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published_or_final_version / abstract / Medicine / Master / Master of Philosophy

The normal development of adipose tissue lipolysis as measured by glycerol release was studied in epididymal fat pads of Sprague-Dawley rats between 4 and 16 weeks of age and correlated with changes in fat cell size.For each age group studied, 4 weeks, 8 weeks, and 16 weeks of age, basal (no hormone present) and hormone stimulated lipolytic activity were observed for two concentrations of epinephrine were used, maximal (10,00 nM) and minimal (10 nM). Basal levels of glycerol were not linear. There was an increase between 4 and 8 weeks of age followed by a decrease between 8 and 16 weeks of age. The maximal dosage of hormone evoked a large increase in 9lYcerol production between 4 and 8 weeks, which was followed by a decrease between 8 and 16 weeks of age. The minimal dosage of epinephrine, although not significant, showed a decrease in glycerol production from 4 to 16 weeks of age. Fat cell size continued to increase between 4 and 16 weeks. Both fat cell diameter and volumes underwent a linear increase with age. However, the change was not reflected in epinephrine stimulated glycerol release. Therefore, glycerol release is inversely correlated with fat cell size during early development.The results indicate that age influences hormone stimulated lipolysis and is not dependent on cell size. Although the mechanism for the decreased lipolytic response of the isolated adipocytes was not discovered, it is believed that it may be due in part to a reduced number of receptors and to a reduced sensitivity of the cellular enzymatic system underlying lipolysis. / School of Physical Education

Thesis (Ph. D.)--Michigan State University. Dept. of Animal Science, 2006. / Title from PDF t.p. (viewed on Nov. 16, 2008) Includes bibliographical references. Also issued in print.

Thesis (M. Phil.)--University of Hong Kong, 2007. / Title proper from title frame. Also available in printed format.

Thesis (M.Med.Sc.)--University of Hong Kong, 2004. / Also available in print.

Thesis (Ph. D.)--Georgia State University, 2005. / Timothy Bartness, committee chair; Elliott Albers, Ruth Harris , Sarah Pallas, committee members. Electronic text (181 p. : ill.)) : digital, PDF file. Description based on contents viewed July 17, 2007. Includes bibliographical references (p. 148-181).

Thesis (M.S.)--University of Massachusetts Amherst, 2008. / Includes bibliographical references (p. 58-62).

Orientador: Ellen Cristini de Freitas / Banca: Julio Sergio Marchini / Banca: Adelino Sanchez Ramos da Silva / Resumo: Objetivo: O objetivo desse estudo foi de avaliar os efeitos da suplementação de taurine no tecido adipose em ratos obesos treinados. Métodos: Ratos machos Wistar foram alimentados com dieta controle e hipercalórica para induzir a obesidade, e divididos em 4 grupos: controle (CT, dieta controle, n =6); sedentário (SD, dieta hipercalórica, n=6); sedentátio taurina (SDTAU; dieta hipercalórica e suplementação de taurina; n=6); treinado (TR; dieta hipercalórica e exercício físico; n=6), treinado taurina (TRTAU; dieta hipercalórica, suplementação de taurina e exercício físico; n =6). Resultados: Foi observado um aumento significativo do peso dos animais dos grupos SD e SDTAU em comparação com grupos de TR e TRTAU. Observou-se que os grupos que foram suplementados com taurina (SDTAU e TRTAU) apresentaram um aumento significativo na concentração sérica de taurina. A área total do grupo de animais SDTAU foi 132% superior em relação ao grupo TRTAU (p <0,0073). Em relação à área de gordura foi observada diferença significativa no grupo SDTAU quando comparado com os grupos treinados associados ou não com a suplementação de taurina. O Os grupos SDTAU e SD apresentaram maior peso da gordura epididimal (p <0,0001), enquanto que o valor mais baixo foi observado no grupo TRTAU. Em relação ao tamanho dos adipócitos grupos houve diferença estatisticamente significativa entre eles. Conclusão: Com base nos resultados apresentados, pode concluir-se que oito semanas de suplementação com taurina associado com exercício foi capaz de reduzir a gordura visceral e diminuir o peso da gordura epididimal. No entanto, a suplementação de taurina com e sem o exercício não causaram mudanças no tamanho do adipócito. / Abstract: Pupose: The objective of this study was to evaluate the effects of taurine supplementation in adipose tissue of obese trained mice. Methods: Male Wistar mice were fed with control or hypercaloric diet to induce obesity, and divided into 4 groups: control (CT, control diet, n =6); sedentary (SD, high calorie diet, n= 6); taurine sedentary (SDTAU, high calorie diet with taurine supplementation, n=6); trained (TR, high calorie diet and physical exercise, n=6), taurine trained (TRTAU, high calorie diet with taurine supplementation and physical exercise, n=6). Results: A significant increase in the weight of animals in SD and SDTAU groups compared to groups TR and TRTAU. It is observed that the groups that were supplemented with taurine (SDTAU and TRTAU) showed a significant increase in the blood taurine concentration. The total area of the animals SDTAU group was 132 % higher compared to TRTAU group (p< 0.0073). Regarding fat area was observed significant difference in SDTAU group when compared with to the trained groups associated or not with taurine supplementation. SDTAU and the SD group showed greater weight of epididymal fat (p< 0.0001), while the lowest value was observed in TRTAU group. Regarding the size of adipocytes groups there was significant statistically difference between them. Conclusion: Based on the results presented, it can be concluded that eight weeks of supplementation with taurine associated with exercise was able to reduce visceral fat and decrease the weight of epididymal fat. However, taurine supplementation with and without exercise have not caused changes in the size of the adipocyte. / Mestre

