Long Term Conditions (LTCs) with co-morbid common mental health conditions of anxiety and depression present a significant challenge for UK health and social care services. Depression and anxiety are common in heart failure (HF) patient populations and research suggests depression has a detrimental effect on a range of health outcomes, including Health related Quality of Life (HRQoL). The impact of anxiety is relatively under-researched in this patient group. In this doctoral study a systematic review was conducted to consolidate the evidence base for the prevalence and variance of rates of anxiety in HF patients. Importantly, the relative contribution of anxiety symptoms, measured using the Hospital Anxiety and Depression Scale (HADS), to reported HRQoL , measured using the Kansas City Cardiomyopathy Questionnarie (KCCQ) was examined in a cross-sectional survey of 158 HF patients attending specialist HF outpatient clinics. The systematic review identified 72 studies, with reported rates of anxiety varying dramatically, ranging from 6.2% to 72.3%. The random effects pooled prevalence estimate for anxiety disorders was 13.01% (95% CI 9.3% - 16.9%), for probable clinically significant anxiety was 28.8% (95% CI 23.3% - 34.3%) and the random effects pooled prevalence estimate for elevated symptoms of anxiety was 55.5% (95% CI 48.1% - 62.8%). Not all tools used to assess anxiety were population appropriate. In the survey multivariate analysis found that anxiety symptoms, did not account for a significant proportion of unique variance in HRQoL scores. Higher levels of physical symptom burden, depression and an increased number of physical co-morbidities predominantly account for 69% of the variance in HRQoL (F13,125 = p <0.0005). The findings highlight the need for accurate and valid measurement of anxiety and depression within the context of a physical LTC. Anxiety and depression are common in HF patients and the evidence suggests depression in particular predicts reported HRQoL. Further research is required to understand more about the role of anxiety in influencing patient’s health outcomes.

A Hipertensão Arterial Sistêmica (HAS) é uma doença crônica não transmissível com etiologia multifatorial e uma das principais causas de doenças cardiovasculares que são responsáveis pela maioria das mortes mundiais. Por ser tratar de uma doença de alta prevalência e na maioria das vezes assintomática, a adesão do hipertenso ao tratamento tem uma representação muito baixa, o que requer a intervenção educacional dos profissionais da saúde no tratamento, na prevenção das complicações e na manutenção da vida. A qualidade de vida relacionada à saúde (QVRS) dos indivíduos com hipertensão arterial é menor comparada com a população geral. A avaliação dos fatores que influenciam na QVRS dos hipertensos pode servir de subsídios no planejamento de estratégias de tratamento mais eficazes para essa população. Objetivos: Caracterizar os indivíduos com hipertensão arterial participantes do grupo de convivência educativa segundo as variáveis: sócio-demográficas e econômica; hábitos de vida (atividade física, tabagismo, consumo de bebida alcoólica); dados relacionados a HAS(co-morbidades, uso de medicamentos anti-hipertensivos, controle dos níveis pressóricos, tempo de progressão da HAS) e tempo de participação nas atividades educativas em grupo, comparar a QVRS entre hipertensos participantes do grupo de convivência educativa com as variáveis sócio-demográficas, econômicas e clínicas e avaliar a contribuição do grupo de convivência na qualidade de vida dos hipertensos. Material e Métodos: Foi realizado um estudo descritivo do tipo transversal com 131 sujeitos com idade superior a 18 anos e diagnóstico de hipertensão arterial, residentes no município de Sacramento-MG, cadastrados no grupo de convivência no período mínimo de um ano anterior a data da entrevista. Os instrumentos utilizados para a coleta de dados foram: instrumento para caracterização da população quanto aos dados clínicos e sóciodemográficos e econômicos e o Medical Outcomes Short-Form Health Survey (SF-36) para avaliação da QVRS. Resultados: Dos pacientes, 98 eram mulheres e 33 homens, a maioria idosa 88(67,2%), com predomínio na faixa etária de 60 a 69 anos 43(32,8%) e ganham igual ou menos que um salário mínimo por mês 88(67,2%). As dimensões do SF-36 que obtiveram menores escores foram: vitalidade (64,4) e dor (70,3), enquanto as dimensões que apresentaram maiores escores foram: aspectos sociais (86,7) e capacidade funcional (79,4). Os fatores que apresentaram relação com a variação dos escores médios e correlação das dimensões do SF-36 foram: renda, atividade física, número de morbidades, diabetes, obesidade. A participação no grupo apresentou relação estatisticamente significante apenas no domínio saúde mental. Conclusão: Clinicamente os resultados mostraram relevância para intervenções educativas pela equipe de saúde. Os enfermeiros como elementos constituintes destas equipes devem estar presentes e ativos em todas as etapas desse trabalho, desde o planejamento, execução e avaliação colaborando na busca de meios efetivos que vão de encontro com a melhoria da qualidade de vida dessa população. / Arterial Hypertension is a non-transmissible chronic disease with multifactorial etiology and it is one of the main causes of cardiovascular diseases which are the leading cause of death in the world. Since the disease is characterized as having a high prevalence rate and in most cases it is asymptomatic, the treatment adherence rate is low, therefore requiring educational intervention from health professionals during the treatment in order to prevent complications and to keep the patient alive. Health-related quality of life (HRQoL) in patients with high blood pressure is reduced when compared to the general population. The evaluation of factors influencing on the HRQoL of high blood pressure patients point to the strategic planning of more efficient treatments to this population. Aims: Characterize the high blood pressure patients participating in the educational gathering group according to the following variables: socio-demographics and economics; lifestyles (physical activity, smoking, drinking); data related to systemic arterial hypertension (comorbidity, use of antidepressive drugs, blood pressure rate control, systemic arterial hypertension progression rate) and participation time in educational group activities, comparison of HRQoL among the group participating patients with the socio-demographical, economical and clinical variables and evaluate the contribution of the group to the quality of life of the participating patients. Methods and Materials: It was performed a descriptive cross-sectional study with 131 individuals over 18 years of age who suffered from high blood pressure. The patients lived in the city of Sacramento ? MG and had been participating in the gathering group for at least one year prior to the interview. The following tools were used to collect the data: Tools to characterize the population according to clinical, socio-demographical and economical data; Medical Outcomes Short-Form Health Survey (SF-36) to evaluate HRQoL. Results: From the total of 131 patients, 98 were female and 33 were male. Most of them (88 patients or 67.2%) were in an advanced age ranging from 60 to 69 years old (43 patients or 32.8%) and earned minimal wage or less (88 patients or 67.2%). The SF-36 dimensions with the lowest scores were: Vitality (64.4) and pain (70.3), whereas the dimensions with the highest scores were: Social functioning (86.7) and functional status (79.4). The factors presenting relation to the average score variation and dimension correlation in the SF-36 were: Income; physical activity; death rate; diabetes, obesity. The participation in the group was statiscally significant relation only to the mental health dimension. Conclusion: The results clinically showed the relevance of educational interventions performed by the health team. The nurses, as part of this team, must be present and active in all the stages of this work, planning, performing and searching for effective methods that lead to the improvement of life quality for this population.

Among the 14 million persons living in the United States with current or remitted cancer, poor physical health-related quality of life (HRQL) is a significant concern. However, self-compassion (i.e., common humanity, mindfulness, self-kindness) may be a protective factor, either directly or indirectly, by allowing for a sense of empowerment and control over illness, and in turn, facilitating engagement in treatment and positive perceptions of health. Serial mediation analyses among persons living with current (n = 67) or remitted (n = 168) cancer lend support for a positive, direct association between self-compassion and physical HRQL, as well as indirect effects via internal perceived control and, to a lesser degree, treatment adherence. Mixed findings, especially among cancer patients, highlight limitations of resiliency traits while also supporting the notion that self-compassion interventions (e.g., Mindful Self-Compassion Training) may have positive implications for health-related control beliefs, behaviors, and quality of life in the cancer population.

