京都大学 / 新制・論文博士 / 博士(医学) / 乙第13450号 / 論医博第2243号 / 新制||医||1054(附属図書館) / (主査)教授 稲垣 暢也, 教授 妹尾 浩, 教授 小濱 和貴 / 学位規則第4条第2項該当 / Doctor of Medical Science / Kyoto University / DFAM

The American public is bombarded with chemically fragranced products every day, typically in combination with each other. These products can include cosmetics, perfumes, detergents, air fresheners, soaps, and deodorants. Contained in these fragranced products are chemicals that can be harmful to child health and development. Many articles have been published examining the chemicals found in fragranced products and the effects that these chemicals can have on the human body. This integrated literature review examines empirical evidence related to the health and safety of particular chemicals used in these products. Nurses need to be aware of the actual and potential harms from the chemicals used in the self-regulating cosmetic industry and can advocate for public policies that promote a safer environment, therefore protecting the health and wellbeing of children.

京都大学 / 新制・課程博士 / 博士(医学) / 甲第24506号 / 医博第4948号 / 新制||医||1064(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 万代 昌紀, 教授 松田 秀一, 教授 中本 裕士 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

Ett foster har inte samma blodflöde och resistans mot förändringar i sin miljö som en vuxen människa har och kan vid små temperaturförändringar orsakas skada i till exempel den utvecklande hjärnan. Vid ultraljudsundersökning finns bevisat en viss värmeökning, men det råder ovisshet kring hur stor denna skulle kunna bli under en längre tids exponering av ultraljud. Syftet med detta arbete var att undersöka värmeutvecklingen vid obstetriskt ultraljud genom att utforma en 3D-modell i mjukvarumiljön COMSOL Multiphysics version 6.0. En modell kan bidra med kunskap för att besluta kring om riskerna med temperaturökning hos foster till följd av ultraljud behöver studeras vidare. Resultaten av framtagen modellering visade på en mycket liten uppvärmningseffekt. Slutsatsen drogs att om modellen i 3D ska kunna göra trovärdiga beräkningar i programmet krävs en mer avancerad dator än vanligt, med betydligt större minneskapacitet. Vidare utveckling av modell i COMSOL bör göras i 2D, alternativt med en mer avancerad dator, för att få tillförlitliga resultat. / A fetus does not have the same blood perfusion and resistance to changes in its environment as an adult and small changes in temperature can cause irreversible damage for example to the fetal brain. Ultrasound examinations are proven to cause some heat gain but there are uncertainties regarding the amount of heat gain during a longer time of ultrasound exposure. The purpose of this study was to analyse the heat development during obstetric ultrasound by designing a 3D-model in the software environment COMSOL Multiphysics version 6.0. A model could contribute to knowledge in making an informed decision whether the risks of heating in a fetus because of ultrasound are necessary to study further. The results of the developed model showed a very small heating effect. The conclusion was made that if the model in 3D is to be able to make correct calculations in the programme it is required to use a more advanced computer than usual, with significantly greater memory capacity. Further development of a model in COMSOL should be made in 2D, or with a more advanced computer, to get reliable results.

BACKGROUND: Fetal movement count (FMC) is a non-invasive tool used to evaluate fetal well-being and prevent stillbirth. FMC decrease the chances of stillbirth occurrence (Tveit et al., 2009), but in other countries, research shows that women are not taught about the benefits of FMC (Berndl, O'Connel, & Mcload, 2013). The purposes of this study were to discover 1) the knowledge of pregnant women in their third trimester about FMC and 2) sources through which women learn about FMC. METHODOLOGY: The study is a quantitative descriptive design. An original survey consisting of 12 questions was created for the study. Inclusion criteria included women who were in their third trimester (28 weeks of gestation or more), were 18 years old or older, and speak and read English fluently. Consent to take the anonymous survey was implied by completing and returning the survey. Participants were recruited from childbirth and newborn parenting classes. RESULTS: The investigator surveyed 36 women. Eighty-three percent of women (N=30) know what FMC is. All women were seen by a physician, and 50% of them (N=18) were taught about FMC by their providers. In spite of knowing what FMC is, 50% women (15 of the 30) responded incorrectly to specific questions about FMC. DISCUSSION: Women have misconceptions about fetal movement, and about the importance of FMC. This misconception can lead women to less benefit from using FMC tools. Providers need to improve their method of transmitting information about FMC and provide detailed education about fetal movement.

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Obese, female Spraque-Dawley rats were assigned, on a weight basis, to one of three dietary treatments: ad lib, 15% caloric restriction, and 30% caloric restriction. All other nutrients were fed at levels to meet dietary requirements. Each treatment groups was further sub-divided into pregnant and non-pregnant animals. Rats were sacrificed on Day 20 of gestation and fetuses were taken by Caesearean section. Maternal and fetal body composition, maternal serum protein concentrations were examined. Weight change for pregnant rats was +85 gms in the ad lib-fed group, +82 gms in the 15% calorie restricted group, and +56 gms in the 30% calorie restricted group. Weight changes for the non-pregnant rats for 20 days of dietary treatment were +53 gms, +18 gms, and -7 gms respectively. Fetal body nitrogen and average pup weight did not differ between treatment groups. Total maternal body nitrogen was not decreased during pregnancy in ad lib-fed and 15% calorically restricted animals. It did decrease in 30% calorically restricted animals. Ad lib-fed animals showed no changes in total body fat. Animals on the 15% calorie restriction diet showed no change in total body fat percentages. Animals on the 30% calorie restriction showed a 10% decrease in total body fat content as compared to the ad lib and 15% restricted pregnant group. Serum protein levels decreased in pregnant animals as caloric restriction increased. Serum protein levels in nonpregnant animals increased as dietary restriction increased. The fetal compartment was not affected by maternal caloric restriction up to 30% provided that all other nutrients were adequate. Maternal stores were affected at a level of 30% caloric restriction. / Master of Science

The placenta plays a vital role in a healthy pregnancy by supporting the intricacies of fetal development. Over 10% of pregnancies experience impaired placental function, resulting in the loss of critical neuroactive steroids the fetal brain cannot yet make, thus leaving them vulnerable to perinatal brain injury and abnormal neurodevelopment. However, this vulnerability is not always equal. Many neurodevelopmental disorders exhibit a sex bias in incidence and severity. I hypothesize that loss of placental support during pregnancy results in sex differences in both behavioral presentation as well as on the cellular and transcriptomic levels. Utilizing the akr1c14cyp19aKO (plKO) mouse model, which features placenta-specific allopregnanolone (ALLO) knockdown, I investigated the sex specific impact of placental hormones on cerebellar development. Here I show that placental ALLO is essential for cerebellar white matter development and inflammatory regulation via microglial function. Male mice without placental ALLO exhibit signs of placental inflammation, accelerated postnatal myelination, and defects in microglial phagocytosis of excess myelin. Alternatively, females seem to be more resilient with a progressive anti-inflammatory profile across development and reduced myelination. Additionally male plKO show autism-like behaviors such as deficits in social behavior and increased stereotyped behavior. The females do not exhibit this phenotype. My main goals were threefold; to investigate how male and female inflammatory profiles differ and where this difference originates, to investigate how this inflammation impacts microglia and thereby oligodendrocytes, and how I can alter microglial function in a way to improve plKO outcomes. Mechanistically, these changes appear to be in part due to baseline sex differences in response to inflammatory stimuli which prime microglia to differentially support the surrounding white matter. Together, this work supports a novel link between placental ALLO loss, microglial function, and sex specific presentation of neurodevelopmental disorders.

No description available.