Thesis (M.S.)--Miami University, Dept. of Botany, 2006. / Title from first page of PDF document. Includes bibliographical references (p. 95-102).

Master of Agribusiness / Department of Agricultural Economics / Allen Featherstone / For the past 25 years, Free Trade Agreements (FTA) in Asia have been increasing. This allows for a potential expansion of exports into Asia for a variety of goods. However usually these agreements have not covered agricultural products. The most recent multilateral agreement currently includes agricultural products and agricultural trade. U.S. pork exports have been on the rise with Asian countries. Trade openness with Asian countries allows U.S. pork companies to gain a market in the region. This thesis estimates the economic impact that FTA’s and multilateral agreements have on pork exports, through the level of open markets measured by Freedom House. Using regression analysis, this research examines the determinants to U.S. pork exports, where trade openness is a major independent variable. Pork is a popular meat preference in East Asia. A regression analysis was estimated to determine the shift along the demand curve of U.S. pork exports to three East Asian countries, China, Japan, and South Korea. Overall all three countries showed their trade openness being weakly associated with the U.S. pork export demand to that particular country during the years of 1995–2013.

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The purpose of this thesis is to review the English language material concerning the beginning of bronze technology in East Asia in order to evaluate the evidence for the birth of bronze metallurgy in East Asia. The method of investigation was first to study published and unpublished material on North, Central and South East Asia. This study included the history of research under the categories of method, theory, and chronology of archaeological investigations, and hypotheses on origins and routes of bronze technology in East Asia. The examination of bronze metallurgy followed. This comprised the ramifications of the occurrence of copper-working, the production and analysis of the alloy bronze, the method of production of bronze objects, the dating of bronze artifacts and the social context of bronze production. The next step in the study was to explore the Neolithic stages of culture in the diverse areas in order to examine the precursors of bronze-producing societies and to determine the earliest bronze assemblages. The earliest bronze assemblages were in turn investigated. The metal objects, both copper and bronze, in these assemblages were tabulated and compared chronologically. The categories of metal objects were used to illustrate the relative sociocultural integration of each bronze producing group. Evidence of casting of the metal in the assemblages was compared to ascertain the similarities, if any, among production procedures. Chemical analyses of the bronze in the assemblages were tabulated for comparison and examination of relationships. Finally, similar types of artifacts in the assemblages were tabulated for stylistic comparison. The general conclusions from these investigations are that the four assemblages of earliest bronze technology in East Asia are from Minusinsk in southern Siberia, Erh-li-t'ou in North China, Ta-p'o-na in southwest China and Non Nok Tha in northeastern Thailand. Of these assemblages, neither Minusinsk nor Ta-p'o-na demonstrated the beginning of bronze production. The archaeological evidence does not establish the beginning of bronze metallurgy as being shown at either Erh-li-t'ou or at Non Nok Tha but the possibility exists for either indigenous development from external stimulus or separate invention with no outside stimulus of any kind for either area. This study has demonstrated the existence of different technologies, different levels of social integration and different social contexts for bronze in all four early assemblages. Thus it has also demonstrated that the beginning of bronze production did not have to occur in urban or state environments. / Arts, Faculty of / Anthropology, Department of / Graduate

Since the end of the Sino-Vietnamese War in 1979, Northeast Asia and its comprising countries have avoided international conflict as well as any regional set has done over the past few decades. The absence of nuclear weapons among Japan, South Korea, and Taiwan, in particular, is striking, given their technological and scientific capabilities. Though each of those countries has come close at times to developing their own nuclear weapons, one factor or another contributed to the failure of those upstart programs. The United States has played a significant role in all of them. Still, other factors remain. The purpose of this thesis is to determine in detail what caused the lack of a nuclear arms race in northeast Asia, beyond the American angle, as far as could be done. Existential threats exist to each country involved in the study, theoretically and tactically. Additionally, what causes an outlier like North Korea, which has boldly moved forward with nuclear weapons development? An important work by Scott Sagan is utilized in the thesis to assist with developing some far-reaching conclusions, with great importance to other parts of the world, beyond northeast Asia. Other literature can assist with those conclusions, as well. The framework of this thesis will be to intermingle a somewhat amended version of Sagan's nuclear proliferation rationalizations with historical analyses to draft some region-specific conclusions about why northeast Asia has not had a nuclear arms race. Processes going on between countries, within countries, and among countries, militarily, culturally, and economically, play such important roles than none can be discarded. The economic power centered on the capitalist core of northeast Asia can show how nuclear weapons acquisition is no longer among the things necessary to gain international respect or even security.