Orientador: Erika Veruska Paiva Ortolan / Banca: Mauro Volpi / Banca: Dionisia Aparecida Cusin Lamônica / Resumo: Paralisia cerebral (PC) descreve um grupo de anormalidades permanentes do desenvolvimento, do movimento e da postura, causando limitação da atividade, que são atribuídas a um distúrbio não progressivo que ocorreu no cérebro em desenvolvimento do feto ou do bebê. As alterações motoras da paralisia cerebral são frequentemente acompanhadas de distúrbios da sensação, percepção, cognição, comunicação, comportamento e por problemas musculoesqueléticos secundários1. A paralisia cerebral está entre as causas mais comuns de incapacidade crônica na infância, com uma incidência entre 2 e 2,5 por 1000 nascidos vivos nos países desenvolvidos 2-4. Embora a lesão cerebral primária seja não-progressiva, a patologia é permanente e muitas das manifestações clínicas, incluindo as consequências musculoesqueléticas, são adquiridas e progressivas com o tempo. Entre 25% e 35% dessas crianças são gravemente comprometidas e apresentam dificuldades com suas atividades da vida diária (AVD), comunicação, mobilidade, e consequentemente com sua saúde, e por isso são dependentes de seus cuidadores para a maioria das suas necessidades. Essas condições têm um impacto significativo durante toda a vida dessas crianças, de seus cuidadores e familiares, e para as instituições responsáveis pelos seus cuidados e bem estar 5-7 / Abstract: The consideration of quality of life related to health is crucial for planning and maintaining a system of patient-centered care. Until recently there have been no sutiable instruments to assess health related quality of life (HRQoL) of children and adolescents with severe, non-ambulant cerebral palsy (GMFCS functional levels IV and V). The "Caregiver Priorities and Child Health Index of Life with Disabilities Questionnaire" (CPCHILD©) was developed in English specifically for this population, and has been validated in Canada. The aim of this study was to translate and adapt the CPCHILD© Questionnaire into Portuguese of Brazil, allowing researchers in Brazil to have this important tool in measuring health related quality of life in this population, besides the possibility of comparison with other studies that used the same questionnaire in other languages. The cross-cultural adaptation included two forward and back translations by independent translators, an assessment of the two versions by an expert committee, and the development of a pre-final version which was tested on 30 caregivers of children (5 -18) with severe CP (GMFCS IV & V). The caregivers' comments about the pre-final version were assessed by the expert committee and incorporated in the development of the final version. Despite the relative equivalence between the two translations, some items required adaptations for the synthesized version. Certain modifications were necessary in the pre-final version to achieve idiomatic equivalence. The modifications accounted for the socioeconomic and cultural levels of the target population. Following the pre-test, we modified language that was difficult to understand, and certain items were adapted for the final version / Mestre

The human immunodeficiency virus (HIV) together with acquired immunodeficiency syndrome (AIDS) is a world wide pandemic. Sub Sahara Africa, of which South Africa forms a part, is host to the highest HIV population in the world. In the light of this, it is significant to conduct a study of the effect that aerobic exercise might have on the management of disease symptoms. HIV and AIDS seriously affect the quality of life of the infected person. Decreased quality of life leads to decreases in productivity and increase in absenteeism. This has a negative effect on the economy. Several symptoms of HIV and AIDS cause quality of life to decrease. In this study the following parameters of health related quality of life were investigated: body composition, functional capacity, pain, anxiety and depression and fatigue. Absenteeism was monitored. The study further investigates how and why each of these parameters affects health related quality of life, and also the effect of aerobic exercise on the above mentioned