The global objectives of this research are to develop a liver-specific magnetic resonance (MR) image registration and segmentation algorithms and to find highly correlated MR imaging features that help automatically score the severity of chronic liver disease (CLD). For a concise analysis of liver disease, time sequences of 3-D MR images should be preprocessed through an image registration to compensate for the patient motion, respiration, or tissue motion. To register contrast-enhanced MR image volume sequences, we propose a novel version of the demons algorithm that is based on a bi-directional local correlation coefficient (Bi-LCC) scheme. This scheme improves the speed at which a convergent sequence approaches to the optimum state and achieves the higher accuracy. Furthermore, the simple and parallelizable hierarchy of the Bi-LCC demons can be implemented on a graphics processing unit (GPU) using OpenCL. To automate segmentation of the liver parenchyma regions, an edge function-scaled region-based active contour (ESRAC), which hybridizes gradient and regional statistical information, with approximate partitions of the liver was proposed. Next, a significant purpose in grading liver disease is to assess the level of remaining liver function and to estimate regional liver function. On motion-corrected and segmented liver parenchyma regions, for quantitative analysis of the hepatic extraction of liver-specific MRI contrast agent, liver signal intensity change is evaluated from hepatobiliary phases (3-20 minutes), and parenchymal texture features are deduced from the equilibrium (3 minutes) phase. To build a classifier using texture features, a set of training input and output values, which is estimated by experts as a score of malignancy, trains the supervised learning algorithm using a multivariate normal distribution model and a maximum a posterior (MAP) decision rule. We validate the classifier by assessing the prediction accuracy with a set of testing data.

The objectives of the work presented were to 1) fabricate reproducible nanorod array SERS substrates, 2) detection of bacteria using nanorod substrates, 3) detection of DNA hybridization using nanorod substrates and 4) critically evaluate the sensing method. Important findings from this work are as follows. A novel method for batch fabrication of substrates for surface enhanced Raman scattering (SERS) has been developed using a modified platen machined to fit in a commercial electron beam evaporator. The use of this holder enables simultaneous deposition of silver nanorod (AgNR) arrays onto six microscope slide substrates utilizing glancing angle deposition. In addition to multiple substrate fabrication, patterning of the AgNR substrates with 36 wells allows for physical isolation of low volume samples. The well-to-well, slide-to-slide, and batch-to-batch variability in both physical characteristics and SERS response of substrates prepared via this method was nominal. A critical issue in the continued development of AgNR substrates is their stability over time, and the potential impact on the SERS response. The thermal stability of the arrays was investigated and changes in surface morphology were evaluated using scanning electron microscopy and x-ray diffraction and correlated with changes in SERS enhancement. The findings suggest that the shelf-life of AgNR arrays is limited by migration of silver on the surface. Continued characterization of the AgNR arrays was carried out using fluorescent polystyrene microspheres of two different sizes. Theory suggests that enhancement between nanorods would be significantly greater than at the tops due to contributing electromagnetic fields from each nanostructure. In contrast to the theory, SERS response of microspheres confined to the tops of the AgNR array was significantly greater than that for beads located within the array. The location of the microspheres was established using optical fluorescence and scanning electron microscopy. The application of SERS to characterizing pathogens such as bacteria and viruses is an active area of investigation. AgNR array-based SERS substrates have enabled detection of pathogens present in biofluids. Specifically, several publications have focused on determining the spectral bands characteristic of bacteria from different species and cell lines. Studies were carried out on three strains of bacteria as well as the medium in which the bacteria were grown. The spectra of the bacteria and medium were surprisingly similar, so additional spectra were acquired for commonly used bacterial growth media. In many instances, these spectra were similar to published spectra purportedly characteristic of specific bacterial species. In addition to bacterial samples, nucleic acid hybridization assays were investigated. Oligonucleotide pairs specifically designed to detect respiratory syncytial virus (RSV) in nasal fluids were prepared and evaluated. SERS spectra acquired on oligos, alone or in combination, contain the known spectral signatures of the nucleosides that comprise the oligo. However, spectra acquired on an oligo with a 5'- or 3' thiol were distinctly different from that acquired on the identical oligo without a thiol pendant group suggesting some control over the orientation of the oligo on the nanorod surface. The signal enhancement in SERS depends markedly upon the location of the probe relative to the substrate surface. By systematic placement of nucleotide markers along the oligo chain, the point at which the nucleotide disappears from the spectrum was identified. The overall findings for AgNR SERS substrates suggest that the applicability of SERS for detecting nucleic acid hybridization is limited. The strong distance dependence coupled with the lack of substrate stability at temperatures required for annealing oligos during hybridization suggest that AgNRs are not the platform to use for hybridization assays.

