The neurovisceral integration model (NVM) proposes that an organisms ability to flexibly adapt to their environment is related to biological flexibility within the central autonomic network. One important aspect of this flexibility is behavioral inhibition (Thayer and Friedman, 2002). During a behavioral inhibition task, the central autonomic network (CAN), which is comprised of a series of feedback loops, must be able to integrate information and react to these inputs flexibly to facilitate optimal performance. The functioning of the CAN is shown to be associated with respiratory sinus arrhythmia (RSA), as the vagus nerve is part of this feedback system. While the NVM has been examined through neural imaging and RSA, only a few studies have examined these measures simultaneously during the neuroimaging procedure. Furthermore, these studies were done at rest or used tasks that were not targeted at processes associated with the NVM, such as behavior inhibition and cognitive flexibility. For this reason, the present study assessed RSA and neural activation in the prefrontal cortex simultaneously while subjects completed a behavior inhibition task. Using a series of go/no-go tasks, RSA and functional near-infrared spectroscopy (fNIRS) were collected to investigate the relationship between prefrontal activation and vagal activity at rest and during behavioral inhibition. There are three primary aims of this study. First, examine prefrontal activation during various inhibition tasks through fNIRS. Second, evaluate the NVM during a cognitive task using simultaneous fNIRS and RSA analysis. Third, relate task performance, imaging, and RSA measures during behavioral inhibition to deficits in flexible everyday responding, as indicated by self-report measures of behavior. Doing so will elucidate the connection with prefrontal activation and RSA as proposed by the NVM model and determine whether neural and RSA metrics can be related to broader symptoms of inflexibility. / PHD / The neurovisceral integration model (NVM) proposes that the ability to adapt to the environment is related to biological flexibility within the brain. One important aspect of the ability to adapt to the environment is behavior inhibition (e.g., the ability to stop from engaging in a habitual response, Thayer & Friedman, 2002). During a behavior inhibition task, the brain must be able to integrate information and react to these inputs flexibly to facilitate optimal performance. The brain’s ability to do this is related to a measure of heart activity known as respiratory sinus arrhythmia (RSA). The present study assessed RSA and brain activity while subjects completed a behavior inhibition task. Neural activation was measured through functional near-infrared spectroscopy (fNIRS). fNIRS measures the amount of oxygenated blood in different areas of the brain. Greater concentrations of oxygenated blood indicated greater brain activity in an area. Through simultaneous fNIRS and RSA measurement the present study examined their relationship during various inhibition tasks. Doing so clarified the connection between brain activation and RSA as proposed by the NVM model.

京都大学 / 新制・課程博士 / 博士(教育学) / 甲第24353号 / 教博第283号 / 新制||教||214(附属図書館) / 京都大学大学院教育学研究科教育科学専攻 / (主査)教授 MANALO Emmanuel, 教授 楠見 孝, 准教授 野村 理朗 / 学位規則第4条第1項該当 / Doctor of Philosophy (Education) / Kyoto University / DGAM

The ability to maintain balance is based on various processes of motor control in complex neural networks of subcortical and cortical brain structures. However, knowledge on brain processing during the execution of whole-body balance tasks is still limited. In the present study, we investigated brain activity during slacklining, a task with a high demand on balance capabilities, which is frequently used as supplementary training in various sports disciplines as well as for lower extremity prevention and rehabilitation purposes in clinical settings. We assessed hemodynamic response alterations in sensorimotor brain areas using functional near-infrared spectroscopy (fNIRS) during standing (ST) and walking (WA) on a slackline in 16 advanced slackliners. We expected to observe task-related differences between both conditions as well as associations between cortical activity and slacklining experience. While our results revealed hemodynamic response alterations in sensorimotor brain regions such as primary motor cortex (M1), premotor cortex (PMC), and supplementary motor cortex (SMA) during both conditions, we did not observe differential effects between ST and WA nor associations between cortical activity and slacklining experience. In summary, these findings provide novel insights into brain processing during a whole-body balance task and its relation to balance expertise. As maintaining balance is considered an important prerequisite in daily life and crucial in the context of prevention and rehabilitation, future studies should extend these findings by quantifying brain processing during task execution on a whole-brain level.