parameters. The body composition of HIV positive persons is affected in one of three ways: wasting of muscle mass due to the virus, obesity because of too high energy intake and too little activity in an attempt to stop wasting, or lipodystrophy due to anti retroviral therapy. HIV patients have a decreased functional capacity. This may lead to fatigue, another common symptom in HIV patients. The prevalence of anxiety and depression is high in the HIV population, and even more so in South Africa. It is clear from the literature that aerobic exercise for HIV patients is safe. It is also clear that aerobic exercise has a positive effect on the mentioned parameters – not only on the HIV population, but also on other diseases and the healthy population. Thus the assumption was made that aerobic exercise can be used as a tool to increase health related quality of life in HIV positive persons. Initially, a quantitative pre-post test experimental design was proposed. In an attempt to recruit enough participants, the discovery was made that HIV is still a highly stigmatised disease in both Mpumalanga and Gauteng. After eighteen months of negotiations with AIDS clinics, mine groups and a newspaper advertisement, only three participants were enrolled. It must be kept in mind, however, that an important factor which influenced recruitment of participants was availability of funds. The indication was that HIV patients are willing to participate if there is proper compensation. In order to continue with the study, the design changed to a case study. It combined two approaches: qualitative and quantitative. This seems to work well in HIV research. The qualitative and quantitative data supported each other and provided the bigger picture. The results of this study support the expectation that aerobic exercise enhances the quality of life in HIV infected persons. Body composition and functional capacity improved. Feelings of anxiety and depression decreased and there were indications that pain and fatigue decreased as well. Absenteeism from work decreased in one person. The conclusion was made that aerobic exercise definitely contributes to the enhancement of quality of life in HIV positive employees. Biokineticists, as exercise specialists, are ideally positioned to provide exercise tests and program prescriptions to this population and should play a bigger role in the management of HIV and AIDS symptoms. Copyright / Dissertation (MA)--University of Pretoria, 2008. / Biokinetics, Sport and Leisure Sciences / unrestricted

In der vorliegenden Untersuchung sollte ein möglicher Zusammenhang zwischen mundgesundheitsbezogener Lebensqualität (MLQ) und Depression untersucht und bei prothetischen Patienten und Personen der Allgemeinbevölkerung vergleichend betrachtet werden. Es handelt sich um eine Querschnittsstudie, in welche 311 zahnärztlich-prothetische Patienten und 811 erwachsene Probanden der Bundesrepublik Deutschland einbezogen wurden. Zur Erfassung von MLQ und Depression wurden als standardisierte Instrumente zum einen die deutsche Version des Oral Health Impact Profile (OHIP) und zum anderen das Vereinfachte-Beck-Depressions-Inventar (BDI-V) eingesetzt. Die statistischen Zusammenhänge der Konstrukte wurden mit Hilfe von Korrelationsanalysen sowie Strukturgleichungsmodellen ermittelt. Die konfundierenden Variablen Alter und Geschlecht wurden dabei kontrolliert. In beiden Populationen wurde ein signifikanter Zusammenhang zwischen Depression und MLQ festgestellt. Diese gegenseitige Beeinflussung zwischen MLQ sowie deren Dimensionen und der Depression war jedoch zwischen den beiden Probandengruppen signifikant unterschiedlich stark ausgeprägt. Bei den prothetischen Patienten war der Zusammenhang nur halb so stark ausgeprägt wie bei den Personen der Allgemeinbevölkerung. Die OHIP-Dimension „Psychosozialer Einfluss“ der MLQ korrelierte in beiden Probandengruppen signifikant stärker mit Depression als die anderen Dimensionen. Folglich könnte sie auf eine mögliche Depression hinweisen und als zahnärztliches Diagnostikum eingesetzt werden. Zudem legt diese Studie nahe, dass eine eingeschränkte MLQ möglicherweise erst zeitversetzt zu depressiven Symptomen führen kann.

