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The goal of the master ́s thesis is to study index methods, spatial data type objects in PostgreSQL database systems and to create SP-GiST index by quadtree in the PostGIS. The PostGIS is spatial database, which extends of PostgreSQL. PostGIS adds support for geographic and spatial objects. It is a big benefit. PostGIS has its own data types, methods and GiST index too, but there is SP-GiST index missing, therefore master's thesis was created.

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Despite the fact that Molecular Simulation systems represent a major research tool in multiple scientific and engineering fields, there is still a lack of systems for effective data management and fast data retrieval and processing. This is mainly due to the nature of MS which generate a very large amount of data - a system usually encompass millions of data information, and one query usually runs for tens of thousands of time frames. For this purpose, we designed and developed a new application, DCMS (A data Analytics and Management System for molecular Simulation), that intends to speed up the process of new discovery in the medical/physics fields. DCMS stores simulation data in a database; and provides users with a user-friendly interface to upload, retrieve, query, and analyze MS data without having to deal with any raw data. In addition, we also created a new indexing scheme, the Time-Parameterized Spatial (TPS) tree, to accelerate query processing through indexes that take advantage of the locality relationships between atoms. The tree was implemented directly inside the PostgreSQL kernel, on top of the SP-GiST platform. Along with this new tree, two new data types were also defined, as well as new algorithms for five data points' retrieval queries.

This study investigated age differences in generalization of causal value employing similarity as a cue to causality. Exemplars from six food categories (A+, B-, C+, D-. E+, F-) were presented to both young and older adults in two contiguous training phases. Training Phase 1 included exemplars from categories A+, B-, C+, D-. Training Phase 2 included exemplars from A+, B-, E+, F-. Foods in the “+” categories were paired with an outcome of sickness and foods in the “-” categories were not paired with sickness. Tests of causal judgment and exemplar recognition were conducted. For causal judgment, individual exemplars experienced during training and novel exemplars from all six categories were presented. For categories A+ and B-, the categories experienced in both training phases, young and older groups generalized the causal value to the category label and to all exemplars regardless of whether they were experienced in training or were novel. For categories experienced only once in training (C+, D-, E+, F-), both groups were better able to successfully judge causal value for experienced exemplars than novel exemplars. For young and older adults, experience made a difference in the ability to generalize causal value. Experienced and novel exemplars were also presented for recognition. Participants in both age groups showed a false memory effect for individual exemplars from the more experienced categories (A+, B-) suggesting that the process that allowed them to generalize causal value also interfered with their memory for individual exemplars. There was a difference between the younger and older groups for the categories that were only experienced once in training (C+, D-, E+, F-). In this case, younger participants showed better recognition than older adults for the individual exemplars. Older adults showed the same false memory effects for these categories as they showed for categories A+ and B-. These findings suggest that older adults generalize causal value as well as younger adults, but they are less able to distinguish individual exemplars. This discrepancy may be explained by differences in ability to use verbatim and gist. Older adults’ reduced verbatim processing leads to default gist encoding that enables them to focus on category level features but not process detailed exemplar identity (Brainerd & Reyna, 1990). Younger adults appear to have a flexibility that enables them to encode and retrieve both category-level gist and verbatim individualexemplar features when the task calls for it.

Background: GISTs are gastrointestinal mesenchymal tumours that express the type III receptor tyrosine kinase KIT. The KIT proto-oncogene encodes the receptor KIT. Most GISTs have gain-of-function mutations in the KIT or PDGFRA gene. The tyrosine kinase is therefore continuously activated leading to ligand-independent dimerization. Imatinib mesylate (Glivec®) is considered to be the first-line palliative treatment. The activated form of the KIT receptor tyrosine kinase is inhibited by imatinib. The aim of the study was to compare the survival of patients treated with either adjuvant or down-staging imatinib with historic controls treated with radical surgery (R0) only. Methods: A historic control group was chosen from a population-based series from western Sweden (population 1.6 million) that matched the adjuvant (n=23) and down-staging (n=7) groups respectively. Mutation analysis was performed in all cases with bidirectional direct sequencing. The recurrence-free survival was calculated. Results: There was only one recurrence (4 %) in the adjuvant group, and no recurrences in the down-staging study group, compared to 32/48 patients (67 %) in the control group. Tumour size decreased in diameter from 20 cm to 11 cm with down-staging treatment. Conclusion: Adjuvant imatinib improves recurrence-free survival in R0 resected patients. Down-staging treatment with imatinib is recommended for patients with large tumours or metastases. The importance of mutation analysis was established.

<p>Background: GISTs are gastrointestinal mesenchymal tumours that express the type III receptor tyrosine kinase KIT. The KIT proto-oncogene encodes the receptor KIT. Most GISTs have gain-of-function mutations in the KIT or PDGFRA gene. The tyrosine kinase is therefore continuously activated leading to ligand-independent dimerization. Imatinib mesylate (Glivec®) is considered to be the first-line palliative treatment. The activated form of the KIT receptor tyrosine kinase is inhibited by imatinib. The aim of the study was to compare the survival of patients treated with either adjuvant or down-staging imatinib with historic controls treated with radical surgery (R0) only.</p><p>Methods: A historic control group was chosen from a population-based series from western Sweden (population 1.6 million) that matched the adjuvant (n=23) and down-staging (n=7) groups respectively. Mutation analysis was performed in all cases with bidirectional direct sequencing. The recurrence-free survival was calculated.</p><p>Results: There was only one recurrence (4 %) in the adjuvant group, and no recurrences in the down-staging study group, compared to 32/48 patients (67 %) in the control group. Tumour size decreased in diameter from 20 cm to 11 cm with down-staging treatment.</p><p>Conclusion: Adjuvant imatinib improves recurrence-free survival in R0 resected patients. Down-staging treatment with imatinib is recommended for patients with large tumours or metastases. The importance of mutation analysis was established.</p>

This thesis is an expansion of an ongoing examination of gist and verbatim memory in young adults with language-learning disabilities (LLD) using the DRM paradigm (Deese, 1959; Roediger & McDermott, 1995). This study uses lists based on situation semantic features in addition to DRM lists based on backwards associative strength (BAS), which were categorized as strong-, mid-, and low-BAS (Stadler, Roediger, & McDermott, 1999). Items in each list (e.g., bacon, toast, cereal, muffin) related to a non-presented word (e.g., breakfast): the critical lure (CL). BAS is a measure of the likelihood that a list item will elicit the CL. Thirty young adults participated in this study and were divided into three groups: true LLD, compensated LLD, and typically developing (TD). Participants listened to word lists and verbally recalled the words they remembered hearing. Accurate recall was an indicator of verbatim memory; CL recall was an indicator of gist memory. The true LLD group recalled CL at a significantly higher rate than the other groups in the case of the situation lists; additionally, the compensated LLD group recalled CL for the low-BAS lists at a significantly higher rate than the other groups. These findings suggest that the LLD participants may process semantic information differently or may rely on gist memory to a greater extent than the TD controls. Results also indicated list type differences for both verbatim and gist recalls, supporting the effects of both semantic features and BAS together with other factors. / text

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