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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
951

Exploring the effects of dietary fatty acids and iron on modulating sensitivity of lymphomas to ferroptosis

Ahmed, Eman Riaz January 2024 (has links)
Ferroptosis is an iron-dependent form of cell death driven by peroxidation of phospholipids with polyunsaturated fatty acyl (PUFA) tails. Dietary factors, such as fatty acids and iron, regulate ferroptosis. Moreover, the incidence and progression of several cancers is correlated with diet; models of lymphoma have shown sensitivity to ferroptosis. We investigated the effects of altering dietary factors linked to ferroptosis on diffuse large B cell lymphomas (DLBCL). We found that DLBCL cells undergo ferroptosis in response to iron and PUFA treatments in vitro, and that their growth in xenograft models is substantially reduced. We observed that monounsaturated fatty acids (MUFAs), in contrast, suppress ferroptosis and promote growth in DLBCL cell and animal models. The inhibitory effect of the ferroptosis inducer imidazole ketone erastin (IKE) on DLBCL xenograft growth was lessened by dietary MUFA. Ferroptosis linked fatty acids and iron thus impact the growth and response to ferroptosis treatment of DLBCL tumors.
952

The Effects of the Secondary Carbon Source Glycerol on the Lipid Accumulation and Fatty Acid Profile of Rhodotorula Glutinis

Easterling, Emily Ruth Echols 11 August 2007 (has links)
Producing biodiesel from triacylglycerol (TAG) generates glycerol as a byproduct which could be recycled and used to grow the oleaginous yeast Rhodotorula glutinis. R. glutinis has the ability to produce up to 70% of its weight in the form of TAG. This study is designed to determine the effects of glycerol on the TAG and fatty acids produced by R. glutinis. After 24 hrs, R. glutinis cultured on medium containing dextrose, xylose, glycerol, dextrose and xylose, xylose and glycerol, or dextrose and glycerol accumulated 16, 12, 25, 10, 21, and 34% TAG on a dry weight basis, respectively. The fatty acids derived from R. glutinis were mostly saturated, however, cells cultivated on glycerol alone had the highest degree of unsaturated fatty acids (53%). Growth on dextrose may be enhanced by the addition of glycerol, but it cannot be determined if using glycerol as a secondary carbon substrate enhances lipid production.
953

Omega-3 Fatty Acids and Heart Failure

O'Shea, Karen Michelle 23 January 2010 (has links)
No description available.
954

CEACAM1: A Common Regulator of Fat Metabolism and Cell Proliferation

Lee, Sang Jun 02 September 2008 (has links)
No description available.
955

A New Polyacetylenic Alcohol in Fistulina Hepatica: Progress Towards the Identification of Acetylenases in Basidiomycetes

Huffman, Errol A., Sr. 02 May 2002 (has links)
No description available.
956

Hepatic Lrp1 deficiency and the development of nonalcoholic fatty liver disease

Hamlin, Allyson January 2017 (has links)
No description available.
957

Fundamental Surface Properties of Simple Fatty Acid Model Systems of Sea Spray Aerosols and the Sea Surface Microlayer

Rudd, Bethany A. 25 July 2018 (has links)
No description available.
958

Induction of the Lipid Regulator PPAR-Delta in FoxO1 Overexpressed Skeletal Muscle

Markovic, Vesna 14 December 2018 (has links)
No description available.
959

Prevalence and Determinants of Hepatic Steatosis in Young Adult Women

Xanthakos, Stavra A. 28 September 2006 (has links)
No description available.
960

Biodegradation Patterns and Toxicity of the Constituents of Canola Oil

Zhao, Yuechen 16 July 2009 (has links)
No description available.

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