This paper establishes Low-Tension-Gas (LTG) as a method for sub-miscible tertiary recovery in tight sandstone and carbonate reservoirs. The LTG process involves the use of a low foam quality surfactant-gas solution to mobilize and then displace residual crude after waterflood. It replicates the existing Alkali-Surfactant-Polymer (ASP) process in its creation of an ultra-low oil-water interfacial tension (IFT) environment for oil mobilization, but instead supplements the use of foam over polymer for mobility control. By replacing polymer with foam, chemical Enhanced Oil Recovery (EOR) methods can be expanded into sub-30 mD formations where polymer is impractical due to plugging, shear, or the requirement to use a low molecular weight polymer. Overall results indicate favorable mobilization and displacement of residual crude oil in both tight carbonate and tight sandstone reservoirs. Tertiary recovery of 75-95% ROIP was achieved for cores with 2-15 mD permeability, with similar oil bank and other ASP analogous process attributes observed. Moreover, similar recovery was achieved during testing at high initial oil saturation (56%), indicating high process tolerance to oil saturation and potential application for implementation at secondary recovery. In addition, a number of tools and relations were developed to improve the predictive relationship between observed coreflood properties and actual mobilization or displacement mechanisms which impact reservoir-scale flooding. These relations include qualitative dispersion comparison and calculation of in-situ gas saturation, macroscopic mobility ratio at the displacement fronts, and apparent viscosity of injected fluids. These tools were validated through use of reference gas and surfactant floods and indicate that stable macroscopic displacement can be achieved through LTG flooding in tight formations. Furthermore, to better reflect actual reservoir conditions where localized fractional flow of gas can vary substantially depending on mixing or gravity phenomenon, two additional sets of data were developed to empirically model behavior. Through testing of LTG co-injection at a number of discrete fractional flow values over a wide range, recovery was shown to achieve a relative maximum at 50% gas fractional flow which also corresponded with optimal observed mobility control as measured by the previously established tools. Likewise, through testing of surfactant-alternating-gas (SAG) injection cycling, displacement and overall recovery were shown to be improved versus reference co-injection flooding. Finally, by comparing the observed displacement and mobility data among co-injection and surfactant-alternating-gas floods, a new displacement mechanism is introduced to better relate actual displacement conditions with observed macroscopic mobility data. This mechanism emphasizes the role of liquid rate in actual displacement processes and a mostly static gas saturation (independent of gas rate) in altering liquid relative permeability and diverting injected liquid into lower permeability zones. / text

ITC/USA 2014 Conference Proceedings / The Fiftieth Annual International Telemetering Conference and Technical Exhibition / October 20-23, 2014 / Town and Country Resort & Convention Center, San Diego, CA / One of the initial control room capabilities to be demonstrated by iNET program is the ability to provide data displays in the control room that do not contain data dropouts. This concept is called PCM Backfill where PCM data is both transmitted via traditional SST and recorded onboard via an iNET compatible recorder. When data dropouts occur, data requests are made over the telemetry network to the recorder for the missing portions of the PCM data stream. The retrieved data is sent over the telemetry network to the backfill application and ultimately delivered to a pristine data display. The integration of traditional SST and the PCM Backfill capability provides both real-time safety of flight data side-by-side with pristine data suitable for advanced analysis.

