Made available in DSpace on 2014-08-13T14:50:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-05-08Bitstream added on 2014-08-13T18:00:55Z : No. of bitstreams: 1 000750710.pdf: 832145 bytes, checksum: 2b135f4526d2bc2da676628715a1e741 (MD5) / O presente estudo identificou características sociodemográficas, da saúde física e mental, percepções e expectativas ao atendimento e diagnóstico de pacientes com suspeita de câncer de cabeça e pescoço. Avaliou-se 49 pacientes de dois centros de diagnóstico oral. O delineamento constou de dois Momentos: pré-biópsia (M1) e pósdiagnóstico (M2). No M1, investigaram-se dados sociodemográficos, apoio social e estilo de vida (questionário), sintomas ansiosos (Inventário de Ansiedade Traço- Estado, IDATE), depressivos (Inventário de Depressão de Beck, BDI) e uso de álcool (Alcohol Use Disorders Identification Test, AUDIT); motivo da consulta, sentimentos, percepção do problema e expectativas sobre diagnóstico e atendimento (entrevista). No M2, reavaliaram-se sintomas ansiosos (IDATE-Estado) e depressivos (BDI), percepções e sentimentos ao diagnóstico, enfrentamento, expectativas e a satisfação com o atendimento (entrevista) dos 29 pacientes com diagnóstico de câncer. As respostas às entrevistas foram categorizadas. Utilizou-se de análises descritivas e bivariadas (chi-quadrado ou exato de Fisher, Goodman e Wilcoxon – p<0.05). Resultados: na amostra total, predominaram: homens (73,4%), idade de 59 anos, 4,5 anos de estudo, ocupação remunerada (40,8%), rendimento de R$ 670,65, viver com companheiro 61,2% e com parentes 87,8%, relatar sentimento de apoio social 83,7%, ter religião 93,9%, tabagismo e etilismo 44,9%, ter problemas de saúde 45,0% e autoavaliação da “saúde boa” 69,4%. O tempo médio de observação da lesão foi de seis meses, sendo a maioria intraoral (83,7%) e encaminhados por dentistas 51,0%. No M1, 53,9% das mulheres foram consideradas caso para ansiedade-Traço, 61,5% para Estado e 46,2% para sintomas depressivos; e 36,1% dos homens apresentaram risco para de uso de álcool. Observou-se que 61,2% dos pacientes relataram percepções realistas sobre sua saúde, satisfação com atendimento ... / This study aimed to describe the sociodemographic characteristics, lifestyle, and physical and mental health status of patients with head and neck cancer, as well as identify their perceptions and expectations regarding care and diagnosis. 49 patients were evaluated before and after diagnosis communication as they were submitted to biopsies in two diagnostic oral centers. Before the diagnosis (moment 1), the sociodemographic and lifestyle variables were evaluated using a questionnaire and validated instruments to assess anxiety (State - Trait Anxiety Inventory, STAI), depression (Beck Depression Inventory, BDI) and alcohol abuse (Alcohol Use Disorders Identification Test, AUDIT); reason for examination, feelings, perception of the problem, and expectations were investigated through a structured interview. After cancer diagnosis (moment 2), 29 patients had some aspects reassessed: anxiety, depression levels, perceptions, feelings about the disease, and expectations towards medical and dental care. Were also investigated coping and satisfaction with the service received from dentists. Data collected during the interviews were categorized and a descriptive and bivariate analysis (Qui-square, fisher, Goodman and Wilcoson – p<0,05) to other variables. The initial sample consisted mostly of males (73.4%) (mean age of 59 years), with four and a half years of study, employed (40.8%), low income (53,0%), having a partner (61.2%), living with relatives (87.8%), having feelings of social support (83.7%) and a religion (93.9%), smoking (44.9%) and (45.0%) drinking habits, and classified their health as “good” (69.4%). The mean time between observation of symptoms and seeking for help was six months, which were mostly intraoral lesions (83.7%), referred by dentists (51.1%). Before diagnosis (Moment 1), women had a high prevalence for anxiety-trait (53.9%), state (61.5%) and depressive symptoms (46.2%). Men had a higher frequency of risky use of ...

