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SAMMANFATTNINGSyfte: Att med kvantitativa metoder försöka finna faktorer som kan förklara skillnaderna i mängd antibiotikaförskrivning mellan tandläkare i Skåne och Västerbotten i Sverige.Metod: I denna utredande demografiska studie, gjordes en initial sökning i databasen Pubmed för att finna kvantitativa faktorer som påverkar tandläkares antibiotikaförskrivning. Statistiska uppgifter hämtades sedan från olika svenska register och tolkades för resultatet.Resultat: Ingen enskild faktor som undersöktes kunde förklara den högre förskrivningen av antibiotika som ses i Skåne. Resultaten stödjer hypotesen att det inte finns någon kvantitativ faktor som kan förklara Skånes förskrivning av antibiotika. Slutsats: Skillnader i mängd ordinerad antibiotika mellan de två regionerna i Sverige kunde inte förklaras genom att undersöka de kvantitativa faktorerna som använts i denna studie. Skillnader i förskrivning är troligen ett resultat av kvalitativa faktorer och fler studier inom området efterfrågas.Nyckelord: antibiotika, förskrivning, tandvård, Sverige / ABSTRACTAim: With quantitative methods try to find factors able to explain the differences in antibiotic prescription between dentists in Skane and Vasterbotten in Sweden.Methodology: In this investigating demographic study, a database (Pubmed) search was initially made to find factors affecting antibiotic prescription by dentists. Statistical data from various Swedish registers was then extracted and interpreted for the results.Results: No single factor investigated was able to explain the higher antibiotic prescribing seen in Skane. The results did not support the hypothesis that Skane have more acute dental treatments and surgery and therefore also have a demand for a more extensive antibiotic prescribing. Infact the relationship was reversed between Skane and Vasterbotten. Conclusion: Differences in amount prescribed antibiotics between the different regions I Sweden could not be explained investigating the quantitative factors used in this study. Differences in prescribing are more likely the result of qualitative factors and more studies are requested.Keywords: antibiotics, dental, prescribing, Sweden

Yes / Patients' pharmacogenetic data could be used to improve adherence to antipsychotic medication by increasing the likelihood of therapeutic response and reducing the prevalence of adverse drug reactions.

Yes / Background: The place of opioids in the management of chronic, non-cancer pain is limited. Even so their use is escalating, leading to concerns that patients are prescribed strong opioids inappropriately and alternatives to medication are under-used. We aimed to understand the processes which bring about and perpetuate long-term prescribing of opioids for chronic, non-cancer pain. Methods: We held semi-structured interviews with patients and focus groups with general practitioners (GPs). Participants included 23 patients currently prescribed long-term opioids and 15 GPs from Leeds and Bradford, United Kingdom (UK). We used a grounded approach to the analysis of transcripts. Results: Patients are driven by the needs for pain relief, explanation, and improvement or maintenance of quality of life. GPs’ responses are shaped by how UK general practice is organised, available therapeutic choices and their expertise in managing chronic pain, especially when facing diagnostic uncertainty or when their own approach is at odds with the patient’s wishes. Four features of the resulting transaction between patients and doctors influence prescribing: lack of clarity of strategy, including the risk of any plans being subverted by urgent demands; lack of certainty about locus of control in decision-making, especially in relation to prescribing; continuity in the doctor-patient relationship; and mutuality and trust. Conclusions: Problematic prescribing occurs when patients experience repeated consultations that do not meet their needs and GPs feel unable to negotiate alternative approaches to treatment. Therapeutic short-termism is perpetuated by inconsistent clinical encounters and the absence of mutually-agreed formulations of underlying problems and plans of action. Apart from commissioning improved access to appropriate specialist services, general practices should also consider how they manage problematic opioid prescribing and be prepared to set boundaries with patients. / National Institute for Health Research (NIHR) under its Research for Patient Benefit Programme (Grant Reference Number PB-PG- 1010–23041).

