År 2013 var den globala omsättningen för modeindustrin ca 76 tusen miljarder svenska kronor (Office of Textiles and Apparel, 2014). Bara i Sverige omsattes det 229 miljarder svenska kronor år 2012 inom denna sektor, en ökning på 11 % från föregående år (Tillväxtverket, 2014). Att modebranschen är under ständig utveckling och ökar i tillväxt kan man se då dessa siffror stiger varje år. Statistik från 2014 visar att trots denna ökning så överlever endast 47 % av nystartade modeföretag de tre första åren (Statistic Brain, 2014). Så hur lyckas man som modeföretag i early stage-fasen att med begränsade resurser stärka sitt varumärke och hålla sig kvar på marknaden? I denna studie berörs olika delar så som traditionell marknadsföring, okonventionell marknadsföring, branding samt transparens, där huvudfokus ligger på företag i early stage- fasen av sin uppstart. I uppsatsen genomfördes sju intervjuer med svenska modeföretag som är eller nyligen varit i denna fas för att få ett resultat med så hög validitet som möjligt. Brist på kunskap och kapital är inte ovanligt i denna bransch och med ökad medvetenhet hos konsumenter om de olika processerna, så kan det ibland uppstå svårigheter att försvara sig som nystartat företag. Då modebranschen är i ständig rörelse med stora förändringar från säsong till säsong måste man som nytt företag vara beredd på reformation samt att alltid tänka innovativt. Det är även viktigt att vara uppmärksam på kommande och rådande trender gällande alla aktiviteter ett företag arbetar med. Eftersom olika marknadsföringsstrategier både kan hjälpa och stjälpa ett varumärkes position på marknaden är den stora utmaningen att hitta rätt metod för just sitt företag (Easy, M. 2009). Resultatet av denna studie kommer alltså att bygga på de kvalitativa intervjuer som genomförts med de utvalda företag som har valt att medverka. De beskriver hur deras uppstart sett ut när det kommer till branding samt hur de i olika kanaler väljer att marknadsföra sig. I dessa intervjuer tittar vi även närmare på hur de lyckades starta sin verksamhet och vilka kapitalmedel de använt, deras syn på okonventionell marknadsföring samt hur marknadsföring och branding hänger samman.

Advances in diagnostic tools and disease slowing treatments have led to an increased focus on diagnosing Alzheimer's disease (AD) during the early stages of the disease. Early diagnosis of AD improves quality of life for patients and caregivers by allowing for participation in disease slowing interventions. However, early diagnosis of AD may have unintentional psychological and social consequences for patients and caregivers. To combat these potential consequences, it is important that psychosocial interventions, such as support groups, are available at the time of diagnosis. A review of literature demonstrated that early stage AD patients and their informal caregivers benefited from support groups attended by both patients and caregivers, referred to as early stage AD patient-caregiver dyad (PCD) support groups. However, there is a gap in knowledge regarding the need for early stage AD PCD support groups in rural areas. The purpose of this study was to evaluate the need for early stage AD PCD support groups in rural WA.A needs assessment survey was developed and distributed for a period of one month to four clinics and one senior center in five rural WA towns. Twelve informal caregivers and five community members who did not have AD or care for someone with early stage AD were included in data analysis. Results demonstrated that participants lacked information about early stage AD PCD support groups and barriers to accessing these groups. Even with a lack of information about early stage AD PCD support groups, a majority of participants indicated that these groups would address their many unmet needs, and 52.9% of participants were likely to participate in early stage AD PCD support groups. Further studies should be performed to capture the need for early stage AD PCD support groups in rural WA.