Made available in DSpace on 2014-08-13T14:50:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-07-17Bitstream added on 2014-08-13T18:00:53Z : No. of bitstreams: 1 000750768.pdf: 1405991 bytes, checksum: 68568a010dcdca88df8b22b4614eb667 (MD5) / O carcinoma espinocelular (CEC) é tumor maligno das células espinhosas da epiderme caracterizado por evolução mais rápida, maior poder invasivo e metastático em relação ao carcinoma basocelular (CBC). A área mais profunda e infiltrativa do CEC, conhecida como fronte de invasão, revela células neoplásicas malignas com menor grau de diferenciação comparadas à totalidade da lesão. Estudos recentes demonstram a influência do padrão do fronte de invasão tumoral no prognóstico de CEC de laringe e colo uterino. Contudo, não há estudos sobre o mesmo em relação a CEC cutâneos de cabeça e pescoço. Estudar as características clínicas, histopatológicas e perfil imuno-histoquímico do CEC de cabeça e pescoço e fronte de invasão tumoral, correlacionando-o com comportamento biológico. O estudo foi do tipo coorte retrospectivo, sendo selecionados os pacientes que tiveram diagnóstico de CEC de cabeça e pescoço confirmados pelo exame anatomopatológico no período de 1999 a 2009. A avaliação do fronte de invasão tumoral foi realizada empregando-se imuno-histoquímica para E-caderina, ki-67 e p53. Resultados: O tipo de fronte de invasão, bem como as expressões de E-caderina e ki-67, seja em sítio superficial ou profundo, não apresentaram associação com os critérios prognósticos histopatológicos. Os achados mostraram que a E-caderina, o p53 e o ki-67 foram mais expressos em tumores com tamanho ˃ 2cm. Em relação a espessura do tumor, observamos que o p53 foi mais expresso na profundidade nas lesões mais espessas (índice de Breslow maior que 2mm), e que foi acompanhada também pela expressão maior do Ki-67.A expressão de p53 em sítio superficial teve associação inversa com o critério de espessura (p<0,049) e, em sítio profundo, teve associação direta com a intensidade do processo inflamatório local (p<0,046). O tipo de fronte de invasão, bem como as expressões de E-caderina, ki-67 e p53, em sítios ... / The Squamous Cell Carcinoma (SCC) is a malignant epidermal tumor of squamous epithelial cells, characterized for greater aggressiveness much higher incidence of metastasis than Basal Cell Carcinoma (BCC). The deepest invading tumor area, known as invasive tumor front usually disclose less differentiated malignant cells, compared with the whole lesion. Recent studies demonstrate the influence of the invasive tumor front pattern on the prognosis of larynx and uterine cervix SCC. However, there is no studies about that on cutaneuos SCC of the head and neck. To study the clinical, histopathological and immunohistochemical profile of the SCC from head and neck and its invasive tumor front, correlating it with its biological behavior. The study was a retrospective type coorte, where the patients with histopathological diagnosis of head and neck cutaneous SCC among 1999 to 2009 were selected. The evaluation of invasive tumor front was immunohistochemistry for E-cadherin, ki-67 and p53. The pattern of invasive tumor front, as well as E-cadherin and ki-67 expressions, at superficial and deep sites, did not present association with histopathological prognostic criteria. The findings showed that E-cadherin, p53 and Ki-67 were more highly expressed in tumors with size ˃ 2cm. Regarding the thickness of the tumor, we observed that p53 was expressed in depth in thicker lesions (Breslow thickness greater than 2 mm), which was also accompanied by higher expression of Ki-67. p53 expression, at superficial site, had inverse association with thickness criteria (p<0,049) and, at deep site, had direct association with local inflammatory process intensity (p<0,046). The invasive tumor front, as well as E-cadherin, ki-67 and p53 expressions, at superficial and deep sites, did not demonstrate impact on free disease survival. The characteristics of invasive tumor front did not correlate with prognosis in cutaneuos SCC of the head and neck regarding to the ...

