that thermal annealing changes significantly the magnetostriction. In addition, we prove that low magnetostriction exhibits no crystallographic orientation dependence. Magnetostriction tests carried out under a mechanical loading show that a microstructure mainly composed magnetic domains separated by 180$^circ$ domain walls can explain the behaviour. The presence of this magnetic configuration was confirmed by magneto optical microscopy observations (Kerr effect) associated with a macroscopic geometry effect and residual magnetic field in the furnaces. A multiscale modeling of the low magnetostriction has been proposed next. This modeling helps us to confirm the requirement of about 80% of grains composed of a bi-domain magnetic structure to simulate low magnetostrictive behaviour in accordance with experiments.

The subject of this thesis is outdoor mathematics education for pupils aged 11- 15 in the con- text of the city of Pilsen. The main aim was to design a series of outdoor mathematics activities for lower secondary education students. A reference is made to the space within the Framework Educational Programme for Basic Education for the use of interdisciplinary integration and cross-curricular links, for which outdoor learning can be suitable. The work summarizes the findings on motivation, identifies the specifics of mathematics as a teaching subject and highlights the constructivist principles of teaching in the context of the results of the Czech School Inspectorate's investigation into mathematics.The most important barriers and benefits of outdoor education are summarised here as well as its conception and a few of the readily available sources of inspiration for outdoor mathematics for lower secondary education pupils. The designed activities described in the practical part of the thesis are tailored to specific locations of the city of Pilsen. They refer to the expected outcomes of the Framework Educational Programme for Basic Education and combine the selected mathematical topics into one piece together with the chosen outdoor environ- ment. The thesis highlights the positives of outdoor...

京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第18546号 / 医博第3939号 / 新制||医||1006(附属図書館) / 31446 / 京都大学大学院医学研究科医学専攻 / (主査)教授 武田 俊一, 教授 松田 文彦, 教授 小松 賢志 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DGAM

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<p dir="ltr">Loneliness is a perceived discrepancy between desired and experienced social relationships, which may arise from perceived lack of intimate attachment to another person (e.g., friend) or lack of involvement in larger networks (e.g., peer groups). The current study examined and compared how different aspects of friendship and peer group involvement predicted loneliness of Indonesian adolescents. Participants were 754 twelfth-grade Indonesian students (413 girls, mean age = 16.5 years). Loneliness was self-reported. Reciprocated friendships were calculated from within-grade nominations and friendship quality was obtained from ratings pertaining to each nominated friend. Peer groups were generated from Social Cognitive Mapping (SCM) and status indices were calculated from SCM and peer nominations. A concurrent SEM model was tested where quantity and self- and friend-perceived quality of friendship, group membership (i.e., within-group centrality), and status of the group in the larger network (i.e., group centrality status and group popularity status) predicted loneliness. All predictors had unique negative effects on loneliness with generally similar effect sizes except for friend-perceived friendship quality. An interaction between within-group centrality and group popularity status was found for boys. The results revealed that quantity and quality of friendship as well as position in the peer group and the status of the peer group were associated with loneliness. Being central in a group may be more important for those in low-status groups than high-status groups. Group-related indices were comparable to friendship indices as predictors of loneliness, which may be shaped by Indonesian culture where group involvement is valued more than intimate friendships.</p>

Yes / Immunotherapy treatments can be essential sometimes and a waste of valuable resources in other cases, depending on the diagnosis results. Therefore, researchers in immunotherapy need to be updated on the current status of research by exploring: application domains e.g. warts, datasets e.g. immunotherapy, classifiers or algorithms e.g. kNN and software tools. The research objectives were: 1) to study the immunotherapy-related published literature from a supervised machine learning perspective. In addition, to reproduce immunotherapy classifiers reported in research papers. 2) To find gaps and challenges both in publications and practical work, which may be the basis for further research. Immunotherapy, diabetes, cryotherapy, exasens data and ”one unbalanced dataset” are explored. The results are compared with published literature. To address the found gaps in further research: novel experiments, unbalanced studies, focus on effectiveness and a new classifier algorithm are suggested.

Background: The exponential growth of the aging population makes research on reversing frailty increasingly important. Objective: To explore the concept of reversing frailty in older adults and identify existing interventions that achieve frailty reversal as an outcome. Methods: We used a five-stage scoping review methodology outlined by Arksey and O’Malley and enhanced by Joanna Briggs, Levac, and colleagues. We critically appraised all eligible studies and synthesized data using descriptive and narrative analyzes. We searched CINAHL, EMBASE, PubMed, and Web of Science. Results: The concept of reversing frailty seems complex, and no standard intervention exists.That notwithstanding, a few types of single- or multi-component intervention characteristics showed effectiveness in reversing frailty. Conclusion: Frailty can be reversed. However, concept analysis is needed to clarify and define reverse frailty. To ensure maximum effectiveness, the identified interventions, ranging from mostly physical activity to a combination of physical activity and nutrition, could be tailored to each individual’s needs.