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人類乳頭瘤病毒 (HPV) 是引起宮頸癌的必要條件。在高危型HPV中，以HPV16在癌症樣本中最為常見，其全球盛行率達50%以上。近年來，用以辨認HPV16變異子譜系的序列特徵已經建立。雖然這個系統建基於全球的HPV16變異株，但是它只包含了四個亞洲地區。為了改善這個系統於亞洲樣本的準確性，是次研究收集了更多亞洲地區的序列。 / 是次研究提供了在香港和韓國收集的HPV16樣本的系統發生史及序列變異 (LCR、E6 和 E7)。此外，是次研究也檢測了HPV16變異株的在兩地的分佈和致癌風險。 / 是次研究從香港和韓國收集了329個HPV16呈陽性的宮頸樣本。利用LCR、E6、E7 和整合的LCR-E6基因序列以極大似然法來構建HPV16變異株的系統發生樹。序列變異會按照系統發生樹之拓撲結構來分類並詳細描述。卡方檢驗或費雪精確性檢定用於分析HPV16變異株在兩地的分佈和致癌風險。 / 是次研究結果顯示用以辨認HPV16變異子譜系的序列特徵需加以改善。我們建議採用A7287C/T作為亞洲子譜系的序列特徵，以替代原有的A7287C。有關HPV16變異株的地理分佈，亞洲和歐洲的變異株在香港 (亞洲變異株: 70%，歐洲變異株: 25.3%) 和韓國 (亞洲變異株: 61.2%，歐洲變異株: 20.2%) 均十分普遍。另外，1和2型亞美變異株在香港和韓國的分佈有著明顯差別 (1型亞美變異株: 2% 與12.4%，P < 0.001; 2型亞美變異株: 0% 與2.8%，P = 0.04)。 / 另外，是次研究發現亞洲子譜系於韓國民族中呈較高致癌風險 [比值比 (95% 置信區間) 2.02 (1.03-3.99)]。在進化支中，E6的第五進化支[2.44 (1.27-4.74)]和E7的第三進化支[2.02 (1.03-3.99)]也於韓國民族中呈較高致癌風險。在SNP中，E6 T178G [2.17 (1.11-4.23)]、兩個E7的SNPs (A647G [1.73 (0.88-3.42)]、T846C [2.27 (1.16-4.49)]) 和9個LCR SNPs (A7175C, T7177C, T7201C, C7270T, A7730C, G7842A [2.02 (1.03-3.99)], A7289C [2.04 (1.05-3.96)], T7781C [2.07 (1.02-4.22)] 和 C24T [2.36 (1.20-4.66)])於韓國民族中也呈較高致癌風險。這些進化支和SNPs都與亞洲子譜系有關聯。在香港方面，兩個LCR SNPs (A7289C [1.89 (0.92-3.87)] 和 T7781C [2.07 (0.92-4.71)])呈較高致癌風險。 / 是次研究發現的高危SNPs和進化支需要進一步的大型流行病學研究和生物化學實驗來核實。這些序列特徵可作為生物標誌物以檢測出與HPV有關的早期宮頸病變。 / Human papillomavirus (HPV) is necessary for the development of cervical cancer. Of those high-risk HPV types, HPV16 is the most common type detected in cervical cancer and accounts for a prevalence of greater than 50% worldwide. Recently, a sequence signature-based system for identifying the sub-lineages of HPV16 variants has been established. Although this system was developed from HPV16 variants collected worldwide, only four Asian regions were included. To improve the accuracy of this sub-lineage classification system for Asian samples, more sequence data from Asian regions were included in the current study. / The current study provided data on the phylogeny and the sequence variation of Long control region (LCR), E6 and E7 open reading frames (ORFs) of HPV16 isolates collected in Hong Kong and Korea. The distribution of HPV16 variants between two regions and the risk association of HPV16 variants with cervical cancer development were also examined. / A total of 329 HPV16-positive cervical samples were collected from Hong Kong and Korea. The phylogenetic trees were constructed for the LCR, E6, E7 and concatenated LCR-E6 sequences using the maximum likelihood method. The sequence variation of each region was delineated and grouped according to the tree topology. The distribution and risk association of HPV16 variants were examined using the chi-square test or Fisher’s exact test as appropriate. / The results showed that the previously described sequence signatures for classifying sub-lineages of HPV16 variants required further improvement, especially for the Asian sub-lineage. We proposed A7287C/T as a signature SNP of the Asian sub-lineage rather than A7287C as suggested by Cornet et al. In regard to the distribution of HPV16 variants, the Asian (As) and European (Eur) variants were commonly found in Hong Kong (As: 70%, Eur: 25.3%) and Korea (As: 61.2%, Eur: 20.2%). Furthermore, Asian American-1 and 2 (AA1 and AA2) variants were found to distribute significantly different between Hong Kong