This dissertation research focused on breast cancer and social determinants that have been shown to influence the outcomes of this devastating disease. Although heart disease is the leading cause of death for women, more women feel that they will die from breast cancer. Breast cancer is the most common diagnosed cancer in women exacting an emotional and economic hardship for many women. There are no known causes of breast cancer, but there are certain genetic and social factors that pre-dispose women to this disease. Also, diagnosis at later stages of disease has been shown to have adverse outcomes for many. This research examined the effects that social determinants had on breast cancer stage of diagnosis. The social determinants researched to examine their influence on breast cancer outcomes were race, geographical location, health insurance, and income. Also, this research examined the influence of Public Health Law, 101-354, enacted to decrease health disparity from breast and cervical cancer for minorities and medically underserved women had on breast cancer diagnosis for women enrolled in the Mississippi Breast and Cervical Cancer Program. Complimentary to PHL 101-354, Public Health Law 106-354, the Breast and Cervical Cancer Treatment Act, was enacted giving states the option of providing health insurance through Medicaid for eligible women with a diagnosis of cancer of the breast or cervix, including precancerous conditions, for treatment services. The results of this study revealed that race and health insurance were the two major factors that negatively impacted stages of breast cancer diagnoses. Although hypothesized, geographical location and income did not significantly affect late stage breast cancer rates.

Robotic-assisted segmentectomy is a pulmonary resection procedure that is emerging as an alternative to lobectomy for the treatment of early-stage lung cancer tumours less than 2 cm in maximal diameter. Segmentectomy offers better lung function after surgery by only removing a few segments of the lobe that contain the tumour, and sparing remaining healthy lung tissue. As tumours are being more frequently detected in their early-stages, segmentectomy has gained considerable attention for its potential as a primary treatment option for suspected nodules less than 3 cm in maximal diameter. However, there is a reluctance in adopting segmentectomy due to technical challenges while performing the operation, and the lack of high-quality prospective data compared to lobectomy, which is the current standard of care. From a technical standpoint, segmentectomy is difficult to perform because the pulmonary lines that separate segments, or intersegmental planes, are invisible. This poses a challenge for the operating surgeon in determining where to resect the lung tissue to obtain adequate margin distance from the tumour. Near-infrared mapping (NIF) with indocyanine green dye (ICG) is a recent advancement in robotic-assisted segmentectomy that provides a complete delineation of the intersegmental plane. Previous work at our center has also shown that this technique was associated with an increase in the oncological margin distance compared to the surgeons’ initially estimated resection line. Given that segmentectomy is associated with a learning curve, we evaluated whether this was observed due to our early experience in robotic-assisted segmentectomy, and hypothesized that the added benefit of ICG would diminish as more cases were performed. In Chapter 2, we used a temporal analysis to monitor surgeon experience over time, and found that the clinical utility of NIF mapping diminished after approximately 42 cases with ICG, and the surgeon began to identify the location of the intersegmental plane more accurately and consistently without ICG injection since. The second barrier in the adoption of segmentectomy is the lack of high quality-prospective data. Current evidence pertaining to the effectiveness of segmentectomy in terms of cancer-related outcomes is inconclusive and difficult to generalize to the current lung cancer population. In Chapter 3, we performed a secondary analysis of a prospectively collected database of participants who underwent robotic-assisted segmentectomy or lobectomy for tumours less than 3 cm. The oncological efficacy of segmentectomy can be evaluated by the measuring the number of lymph node stations sampled intraoperatively and rates of nodal upstaging, and comparing these outcomes to pulmonary lobectomy. These are important surrogate outcomes that can be readily evaluated, and have been shown to predict overall survival after lung resection. We observed that these outcomes, including overall survival, were similar between patients who underwent segmentectomy and lobectomy for tumours less than 3 cm. While these findings were consistent for patients that underwent segmentectomy for tumours between 2 and 3 cm, recurrence-free survival was found to be significantly lower after segmentectomy compared to lobectomy. In conclusion, the clinical utility of near-infrared mapping diminishes over time, which is indicative of an improved ability to perform robotic-assisted segmentectomy as more cases were attempted. Second, adequate lymph node evaluation can be expected after segmentectomy, reducing the likelihood of missing positive lymph nodes. Although patients who underwent segmentectomy for tumours greater than 2 cm may be at a greater risk of experiencing recurrence compared to lobectomy, this population did not experience any reductions in overall survival. / Thesis / Master of Health Sciences (MSc)

