在創業的過程中，資源與整體能力的累積是依循漸進的。從一開始的小團隊、小規模經營，到後來以組織戰擴張營業額與營運績效，可謂是成功創業案例中，相當重要的歷程。如何能創業成功，創業的演變歷程扮演了相當關鍵的角色。有道是「萬丈高樓平地起」，一個企業要能克服瓶頸，才能成長茁壯。 如何能夠讓創業的過程中更有效管理，就是本研究欲探討的重點。本研究利用Tuckman在1977年所發表的團隊發展歷程理論，整合了個案研究，並透過創業家的訪談，進行團隊與創業管理的探討。透過團隊發展歷程理論中，對於形成階段、風暴階段、規範階段、表現階段、終止階段等團隊發展歷程五大階段的分析，了解到銷貨與通路管理、人力資源管理、財務管理、研發管理、生產管理等等議題，並且結合文獻回顧與專家訪談的方式，作出結論與建議。 在個案選擇的部分，本研究是以電子相關的創業作為個案，其中的C公司是經營DRAM與FLASH的銷貨作為營運主力，H公司則是以電源管理相關的電子零組件、模組作為利基點。整體來說，本研究以電子相關的創業團隊探討為主，希望能對產業界與學術界有所助益。 / In the course of establishing a business, resources and overall capacity usually accumulate step by step. It begins with a small team, small-scale operation and gradually expands its turnover and performance, which can be described as an indispensible process among any successful cases, and the entrepreneurial developmental process also plays a critical role. As a saying goes, "Every skyscraper starts from scratch", a company must be able to overcome its bottlenecks in order to grow. How to make management more efficient during the developmental process is the focus of this study. This study utilizes the theory of Team Developmental Process published by Tuckman in 1977, integrating case studies and interviews with entrepreneurs to discuss team and entrepreneurial management. Analyzing the theory of team development process, which includes forming stage, storming stage, norming stage, performing stage, and adjourning stage, I gained an insight into several issues such as the sales and channel management, human resources management, financial management, R & D management, production management. Combining literature review and interviews with experts, I reach my conclusions with some suggestions at the end. In terms of case selection, this study uses electronics-related firms as case study, among which, the sales of C Company specializes on DRAM and FLASH, whereas H Company on power management, electronic components and modules as its niche point. Overall, this study focuses on electronics-related entrepreneurial team, hoping to be helpful to the industry as well as the academia.

As depicted in Chapter I, 2-oxoglutarate- (2OG) dependent oxygenases are ubiquitous in living systems and display a wide range of cellular functions, spanning metabolism, transcription, and translation. Although functionally diverse, the 2OG oxygenases share a high degree of structural similarities between their catalytic sites. From a medicinal chemistry point of view, the combination of biological diversity and structural similarity presents a rather challenging task for the development of selective small molecules for functional studies in vivo. The non-selective metal chelator 8-hydroxyquinoline (8HQ) was used as a template for the generation of tool compound <b>I</b> for the KDM4 subfamily of histone demethylases via application of the Betti reaction. Structural analogue <b>II</b> was used as the corresponding negative control (Figure A). These compounds were characterised in vitro against a range of 2OG oxygenases and subsequently used for studies in cells. <b>I</b> displays selectivity for KDM4 and increases the level of the H3K9me3 histone mark in cells. It has an effect on the post-translational modification pattern of histone H3, but not other histones, and reduces the viability of lung cancer cells, but not normal lung cells, derived from the same patient. <b>I</b> also stabilises hypoxia-inducable factor HIF in cells via a mechanism which seems to be independent from prolyl hydroxylase inhibition. This work is described in Chapters II and III. The chemical biology research in epigenetics is complemented by qualitative analysis conducted in the social sciences at Said Business School. With a global view on how innovation occurs and may actively be fostered, Chapter IV focuses on the potential of epigenetics in drug discovery and how this process may actively be promoted within the framework of open innovation. Areas of focus include considerations of incremental and disruptive technology; how to claim, demarcate, and control the market; how knowledge brokering occurs; and insights about process, management, organisation, and culture of open innovation. In contrast to the open-skies approach adopted for the development of a tool compound in Chapters II and III, a focused-library approach was taken for the generation of a tool compound for the OGFOD1 ribosomal prolyl hydroxylase. The development of a suitable in vitro activity assay for OGFOD1 in Chapter V enabled the development of lead compound <b>III</b> in Chapter VI. <b>III</b> is selective for OGFOD1 against the structurally closely related prolyl hydroxylase PHD2.