Orientador: Ana Maria Teresa de Abreu Ramos Cerqueira / Coorientador: Antonio Bento Alves de Moraes / Banca: Gimol Benzaquen Perosa / Banca: Márcio Ajudante Lopes / Resumo: O presente estudo identificou características sociodemográficas, da saúde física e mental, percepções e expectativas ao atendimento e diagnóstico de pacientes com suspeita de câncer de cabeça e pescoço. Avaliou-se 49 pacientes de dois centros de diagnóstico oral. O delineamento constou de dois Momentos: pré-biópsia (M1) e pósdiagnóstico (M2). No M1, investigaram-se dados sociodemográficos, apoio social e estilo de vida (questionário), sintomas ansiosos (Inventário de Ansiedade Traço- Estado, IDATE), depressivos (Inventário de Depressão de Beck, BDI) e uso de álcool (Alcohol Use Disorders Identification Test, AUDIT); motivo da consulta, sentimentos, percepção do problema e expectativas sobre diagnóstico e atendimento (entrevista). No M2, reavaliaram-se sintomas ansiosos (IDATE-Estado) e depressivos (BDI), percepções e sentimentos ao diagnóstico, enfrentamento, expectativas e a satisfação com o atendimento (entrevista) dos 29 pacientes com diagnóstico de câncer. As respostas às entrevistas foram categorizadas. Utilizou-se de análises descritivas e bivariadas (chi-quadrado ou exato de Fisher, Goodman e Wilcoxon - p<0.05). Resultados: na amostra total, predominaram: homens (73,4%), idade de 59 anos, 4,5 anos de estudo, ocupação remunerada (40,8%), rendimento de R$ 670,65, viver com companheiro 61,2% e com parentes 87,8%, relatar sentimento de apoio social 83,7%, ter religião 93,9%, tabagismo e etilismo 44,9%, ter problemas de saúde 45,0% e autoavaliação da "saúde boa" 69,4%. O tempo médio de observação da lesão foi de seis meses, sendo a maioria intraoral (83,7%) e encaminhados por dentistas 51,0%. No M1, 53,9% das mulheres foram consideradas caso para ansiedade-Traço, 61,5% para Estado e 46,2% para sintomas depressivos; e 36,1% dos homens apresentaram risco para de uso de álcool. Observou-se que 61,2% dos pacientes relataram percepções realistas sobre sua saúde, satisfação com atendimento ... / Abstract: This study aimed to describe the sociodemographic characteristics, lifestyle, and physical and mental health status of patients with head and neck cancer, as well as identify their perceptions and expectations regarding care and diagnosis. 49 patients were evaluated before and after diagnosis communication as they were submitted to biopsies in two diagnostic oral centers. Before the diagnosis (moment 1), the sociodemographic and lifestyle variables were evaluated using a questionnaire and validated instruments to assess anxiety (State - Trait Anxiety Inventory, STAI), depression (Beck Depression Inventory, BDI) and alcohol abuse (Alcohol Use Disorders Identification Test, AUDIT); reason for examination, feelings, perception of the problem, and expectations were investigated through a structured interview. After cancer diagnosis (moment 2), 29 patients had some aspects reassessed: anxiety, depression levels, perceptions, feelings about the disease, and expectations towards medical and dental care. Were also investigated coping and satisfaction with the service received from dentists. Data collected during the interviews were categorized and a descriptive and bivariate analysis (Qui-square, fisher, Goodman and Wilcoson - p<0,05) to other variables. The initial sample consisted mostly of males (73.4%) (mean age of 59 years), with four and a half years of study, employed (40.8%), low income (53,0%), having a partner (61.2%), living with relatives (87.8%), having feelings of social support (83.7%) and a religion (93.9%), smoking (44.9%) and (45.0%) drinking habits, and classified their health as "good" (69.4%). The mean time between observation of symptoms and seeking for help was six months, which were mostly intraoral lesions (83.7%), referred by dentists (51.1%). Before diagnosis (Moment 1), women had a high prevalence for anxiety-trait (53.9%), state (61.5%) and depressive symptoms (46.2%). Men had a higher frequency of risky use of ... / Mestre

Made available in DSpace on 2015-01-26T13:21:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-02-21Bitstream added on 2015-01-26T13:30:41Z : No. of bitstreams: 1 000797801.pdf: 392872 bytes, checksum: 2e9943243559df567ee5fe0c4b6b1dbf (MD5) / Cada ano, mais de 600.000 casos de câncer de cabeça e pescoço são diagnosticados mundialmente, alguns com prognóstico desfavorável devido ao desenvolvimento de segundos tumores primários nos pulmões, esôfago ou em áreas previamente irradiadas ou operadas. Este estudo tem como objetivo verificar a incidência de segundos tumores primários em pacientes com câncer de cabeça e pescoço num seguimento de 7 anos, identificar o tempo entre o diagnóstico do primeiro tumor e do segundo tumor primário e o tempo de sobrevivência entre diagnóstico inicial e o óbito. Foram utilizados 1061 prontuários de pacientes com neoplasia de cabeça e pescoço do serviço de Registro Hospitalar de Câncer do Hospital Amaral Carvalho de Jaú. Neste estudo, 8,95% dos pacientes com câncer de cabeça e pescoço desenvolveram segundo tumor primário de esôfago e laringe. A maioria dos segundos tumores primários se desenvolveu antes de cinco anos de seguimento, após o diagnóstico do tumor primário. O tempo de vida médio estimado para todos os pacientes avaliados que foram a óbito foi de 1,8 anos / Each year, more than 600.000 cases of head and neck cancer are diagnosed worldwide, someone with unfavorable prognosis due to the development of second primary tumors in the lungs, esophagus or in areas previously irradiated or operated. This study aims to determine the incidence of second primary tumors in patients with head and neck cancer in follow up 7 years , identify the time between diagnosis of the first primary and second primary tumor and survival time between initial diagnosis and death. We used medical records of 1061 patients with head and neck cancer service registry Hospital Cancer Hospital Amaral Carvalho de Jaú. In this study, 8.95% of patients with head and neck cancer developed second primary tumor of the esophagus and larynx. Most second primary tumors developed before five years of follow-up after diagnosis of the primary tumor. The average life span estimated for all patients who died was 1.8 years