Yes / Background In the United Kingdom, nurses and pharmacists who have undertaken additional post-registration training can prescribe medicines for any medical condition within their competence (non-medical prescribers, NMPs), but little is known about patients' experiences and perceptions of this service. Objective to obtain feedback from primary care patients on the impact of prescribing by nurse independent prescribers (NIPs) and pharmacist independent prescribers (PIPs) on experiences of the consultation, the patient–professional relationship, access to medicines, quality of care, choice, knowledge, patient-reported adherence and control of their condition. Design Two cross-sectional postal surveys. Setting and participants Patients prescribed for by either NIPs or PIPs in six general practices from different regions in England. Results 30% of patients responded (294/975; 149/525 NIPs; 145/450 PIPs). Most said they were very satisfied with their last visit (94%; 87%), they were told as much as they wanted to know about their medicines (88%; 80%), and felt the independent prescriber really understood their point of view (87%; 75%). They had a good relationship with (89%; 79%) and confidence in (84%; 77%) their NMP. When comparing NMP and doctor prescribing services, most patients reported no difference in their experience of care provided, including access to it, control of condition, support for adherence, quality and safety of care. Discussion and conclusions Patients had positive perceptions and experience from their NMP visit. NMPs were well received, and patients' responses indicated the establishment of rapport. They did not express a strong preference for care provided by either their non-medical or medical prescriber. / Policy Research Programme in the Department of Health

No / Aim. To determine the adequacy of initial nurse independent prescribingeducation and identify continuing professional development and clinicalgovernance strategies in place for non-medical prescribing.Background. In 2006, new legislation in England enabled nurses with anindependent prescribing qualification to prescribe, within their competence. In 2006,non-medical prescribing policies released by the Department of Health outlinedthe recommendations for education, continuing professional development andgovernance of non-medical prescribing; however, there was no evidence on a nationalscale about the exte nt of implementation and effectiveness of these strategies.Design. National surveys of: (i) nurse independent prescribers; and (ii) non-medical prescribing leaders in England.Methods. Questionnaire surveys (August 2008–February 2009) coveringeducational preparation, prescribing practice (nurse independent prescribers) andstructures/processes for support and governance (non-medical prescribing leaders).Results. Response rates were 65% (976 prescribers) and 52% (87 leaders). Mostnurses felt their prescribing course met their learning needs and stated courseoutcomes and that they had adequate development and support for prescribing tomaintain patient safety. Some types of community nurse prescribers had less accessto support and development. The prescribing leaders reported lacking systems toensure continuity of non-medical prescribing and monitoring patient experience.Conclusion. Educational programmes of preparation for nurse prescribing werereported to be operating satisfactorily and providing fit-for-purpose preparationfor the expansion to the scope of nurse independent prescribing. Most clinicalgovernance and risk management strategies for prescribing were in place inprimary and secondary care. / Department of Health (UK)

Yes / Health Services Research and Pharmacy Practice Conference Abstracts: Partnerships in Healthcare: Advancing Sustainable Medicines Optimisation 17–18 April 2023 University of Bradford.

No / In recent years, as the prevalence of prescribers has increased, there has been discord and confusion around exactly how to refer to prescribers who are not doctors (Nuttall and Rutt-Howard, 2020). Professional regulators continue to define prescribers by specific profession, using terms such as ‘nurse prescriber’ (Nursing and Midwifery Council, 2018a), ‘pharmacist prescriber’ (General Pharmaceutical Society, 2018) and ‘allied health professional prescriber’ (Health and Care Professions Council, 2016). However, there is a broader range of literature using the collective term of ‘non-medical prescribers’ (All Wales Medicines Strategy Group, 2017; Department of Health Northern Ireland, 2020; NHS England, 2020; Scottish Government, 2020), highlighting the multidisciplinary nature of contemporary prescribing practices across the UK, and the shared responsibility of prescribers for assuring safe and effective practice. Within this chapter, we refer to prescribers collectively, as non-medical prescribers. Although this chapter has been written with the four countries of the UK in mind, it is important that you consider any country-specific, and profession-specific guidelines.

