Ovarian cancer (OC) is the fifth most common cancer among women and has the highest mortality of any cancer of the female reproductive system. The majority (61%) of OC cases are diagnosed at a distant stage. Because diagnoses occur most commonly at a late-stage and prognosis for advanced disease is poor, research focusing on the development of effective OC screening methods to facilitate early detection in high-risk, asymptomatic women is fundamental in reducing OC-specific mortality. Presently, there is no screening modality proven efficacious in reducing OC-mortality. However, transvaginal ultrasonography (TVS) has shown value in early detection of OC. TVS presents with the possibility of false positive results which occur when a women receives an abnormal TVS screening test result that is deemed benign following repeat testing (about 7% of the time). The purpose of this dissertation was to evaluate the impact of false positive TVS screening test results on a variety of psychological and behavioral outcomes using mixed and trajectory statistical modeling. The three specific aims of this dissertation were to 1) compare psychological and behavioral outcomes between women receiving normal and false positive results, 2) identify characteristics of women receiving false positive results associated with increased OC-specific distress and 3) characterize distress trajectories following receipt of false positive results. Analyses included a subset of women participating in an experimental study conducted through the University of Kentucky Ovarian Cancer Screening Program. 750 women completed longitudinal assessments: 375 false positive and 375 normal results. Mixed and group-based trajectory modeling were used to evaluate the specific aims. Results suggest women receiving false positive TVS result experience increased OC-specific distress compared to women receiving normal results. Among those receiving false positives, less education, no history of an abnormal screening test result, less optimism and more social constraint were associated with increased OC-specific distress. Family history was associated with increased distress among women with monitoring informational coping styles. Three distinct trajectories characterize the trajectory of distress over a four-month study period. Although decreasing over time, a notable proportion of women experience sustained high levels of OC-specific distress.

Background: Childhood excess weight and family food insecurity are food-system related public health problems that exist in Canada. Since both relate to issues of food accessibility and availability, which have elements of “place”, they may share common risk factors in the local environment that are amenable to intervention. In this area of research, the literature derives mostly from a US context, and there is a dearth of high quality evidence, specifically from longitudinal studies. Objectives: The main objectives of this thesis were to examine the adjusted associations between the place factors: material deprivation, social deprivation, social cohesion, disorder, and living location, with change in child BMI Z-score and with change in family food insecurity status in a Canadian cohort of children. Methods: The Québec Longitudinal Study of Child Development was used to meet the main objectives of this thesis. Response data from six collection cycles (4 – 10 years of age) were used in three main analyses. The first analysis examined change in child BMI Z-score as a function of the place factors using mixed models regression. The second analysis examined change in child BMI Z-score as a function of place factors using group-based trajectory modeling. The third and final analysis examined change in family food insecurity status as a function of the place factors using generalized estimating equations. Results: Social deprivation, social cohesion and disorder were strongly and positively associated with family food insecurity, increasing the odds by 45-76%. These place factors, on the other hand, were not consistently associated with child weight status. Material deprivation was not important for either outcome, except for a slight positive association in the mixed models analysis of child weight status. Living location was not important in explaining family food insecurity. On the other hand, it was associated with child weight status in both analyses, but the nature of the relationship is still unclear. Conclusions: Results do not suggest that addressing similar place factors may alleviate both child excess weight and family food insecurity. More high quality longitudinal and experimental studies are needed to clarify relationships between the local environment and child weight status and family food insecurity.

Basierend auf den Erfahrungen der Mitarbeiter der confuture Innovationssysteme GmbH auf den Gebieten der Entwicklung von internetbasierten Anwendungssystemen und Groupware-Anwendungen sowie den Mitarbeitern des Instituts für Wirtschaftsinformatik der Universität Leipzig (IWi) bei der Entwicklung, Einführung und Betrieb von e-Learning-Systemen im Projekt „Winfoline“ wurde im Jahre 2003 der Prototyp eines modularen, frei konfigurierbaren e-Learning Systems entwickelt.

With the advent of quantum computers, the security of number-theoretic cryptography has been compromised. Consequently, new cryptosystems have been suggested in the field of non-commutative group theory. In this thesis, we provide all the necessary background to understand and work with the Artin groups. We then show that Artin groups of finite type and Artin groups of large type possess an easily-computable normal form by explicitly writing the algorithms. This solution to the word problem makes these groups candidates to be cryptographic platforms. Finally, we present some combinatorial problems that can be used in group-based cryptography and we conjecture, through empirical evidence, that the conjugacy problem in Artin groups of large type is not a hard problem.