Das Ziel der vorliegenden Arbeit war es die Mundgesundheit sowie die mundgesundheitsbezogene Lebensqualität (MLQ) von Patienten mit rheumatoider Arthritis (RA) zu erfassen und mit Allgemeingesunden zu vergleichen. Des Weiteren wurden das Mundhygiene- sowie das zahnärztliche Verhalten erfasst. In die Untersuchung wurden RA-Patienten gemäß den ACR-Kriterien einbezogen. Entsprechend des Alters, Geschlechtes und Rauchverhalten der RA-Patienten wurde soweit möglich eine Kontrollgruppe aus Allgemeingesunden zusammengestellt (Matching). Für die Erfassung der Mundgesundheit wurden alle Probanden hinsichtlich dentaler (DMF-T) und parodontaler Befunde (Sondierungstiefen = ST, Blutung auf Sondierung = BOP sowie klinischer Attachmentverlust = AV) untersucht. Anhand von ST und/oder AV erfolgte die Einteilung der Parodontalerkrankung nach Schweregrad in: gesund/milde, moderate oder ausgeprägte Parodontitis. Die subjektiv wahrgenommene MLQ wurde mit Hilfe des Oral Health Impact Profile G14 (OHIP G14) erfasst. Das Mundhygiene- und zahnärztliche Verhalten wurde im Rahmen einer Befragung mit Hilfe eines speziellen Fragebogens erhoben. Insgesamt wurden 103 RA-Patienten und 104 Gesunde einbezogen. Hinsichtlich dentaler Befunde (DMF-T) sowie gingivaler Entzündung (PBI) konnten keine signifikanten Unterschiede zwischen beiden Gruppen festgestellt werden, jedoch wiesen die RA-Patienten eine größere Anzahl fehlender Zähne (M-T) auf. Beim parodontalen Befund konnten in der RA-Gruppe geringfügige aber signifikant bessere parodontale Zustände (ST, AV und Parodontitisschweregrad) im Vergleich zur Kontrollgruppe detektiert werden. Jedoch wurde im Vergleich zur Kontrollgruppe ein signifikant höherer BOP festgestellt. Im Mundhygiene- und zahnärztlichen Verhalten zeigten sich zwischen beiden Gruppen nur geringfügige Unterschiede. So zeigten sich insbesondere signifikante Differenzen beim Informationsstand über Mundhygienemaßnahmen sowie den –hilfsmitteln; dabei wiesen RA-Patienten vornehmlich Defizite auf. Die untersuchten RA-Patienten nahmen eine signifikant höhere Beeinträchtigung in der MLQ wahr, als die Kontrollgruppe. Dabei ist diese subjektive Einschätzung der MLQ scheinbar unabhängig von der vorliegenden Mundgesundheitssituation (dental sowie parodontal). Hingegen war bei den allgemeingesunden Probanden ein signifikanter Zusammenhang von schlechteren dentalen und parodontalen Mundgesundheitszuständen mit einer zunehmenden Beeinträchtigung der MLQ zu verzeichnen. Weitere Einflussfaktoren, wie Geschlecht und Rauchverhalten, lassen sowohl bei den RA-Patienten als auch in der Kontrollgruppe keinen Einfluss auf die MLQ erkennen. Während bei den allgemeingesunden Probanden für das Alter ebenfalls kein Zusammenhang mit der MLQ festgestellt wurde, war in der RA-Gruppe ein signifikanter Einfluss des Alters (>60 Jahre) zu erkennen.:Inhalt 1. Einleitung 1.1 Erkrankungen der Mundhöhle 1.1.1 Karies 1.1.2 Parodontitis 1.2 Rheumatoide Arthritis 1.3 Zusammenhang zwischen Mundgesundheit und Rheumatoider Arthritis 1.4 Mundgesundheitsbezogene Lebensqualität und Rheumatoide Arthritis 1.5 Zielsetzung und Fragestellung 2. Publikationsmanuskript 3. Zusammenfassung der Arbeit 4. Ausblick 5. Literatur 6. Wissenschaftliche Präsentationen 7. Darstellung des eigenen Beitrages 8. Erklärung über die eigenständige Abfassung der Arbeit 9. Lebenslauf 10. Danksagung