Made available in DSpace on 2014-08-13T14:50:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-03-28Bitstream added on 2014-08-13T18:00:05Z : No. of bitstreams: 1 000767273.pdf: 813036 bytes, checksum: 1f4cef23671bdff7ab7f46d510271cca (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Objetivo: O objetivo desse estudo foi de avaliar os efeitos da suplementação de taurine no tecido adipose em ratos obesos treinados. Métodos: Ratos machos Wistar foram alimentados com dieta controle e hipercalórica para induzir a obesidade, e divididos em 4 grupos: controle (CT, dieta controle, n =6); sedentário (SD, dieta hipercalórica, n=6); sedentátio taurina (SDTAU; dieta hipercalórica e suplementação de taurina; n=6); treinado (TR; dieta hipercalórica e exercício físico; n=6), treinado taurina (TRTAU; dieta hipercalórica, suplementação de taurina e exercício físico; n =6). Resultados: Foi observado um aumento significativo do peso dos animais dos grupos SD e SDTAU em comparação com grupos de TR e TRTAU. Observou-se que os grupos que foram suplementados com taurina (SDTAU e TRTAU) apresentaram um aumento significativo na concentração sérica de taurina. A área total do grupo de animais SDTAU foi 132% superior em relação ao grupo TRTAU (p <0,0073). Em relação à área de gordura foi observada diferença significativa no grupo SDTAU quando comparado com os grupos treinados associados ou não com a suplementação de taurina. O Os grupos SDTAU e SD apresentaram maior peso da gordura epididimal (p <0,0001), enquanto que o valor mais baixo foi observado no grupo TRTAU. Em relação ao tamanho dos adipócitos grupos houve diferença estatisticamente significativa entre eles. Conclusão: Com base nos resultados apresentados, pode concluir-se que oito semanas de suplementação com taurina associado com exercício foi capaz de reduzir a gordura visceral e diminuir o peso da gordura epididimal. No entanto, a suplementação de taurina com e sem o exercício não causaram mudanças no tamanho do adipócito. / Pupose: The objective of this study was to evaluate the effects of taurine supplementation in adipose tissue of obese trained mice. Methods: Male Wistar mice were fed with control or hypercaloric diet to induce obesity, and divided into 4 groups: control (CT, control diet, n =6); sedentary (SD, high calorie diet, n= 6); taurine sedentary (SDTAU, high calorie diet with taurine supplementation, n=6); trained (TR, high calorie diet and physical exercise, n=6), taurine trained (TRTAU, high calorie diet with taurine supplementation and physical exercise, n=6). Results: A significant increase in the weight of animals in SD and SDTAU groups compared to groups TR and TRTAU. It is observed that the groups that were supplemented with taurine (SDTAU and TRTAU) showed a significant increase in the blood taurine concentration. The total area of the animals SDTAU group was 132 % higher compared to TRTAU group (p< 0.0073). Regarding fat area was observed significant difference in SDTAU group when compared with to the trained groups associated or not with taurine supplementation. SDTAU and the SD group showed greater weight of epididymal fat (p< 0.0001), while the lowest value was observed in TRTAU group. Regarding the size of adipocytes groups there was significant statistically difference between them. Conclusion: Based on the results presented, it can be concluded that eight weeks of supplementation with taurine associated with exercise was able to reduce visceral fat and decrease the weight of epididymal fat. However, taurine supplementation with and without exercise have not caused changes in the size of the adipocyte.