and Korea (AA1: 2% versus 12.4%, P < 0.001; AA2: 0% versus 2.8%, P = 0.04). / A key finding was that variants of the Asian sub-lineage carried a higher oncogenicity among Korean population [odds ratio (95% confidence interval) = 2.02 (1.03-3.99)]. In clade level, E6 clade 5 [2.44 (1.27-4.74)] and E7 clade 3 [2.02 (1.03-3.99)] were found to carry a higher oncogenicity among Korean population. In SNP level, E6 T178G [2.17 (1.11-4.23)], two SNPs of E7 ORF (A647G [1.73 (0.88-3.42)] and T846C [2.27 (1.16-4.49)]) and nine SNPs of LCR (A7175C, T7177C, T7201C, C7270T, A7730C, G7842A [2.02 (1.03-3.99)], A7289C [2.04 (1.05-3.96)], T7781C [2.07 (1.02-4.22)] and C24T [2.36 (1.20-4.66)]) were also found to carry a higher oncogenicity among Korean population. Those clades and SNPs were linked to the Asian sub-lineage. In contrast, only two SNPs of LCR (A7289C [1.89 (0.92-3.87)] and T7781C [2.07 (0.92-4.71)]) were found to associate with a higher oncogenicity among Hong Kong population. / The risk associations of SNPs, clades of the HPV16 Asian sub-lineage revealed by the current study should be verified by large-scale epidemiological studies and biochemical experiments. These signatures may serve as biomarkers for early detection of HPV-related cervical neoplasia. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Ma, Tsz Ue. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2013. / Includes bibliographical references (leaves 148-156). / Abstracts also in Chinese. / Abstract of Thesis --- p.I / 論文摘要 --- p.V / Acknowledgements --- p.VIII / Contents --- p.X / Figures --- p.XIII / Tables --- p.XIV / Abbreviations --- p.XVI / Chapter Chapter 1 --- Introduction --- p.1 / Chapter 1.1 --- History of Human Papillomavirus --- p.2 / Chapter 1.2 --- Biology of Human Papillomavirus --- p.4 / Chapter 1.2.1 --- Genome Organization and Protein Functions --- p.4 / Chapter 1.2.1.1 --- E5 Protein --- p.7 / Chapter 1.2.1.2 --- E6 Protein --- p.8 / Chapter 1.2.1.3 --- E7 Protein --- p.9 / Chapter 1.2.2 --- Life Cycle of Human Papillomavirus --- p.10 / Chapter 1.2.3 --- Taxonomy of Human Papillomavirus --- p.12 / Chapter 1.3 --- Cervical Cancer --- p.16 / Chapter 1.3.1 --- Natural History --- p.16 / Chapter 1.3.2 --- Risk Factors --- p.17 / Chapter 1.4 --- Epidemiology of Cervical Cancer --- p.19 / Chapter 1.4.1 --- Global Disease Burden --- p.19 / Chapter 1.4.2 --- Disease Burden in Hong Kong --- p.21 / Chapter 1.4.3 --- Disease Burden in South Korea --- p.22 / Chapter 1.5 --- Human Papillomavirus Type 16 --- p.23 / Chapter 1.6 --- Background and Objectives --- p.27 / Chapter Chapter 2 --- Materials and Methods --- p.30 / Chapter 2.1 --- Study Design --- p.31 / Chapter 2.2 --- Study Samples --- p.35 / Chapter 2.2.1 --- HPV16-Positive Samples --- p.35 / Chapter 2.2.2 --- Samples with Unknown HPV Status --- p.36 / Chapter 2.3 --- Laboratory Methods --- p.39 / Chapter 2.3.1 --- DNA Extraction --- p.39 / Chapter 2.3.2 --- Polymerase Chain Reaction --- p.40 / Chapter 2.3.2.1 --- PGMY09/11 PCR --- p.40 / Chapter 2.3.2.2 --- HPV16-Specific PCR --- p.42 / Chapter 2.3.3 --- Genotyping of HPV --- p.48 / Chapter 2.3.4 --- Purification of PCR Products --- p.51 / Chapter 2.3.5 --- Sequencing Reaction --- p.52 / Chapter 2.4 --- Data Analysis --- p.54 / Chapter 2.4.1 --- Sequence Edit and Alignment --- p.54 / Chapter 2.4.2 --- Sequence Variation of HPV16 Variants --- p.56 / Chapter 2.4.3 --- Construction of Phylogenetic Tree --- p.56 / Chapter 2.4.4 --- Distribution and Comparison of HPV16 Variants in Hong Kong and Korea --- p.57 / Chapter 2.4.5 --- Distribution of HPV16 Variants in Normal and Cancer Samples and Risk Association Study --- p.58 / Chapter Chapter 3 --- Results --- p.59 / Chapter 3.1 --- Study Samples --- p.60 / Chapter 3.1.1 --- HPV16-Positive Samples --- p.60 / Chapter 3.1.2 --- Samples with Unknown HPV Status --- p.61 / Chapter 3.2 --- Sub-lineage Identification of HPV16 Variants --- p.63 / Chapter 3.2.1 --- Based on the Phylogenetic Analysis in the Current Study --- p.63 / Chapter 3.2.1.1 --- Concatenated LCR-E6 Phylogenetic Tree --- p.63 / Chapter 3.2.1.2 --- LCR Phylogenetic Tree --- p.66 / Chapter 3.2.1.3 --- E6 Phylogenetic Tree --- p.69 / Chapter 3.2.2 --- Based on the Single Nucleotide Polymorphisms Proposed by Cornet et al. --- p.74 / Chapter 3.2.2.1 --- Single Nucleotide Polymorphisms of LCR Sequence --- p.74 / Chapter 3.2.2.2 --- Single Nucleotide Polymorphisms of E6 Open Reading Frame --- p.78 / Chapter 3.3 --- Sequence Variation of HPV16 Variants --- p.82 / Chapter 3.3.1 --- LCR Sequence --- p.82 / Chapter 3.3.2 --- E6 Open Reading Frame --- p.91 / Chapter 3.3.3 --- E7 Open Reading Frame --- p.95 / Chapter 3.4 --- Distribution of HPV16 Variants in Hong Kong and Korea --- p.100 / Chapter 3.4.1 --- Sub-lineage Level --- p.100 / Chapter 3.4.2 --- Clade Level of E6 Open Reading Frame --- p.101 / Chapter 3.4.3 --- Clade Level of E7 Open Reading Frame --- p.102 / Chapter 3.4.4 --- Single Nucleotide Polymorphisms Level --- p.105 / Chapter 3.4.4.1 --- LCR Sequence --- p.105 / Chapter 3.4.4.2 --- E6 Open Reading Frame --- p.107 / Chapter 3.4.4.3 --- E7 Open Reading Frame --- p.108 / Chapter 3.5 --- Risk Association and distribution of HPV16 Variants in normal and Cancer samples --- p.112 / Chapter 3.5.1 --- Sub-lineage Level --- p.112 / Chapter 3.5.2 --- Clade Level of E6 Open Reading Frame --- p.114 / Chapter 3.5.3 --- Clade Level of E7 Open Reading Frame --- p.115 / Chapter 3.5.4 --- Single Nucleotide Polymorphisms Level --- p.122 / Chapter 3.5.4.1 --- LCR Sequence --- p.122 / Chapter 3.5.4.2 --- E6 Open Reading Frame --- p.125 / Chapter 3.5.4.3 --- E7 Open Reading Frame --- p.126 / Chapter Chapter 4 --- Discussion --- p.132 / Chapter 4.1 --- HPV16 Variant Sub-lineages --- p.133 / Chapter 4.2 --- Comparison of HPV16 variants between Hong Kong and Korea --- p.137 / Chapter 4.3 --- Risk Association of HPV16 Variants --- p.138 / Chapter 4.4 --- Strength and Weakness --- p.144 / Chapter 4.5 --- Implications for Future Work --- p.146 / References --- p.148

Cheang Chi-chiu. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2003. / Includes bibliographical references (leaves 126-136). / Abstracts in English and Chinese. / Abstract --- p.i / Acknowledgements --- p.vi / Contents --- p.viii / List of Tables --- p.xi / List of Figures --- p.xiii / Chapter CHAPTER 1: --- Introduction and Background --- p.1 / Chapter 1.1 --- Ecology and distribution of the genus Sargassum --- p.1 / Chapter 1.2 --- Classical taxonomy of the genus Sargassum and associated problems --- p.2 / Chapter 1.3 --- Recent approaches on taxonomic studies of Sargassum --- p.4 / Chapter 1.3.1 --- Morphological studies --- p.4 / Chapter 1.3.2 --- Genetic studies --- p.5 / Chapter 1.3.3 --- Integration of genetic and morphological studies --- p.7 / Chapter 1.4 --- Phylogeographic distribution and population dispersal --- p.8 / Chapter 1.5 --- Description of species --- p.11 / Chapter 1.6 --- Objectives --- p.14 / Chapter 1.7 --- Layout of the thesis --- p.15 / Chapter CHAPTER 2: --- Morphological Examination on Sargassum hemiphyllum --- p.17 / Chapter 2.1 --- Introduction --- p.17 / Chapter 2.2 --- Methodology --- p.18 / Chapter 2.2.1 --- Sampling locations and treatment of specimens --- p.18 / Chapter 2.2.2 --- Morphological measurement --- p.22 / Chapter 2.2.3 --- Data analysis and statistical tests --- p.28 / Chapter 2.3 --- Results --- p.31 / Chapter 2.3.1 --- Choosing parameters from preliminary results --- p.31 / Chapter 2.3.2 --- Analysis on the main data set --- p.40 / Chapter 2.3.2.1 --- Layout of the data set --- p.40 / Chapter 2.3.2.2 --- Spatially conservable vs. variable parameters --- p.51 / Chapter 2.3.3 --- Conservable morphological parameters- consensus of specimens --- p.58 / Chapter 2.3.4 --- Variable morphological parameters- variation among specimens based on categorical parameters --- p.58 / Chapter 2.3.5 --- Differentiation of populations based on measurable and numerical parameters --- p.63 / Chapter 2.4 --- Discussion --- p.74 / Chapter 2.4.1 --- Temporal vs. spatial variation in the morphology of Sargassum hemiphyllum --- p.74 / Chapter 2.4.2 --- Spatially conservable characters for the taxonomic identification of Sargassum hemiphyllum --- p.77 / Chapter 2.4.3 --- Variation within Sargassum hemiphyllum --- p.77 / Chapter 2.4.4 --- Variation along the biogeographical gradient --- p.79 / Chapter CHAPTER 3: --- Genetic Analysis of RbcL-S Spacer in Sargassum hemiphyllum --- p.82 / Chapter 3.1 --- Introduction --- p.82 / Chapter 3.2 --- Methodology --- p.87 / Chapter 3.2.1 --- Extraction and purification of DNA --- p.87 / Chapter 3.2.2 --- Polymerase chain reaction (PCR) and gel electrophoresis --- p.87 / Chapter 3.2.3 --- Purification of PCR product --- p.90 / Chapter 3.2.4 --- DNA sequencing --- p.90 / Chapter 3.2.5 --- RFLP study --- p.92 / Chapter 3.2.6 --- Sequence alignment and analysis --- p.92 / Chapter 3.3 --- Results --- p.93 / Chapter 3.3.1 --- Extraction and PCR amplification --- p.93 / Chapter 3.3.2 --- Pilot study --- p.97 / Chapter 3.3.3 --- RFLP study --- p.103 / Chapter 3.4 --- Discussion --- p.108 / Chapter 3.4.1 --- Suitability of RbcL-S spacer as genetic marker at population level --- p.108 / Chapter 3.4.2 --- Two clades vs. two varieties of S. hemiphyllum --- p.109 / Chapter 3.4.3 --- Reproductive barrier --- p.110 / Chapter CHAPTER 4: --- General Discussion --- p.113 / Chapter 4.1 --- Morphological and genetic data- consistence or conflict --- p.113 / Chapter 4.2 --- Latitudinal gradient of seawater temperature in the Pacific NW --- p.115 / Chapter 4.3 --- Fluctuation in seawater salinity in the Pacific NW --- p.118 / Chapter 4.4 --- Possible initiation of speciation --- p.122 / Chapter 4.5 --- Works to be done in the future --- p.123 / References --- p.126

University of Macau / Faculty of Social Sciences and Humanities / Department of Government and Public Administration

No description available.