Among persons living with, or recovering from, chronic illness, poor physical health-related quality of life is a concern, as current and residual illness symptoms and treatment side effects may deleteriously impact physical functioning and fulfillment of daily roles. Numerous cognitive, emotional, and behavioral factors may impact perceptions of health status. Optimism, for example, is conceptualized as belief in the occurrence of positive future outcomes, and is beneficially associated with physical health-related quality of life. Further, optimism may contribute to enhanced perceptions of control and efficacy over disease symptoms and general health, manifesting as proactive health behaviors (e.g., wellness behaviors; treatment adherence) and, in turn, improved health-related quality of life. Across independent samples of persons living with remitted cancer (N = 164) or fibromyalgia (N = 508), we examined the serial mediating effects of health-related self-efficacy and proactive health behaviors in the relation between dispositional optimism and physical health-related quality of life. Participants completed online self-report measures, including the Life Orientation Test – Revised, Control Beliefs Inventory, Multidimensional Health Profile – Health Functioning Index, Wellness Behaviors Inventory, Medical Outcomes Study General Treatment Adherence Scale, and the Short-Form Health Survey. Significant serial mediation was observed across samples; higher dispositional optimism was associated with greater health-related self-efficacy and, in turn, greater engagement in proactive health behaviors and better physical health-related quality of life. For persons with remitted cancer, absence of other specific indirect effects indicates a need to consider the potential impact of unique aspects of disease, such as late effects of treatment or fear of recurrence, that may limit the beneficial effects of optimism exclusively through health-related self-efficacy or wellness behaviors. For persons with fibromyalgia, we found specific indirect effects through each mediating variable, lending support for the decoupling of cognitive and behavioral factors, consistent with pathophysiological and psychosomatic explanations of illness symptoms and approaches to treatment. Interventions designed to enhance optimism (e.g., cognitive-behavioral therapy; best possible self exercise) or self-efficacy (e.g., exercise skills training) may have positive downstream effects on health behavior engagement and perceptions of physical health-related quality of life among individuals living with remitted cancer or fibromyalgia.

Die Nierentransplantation stellt aktuell die Therapie der Wahl für Patienten mit terminaler chronischer Niereninsuffizienz dar. Dabei ist die Lebendspende der postmortalen Transplantation vorzuziehen, sofern ein passender Organspender zur Verfügung steht. Welchen Stellenwert einzelne Einflussfaktoren und Aspekte für das körperliche und seelische Wohlbefinden einnehmen, soll in dieser Arbeit an den 1997 – 2014 ope- rierten Patienten des Transplantationszentrums Dresden untersucht werden. Zusammenfassend beschäftigt sich diese Studie mit der gesundheitsbezogenen Lebensqualität von Spendern und Empfängern nach einer Lebendnierentransplantation. Die Ergebnisse sollen dazu beitragen, die perioperative Therapie und Betreuung zu optimieren sowie dem persönlichen Umfeld Hinweise zur Unterstützung ihrer Angehörigen aufzuzeigen.:Inhaltsverzeichnis Abbildungs- und