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Exploring the effects of dietary fatty acids and iron on modulating sensitivity of lymphomas to ferroptosisAhmed, Eman Riaz January 2024 (has links)
Ferroptosis is an iron-dependent form of cell death driven by peroxidation of phospholipids with polyunsaturated fatty acyl (PUFA) tails. Dietary factors, such as fatty acids and iron, regulate ferroptosis. Moreover, the incidence and progression of several cancers is correlated with diet; models of lymphoma have shown sensitivity to ferroptosis.
We investigated the effects of altering dietary factors linked to ferroptosis on diffuse large B cell lymphomas (DLBCL). We found that DLBCL cells undergo ferroptosis in response to iron and PUFA treatments in vitro, and that their growth in xenograft models is substantially reduced. We observed that monounsaturated fatty acids (MUFAs), in contrast, suppress ferroptosis and promote growth in DLBCL cell and animal models. The inhibitory effect of the ferroptosis inducer imidazole ketone erastin (IKE) on DLBCL xenograft growth was lessened by dietary MUFA. Ferroptosis linked fatty acids and iron thus impact the growth and response to ferroptosis treatment of DLBCL tumors.
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The Effects of the Secondary Carbon Source Glycerol on the Lipid Accumulation and Fatty Acid Profile of Rhodotorula GlutinisEasterling, Emily Ruth Echols 11 August 2007 (has links)
Producing biodiesel from triacylglycerol (TAG) generates glycerol as a byproduct which could be recycled and used to grow the oleaginous yeast Rhodotorula glutinis. R. glutinis has the ability to produce up to 70% of its weight in the form of TAG. This study is designed to determine the effects of glycerol on the TAG and fatty acids produced by R. glutinis. After 24 hrs, R. glutinis cultured on medium containing dextrose, xylose, glycerol, dextrose and xylose, xylose and glycerol, or dextrose and glycerol accumulated 16, 12, 25, 10, 21, and 34% TAG on a dry weight basis, respectively. The fatty acids derived from R. glutinis were mostly saturated, however, cells cultivated on glycerol alone had the highest degree of unsaturated fatty acids (53%). Growth on dextrose may be enhanced by the addition of glycerol, but it cannot be determined if using glycerol as a secondary carbon substrate enhances lipid production.
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Omega-3 Fatty Acids and Heart FailureO'Shea, Karen Michelle 23 January 2010 (has links)
No description available.
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CEACAM1: A Common Regulator of Fat Metabolism and Cell ProliferationLee, Sang Jun 02 September 2008 (has links)
No description available.
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A New Polyacetylenic Alcohol in Fistulina Hepatica: Progress Towards the Identification of Acetylenases in BasidiomycetesHuffman, Errol A., Sr. 02 May 2002 (has links)
No description available.
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Hepatic Lrp1 deficiency and the development of nonalcoholic fatty liver diseaseHamlin, Allyson January 2017 (has links)
No description available.
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Fundamental Surface Properties of Simple Fatty Acid Model Systems of Sea Spray Aerosols and the Sea Surface MicrolayerRudd, Bethany A. 25 July 2018 (has links)
No description available.
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Induction of the Lipid Regulator PPAR-Delta in FoxO1 Overexpressed Skeletal MuscleMarkovic, Vesna 14 December 2018 (has links)
No description available.
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Prevalence and Determinants of Hepatic Steatosis in Young Adult WomenXanthakos, Stavra A. 28 September 2006 (has links)
No description available.
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Biodegradation Patterns and Toxicity of the Constituents of Canola OilZhao, Yuechen 16 July 2009 (has links)
No description available.
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