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Exercise induced hemolysis, inflammation and hepcidin activity in endurance trained runnersPeeling, Peter Daniel January 2009 (has links)
[Truncated abstract] Iron is a trace mineral used by the body in many physiological processes that are essential to athletic performance. Commonly, the body's iron stores are compromised by exercise via several well established mechanisms. One such mechanism is the destruction of red blood cells (hemolysis), in response to the mechanical stress and circulatory strain of exercise. Although it appears that a force-dependent relationship between the heel-strike of the running gait and ground contact exists, the effects of the intensity trained at and the ground surface type trained upon have not been documented. Similarly, the effects of a cumulative training stress (i.e. multiple daily sessions) has not been examined. In addition to hemolysis, exercise also invokes an inflammatory response that results in an up-regulation of the cytokine interleukin-6 (IL-6). This cytokine is the primary mediator of hepcidin expression, a liver-produced hormone that regulates iron metabolism in the gut and in macrophages. The influence of exercise on hepcidin expression is relatively unknown, and as such it is possible that this hormone may be a mitigating factor implicated in athletic-induced iron deficiency. Therefore, the purpose of this thesis was to investigate the effect of different training frequencies, intensities and ground surfaces on the hemolytic response. In addition, the impact of exercise-induced inflammation on hepcidin expression in the 24 h post-exercise was investigated, with the aim of determining whether this hormone may be a potential new mechanism associated with athletic-induced iron deficiency. Finally, an interaction between hemolysis and hepcidin activity was examined to investigate their potential combined effect on iron status in the 24 h post-exercise. ... Venous blood and urine samples were collected pre- and immediately post-exercise, and at 3 and 24 h of recovery. Samples were analysed for circulating levels of IL-6, free Hb, Hp, serum iron, ferritin and urinary hepcidin activity. At the conclusion of both the T1 and T2 interval runs, the free Hb and serum Hp were significantly increased (p<0.05) from pre-exercise levels. Furthermore, a cumulative effect of two running sessions was shown in the T2 trial, via a further significant fall in serum Hp. The IL-6 and hepcidin activity were significantly increased after each running session (p<0.05) with no cumulative effect seen. Serum iron and ferritin were significantly increased post-exercise after each interval run (p<0.05), but were not influenced by the addition of a prior LSD run 12 h earlier. As a result, this investigation showed a cumulative effect of consecutive training sessions on RBC destruction in male athletes. Furthermore, post-exercise increases to serum iron and hepcidin, and their interaction was suggested to have potential implications for an athlete's iron status. Overall, the findings of this thesis show that hemolysis is evident at the conclusion of endurance running, and is influenced by training intensity and frequency. The results enabled a time-line for hepcidin expression post-exercise to be established, and the implications of increases to the activity of this hormone, in association with the hemolytic changes seen with endurance exercise are discussed.
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Cardiac and vascular adaptations to exercise training in elite athletes and obese adolescentsNaylor, Louise Haleh January 2006 (has links)
[Truncated abstract] This thesis concerns itself primarily with the impact of exercise training on cardiac and vascular adaptations in humans. It contains longitudinal studies of individuals at either end of the physical activity spectrum; young elite athletes and obese children and adolescents. The study of these diverse groups was intentional, as a particular interest was to investigate the possible inter-relationships between morphological adaptations in the heart, evident in both obese and athletic populations, and the possible consequences of such adaptations for cardiac function. Whilst there exists a long tradition of echocardiographic assessment of cardiac dimensions and mass in both athletic and clinical populations, investigation of the impact of each of these “conditions” on cardiac diastolic function is novel, and has been facilitated by recent advances in the technical approach to diastolic function assessment in humans. Studies presented in the following chapters utilise advanced echocardiography imaging combined with pulse wave and tissue Doppler approaches to investigate the effects of exercise training regimen on wall thickness and ventricular mass, as well as diastolic function indices. State-of-the-art vascular imaging approaches have also been used in these populations to determine whether changes in vascular wall thickness, diameter or function occur with training in the elite athletes or obese youth.
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The Effects of Physical Activity on Bone Density in Adolescent FemalesGluck, Beth January 2004 (has links) (PDF)
No description available.
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Impact of batting skill on pacing during repeated sprints between the wickets.Elliott, Andrea January 2014 (has links)
Introduction: With batting in cricket, there is no known end point, making the allocation of resources and the development of a suitable pacing strategy more difficult. How batsmen allocate resources and pace themselves when repeatedly sprinting between the wickets is therefore not known. According to the ‘anticipatory feedback’ model, the level of expertise/experience has a substantial influence on the development of a suitable pacing strategy. Skilled or experienced batsmen may therefore have a greater ability to develop and implement a pacing strategy compared to that of novice or less-skilled batsmen. Purpose: To assess whether the absence of a known end point at the beginning of repeated sprint bouts between the wickets effects how batsmen pace themselves comparing skilled and less-skilled batsmen. Methods: Twenty-four male cricketers from a university league were selected. Twelve skilled batsmen (players in the top five batting order), and 12 less-skilled batsmen (players in the bottom five batting order) completed three experimental. All trials required batsmen to complete the same number of shuttle sprints (14 shuttles and therefore 28 runs), while only the information provided before each trial differed. Control Trial: This trial is also referred to as the ‘informed’ trial as the batsmen are aware of the exercise requirements (end point). Unknown Trial: The batsmen were not informed of the exercise end point and were required to run on command for an indefinite period (28 runs). Deceptive Trial: Batsmen’ were incorrectly informed with regards to the number of sprints (told they were only doing 14 runs when in fact they were doing 28 runs). Muscle activity, sprint times and RPE measures were obtained during all three trials and compared. Results: Significant (p<0.05) group effects were apparent for sprint times and, ‘central’ and ‘local’ RPE. Specifically, skilled batsmen obtained the faster mean sprint times, and less-skilled batsmen reported the higher mean ‘central’ and ‘local’ RPE values in all three experimental trials. There were no significant group effects for muscle activation. Skilled batsmen did however have lower muscle activation compared to less-skilled batsmen in all three trials. Furthermore, general trends revealed that sprint times and muscle activation decreased over time (from shuttle 1 to shuttle 14), and RPE (‘central’ and ‘local’) ratings increased, regardless of the experimental trials. Skilled batsmen performed the best in all three trials. This was determined by the attainment of faster sprint times, lower muscle activation and low RPE ratings in each of the three trials. The assessment of the relationship of the dependent variables measured in each trial, did however suggest that skilled batsmen performed best in the deceptive trial while less-skilled batsmen performed best in the control trial. Skilled batsmen thus showed superior performance when trial requirements were unclear. Less-skilled batsmen however, were seen to experience decrements in performance when information regarding the end point was unknown or misleading. Conclusion: It can thus be concluded that previous experience facilitates in the obtainment of improved sprint times between the wickets, especially when the exact end point is unknown.