Η χρήση των πολυμερών στον τομέα της ιατρικής βιομηχανίας κερδίζει ολοένα και μεγαλύτερο έδαφος τα τελευταία χρόνια έχοντας ήδη κάνει ισχυρή την παρουσία τους σε ένα ευρύ πεδίο κλάδων της βιοϊατρικής όπως στη μηχανική ιστών, στην εμφύτευση ιατρικών συσκευών και τεχνητών οργάνων, στην προσθετική και την οφθαλμολογία, στην οδοντιατρική και την αποκατάσταση οστών, στη χημειοθεραπεία και σε ποικιλία άλλων ιατρικών εφαρμογών. Με τη χρήση πολυμερικών συστημάτων μεταφοράς δραστικών ουσιών καθίσταται ικανή η ελεγχόμενη αργή αποδέσμευση φαρμάκων στο σώμα καθώς και η στοχευμένη απελευθέρωσή τους σε σημεία όπου υπάρχουν φλεγμονές ή όγκοι. Τοιουτοτρόπως, χημειοθεραπείες με χρήση βιοπολυμερών ως διαμεσολαβητές, προβάλλουν ως δυνητικές υποψήφιοι στην αντιμετώπιση του καρκίνου του εγκεφάλου με ενθαρρυντικά αποτελέσματα. Συγκρινόμενη με την τυπική συστημική χημειοθεραπεία, η ενδοογκική απελευθέρωση φαρμάκου με τη χρήση βιοπολυμερών θεωρητικώς παρουσιάζει αρκετά πλεονεκτήματα: τα βιοπολυμερή μπορούν να μεταφέρουν το φάρμακο απευθείας στον όγκο-στόχο αυξάνοντας τη συγκέντρωση τοπικά και παράλληλα μειώνοντας τη συστημική τοξικότητα· μπορούν έτσι να χρησιμοποιούνται στη θεραπεία ανοσοκατασταλμένων ασθενών που δεν μπορούν να υποβληθούν σε συστημική χημειοθεραπεία. Από τη στιγμή που είναι απαραίτητη η ποσοτικοποίηση των φαρμάκων για τον χαρακτηρισμό των συστημάτων αποδέσμευσης και για μελέτες φαρμακοκινητικής, θα πρέπει να επιλέγεται η καταλληλότερη μέθοδος ποσοτικοποίησης παρέχοντας υψηλή ευαισθησία και ακρίβεια, εξασφαλίζοντας μεγάλη ανιχνευτική ικανότητα ακόμη και για πολύ χαμηλές συγκεντρώσεις. Στην παρούσα εργασία δύο αναλυτικές τεχνικές, η απορρόφηση υπεριώδους-ορατού και η επιφανειακή ενίσχυση της σκέδασης Raman (Surface Enhanced Raman Scattering, SERS), χρησιμοποιήθηκαν για την ποσοτική εκτίμηση του αντινεοπλασματικού φαρμάκου Mitoxantrone και του αντιμυκητιακού παράγοντα Ambisome (Αμφοτερισίνη Β) που αποδεσμεύτηκαν από βιοσυμβατές πολυμερικές μήτρες συμπολυμερούς αιθυλενίου-οξικού βινυλεστέρα, συμπολυμερούς γλυκολικού-γαλακτικού οξέος και πολυπροπυλενίου. Το SERS είναι ένα νέο, εναλλακτικό, ταχύ και μη καταστροφικό εργαλείο που μπορεί να βρεί εφαρμογή και στην ποσοτική εκτίμηση ουσιών πάρα πολύ χαμηλών συγκεντρώσεων. Χάρις στην ενίσχυση που παρέχεται στο σήμα Raman από τα νανο-εκτραχυμένα υποστρώματα ευγενών μετάλλων ή τα νανο-συσσωματώματα κολλοειδών διαλυμάτων ευγενών μετάλλων, έχει αναφερθεί ακόμη και συλλογή φάσματος SERS από ένα μόνο μόριο. Συνεπώς, η εφαρμογή του SERS σε μελέτες ουσιών εξαιρετικά χαμηλών συγκεντρώσεων φαίνεται να είναι πολύ ενδιαφέρουσα. Κατασκευάστηκαν πολυμερικά υμένια με εγκλωβισμένες τις δραστικές ουσίες και η μελέτη αποδέσμευσης πραγματοποιήθηκε σε νερό. Ποσοτικές μετρήσεις με τη χρήση του SERS σε πολύ μικρές συγκεντρώσεις έδειξαν μεγαλύτερη ανιχνευτική ευαισθησία σε σχέση με αυτές που πραγματοποιήθηκαν με την απορρόφηση UV-Vis. Συμπερασματικά, το SERS δείχνει ικανό στον ποσοτικό προσδιορισμό ενεργών ουσιών που αποδεσμεύονται από βιοσυμβατά πολυμερικά συστήματα μεταφοράς δραστικών ουσιών σε πολύ μικρές συγκεντρώσεις. / The application of polymeric materials for medical purposes is growing very fast. Polymers have found applications in such diverse biomedical fields as tissue engineering, implantation of medical devices and artificial organs, prosthesis, ophthalmology, dentistry, bone repair, chemotherapy and many other medical fields. Polymer-based delivery systems enable controlled slow release of drugs into the body and also they make possible targeting of drugs into sites of inflammation or tumors. Thus, biopolymer-mediated chemotherapy has shown promising results in the treatment of brain tumors. When compared to conventional systemic chemotherapy, intratumoral biopolymer-mediated drug delivery has several theoretical advantages: Biopolymers can deliver drugs into the tumor bed, thus maximizing local concentration while minimizing systemic toxicity. They may therefore be employed in the treatment of immunodepressed patients etc. Since drugs need to be quantified for drug delivery system characterization, intracellular distribution studies, free or vehicular, and for pharmacokinetic assays, the most suitable quantification method must be chosen. It should have a high sensitivity, specificity and