Orientador: Marcone Lima Sobreira / Resumo: A tese foi subdividida em quatro capítulos, todos redigidos no formato de artigos científicos. O primeiro capítulo, denominado “POLIDOCANOL VERSUS GLICOSE PARA O TRATAMENTO ESCLEROTERÁPICO DE TELANGIECTASIAS DOS MEMBROS INFERIORES: PROTOCOLOS PARA UM ESTUDO CLÍNICO, RANDOMIZADO E CONTROLADO - PG3T” foi cadastrado no site de registro de estudos clínicos dos Estados Unidos da América controlado pelo Food and Drug Administration (EUA, FDA) sob o registro número NCT02657252, com intenção de ampliar a relevância e veracidade do estudo, sendo redigido em tempo verbal futuro; o segundo capítulo, denominado “ESTUDO CLÍNICO, RANDOMIZADO, CONTROLADO E TRIPLO CEGO PARA COMPARAR POLIDOCANOL DILUIDO EM GLICOSE VERSUS GLICOSE PURA PARA O TRATAMENTO DE TELANGIECTASIAS EM MEMBROS INFERIORES - PG3T”, apresenta os resultados obtidos com a aplicação clínica do primeiro protocolo de pesquisa, sendo redigido em tempo verbal passado; o terceiro capítulo, denominado “POLIDOCANOL VERSUS GLICOSE PARA O TRATAMENTO ESCLEROTERÁPICO DE VEIAS RETICULARES DOS MEMBROS INFERIORES: PROTOCOLOS PARA UM ESTUDO CLÍNICO, RANDOMIZADO E CONTROLADO” foi cadastrado no site de registro de estudos clínicos dos EUA controlado pelo FDA (Estados Unidos da América, Food and Drug Administration) sob o registro número NCT02054325, com intenção de ampliar a relevância e veracidade do estudo, sendo redigido em tempo verbal futuro; o quarto capítulo, denominado “ESTUDO CLÍNICO, RANDOMIZADO, CONTROLADO E TRIPLO CEGO PARA COMPARAR... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: The thesis was divided into four chapters, all written in the papers format. The first chapter, entitled " POLIDOCANOL VERSUS GLUCOSE FOR SCLEROTHERAPY TREATMENT OF TELANGIECTASIS OF THE LOWER LIMBS: STUDY PROTOCOL FOR A RANDOMIZED CONTROLLED TRIAL - PG3T " was registered in the clinical trials registration site of the United States controlled by the Food and Drug Administration (US FDA) under the registration number NCT02657252, intended to increase the relevance and veracity of the study, being written in the future tense; the second chapter, called "clinical study TRIPLE BLIND CLINICAL TRIAL COMPARING POLIDOCANOL VESUS HYPERTONIC GLUCOSE TO TELANGIECTASIS TREATMENT IN LOWER LIMB - PG3T" presents the results obtained with the clinical application of the first research protocol, It is written in the past tense; the third chapter, called " POLIDOCANOL VERSUS GLUCOSE FOR THE VEIN OF SCLEROTHERAPEUTIC TREATMENT RETICULAR OF LOWER LIMBS: PROTOCOLS FOR A CLINICAL STUDY, RANDOMIZED CONTROLLED TRIAL " was registered in the US clinical trial registry site controlled by the FDA (United States, Food and Drug Administration) under the number NCT02054325 record, intended to increase the relevance and veracity of the study, and written in future tense; the fourth chapter, called " RANDOMIZED, CONTROLLED AND TRIPLE BLIND CLINICAL TRIAL COMPARING POLIDOCANOL DILUTED IN GLUCOSE VESUS PURE GLUCOSE TO TREATMENT OF RETICULAR VEIN IN LOWER LIMBS" presents the results to the clinical application... (Complete abstract click electronic access below) / Doutor

L'imagerie en tenseur de diffusion (DTI) est basée sur la mesure de la mobilité des molécules d'eau permettant l'analyse de la microarchitecture du tissu cérébral. Le trajet des fibres blanches peut être alors reconstruit par des méthodes de tractographie déterministes basées sur la direction principale de la diffusion. Toutefois elle repose sur des outils mathématiques complexes donnant un regard indirect sur les structures anatomiques, et sa validation est un enjeu majeur. Notre objectif a été de concevoir un objet-Test (OT) tri-Dimensionnel permettant la validation de la diffusion dans des faisceaux de fibres imitant l'organisation cérébrale. Cet OT se compose de trois modules: BOITE, SOLUTION, FIBRE réalisés en impression 3D. Il se compose de solutions de glucose et de fibres de dyneema orientées dans les trois orientations de l’espace. Nous nous sommes intéressés au développement d'une méthode de contrôle qualité des mesures quantitatives de diffusion dans le module SOLUTION. / Diffusion Tensor Imaging (DTI) is based on the measurement of water diffusion mobility in order to investigate brain microarchitecture and white fiber connectivity. The trajectory of white fibers bundles can be reconstructed by deterministic tractography methods depending on the principal direction of diffusion in tissu. However, tractography consist to complex mathematical algorithms reflecting an indirect visualization of white fibers. Our goal consisted to design a 3D phantom which imitates brain's diffusion properties, offering different degrees of diffusion mobility and imitating the organization of brain fibers. The phantom consists of three components 3D-Printing: BOX, SOLUTION, FIBER. The phantom was composed of various glucose solutions and dyneema synthetical fibers organized in all 3 directions. We developed a quality control of quantitative measurements for the SOLUTION's component. We have lead a comparison of fibers reconstruction between tractography and ground truth in FIBER's component. Results show that : ADC values were ranged on those brain values with glucose solutions; FA,