Thesis (Ph. D.)--University of Wisconsin--Madison, 1973. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (Ph. D.)--University of Missouri-Columbia, 2008. / The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on June 8, 2009) Vita. Includes bibliographical references.

Thesis (Ph. D.)--University of Wollongong, 2005. / Title from PDF t.p. (viewed on Aug. 13, 2005). Includes bibliographical references.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1954. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 403-425).

Thèse (M.A.) -- Université Laval, 2004. / Bibliogr.: f. [160]-170. Publié aussi en version électronique.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1954. / Typescript. Vita. Title from title screen (viewed May 9, 2006). Includes bibliographical references (leaves 403-425). Online version of the print original.

Thesis (Ph. D.)--University of Texas at Austin, 2006. / Vita. Includes bibliographical references.

This research paper studied the first two weeks after President Donald Trump allegedly called African countries “shithole countries” in a bi-partisan meeting on immigration. It explored the frames and emerging themes used by the media when covering the incident and the surrounding issues. Using the framing theory as a theoretical framework, the study examined the six identified news frames through qualitative content analysis. The six frames used in the coverage of the “shithole countries” incident are racial, conflict, consequences, morality, human interest, and policy. The study examined articles from four news sources that lean liberal, conservative, central-liberal, and central conservative. The study indicated that the four news sources all used five of the six frames, as the Wall Street Journal did not use the morality frame at all. The most used frame was the human interest frame, followed by conflict and consequences. The New York Times and the Wall Street Journal used the conflict frame the most. And CNN and FOX used the consequences frame the most.

No description available.

Anualmente, a produção mundial de vinhos gera cerca de 20 milhões de toneladas de resíduos, os quais, na maior parte, são descartados no meio ambiente. Dados prévios demostraram que é possível obter-se compostos flavan-3-ol a partir de diferentes resíduos de vinificação, com significativa atividade antioxidante. Em vista disso, o objetivo deste trabalho foi investigar as atividades neuroprotetora, hepatoprotetora, genotóxica, mutagênica e citotóxica do extrato aquoso de sementes de resíduos de vinificação de Vitis labrusca, variedade Bordo, avaliando o mecanismo de ação do mesmo. Os resultados mostraram que o extrato minimiza os danos oxidativos aos lipídeos e proteínas em córtex cerebral, cerebelo, hipocampo, e no fígado de ratos tratados com pentilenotetrazol. Além disso, o extrato não alterou o comportamento locomotor dos ratos e não apresentou efeito genotóxico (ensaio cometa) ou mutagênico em linfócitos de ratos e células de levedura Saccharomyces cerevisiae, respectivamente. O tratamento com o extrato diminui a depleção das proteínas do complexo I da cadeia transportadora de elétrons na mitocôndria em células de neuroblastoma humano (SH-SY5Y) tratadas com H2O2. Em doses de 0,1 e 1mg/mL, o extrato mostrou-se citotóxico para as linhagens de câncer de fígado (HepG2) e de mama (MCF-7). Este efeito foi acompanhado pelo aumento da produção de óxido nítrico, da expressão de p53 e da fragmentação do DNA. Uma diminuição significativa nos níveis de expressão da PARP total foi observada na linhagem HepG2. Na linhagem MCF-7, o tratamento com o extrato de V. labrusca aumentou a expressão das proteínas Bax e AIF, e diminuiu a expressão da PARP total. A expressão da proteína Her-2 apresentou-se diminuída em células HepG2 e MCF-7 tratadas com o extrato. Estes resultados mostram importantes efeitos biológicos do extrato de resíduos de vinificação de V. labrusca, variedade Bordo. / Submitted by Marcelo Teixeira (mvteixeira@ucs.br) on 2014-06-17T13:06:13Z No. of bitstreams: 1 Tese Gustavo Scola.pdf: 8668323 bytes, checksum: adc4c46aea3167d99be63113958637f3 (MD5) / Made available in DSpace on 2014-06-17T13:06:13Z (GMT). No. of bitstreams: 1 Tese Gustavo Scola.pdf: 8668323 bytes, checksum: adc4c46aea3167d99be63113958637f3 (MD5) / Conselho Nacional de Desenvolvimento Científico e Tecnológico / Every year, the worldwide wine production generates about 20 million tons of waste, which usually end up being discarded in the environment. Previous data showed that it is possible to obtain flavan-3-ol compounds from different winery wastes with significant antioxidant activity. Thus, the aim of this work was to investigate the neuroprotective, hepatoprotective, genotoxic, mutagenic and cytotoxic activities of aqueous winery seeds extract from Vitis labrusca, cv. Bordo. The results showed that the extract minimizes the oxidative damage to lipids and proteins in the cerebral cortex, cerebellum, hippocampus and liver of rats. Also, the extract did not alter locomotor behavior, and it was non-genotoxic (comet assay) or nonmutagenic in lymphocytes from rats, and in Saccharomyces cerevisiae cells, respectively. The treatment with the extract was able to prevent depletion of mitochondrial eletron transfer chain complex I proteins in neuroblastoma cells (SH-SY5Y) treated with H2O2. At doses of 0.1 and 1mg/mL, the extract was found to be cytotoxic to liver (HepG2) and breast (MCF-7) cancer cell lines. This effect was accompanied with an increase in nitric oxide production, increase in the expression of p53, and increase in DNA damage index. A significant decrease in the expression levels of total PARP was observed in HepG2 cell line. In MCF-7 cells, V. labrusca extract treatment increased the expression levels of Bax and AIF proteins, and decreased the expression levels of total PARP. The expression levels of Her-2 protein were found to be decreased in HepG2 and MCF-7 cells after V. labrusca extract treatment. These results show significant biological effects of V. labrusca winery wastes extract, cv. Bordo.