reproducibility and should be capable of measuring at very low concentration range, as well. In the present study, two analytical techniques are utilized to quantitatively evaluate the antineoplastic drug Mitoxantrone and the antifungal agent Ambisome (Amphotericin b) released from active agents-loaded biocompatible polymer matrices poly(propylene), poly(ethylene-co-vinyl acetate), poly(lactic-co-glycolic acid); the UV-Vis absorption and the Surface Enhance Raman Scattering (SERS). SERS is a new, versatile, fast and non destructive tool for the estimation of extremely small amounts of substances. Due to the enhancement provided to the Raman signal by the nano-rough noble-metal substrates or the nano-structured colloidal clusters of noble metals, even single molecule detection has been reported. Therefore, applying SERS to extremely low concentration measurements proves to be challenging. Drug loaded polymer specimens were prepared and the in vitro drug release was determined in water. Fast SERS quantitative measurements showed enhanced sensitivity compared to the UV-Vis absorption; SERS may enable low concentration quantitative assessment of controlled release of drugs from biopolymer-based delivery systems.

Esta pesquisa teve como objetivo principal propor um panorama de integração entre repositórios de dados de pesquisa e publicações científicas baseado no modelo de publicações ampliadas. Do ponto de vista de sua natureza, é básica. Segundo a abordagem é considerada qualitativa, e caracteriza-se por ser uma pesquisa exploratória e bibliográfica. O modelo de análise deste estudo foi composto por três fases. Na primeira fase de análise, foram coletadas literaturas específicas da área por meio da revisão sistemática e, a partir das literaturas, foram extraídos os requisitos indicados e sugeridos para um modelo de publicação ampliada. Na segunda fase de análise, foram selecionados os repositórios de dados de pesquisa através do diretório re3data.org e averiguadas as informações disponibilizadas por meio dos filtros que demonstrassem a utilização de ligações baseadas no modelo de publicação ampliada. Na terceira fase de análise, foi realizada a inspeção das interfaces e identificados os elementos que cada repositório contempla para posteriormente iniciar as análises, observações e comparações dos elementos utilizados nos repositórios com os requisitos estabelecidos por meio da revisão sistemática. Percebeu-se na literatura que há uma tentativa de adicionar uma estrutura utilizando-se requisitos relacionados a metadados, relacionamentos semânticos, entre outros. Verificou-se que parte dessa estrutura indicada na literatura já encontra-se nas interfaces de alguns repositórios identificados no diretório re3data.org. No entanto estes repositórios que contemplam parte da estrutura indicada foram caracterizados como uma minoria. Desta forma, verificou-se uma necessidade crescente, de uma infraestrutura compatível com as publicações ampliadas, tornando-se de extrema importância a utilização de requisitos para as interfaces dos repositórios de dados de pesquisa O cruzamento de informações realizado neste estudo permitiu um maior entendimento do quanto é importante o uso de cada um dos requisitos estipulados, como também foi possível compreender as consequências caso estes requisitos não estejam contemplados nas interfaces de repositórios. Os repositórios de dados de pesquisa deveriam fornecer em suas interfaces as ligações e o acesso às respectivas publicações científicas dos dados registrados para que fosse possível compreender os estudos realizados a partir destes dados. Foi comprovado que esse processo não ocorre na grande parte dos repositórios, o que dificulta a compreensão sobre a origem e o contexto em que foram utilizados esses dados. Percebe-se que os repositórios que não estavam de acordo com os principais requisitos estabelecidos apresentavam características de publicações convencionais como, por exemplo, documentos em PDF, textos em HTML e que não estavam de acordo com padrões da web semântica. Esta proposta de um panorama de integração de dados de pesquisa baseado em publicações ampliadas visa sugerir uma interface que contemple todos os requisitos especificados nesta pesquisa para que se tenha uma infraestrutura