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The Retentive Aspects of Selected Qualities of Fitness as a Function of Inactivity in College MenPoteet, John R. 05 1900 (has links)
The purposes of this study were to (a) investigate the physiological changes produced in college men after a nine-week circuit training and jogging conditioning program, (b) analyze the effects of deconditioning periods of four, six, and eight weeks upon the physical fitness of college men, and (c) compare the developmental and retentive aspects of muscular strength, muscular endurance, circulo-respiratory endurance, and skinfold measurements. Pearson Product-Moment correlations of pre-test measures, post-test measures, differences between pre-test and post-test measures, and differences between post-test and respective retention test measures did not identify any consistent pattern of developmental or retentive relationships. The components of fitness tended to develop and deteriorate independently of each other.
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Quantitative analysis of locomotion to aid lameness detectionWalker, Anna Marie January 2011 (has links)
No description available.
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The effect of continuous assistive-passive exercise on physiological parameters among obese femalesMentz, N.W. (Nick) 10 January 2007 (has links)
Please read the abstract in the section 00front of this document / Dissertation (MA (HMS))--University of Pretoria, 2007. / Biokinetics, Sport and Leisure Sciences / unrestricted
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Use of repeated tests and rolling breath averages affects the precision of quantifying the VO2 response profile in moderate intensity cycling.Pedini, Daniela Marie 08 1900 (has links)
The purpose of this study was to determine whether working in the field of deaf education, as opposed to general education, results in a higher level of technology integration. A secondary goal was to determine if deaf educators who are deaf integrate technology at a higher level than their hearing counterparts. The instrument chosen for this study was the LoTi Technology Use Profile, a tool used to explore the role of technology in the classroom. A total of 92 participates were included in the study of which 48 were regular educators and 44 were deaf educators. The participants were selected from a population pool whereby teachers were presumably pre-disposed to using technology based upon their attendance at a technology training session in the form of a conference or a class. Deaf educators as a whole did not perform as well as general educators on the LoTi scales. Given the fact that the technology-minded general educators who comprised the sample population of this study scored exceptionally high on the LoTi scales, further research is needed to ensure comparability between the two groups. The findings of the current study do suggest, though, that deaf educators who are deaf have the potential to integrate technology to a greater degree than deaf educators who are hearing. Thus, a primary recommendation is to conduct a national LoTi survey of typical, rather than technology-minded, deaf educators as a comparison to the 2004 national survey of typical general educators.
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VO2 response profile in heavy intensity cycling after heavy intensity arm or leg exercise.Ptak, April Louise 12 1900 (has links)
The elevated CO2 levels, elevated temperature, and lower blood pH that may occur during exercise should enhance O2 delivery to the exercising muscles. It was hypothesized that performance of prior exercise (PE) would result in a faster VO2 response, as well as a reduced slow component contribution, in subsequent exercise bouts. Five women (21 ± 1 yr) and 10 men (23 ± 2 yr) performed nine 6-min bouts of heavy intensity cycle ergometer exercise (i.e., above the ventilatory threshold, individually determined by an incremental test). Three bouts were performed without prior heavy exercise (noPE), three were performed 6 min after a 6-min bout of heavy intensity arm cranking (PEA), and three were performed 6 min after a 6-min bout of heavy intensity cycle ergometer exercise (PEL). Breath-by-breath VO2 data from each of the three sets of three tests were combined and fitted to a two-component model, which ignores the cardiodynamic phase. The primary and slow component amplitudes were truncated to reflect actual increases in VO2 in each phase. The effects of PE on the time constant of the primary component were inconsistent. As hypothesized, the amplitude of the slow component was reduced by PE (noPE vs PEA vs. PEL: 25% > 16% < 14%; p < .05). It is concluded that heavy intensity PE affects characteristics of the VO2 profile in a subsequent bout of heavy intensity leg exercise.
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Blood Pressure Regulation During Simulated Orthostatism Prior to and Following Endurance Exercise TrainingStevens, Glen Harold John 05 1900 (has links)
Cardiovascular responses and tolerance to an orthostatic stress were examined in eight men before and after eight months of endurance exercise training. Following training, maximal oxygen consumption and blood volume were increased, and resting heart rate reduced. Orthostatic tolerance was reduced following training in all eight subjects. It was concluded that prolonged endurance training decreased orthostatic tolerance and this decrease in tolerance appeared associated with attenuated baroreflex sensitivity and alterations in autonomic balance secondary to an increased parasympathetic tone noted with training.
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