Made available in DSpace on 2016-03-15T19:32:45Z (GMT). No. of bitstreams: 1 Mauricio Takahashi.pdf: 3377375 bytes, checksum: ece60e39e3d556f50a1a995be5cf53fa (MD5) Previous issue date: 2013-05-23 / This dissertation has built a tool for capturing behavior of the entrepreneur to be able to investigate experimentally if is observed the emergence of cooperative behaviors perceived as potentially spontaneously by entrepreneurs in response to decisions modeled Investors Early Stage (Early Stage) on the strategic interaction between them at the time of the "Closing the Deal" in the industry of Private Equity and Venture Capital (PE / VC), the Theory of Games. To do so, brief review of the theoretical characteristics of the industry Private Equity and Venture Capital is made in order to understand the characteristics of the experiment and understand the peculiarities existing in this type of interaction, in which value creation is long term process and dependent on extensive procedures in which underlies the cooperation of agents. A review of Game Theory was made to search for an alternative to the selfish behavior of non-cooperation. The alternative found is a Nash Equilibrium Perfect in Sub- Infinitely Repeated Games, in which it could be the spontaneous emergence of cooperation, even if the agents are in a situation like the Prisoners' Dilemma, in which the rewards, in the short term are higher for the behaviors of non-cooperation. Then, the Entrepreneurs Game its modeling and implementation, which was used for the construction of the tool data capture. In addiction are presented the two questionnaires that were selected as validation tools of the Game, working as a mapping of control variables aiming future validation of the Game. It was possible to observe a finding, even if only preliminary, that is the "learning effect" observed when analyzing the entrepreneurs responses in which the behavior of noncooperation was terminated. / A presente dissertação construiu uma ferramenta de captação de comportamento do empreendedor que é capaz de investigar de forma experimental se é observado o surgimento de comportamentos tidos como potencialmente cooperativos, de forma espontânea por parte de empreendedores, em resposta às decisões modeladas de Investidores de Estágio Inicial (Early Stage) na interação estratégica entre estes, no momento do Fechamento do Negócio na indústria de Private Equity e Venture Capital (P.E. / V.C.), à luz da Teoria dos Jogos. Para tanto, faz-se uma breve revisão teórica das características da indústria de Private Equity e Venture Capital a fim de se entender as características do experimento e entender as peculiaridades existentes deste tipo de interação, na qual a criação de valor é de longo prazo e dependente de um processo extenso, no qual está subjacente a cooperação dos agentes. Uma revisão da Teoria dos Jogos é feita para que se busque uma alternativa ao comportamento egoísta de não cooperação. A alternativa encontrada é uma situação de Equilíbrio de Nash Perfeito em Sub-Jogos Infinitamente Repetidos, na qual pode haver o surgimento espontâneo de cooperação, mesmo que os agentes estejam em uma situação do tipo Dilema dos Prisioneiros, na qual as recompensas, no curto prazo, são maiores para os comportamentos de não cooperação. Em seguida, são apresentados o jogo e o seu modelamento e implementação, que foi utilizado para a construção da ferramenta de captura de dados. São apresentados, ainda os dois questionários que foram selecionados como instrumentos de validação do jogo, funcionando como um mapeamento de variáveis de controle visando validação futura do jogo. Foi possível se observar um achado, ainda que de forma preliminar, que é o efeito aprendizagem observado ao se analisar as respostas dos empreendedores no qual o comportamento de não cooperação foi extinto.

The main objective was to create a normative model of determining the value of early stage for companies in the seed and start up stage. The model should be applicable to entrepreneurs and investors, taking into account the assessment of the value of qualitative factors. Another aim was to identify the significant factors affecting the value of early stage companies in the seed and start up stage, i.e. at a time when there are no or very little revenues. Based on a research among investors and other experts on the valuation of early stage companies and venture capital, the most significant factors were not only identified, but also determined by their weight. The quality of evaluating investment opportunities has a major impact on the profitability of the investor´s capital. Current knowledge of the key value drivers and the mechanisms of valuation can help businesses to set realistic expectations when trying to raise capital to finance the startup of the project. It is therefore necessary to provide a clear methodological framework applicable to both parties of investing. The actual research was divided into two phases - individual interviews with investors and questionnaires. It was confirmed that the most crucial factors are those associated with quality management and company founders.