compatível com as publicações ampliadas. A partir da investigação e do aprofundamento sobre o tema, foi possível ampliar o conhecimento e detectar os elementos apropriados para propor um panorama de integração entre um repositório de dados de pesquisas e publicações científicas baseando-se em um modelo de publicação ampliada, como também destacar as vantagens da utilização deste modelo. Considera-se que um conjunto de dados disponíveis em um repositório digital, que contemple os requisitos, melhora a recuperação da informação e, consequentemente, aumenta a visibilidade da publicação e de autores. / This research had the main objective to propose an integration landscape between research data repositories and scientific publications based on the model for enhanced publications. From its nature`s point of view, it is basic. According to the approach it is considered a qualitative, is characterized as an exploratory, bibliographic research and a case study as well. The analysis model of this study was constituted of three phases. In first phase of the analyses, specific literatures were colected through the systematic review and from literatures, in addition the suggested requirements and indicated for a model for enhanced publications were extracted, in addition the suggested requirements and indicated for an enhanced publication model were extract. In second phase of the analyses, research data repositories were select through the re3data.org directory and were verified the information provided through the filters which demonstrated the application of links based on the model for enhanced publications. In the third and last phase of the analyses, an inspection of interfaces were realized, and also elements that each repository comprehend were identified to subsequently initiate the analyses, observations and comparisions of the elements used on repositories with the estabilished requirements through systematic review. It was perceived in the literature, that there are an attempt to add a structure by using related requirements to metadata, semantic relationship, among others. Also verified that part of this estructure indicated on literature is available on interfaces of some identified repositories on re3data.org. Although these repositories which comprehend part of the indicated structure were characterized as a minority.( Continue) Therefore, there has been a growing need for an infrastructure compatible with the enhanced publications, aware of the importance for the application of requirements to the interfaces of research data repositories. The crossover of informations realized in this study allowed a greater understanding about the importance to use each one of the stipulated requirements, as well as was possible to understand the consequences in case of these requirements are not be included in the repositories interfaces. Research data repositories should provide on their interfaces the links and access to their respective scientific publications of the recorded data in order to be able to understand the studies carried out from this data. It has been proven that this process does not occur in most repositories, which difficults to understand the origin and context in which these data were used. It was noticed that repositories not in agreement with the main presented established requirements characteristics of conventional publications, as for example PDF documents, HTML texts and which was not in accordance to patterns for semantic web. This proposal for a research data integration model based on enhanced publications aims to suggest an interface that that fulfills all the specified requirements in this research to obtain an infrastructure compatible to enhanced publications. From the investigation and deepening the theme, it was possible to increase the knowledge and to detect the appropriate elements to propose an integration model between a researches data repository and scientific publications based on a model for enhanced publication as well as highlighting the advantages of applying this model. Thus, it is concluded that a set of available data into a digital repository that comprehend the requirements improves the information recovery and, therefore, increases the visibility of publication and authors.