Lee, Kar Ho Francis. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2011. / Includes bibliographical references (leaves 148-163). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract also in Chinese.

HNC incidence and mortality is greater in men and is associated with high risk behaviours and social deprivation. HNC is frequently diagnosed at advanced stages requiring multi-modality treatment which can have a significant impact on appearance and function. Gender can influence health behaviours yet research into male experiences of cancer has primarily focussed on prostate cancer and HNC is an area which is under investigated. The aim of this study was to explore how men with HNC experience appearance and functional change in the first 12 months following diagnosis. Grounded theory methodology (GT) was chosen as the overall purpose of GT is the generation of theory from the data which has explanatory power and advances the understanding of social and psychological phenomena. Retrospective semi-structured interviews were performed with 12 men who were 12 to 24 months post-diagnosis. Key components of GT practice used were simultaneous data collection and analysis, constructing analytic categories from the data, constant comparison, memo-writing and theoretical sampling. Three categories emerged from the data which were inter-related: normalising change; “under siege”: getting through treatment; and reclaiming self. The core category was reconciling change; a new normal which reflects the social and psychological processes involved in accommodating and assimilating change in appearance and function for men with HNC. The substantive theory provides insight into how men with HNC prioritise function and actively distance themselves from concerns regarding appearance. Furthermore, it identifies men who are at risk of social anxiety and isolation due to multiple changes or body incompetence. This study builds on theories of masculinity, body image and disfigurement. The substantive theory developed provides health and social care professionals with new knowledge to support clinical practice and improve care provision.

Indiana University-Purdue University Indianapolis (IUPUI)

Indiana University-Purdue University Indianapolis (IUPUI) / Shoulder pain was constantly reported as a problematic symptom causing dysfunction and quality of life interference after neck dissection in head and neck cancer patients. Due to a lack of conceptual framework and inconsistency of instrument selection, a comparison among previous studies was almost impossible, making it difficult to understand the phenomenon. The current study applied the University of California, San Francisco School of Nursing Symptom Management Model. The purposes of the study were to (a) describe the symptom experience of shoulder pain at 1 month after neck dissection, (b) describe the relationships among symptom experience of shoulder pain, functional status, and quality of life, and (c) identify the contextual variables, concurrent symptoms, and/or adherence predicting symptom experience of shoulder pain, functional status, and/or quality of life. This was a descriptive study with a convenience sample of head and neck cancer patients. The data were collected via a medical record review, a self-administered survey, and a physical examination. The data from 29 patients were entered for descriptive statistics, Pearson correlations, and multiple regressions. At 1 month after surgery, 62% of patients reported they had shoulder pain at some point within a week. Their shoulder pain was from mild to moderate. Fifty-nine percent complained that shoulder pain bothered them about the moderated level. In the final model, symptom experience, shoulder pain, was significantly correlated with one outcome, active shoulder abduction, but not the other, total quality of life, generic quality of life, and head and neck quality of life. Active shoulder abduction was significantly correlated with three quality of life measures. Adding significant predictors of symptom experience and outcomes into the final model, there is a potential that the model would be useful to guide treatment strategies. Treatment for myofascial pain of the levator scapulae could relieve shoulder pain after neck dissection and improve head and neck quality of life. Those with level V dissection were high risk populations of developing shoulder pain. Risk factors of quality of life, which were depression, loss of sensation, and radiation would describe how an intervention could change or unchange the patient’s life.