Different researchers and governments globally have recognised the importance of entrepreneurship in economic growth and job creation. In addition, entrepreneurial activity is crucial, locally and globally. Furthermore, the Global Entrepreneurship Monitor (GEM) recognises the contribution of entrepreneurial activity to economic growth and measures it by means of the total early stage entrepreneurial activity index (TEA). Since the TEA in South Africa is very low, the need exist for an investigation into the reasons thereof. GEM uses the entrepreneurial conditions such as entrepreneurial finance, government policies, government programmes, entrepreneurial education, research and development transfer, commercial and legal infrastructure for entrepreneurship, internal market openness and cultural and social norms to measure entrepreneurial activity. Viewing the different entrepreneurial conditions, education is recognised as one of the largest inhibiters of entrepreneurship since 2001. In this study an investigation on education in South Africa was conducted. The goal of this study was to enhance selected entrepreneurial competencies of grade 11 learners in Business Studies. The literature study indicated that various entrepreneurship views and definitions exist. The focus of this study is on the individual characteristics of the entrepreneurs. The literature study also indicated that different terms exist to describe these individual characteristics of the entrepreneurs. For the purpose of this study the term competency was used. Thirdly the literature study also showed that various entrepreneurial competencies exist. A selection needed to be done and by using the curriculum of Business Studies, grades 10 – 12 only certain competencies were selected. The following entrepreneurial competencies are used in this study: problem solving, creativity, flexibility, risk-taking, goal orientation, planning, teamwork, communication, self-confidence and capacity to learn. In this study a multi-method research design was used. Both quantitative and qualitative research methods were used. An intervention took place with an experimental (23 learners) and control group (24 learners). Firstly the experimental group was exposed to the intervention with the control group attending normal classes. After the completion of the intervention on the experimental group the roles were changed. The intervention of each group consisted of 24 days (28 sessions of between 35 and 43 minutes). In the quantitative research three tests were used to determine the possible enhancement of the selected entrepreneurial competencies. Both the experimental and control group were exposed to the three tests. In the qualitative research observations and interviews were used to measure the possible enhancement of the entrepreneurial competencies. Learners from both the experimental and control group were used in the interviews. The results of the quantitative and qualitative research clearly show an enhancement of entrepreneurial competencies of the learners. Furthermore, the effectiveness of the proposed framework is clearly highlighted. The use of the proposed framework will assist teachers in linking the theory (textbook) and practice (operations of the business in the simulation). In addition, the teacher can expose the learners to entrepreneurial competencies and therefore develop and enhance it. Another advantage is that this teaching approach can be included in the normal Business Studies classes without any interruption of normal school activities. A limitation of the study is the period of the intervention. A recommendation is that the proposed strategy for the enhancement of entrepreneurial can be used through out the academic year for the enhancement of entrepreneurial competencies. This will ensure that the entrepreneurial competencies are focussed on continuously and learners are empowered in this regard. With this study the researcher attempted to address the challenges in education in South Africa through the enhancement of entrepreneurial competencies and thus to address the low TEA. / PhD (Entrepreneurship), North-West University, Potchefstroom Campus, 2014

