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Organizations in highly regulated industries have an increasing need to protect their intellectual assets, because Advanced Persistent Threat (APT) entities are capable of using supply chain attacks to bypass traditional defenses. This work investigates the feasibility of preventing supply chain attacks by isolating the build environment of the software using hardware isolation. Specifically, this work analyzes the extent to which the Intel SGX can guarantee the integrity and authenticity of software produced in Highly Regulated Environments. A theoretical evaluation using assurance cases shows that a hardware isolation approach has the potential to guarantee the integrity and authenticity of the produced software. Security weaknesses in Intel SGX significantly limit the confidence in its ability to secure the build environment. Directions for future work to secure a build environment with a hardware isolation approach are suggested. Most importantly, the guarantees from hardware isolation should be improved, suggestively by choosing a more secure hardware isolation solution, and a proof-of-concept of the approach should be implemented. / Organisationer i mycket reglerade industrier har ett ökat behov av att skydda sina intellektuella tillgångar, eftersom avancerade långvariga hot (APT) har förmågan att använda sig av distributionskedjeattacker för att ta sig förbi existerande skydd. Det här arbetet undersöker möjligheten att skydda sig mot distributionskedjeattacker genom att isolera mjukvarans byggmiljö med hjälp av hårdvaruisolering. Specifikt analyseras till vilken grad Intel SGX kan garantera integriteten och autenticiteten av mjukvara som produceras i mycket reglerade miljöer. En teoretisk evaluering genom assurans visar att hårdvaruisolering har möjligheten att garantera integriteten och autenticiteten hos den producerade mjukvaran. Säkerhetsbrister i Intel SGX begränsar i hög grad förtroendet för dess förmåga att säkra byggmiljön. För vidare forskning föreslås att garantierna från hårdvaruisolering förbättras, förslagsvis genom att välja säkrare hårdvaruisoleringslösningar, samt att en prototyp av lösningen implementeras.

The overview of solved problems is focused on human resources and education. The role of education in regional development, the role of human resources in economic growth and the support of education through public expenditure programs and measure 1.1 of OP HRE are described. Methods of assessing the education and economic performance of the regions are characterized. The theoretical part of the thesis concludes the knowledge economy and education in the context of the problematic of Industry 4.0. The aim of the thesis is to evaluate the educational structure of the population of the Czech Republic and its links with the support of employee training in companies within the area of support 1.1 OP HRE in the period 2007 - 2013 and with the development of regions. Part of the thesis is to capture GDP in individual regions of the Czech Republic in 2005 - 2014. The theoretical work contribution reflects the analysis performed and confirms that the leading positions in the volume of depleted financial resources provided by the 1.1 OP HRE belongs to a structurally problematic and at the same time educationally weak regions. The practical benefits of this thesis are the use of knowledge in the area of corporate education and regional development in the programming period of 2014 - 2020.

L’hypoxie contribue à la guérison cutanée via l’induction de HIF-1 (hypoxia-inducible factor-1). HIF-1 gère l’expression de VEGFA (vascular endothelial growth factor A) en se liant au HRE (hypoxia response element) présent au niveau de son promoteur. Par contre, dans le contexte de la guérison cutanée il est incertain si l’hypoxie et HIF-1 contribuent à l’augmentation de l’expression de VEGFA. Pour vérifier cette hypothèse, la guérison cutanée et l’expression de VEGFA ont été étudiées dans un modèle murine, Vegfa/, possédant un HRE non-fonctionnel dans le promoteur de Vegfa. De manière inattendue, le niveau d’ARNm de Vegfa présent dans la peau intacte des souris mutantes était diminué. Par contre, le niveau d’ARNm de Vegfa dans le tissu de granulation n’était pas altéré par rapport à celui de souris normales. Similairement, le niveau d’ARNm des gènes ciblés par Vegfa, Pdgfb et Sdf-1, étaient aussi comparativement diminués dans la peau intacte des souris mutantes mais aucune différence significative ne fut observée dans le tissu de granulation de plaies. L’analyse histologique des plaies en guérison chez les souris mutantes a démontré un tissu de granulation altéré en quantité et qualité (densité de capillaires). Par contre, la différence dans l’épithélialisation et le taux de guérison cutanée entre les deux populations de souris était non-significative. Les résultats démontrent qu’HIF-1 n’est pas un facteur majeur dans la régulation de Vegfa dans le contexte de la guérison cutanée. Cependant, HIF-1 est nécessaire pour maintenir un niveau d’expression basale (Vegfa et ses gènes cibles) adéquate et est aussi nécessaire pour la formation d’un tissu de granulation de qualité optimal suivant une blessure cutanée. / Hypoxia in skin wounds is thought to contribute to healing through the induction of hypoxia-inducible factor-1 (HIF-1), a key transcriptional regulator of genes associated with healing. HIF-1 regulates the expression of vascular endothelial growth factor A (VEGFA) by binding a hypoxia response element (HRE) in its promoter. Although VEGFA is a key regulator of angiogenesis during healing, whether hypoxia and HIF-1 serve to induce its expression in this context is unknown. To test this hypothesis, we studied VEGFA expression and wound healing in the Vegfa/ mouse model, which lacks a functional HRE in the Vegfa promoter. Unexpectedly, decreased levels of Vegfa mRNA were found in intact skin in Vegfa/ mice, whereas levels in granulation tissue during wound healing were not altered. Likewise, mRNA levels of VEGFA target genes Pdgfb and Sdf-1 were decreased in skin but unchanged in granulation tissue in the Vegfa/ mice. Decreased Vegfa levels in skin could not be attributed to decreased HIF-1 protein expression in the skin of Vegfa/ mice, and were therefore the consequence of a loss of HIF-1 responsiveness of the Vegfa promoter. Histologic analyses of healing wounds in Vegfa/ mice revealed significant defects in granulation tissue, both in terms of quantity and capillary density, although epithelialization and healing rates were unaltered. It can be concluded that HIF-1 is not a major regulator of Vegfa during wound healing. Rather, HIF-1 serves to maintain basal levels of Vegfa and VEGFA target genes in intact skin, required for optimal granulation tissue formation in response to wounding.