There is considerable evidence to suggest that object affordances (see Gibson, 1966) can serve to moderate volitional responses by “priming” the visuomotor system toward certain actions (e.g., Tucker & Ellis, 1998). Typically, these studies assume that shorter voluntary reaction time latencies reflect more efficient movement planning. Questions remain however, as to whether object affordances offer the same motor priming benefits in situations where the temporal window to initiate motor action precludes volitional movements (e.g., during an unexpected balance perturbation). The efficiency of balance reactions to a perturbation is dependent upon the ability for the motor system to generate short latency actions at the onset of instability. Due to the rapid nature of these actions, they are suggested to be regulated by information received prior to the perturbation. In this study, participants sat in a custom-built chair that delivered posterior perturbations and, on each trial, were presented with two of three types of stimuli within their reach (two graspable poles that varied in orientation and a flat non-graspable control). They were instructed to reach and grasp one of the poles at the moment of perturbation so as to mitigate the tilt. To assess cortical activity that may be indicative of motor planning in response to the perception of object affordances, changes in oxyhemoglobin (oxy-Hb) in the right and left premotor cortices were measured using a continuous wave fNIRS system. Results revealed a significant increase (F= 4.62, p= .043) in oxy-Hb in the right and left hemisphere (M = .023 µM) in response to objects that afford an optimal form of grasping action (mitigating excessive supination or pronation of the hand), compared to when no grasping opportunity was present (M = -.051 µM). These results suggest that affordances may be used to prime the system in the event of a balance threat. / Thesis / Master of Science (MSc)

No description available.

The objective of this study was to assess low to high levels of Cognitive Workload by measuring heart rate and cortical blood flow in real-time. Four conditions were implemented into a within-subjects experimental design. Two conditions of difficulty and two conditions of trial order were used to illicit different levels of workload which will be analyzed with psychophysiological equipment. Functional Near-Infrared Spectroscopy (fNIRS) has become more prominent for measuring the blood oxygenation levels in the prefrontal cortex of individuals operating in hazardous work environments, students with learning disabilities, and in research for military training. This is due to the fNIR device being highly mobile, inexpensive, and able to produce a high-spatial resolution of the dorsolateral prefrontal cortex during executive functioning. Heart Rate will be measured by an Electrocardiogram, which will be used in concordance with fNIR oxygenation levels to predict if an individual is in a condition that produces low or high mental workload. Successfully utilizing heart rate and blood oxygenation data as predictors of cognitive workload may validate implementing multiple physiological devices together in real-time and may be a more accurate solution for preventing excessive workload.

Speech production not only relies on spoken (overt speech) but also on silent output (inner speech). Little is known about whether inner and overt speech are processed differently and which neural mechanisms are involved. By simultaneously applying electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS), we tried to disentangle executive control from motor and linguistic processes. A preparation phase was introduced additionally to the examination of overt and inner speech directly during naming (i.e., speech execution). Participants completed a picture-naming paradigm in which the pure preparation phase of a subsequent speech production and the actual speech execution phase could be differentiated. fNIRS results revealed a larger activation for overt rather than inner speech at bilateral prefrontal to parietal regions during the preparation and at bilateral temporal regions during the execution phase. EEG results showed a larger negativity for inner compared to overt speech between 200 and 500 ms during the preparation phase and between 300 and 500 ms during the execution phase. Findings of the preparation phase indicated that differences between inner and overt speech are not exclusively driven by specific linguistic and motor processes but also impacted by inhibitory mechanisms. Results of the execution phase suggest that inhibitory processes operate during phonological code retrieval and encoding.

Studies in adults showed differential neural processing between overt and inner speech. So far, it is unclear whether inner and overt speech are processed differentially in children. The present study examines the pre-activation of the speech network in order to disentangle domain-general executive control from linguistic control of inner and overt speech production in 6- to 7-year-olds by simultaneously applying electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS). Children underwent a picture-naming task in which the pure preparation of a subsequent speech production and the actual execution of speech can be differentiated. The preparation phase does not represent speech per se but it resembles the setting up of the language production network. Only the fNIRS revealed a larger activation for overt, compared to inner, speech over bilateral prefrontal to parietal regions during the preparation phase. Findings suggest that the children’s brain can prepare the subsequent speech production. The preparation for overt and inner speech requires different domain-general executive control. In contrast to adults, the children’s brain did not show differences between inner and overt speech when a concrete linguistic content occurs and a concrete execution is required. This might indicate that domain-specific executive control processes are still under development.

In category learning, explicit processes function through the prefrontal cortex (PFC) and implicit processes function through the basal ganglia. Research suggested that these two systems compete with each other. The goal of this study was to shed light on this theory. 15 undergraduate subjects took part in an event-related experiment that required them to categorize computer-generated line-stimuli, which varied in length and/or angle depending on condition. Subjects participated in an explicit "rule-based" (RB) condition and an implicit "information-integration" (II) condition while connected to a functional near-infrared spectroscopy (fNIRS) apparatus, which measured the hemodynamic response (HR) in their PFC. Each condition contained 2 blocks. We hypothesized that the competition between explicit and implicit systems (COVIS) would be demonstrated if, by block 2, task-accuracy was approximately equal across conditions with PFC activity being comparatively higher in the II condition. This would indicate that subjects could learn the categorization task in both conditions but were only able to decipher an explicit rule in the RB condition; their PFC would struggle to do so in the II condition, resulting in perpetually high activation. In accordance with predictions, results revealed no difference in accuracy across conditions with significant difference in channel activation. There were channel trends (p < .1) which showed PFC activation decrease in the RB condition and increase in the II condition by block 2. While these results support our predictions, they are largely nonsignificant, which could be attributed to the event-related design. Future research should utilize a larger samples size for improved statistical power.