Background: Childhood excess weight and family food insecurity are food-system related public health problems that exist in Canada. Since both relate to issues of food accessibility and availability, which have elements of “place”, they may share common risk factors in the local environment that are amenable to intervention. In this area of research, the literature derives mostly from a US context, and there is a dearth of high quality evidence, specifically from longitudinal studies. Objectives: The main objectives of this thesis were to examine the adjusted associations between the place factors: material deprivation, social deprivation, social cohesion, disorder, and living location, with change in child BMI Z-score and with change in family food insecurity status in a Canadian cohort of children. Methods: The Québec Longitudinal Study of Child Development was used to meet the main objectives of this thesis. Response data from six collection cycles (4 – 10 years of age) were used in three main analyses. The first analysis examined change in child BMI Z-score as a function of the place factors using mixed models regression. The second analysis examined change in child BMI Z-score as a function of place factors using group-based trajectory modeling. The third and final analysis examined change in family food insecurity status as a function of the place factors using generalized estimating equations. Results: Social deprivation, social cohesion and disorder were strongly and positively associated with family food insecurity, increasing the odds by 45-76%. These place factors, on the other hand, were not consistently associated with child weight status. Material deprivation was not important for either outcome, except for a slight positive association in the mixed models analysis of child weight status. Living location was not important in explaining family food insecurity. On the other hand, it was associated with child weight status in both analyses, but the nature of the relationship is still unclear. Conclusions: Results do not suggest that addressing similar place factors may alleviate both child excess weight and family food insecurity. More high quality longitudinal and experimental studies are needed to clarify relationships between the local environment and child weight status and family food insecurity.

Studien undersökte gruppbaserad compassionfokuserad terapi (CFT) i en klinisk miljö hos ungdomar med psykisk ohälsa samt hos omsorgspersoner till ungdomar med psykisk ohälsa. Syftet var att undersöka samband mellan deltagarnas upplevelse av CFT och psykiskt mående före och efter behandling. Deltagarna beskrev fritt sina upplevelser av CFT i en utvärderingsenkät som undersöktes med innehållsanalyser. Psykiskt mående skattades med en anpassad version av The Child Outcome Rating Scale (CORS) och förändring mättes med beroende t-test. Sambandet mellan dessa undersöktes med datan från båda instrumenten. Resultatet visade en övergripande positiv upplevelse av behandlingen. Omsorgspersonernas psykiska mående förbättrades signifikant, men inte ungdomarnas. Ett möjligt samband mellan positiv förändring i psykiskt mående och positiv behandlingsupplevelse syntes. Däremot sågs inget tydligt samband kring försämring i psykiskt mående och en negativ behandlingsupplevelse. CFT tycks vara hjälpsamt för omsorgspersoner till barn med psykisk ohälsa och eventuellt även för ungdomar med psykisk ohälsa men vidare forskning krävs. / The study examined group-based compassion-focused therapy (CFT) for adolescents with mental health problems, and caregivers to adolescents with mental health problems, in a clinical environment. The purpose was to examine the association between participants´ experiences of CFT and changes in psychological distress before and after treatment. Participants freely described their experience in an evaluation questionnaire, which were examined with content analyzes. Psychological distress was rated with a constructed version of The Child Outcome Rating Scale (CORS) and changes were measured with dependent t-test. Comparisons between both assessments examined their association. The results showed positive experiences of the treatment. Caregivers rated a significant improvement in psychological distress, however, adolescents did not. A possible association was discovered between improvement in psychological distress and positive experiences. However, there was no obvious pattern between impairment of psychological distress and negative experiences. CFT seems to be a helpful treatment for caregivers to adolescents with mental health problems and possibly also to adolescents with mental health problems, but further research is required.

Background and Purpose: To investigate the effect of an individualized exercise program versus a generic group-based exercise program on balance, gait, and functional performance of older adults categorized as having mild balance dysfunction and living in residential care facilities. Methods: Single blind randomized control design. One hundred-twenty residents fulfilled screening criteria for mild balance dysfunction based on the BioSwayTM balance and the Multi-Directional Reach Test (MDRT) primary outcome measures. Secondary assessment was completed using the Modified Physical Performance Test (PPT), hand-held dynamometer (lower-limb muscle strength testing), and gait speed analysis. Sixty subjects received individualized treatment from physical therapists (8 weeks). Another sixty subjects received generic group-based exercises (8 weeks). All outcome measures were collected at baseline and post-intervention (ninth week); and BioSwayTM and PPT measures at follow-up (thirteenth week) for the individualized group. Results: Individualized group (n=60) showed significant improvement compared to the group-based group (n=60) on the two BioSwayTM scores (limits of stability, p < .001; and postural stability, p = .016), the MDRT scores (forward reach, p < .001; backward reach, p = .007; right lateral reach, p < .001; and left lateral reach p < .001), the strength scores (hip flexors, p = .010; knee extensors, p = .002; hip abductors, p = .009; and ankle dorsiflexors, p = .025), the PPT outcomes (p < .001), and the gait scores (p = .012). Effect sizes ranged from small to large, with the largest sizes for limits of stability and MDRT. There were no significant differences between groups for the mCTSIB (p = .538). However, 96.7% of subjects in the individualized group scored within one SD of the reference mean, relative to 75% in the group-based group. At follow-up, the individualized group showed significant differences over time with medium to large effect sizes on the PPT (p < .001), limits of stability (p < .001), postural stability (p < .001), and mCTSIB (p = .005) measures. Post-hoc analysis revealed retention of gains for all measures at follow-up, except the mCTSIB. Conclusion: The individualized group showed significant improvements in the areas of balance, strength, mobility, and functional outcomes.