Tabellenverzeichnis Abkürzungsverzeichnis 1. Einleitung 1.1 Funktion der Niere 1.2 Die Niereninsuffizienz 1.3 Nierenersatzverfahren 1.4 Organtransplantation 1.5 Das Transplantationsgesetz 1.6 Lebendnierenspende 1.6.1 Modelle 1.6.2 Voraussetzungen 1.6.2.1 Medizinisch 1.6.2.2 Psychologisch 1.6.2.3 Rechtlich 1.6.3 Durchführung 1.6.4 Vorteile 1.6.5 Risiken 1.6.6 Gesundheitsbezogene Lebensqualität und Transplantation 1.6.6.1 Empfänger 1.6.6.2 Spender 1.7 Entscheidungsfindung 2 Material und Methoden 2.1 Ziele und Fragestellungen 2.2 Durchführung der Datenerhebung 2.3 Beschreibung der Instrumente 2.3.1 BSI-18 2.3.2 Morisky-Score 2.3.3 WHO-5 2.3.4 Beratungsbedarf 2.3.5 LOT-R 2.3.6 BFI-K 2.3.7 F-SozU-22 2.3.8 GBB-24 2.3.9 Item Bundesgesundheitssurvey 2.4 Datenaufbereitung und statistische Auswertung 3 Ergebnisse 3.1 Auswertung nach Spenderstatus 3.1.1 Soziodemographie 3.1.2 Komplikationen 3.1.3 Zufriedenheit 3.1.4 Veränderungen 3.1.5 Psychisches Befinden 3.1.6 Compliance 3.1.7 Lebensqualität 3.1.8 Beratungsbedarf 3.1.9 Persönlichkeit 3.1.10 Soziale Unterstützung 3.1.11 Körperliche Beschwerden 3.2 Auswertung nach Geschlecht 3.2.1 Soziodemographie 3.2.2 Komplikationen 3.2.3 Zufriedenheit 3.2.4 Veränderungen 3.2.5 Psychisches Befinden 3.2.6 Compliance 3.2.7 Lebensqualität 3.2.8 Beratungsbedarf 3.2.9 Persönlichkeit 3.2.10 Soziale Unterstützung 3.2.11 Körperliche Beschwerden 3.3 Auswertung nach Alter 3.3.1 Komplikationen 3.3.2 Zufriedenheit 3.3.3 Veränderungen 3.3.4 Psychisches Befinden 3.3.5 Compliance 3.3.6 Lebensqualität 3.3.7 Beratungsbedarf 3.3.8 Persönlichkeit 3.3.9 Soziale Unterstützung 3.3.10 Körperliche Beschwerden 3.4 Auswertung nach Bildungsstand 3.4.1 Soziodemographie 3.4.2 Komplikationen 3.4.3 Zufriedenheit 3.4.4 Veränderungen 3.4.5 Psychisches Befinden 3.4.6 Compliance 3.4.7 Lebensqualität 3.4.8 Beratungsbedarf 3.4.9 Persönlichkeit 3.4.10 Soziale Unterstützung 3.4.11 Körperliche Beschwerden 3.5 Auswertung nach postoperativem Zeitraum 3.5.1 Komplikationen 3.5.2 Zufriedenheit 3.5.3 Veränderungen 3.5.4 Psychisches Befinden 3.5.5 Compliance 3.5.6 Lebensqualität 3.5.7 Beratungsbedarf 3.5.8 Persönlichkeit 3.5.9 Soziale Unterstützung 3.5.10 Körperliche Beschwerden 3.6 Regressionsanalyse 3.6.1 Zusammenhänge psychische Belastung 3.6.2 Zusammenhänge körperliches Befinden/Beschwerdedruck 3.6.3 Zusammenhänge Lebensqualität 3.6.4 Zusammenhänge soziale Unterstützung 3.6.5 Zusammenhänge Zufriedenheit 3.7 Korrelationsanalyse 4 Diskussion der Studie 4.1 Spender und Empfänger 4.2 Frauen und Männer 4.3 Alter 4.4 Bildungsstand 4.5 Datum der Transplantation 4.6 Studienkritik 4.6.1 Auswahl der Patienten 4.6.2 Durchführung 4.6.3 Auswertung 5 Zusammenfassung 6 Literaturverzeichnis 7 Anhang 7.1 Tabellen 7.2 Fragebogen 7.3 Fragebogen „Nachbefragung“ 7.4 Votum der Ethikkommission 7.5 Anlage 1 7.6 Anlage 2 8 Danksagung

Magister Chirurgiae Dentium (MChD) / Oral Squamous Cell Carcinoma (OSCC) patients suffer from the terrible consequences of the disease and its treatment modalities, and as a result, their Quality of Life (QoL) and Oral Health-related Quality of Life (OHRQoL) is badly affected, especially due to functional limitation, physical disability and psychological disability that they encounter before, during and after treatment. There is a need for more research on OHRQoL of OSCC patients at various treatment intervals. The present study focused on investigating OHRQoL of OSCC patients at the post-treatment phase.