Unsafe driving habits increase the severity of roadway accidents. The behaviors that are generally associated with unsafe driving are influenced by drivers and their decision to engage in dangerous habits. In order to solve this problem, Departments of Transportation use roadside safety campaigns. To gain a comprehensive understanding of the effectiveness of these campaigns, this research study captured five different metrics of effectiveness to understand what messages are effective and how to target messages to different groups of people. Since reading and interpreting the messages produces cognitive activation among participants, a neuroimaging technology called functional near-infrared spectroscopy (fNIRS) was used to measure neurocognitive activation as a proxy for response. The fNIRS system captures this cognitive activation by measuring change in oxygenated blood (oxy-Hb). An increase in oxy-Hb is a proxy for increased task engagement. The first journal paper provides an understanding of what types of messages are perceived as effective, are misunderstood, are memorable, are considered inappropriate, and cause the greatest increase in cognitive engagement. Overall, drivers perceive messages to be effective at changing behavior, but particular messages are perceived as more effective than others. Messages about distracted driving and driving without a seat belt, messages that are intended to produce a negative emotional response, and messages with statistics are the behaviors, emotions, and themes that are most likely to be perceived to change driver behavior. Messages about distracted driving and messages about statistics are most likely to be remembered by drivers. In general, drivers do not find messages used in safety campaigns to be inappropriate. Drivers elicit more cognitive attention to signs about distracted driving and signs with a humorous emotion. The second journal considers the effectiveness of these messages with different target demographics by further investigating the first journal's results by different dependent variables, including age, gender, and risky driving habits of the participants. In the second study, the results from the first study are further examined to determine if some campaigns are more effective among different demographics of drivers. The behavioral results indicated that females, drivers over 65, low-risk and high-risk drivers, and urban and rural drivers perceive the safety campaigns as more effective. The neurological data revealed that younger drivers had more activation in the ventrolateral prefrontal cortex, an area known for semantics and word processing, which might indicate more cognitive attention to these types of messages. This study provides a unique application of using neuroimaging techniques to understand driver response to safety messages. The recommendations for an effective safety campaign are to use messages about distracted driving, messages with an emotional stimulus, and messages about statistics. Messages about word play and rhyme are recommended for appealing to younger demographics. / Master of Science / Messages like "New year, new you, use your blinker" and "May the 4th be with you, text I will not" are increasingly used to catch drivers' attention. The development and use of these non-traditional safety messages are distinctly different than messages previously displayed on highway signs because the intent of these messages is to modify driver behavior rather than just provide information. Unfortunately, there is little empirical evidence measuring how effective these messages are at changing driver behavior or guidance on how to target messages for specific groups of people. The goal of this study was to understand what types of non-traditional safety messages are effective and how to target these messages to different target audiences. Roadway collisions are made more severe when the cause of the incident involves dangerous driving habits, such as distracted, impaired, or aggressive driving. The problem is made even more severe by the fact that the habits that make driving dangerous are affected by the driver's decision to engage in risky driving behavior. The solution to this problem is to gain an understanding of driver preferences and response, a research effort this study will address. Reading and interpreting the messages produces cognitive activation among participants. The study uses functional near-infrared spectroscopy (fNIRS), which allows researchers to capture this cognitive activation by measuring change in oxygenated blood (oxy-Hb). This provides not only the ability to gain a more detailed understanding of driver response, but the ability to triangulate this with what drivers perceive as effective in changing driver behavior. In the first study, the participants felt that campaigns targeting distracted driving, messages with a negative emotion, and campaigns about statistics were significantly more effective at changing driver behavior compared to other behaviors, emotions, and themes. The neurological data revealed that drivers respond more to campaigns about distracted driving. However, the neurological data indicates that humorous messages and messages that fit under the theme word play and rhyme elicit a greater cognitive response. The second study furthers the first study and revealed that females, drivers over 65, low-risk and high-risk drivers, and urban and rural drivers perceive the safety campaigns as more effective. The neurological data revealed that younger and older males and older high-risk drivers respond with greater peak oxy-Hb when compared to other groups of people. This study advances the applicability of fNIRS in traffic related studies.