The moderation function of in-group status position on the relationship between group-based guilt and reparation intention was tested in a 2 (group-based guilt: low versus high) x 2 (status loss: weak versus strong) factorial between-subjects design, using an online survey software program named Qualtrics. The target population was white South African undergraduate students born after 1988 and registered at the University of South Africa. The results of the first Experiment confirmed the hypothesis, that the relationship between group-based guilt and reparation intention becomes less significant the more participants perceive a loss of status for their in-group. However, the hypothesis could not be confirmed in Experiment 2. The results are presented and discussed in detail / Psychology / M.A. (Psychology)

The overarching aim of the present thesis is to gain knowledge about how Rwandan university students understand and practice group-based learning. Specifically, this research takes a social constructivist perspective when examining how second year students within the area of Modern Languages reflect on collaborative writing and peer assessment as means to promote academic writing and active learning. Four studies make up this research. Thus, Study I examines how students carry out self-directed group work in writing. Study II investigates how instructor-guided writing groups can help promote students’ collaborative learning. Study III explores in what ways process writing as instruction method can help develop students’ academic writing abilities and Study IV focuses on how students experience peer assessment and peer feedback on group writing. The data, which are qualitative, were collected by means of interviews carried out with groups of students. The findings show that students perceive and conduct group-based learning in different ways, which can impact the quality of their learning. Also, based on initial support and guidance from the course instructor, most students acknowledged having been able to take stock of their common writing abilities and understand in what ways peer assessment and peer feedback can help them improve, and thus enrich their learning. A few students considered the common writing process time consuming though. In conclusion, some strategies are suggested to further improve group-based learning. / Det övergripande syftet med denna avhandling är att söka kunskap om hur universitetsstudenter i Rwanda förstår och praktiserar gruppbaserat lärande. Teoretiskt utgår den från ett socialkonstruktivistiskt perspektiv med särskilt fokus riktat mot hur studenter inom ämnesområdet moderna språk reflekterar över kollaborativt skrivande och inbördes bedömning som ett sätt att främja akademiskt skrivande och aktivt lärande. Avhandlingen består av fyra studier. I studie I undersöks studenters reflektioner över hur deras självstyrda skrivande i grupp genomförs. Studie II belyser lärarens roll i lärarlett skrivande i grupp och hur det kan påverka studenters kollaborativa lärande. I studie III studeras på vilket sätt metoder som synliggör skrivprocessen kan stödja studenters utveckling inom akademiskt skrivande. Studie IV fokuserar hur studenter erfar inbördes bedömning av skrivande i grupp. Data består av kvalitativa intervjuer genomförda med grupper av studenter under deras andra högskoleår Resultaten visar att studenterna uppfattar och genomför gruppbaserat lärande på olika sätt vilket kan påverka kvaliteten på deras lärande. Givet ett initialt stöd och vägledning från läraren som grund, bekräftade de flesta studenterna att de i grupparbetet kunde utnyttja sin gemensamma skrivförmåga och förstå på vilket sätt inbördes utvärdering kan hjälpa dem att förbättra sitt skrivande och därmed berika deras lärande. Vissa ansåg dock att den gemensamma skrivprocessen var tidsödande. Avslutningsvis föreslås strategier som kan användas för att ytterligare förbättra ett gruppbaserat lärande.

The moderation function of in-group status position on the relationship between group-based guilt and reparation intention was tested in a 2 (group-based guilt: low versus high) x 2 (status loss: weak versus strong) factorial between-subjects design, using an online survey software program named Qualtrics. The target population was white South African undergraduate students born after 1988 and registered at the University of South Africa. The results of the first Experiment confirmed the hypothesis, that the relationship between group-based guilt and reparation intention becomes less significant the more participants perceive a loss of status for their in-group. However, the hypothesis could not be confirmed in Experiment 2. The results are presented and discussed in detail / Psychology / M.A. (Psychology)