Les sujets résidant dans les établissements d'hébergement pour personnes âgées dépendantes (EHPAD) sont fréquemment exposés à une polypathologie et sont polymédiqués, ce qui augmente le risque de prescriptions potentiellement inappropriées (PPI) et ainsi le risque d'événements iatrogènes tels que le décès et l'hospitalisation. La plupart des études réalisées en France sur la PPI se sont focalisées sur des classes médicamenteuses précises, et peu ont évalué l'impact des caractéristiques structurelles et organisationnelles des EHPAD sur la PPI des résidents, indépendamment des caractéristiques individuelles. Cette thèse a eu pour objectif de développer un nouvel indicateur de PPI, reflétant au mieux la prise en charge médicamenteuse globale des résidents d'EHPAD. Les travaux de thèse ont été réalisés sur un échantillon issu de l'étude IQUARE (Impact d'une démarche QUAlité sur l'évolution des pratiques et le déclin fonctionnel des REsidents), étude quasi expérimentale (NCT01703689) évaluant l'impact d'une intervention basée sur l'éducation gériatrique du personnel de l'EHPAD sur des indicateurs de qualité des soins. Dans un premier temps, nous avons construit un outil original de détection de PPI, combinant des critères explicites et implicites, identifiant 71% des résidents avec une PPI à l'inclusion. Des caractéristiques organisationnelle (accès à un avis psychiatrique) et structurelle (présence d'une unité de soins spécialisée) de l'EHPAD expliquaient une part de cette PPI. Dans un second temps, afin de valider la pertinence de cet outil, nous avons évalué l'impact clinique de la PPI sur la survenue d'événements indésirables au cours du suivi. Nous n'avons pas retrouvé de risque augmenté de décès ou d'hospitalisation. Enfin, l'intervention gériatrique générale de l'étude IQUARE a significativement réduit la PPI des résidents à 18 mois. Ces travaux ont fourni des éléments importants à prendre en considération, lors de la construction de nouvelles études visant à modifier les pratiques de prescription et à réduire le nombre de médicaments prescrits chez les résidents d'EHPAD, mais aussi pour déterminer l'impact clinique de ces changements. / Older people living in nursing homes (NHs) suffer from numerous comorbidities and functional decline. Polymedication is frequent in this population. This increases the risk of potentially inappropriate drug prescribing (PIDP), which can lead to adverse drug events such as falls and hospitalization. Most French studies did not examine PPI with a global perspective, but focused on specific drug classes. Moreover, few studies have investigated, irrespective of the individual characteristics of residents, the structural and organizational characteristics of nursing homes on the quality of drug prescribing. Thesis work aimed to develop a new indicator of PIDP, which best reflects the global medication use of residents. Thesis works have been performed using the data of the IQUARE study (Impact d'une démarche Qualité sur l'évolution des pratiques et le déclin fonctionnel des REsidents), a quasi-experimental study (trial registration number: NCT01703689) investigating the impact of an intervention based on geriatric education with NH staff on quality indicators of care. First, we developed an indicator of PIDP, combining explicit and implicit criteria, identifying 71% of PIDP in NH residents at baseline. NH organizational (access to psychiatric advice and/or to hospitalization in a psychiatric unit) and structural (presence of a special care unit for dements) variables explained part of PIDP. In a second part, in order to validate the usefulness of this PIDP detection tool, we verified the long-term clinical impact of PIDP on adverse outcomes (death, number of hospitalizations...). We did not find any significant association between PIDP and death, nor between PIDP and number of hospitalizations. Finally, the general intervention implemented in the IQUARE study significantly reduced PIDP among NH residents at 18-month follow-up. Our research has provided important aspects that should be consider when constructing further new studies seeking to change prescribing patterns and to reduce the total number of drugs taken, but also to determine the final impact of these changes on clinical outcomes.

No / There are 353 NHS hospitals in the United Kingdom, and within these hospitals there is wide variation in the electronic prescribing systems applied. Indeed, only one hospital uses a single system in all of its clinical areas. Medication error is the biggest issue in the health care profession in respect to patient safety—