Different researchers and governments globally have recognised the importance of entrepreneurship in economic growth and job creation. In addition, entrepreneurial activity is crucial, locally and globally. Furthermore, the Global Entrepreneurship Monitor (GEM) recognises the contribution of entrepreneurial activity to economic growth and measures it by means of the total early stage entrepreneurial activity index (TEA). Since the TEA in South Africa is very low, the need exist for an investigation into the reasons thereof. GEM uses the entrepreneurial conditions such as entrepreneurial finance, government policies, government programmes, entrepreneurial education, research and development transfer, commercial and legal infrastructure for entrepreneurship, internal market openness and cultural and social norms to measure entrepreneurial activity. Viewing the different entrepreneurial conditions, education is recognised as one of the largest inhibiters of entrepreneurship since 2001. In this study an investigation on education in South Africa was conducted. The goal of this study was to enhance selected entrepreneurial competencies of grade 11 learners in Business Studies. The literature study indicated that various entrepreneurship views and definitions exist. The focus of this study is on the individual characteristics of the entrepreneurs. The literature study also indicated that different terms exist to describe these individual characteristics of the entrepreneurs. For the purpose of this study the term competency was used. Thirdly the literature study also showed that various entrepreneurial competencies exist. A selection needed to be done and by using the curriculum of Business Studies, grades 10 – 12 only certain competencies were selected. The following entrepreneurial competencies are used in this study: problem solving, creativity, flexibility, risk-taking, goal orientation, planning, teamwork, communication, self-confidence and capacity to learn. In this study a multi-method research design was used. Both quantitative and qualitative research methods were used. An intervention took place with an experimental (23 learners) and control group (24 learners). Firstly the experimental group was exposed to the intervention with the control group attending normal classes. After the completion of the intervention on the experimental group the roles were changed. The intervention of each group consisted of 24 days (28 sessions of between 35 and 43 minutes). In the quantitative research three tests were used to determine the possible enhancement of the selected entrepreneurial competencies. Both the experimental and control group were exposed to the three tests. In the qualitative research observations and interviews were used to measure the possible enhancement of the entrepreneurial competencies. Learners from both the experimental and control group were used in the interviews. The results of the quantitative and qualitative research clearly show an enhancement of entrepreneurial competencies of the learners. Furthermore, the effectiveness of the proposed framework is clearly highlighted. The use of the proposed framework will assist teachers in linking the theory (textbook) and practice (operations of the business in the simulation). In addition, the teacher can expose the learners to entrepreneurial competencies and therefore develop and enhance it. Another advantage is that this teaching approach can be included in the normal Business Studies classes without any interruption of normal school activities. A limitation of the study is the period of the intervention. A recommendation is that the proposed strategy for the enhancement of entrepreneurial can be used through out the academic year for the enhancement of entrepreneurial competencies. This will ensure that the entrepreneurial competencies are focussed on continuously and learners are empowered in this regard. With this study the researcher attempted to address the challenges in education in South Africa through the enhancement of entrepreneurial competencies and thus to address the low TEA. / PhD (Entrepreneurship), North-West University, Potchefstroom Campus, 2014

BACKGROUND:The aim of this study was to evaluate clinico-pathologic specific predictors of recurrence for stage II/III disease. Improving recurrence prediction for resected stage II/III colon cancer patients could alter surveillance strategies, providing opportunities for more informed use of chemotherapy for high risk individuals.METHODS:871 stage II and 265 stage III patients with colon cancers were included. Features studied included surgery date, age, gender, chemotherapy, tumor location, number of positive lymph nodes, tumor differentiation, and lymphovascular and perineural invasion. Time to recurrence was evaluated, using Cox's proportional hazards models. The predictive ability of the multivariable models was evaluated using the concordance (c) index.RESULTS:For stage II cancer patients, estimated recurrence-free survival rates at one, three, five, and seven years following surgery were 98%, 92%, 90%, and 89%. Only T stage was significantly associated with recurrence. Estimated recurrence-free survival rates for stage III patients at one, three, five, and seven years following surgery were 94%, 78%, 70%, and 66%. Higher recurrence rates were seen in patients who didn't receive chemotherapy (p=0.023), with a higher number of positive nodes (p<0.001). The c-index for the stage II model was 0.55 and 0.68 for stage III.CONCLUSIONS:Current clinic-pathologic information is inadequate for prediction of colon cancer recurrence after resection for stage II and IIII patients. Identification and clinical use of molecular markers to identify the earlier stage II and III colon cancer patients at elevated risk of recurrence are needed to improve prognostication of early stage colon cancers.

This analysis examines the impact that personal characteristics like gender, race, years participating in the labor force, education, and previous entrepreneurship have on the amount of funding a startup receives from venture capital investors. Data for the analysis is taken from online venture capital database, Crunchbase, and includes investments made by venture capitalists between the years of 2002 and 2014. Findings from the regression analysis conclude that gender, the number of years a founder has been in the labor force, and a founder’s education background are significant determinants of the amount of funding a company receives in funding rounds. In addition, the sector the company falls under and the venture capital firms that the company seeks investment from are both significant determinants of the amount of funding received by the company and the founder.