Esta pesquisa teve como objetivo principal propor um panorama de integração entre repositórios de dados de pesquisa e publicações científicas baseado no modelo de publicações ampliadas. Do ponto de vista de sua natureza, é básica. Segundo a abordagem é considerada qualitativa, e caracteriza-se por ser uma pesquisa exploratória e bibliográfica. O modelo de análise deste estudo foi composto por três fases. Na primeira fase de análise, foram coletadas literaturas específicas da área por meio da revisão sistemática e, a partir das literaturas, foram extraídos os requisitos indicados e sugeridos para um modelo de publicação ampliada. Na segunda fase de análise, foram selecionados os repositórios de dados de pesquisa através do diretório re3data.org e averiguadas as informações disponibilizadas por meio dos filtros que demonstrassem a utilização de ligações baseadas no modelo de publicação ampliada. Na terceira fase de análise, foi realizada a inspeção das interfaces e identificados os elementos que cada repositório contempla para posteriormente iniciar as análises, observações e comparações dos elementos utilizados nos repositórios com os requisitos estabelecidos por meio da revisão sistemática. Percebeu-se na literatura que há uma tentativa de adicionar uma estrutura utilizando-se requisitos relacionados a metadados, relacionamentos semânticos, entre outros. Verificou-se que parte dessa estrutura indicada na literatura já encontra-se nas interfaces de alguns repositórios identificados no diretório re3data.org. No entanto estes repositórios que contemplam parte da estrutura indicada foram caracterizados como uma minoria. Desta forma, verificou-se uma necessidade crescente, de uma infraestrutura compatível com as publicações ampliadas, tornando-se de extrema importância a utilização de requisitos para as interfaces dos repositórios de dados de pesquisa O cruzamento de informações realizado neste estudo permitiu um maior entendimento do quanto é importante o uso de cada um dos requisitos estipulados, como também foi possível compreender as consequências caso estes requisitos não estejam contemplados nas interfaces de repositórios. Os repositórios de dados de pesquisa deveriam fornecer em suas interfaces as ligações e o acesso às respectivas publicações científicas dos dados registrados para que fosse possível compreender os estudos realizados a partir destes dados. Foi comprovado que esse processo não ocorre na grande parte dos repositórios, o que dificulta a compreensão sobre a origem e o contexto em que foram utilizados esses dados. Percebe-se que os repositórios que não estavam de acordo com os principais requisitos estabelecidos apresentavam características de publicações convencionais como, por exemplo, documentos em PDF, textos em HTML e que não estavam de acordo com padrões da web semântica. Esta proposta de um panorama de integração de dados de pesquisa baseado em publicações ampliadas visa sugerir uma interface que contemple todos os requisitos especificados nesta pesquisa para que se tenha uma infraestrutura compatível com as publicações ampliadas. A partir da investigação e do aprofundamento sobre o tema, foi possível ampliar o conhecimento e detectar os elementos apropriados para propor um panorama de integração entre um repositório de dados de pesquisas e publicações científicas baseando-se em um modelo de publicação ampliada, como também destacar as vantagens da utilização deste modelo. Considera-se que um conjunto de dados disponíveis em um repositório digital, que contemple os requisitos, melhora a recuperação da informação e, consequentemente, aumenta a visibilidade da publicação e de autores. / This research had the main objective to propose an integration landscape between research data repositories and scientific publications based on the model for enhanced publications. From its nature`s point of view, it is basic. According to the approach it is considered a qualitative, is characterized as an exploratory, bibliographic research and a case study as well. The analysis model of this study was constituted of three phases. In first phase of the analyses, specific literatures were colected through the systematic review and from literatures, in addition the suggested requirements and indicated for a model for enhanced publications were extracted, in addition the suggested requirements and indicated for an enhanced publication model were extract. In second phase of the analyses, research data repositories were select through the re3data.org directory and were verified the information provided through the filters which demonstrated the application of links based on the model for enhanced publications. In the third and last phase of the analyses, an inspection of interfaces were realized, and also elements that each repository comprehend were identified to subsequently initiate the analyses, observations and comparisions of the elements used on repositories with the estabilished requirements through systematic review. It was perceived in the literature, that there are an attempt to add a structure by using related requirements to metadata, semantic relationship, among others. Also verified that part of this estructure indicated on literature is available on interfaces of some identified repositories on re3data.org. Although these repositories which comprehend part of the indicated structure were characterized as a minority.