Spelling suggestions: "subject:"selectin"" "subject:"pselectin""
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Direct Comparison of P-Selectin Glycoprotein Ligand-1 and Sialyl Lewis X AdhesionZou, Xiaoyan 29 December 2008 (has links)
No description available.
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A Study of Breast Cancer Cell Adhesion to Endothelium in Response to Cytokine StimulusHenson, Karissa A. 26 July 2010 (has links)
No description available.
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Platelet function of whole blood after short-term cold storage: A prospective in vitro observational study / 全血短時間冷蔵保存の血小板機能:前向き試験管内観察研究Kusudo, Eriko 25 March 2024 (has links)
京都大学 / 新制・課程博士 / 博士(医学) / 甲第25175号 / 医博第5061号 / 京都大学大学院医学研究科医学専攻 / (主査)教授 江藤 浩之, 教授 長尾 美紀, 教授 大鶴 繁 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM
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Molecular Mechanisms of Circulating Tumor Cell Adhesion in Breast Cancer MetastasisShirure, Venktesh S. 10 June 2013 (has links)
No description available.
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The Roles of Selectin Ligands and Innate Immune Responses in Modulating Resistance to Intracellular Bacterial Infections in Murine Hosts with Altered ImmunityAgbayani, Gerard Patrick 29 August 2018 (has links)
Listeria monocytogenes (LM) and Salmonella enterica serovar Typhimurium (ST) are intracellular bacterial pathogens that cause invasive disease in immune-altered individuals, including the immunocompromised and pregnant women. The mechanisms that modulate innate immunity to intracellular infection, particularly during pregnancy, are not well-understood. Functional selectin ligands play critical roles in leukocyte recruitment during inflammation. Increased control of LM infection in functional selectin ligand-deficient (FtDKO) mice is associated with increased levels of circulating innate immune cells, despite defective leukocyte migration compared to WT mice. Adoptive transfer of WT and FtDKO bone marrow (BM) cells to irradiated WT and FtDKO recipients demonstrates that BM reconstitution and the increased neutrophil phenotype of FtDKO mice is independent of functional selectin ligand expression within the host environment. Thus, functional selectin ligand deficiency enhances inherent innate immune resistance to intracellular infection. We then examined the impact of pregnancy-associated immunological changes on maternal susceptibility to intracellular infections. ST infection in pregnant mice results in profound systemic infection, increased fetal loss and enhanced serum and placental expression of pro-inflammatory cytokines. Pregnant mice showed decreased ratios of pro-inflammatory Th17 cells relative to anti-inflammatory regulatory T cells (Tregs) when compared to non-pregnant mice during infection. Functional inactivation of Tregs in vivo restored control of infection and normal Th17-to-Treg ratios, and reduced fetal loss. These indicate that modulation of Th17 and Treg responses impacts maternal and fetal protection from ST infection. Lastly, we examined the roles of type I interferons (IFNs) in modulating innate immunity to intracellular infections during pregnancy. Type I IFN receptor deficiency (IFNAR-/-) enhances immunity to LM and ST in the non-pregnant state by limiting pathogen-induced leukocyte death. We show that pregnant IFNAR-/- mice infected with LM retain increased protection from infection relative to WT controls. In contrast, protection conferred by IFNAR deficiency against ST infection in the non-pregnant state is abrogated during pregnancy. Distinctive maternal responses to LM and ST are associated with differential regulation of leukocyte distribution and cytokine expression in maternal systemic and/or placental compartments. Taken together, modulation of key mechanisms involved in leukocyte recruitment, immune-regulation and cytokine signaling impact host susceptibility to intracellular infections.
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α2,3 Sialylated Breast and Colon Cancer Cells and Extracellular Vesicles Bind to L-selectin Under Flow ConditionsCellars, Nicholas J. 17 September 2020 (has links)
No description available.
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Mechanistic Insights into the Regulation of the E-selectin Ligand Activities of Breast Cancer Cells by microRNA-200c, Notch Signaling, and Exosomal microRNAsShowalter, Christian A. 28 September 2020 (has links)
No description available.
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The Role of Inflammation in the Association Between Autonomic Nervous System Dysregulation and Cognitive Dysfunction in Cardiovascular DiseaseKeary, Therese Anne 18 July 2011 (has links)
No description available.
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A Study of the Impact of Membrane Organization of Glycosphingolipid E-selectin Ligands and Glycoproteins on Head and Neck Cancer Cell Adhesion to Vascular EndotheliumMarshall, Jocelyn R. 03 October 2011 (has links)
No description available.
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Mechanical Deformation and Adhesion of Cells in Model CapillariesChoi, Young Eun January 2011 (has links)
No description available.
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