( Continue) Therefore, there has been a growing need for an infrastructure compatible with the enhanced publications, aware of the importance for the application of requirements to the interfaces of research data repositories. The crossover of informations realized in this study allowed a greater understanding about the importance to use each one of the stipulated requirements, as well as was possible to understand the consequences in case of these requirements are not be included in the repositories interfaces. Research data repositories should provide on their interfaces the links and access to their respective scientific publications of the recorded data in order to be able to understand the studies carried out from this data. It has been proven that this process does not occur in most repositories, which difficults to understand the origin and context in which these data were used. It was noticed that repositories not in agreement with the main presented established requirements characteristics of conventional publications, as for example PDF documents, HTML texts and which was not in accordance to patterns for semantic web. This proposal for a research data integration model based on enhanced publications aims to suggest an interface that that fulfills all the specified requirements in this research to obtain an infrastructure compatible to enhanced publications. From the investigation and deepening the theme, it was possible to increase the knowledge and to detect the appropriate elements to propose an integration model between a researches data repository and scientific publications based on a model for enhanced publication as well as highlighting the advantages of applying this model. Thus, it is concluded that a set of available data into a digital repository that comprehend the requirements improves the information recovery and, therefore, increases the visibility of publication and authors.

With an ever-increasing amount of cyberespionage and cybercrime, any potential attack vector into a computer system is worthy of investigation. One such vector could be through the wireless keyboard the user themselves use and trust. If an attacker was able to intercept the traffic between the keyboard and the computer they could spy on every keystroke that is being sent to the computer. Additionally, they could potentially inject keystrokes as if they were sitting at the computer themselves. This thesis evaluated 10 different keyboards that were purchased in common consumer electronic stores and 8 of them were found to have new substantial flaws that made it possible to reliably listen to every keystroke sent by the keyboards, as well as allow an attacker to send keystrokes to the connected computer, indirectly giving the attacker full control of the computer. It was concluded that wireless keyboards should not be used in situations where sensitive information is handled regardless of what the keyboard manufacturer claims, as it creates a potential attack vector that is otherwise nonexistent. / Med en ständigt ökande mängd cyberspionage och cyberbrottslighet så är alla potentiella vägar in i ett datorsystem värda att undersöka. Ett sätt att ta sig in i ett system skulle kunna vara genom det trådlösa tangentbord som användaren själv använder och litar på. Om en angripare hade möjligheten att fånga upp trafiken mellan tangentbordet och datorn skulle den kunna lyssna på varenda knapptryck som skickades till datorn. Utöver det så skulle en angripare möjligen kunna skicka egna knapptryck till datorn som om den själv satt vid den. Den här uppsatsen har studerat och utvärderat 10 olika tangentbord som köptes i vanliga elektronikaffärer och i 8 av dem hittades nya allvarliga brister som gjorde det möjligt att både avlyssna vad som skrevs samt att kunna skicka knapptryck till datorn som tangentbordet var kopplat till. Detta ledde indirekt till full kontroll över datorn. Slutsatsen som kunde dras var att trådlösa tangentbord inte bör användas i någon situation där känsligt innehåll hanteras, oavsett vad tillverkaren av tangentbordet hävdar. Detta då det öppnar upp en ny attackyta som inte finns om trådlösa tangentbord inte används.

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