Objective: To describe the levels of ANC adequacy and factors related in 3 provinces of Vietnam: Long an, Ben tre and Quang ngai. Method: Data from three rural provinces of Vietnam collected by the Vietnam Australia Primary Health Care Project were analysed using descriptive and analytical statistical techniques including multivariate regression, multipart analysis and hierarchical techniques. A sample of 1335 eligible women was available for analysis. The Andersen Health Behaviour Model was utilised in analyses of ANC utilisation. The Donabedian Quality of Health Model was used in analyses of ANC content and overall adequacy. Results: ANC was inadequate with only 71% of women having some ANC, 51% having initial visits within the first four months, 41% having three or more visits, 35% having three or more visits with the initial visits within the first four months, 17% of women reported three quarter or more of recommended ANC procedures/advice, 12% of women had enough ANC utilisation and fair ANC content. Factors that existed prior to contact with health care providers such as external environment, predisposing and need were related to whether the women seek any ANC and to pregnancy duration at first visits. However, factors that resulted from initial contact with health care providers, such as satisfaction of women with ANC services and health care provider related characteristics, were important in the models examining total number of ANC visits, overall ANC utilisation, content of ANC reported and overall ANC adequacy. Province of residence related to all aspects of ANC adequacy. Different aspects of ANC adequacy were related to each other. Conclusion: ANC adequacy levels in Vietnam were low. To increase the proportions of women who use ANC services and attend ANC early, promotion of ANC should be targeted at women at risk. However, to improve continuation with ANC, ANC content, and overall ANC adequacy, the quality of services provided needs to be improved. To reduce the gap between provinces, priority should be given to less developed provinces. / PhD Doctorate

This study was undertaken with the aim to develop improved measures of health service utilisation (HSU) and direct medical costs following an index injury, utilising large scale datasets linked via anonymous patient identifiers. A cohort of anonymous injury patients resident in Swansea and attending an emergency department (ED) or admitted to hospital between 01/04/2005 and 31/03/2007 were identified and tracked as they progressed through various treatment stages following their index injury, incorporating ED attendances, inpatient stay and outpatient contacts. To determine the extent of the subsequent HSU and direct medical costs associated with the index injury a unique model was developed whereby the numbers, lengths and treatment costs of health service contacts observed amongst the cohort of injured individuals during the follow-up period were compared with the equivalent figures expected in the absence of an injury. On average each index injury was found to lead to an excess of 0.12 (95% Cl 0.11, 0.13) ED attendances, 0.07 (95% Cl 0.06, 0.08) inpatient admissions, 1.00 (95% Cl 0.78, 1.23) inpatient bed days and 0.55 (95% Cl 0.52, 0.58) outpatient contacts being estimated over the follow-up period. Moreover, every index injury resulted in mean excess ED, inpatient and outpatient treatment costs of £12.05 (95% Cl £11.05, £13.05), £492.43 (95% Cl £415.66, £569.21) and £73.30 (95% Cl £68.44, £78.17), respectively, equating to a combined figure of £577.79 (95% Cl £500.32, £655.26). Across the entire injured cohort this amounts to an overall excess direct medical cost total of £17.6 million being incurred, with the equivalent figure for the whole of Wales potentially being as high as £306.4 million. Together with signifying the magnitude of the HSU and direct medical costs resulting from injury, this study has introduced and implemented improved methods for estimating these outcome measures based on the use of anonymous patient record linkage.

Background There is a widespread perception that the health status of rural Australians is poorer than that of urban Australians, characterised by higher mortality, lower life expectancies, and an increased incidence of some diseases. At present this perception is difficult to confirm or refute, in terms of mental illness, because of limited published data on the extent of mental illness in regional Australia. Australians from rural areas are also reported to have less access to appropriate health care compared to their urban counterparts; however, there is limited evidence to support such claims using large population-based epidemiological data. It is not known whether remoteness per se is an important determinant of health. Aim To determine if rural and remote South Australians were disadvantaged in terms of their mental health status and access to health care. The aims were to: 1) determine if prevalence of mental illness and comorbidity were associated with accessibility and remoteness; 2) examine the effects of accessibility and remoteness on health service utilisation; and 3) determine if remoteness per se was an important determinant of mental illness. Methods Prospectively designed, secondary analysis of data from a large cross sectional, population–based health survey, conducted in South Australia (SA) in 2000. In all, 2,454 adults, aged 18 years or more, were randomly selected and interviewed using the Computer Assisted Telephone Interview (CATI) system. CATI is a telephone monitoring system that is an efficient means of assessing self-reported aspects of population health, particularly in rural and remote areas. Psychological distress and depression were assessed using the Kessler 10 (K10) Psychological Distress Scale, the SF-12 measure of health status and self-reported, medically-confirmed mental illness, in the previous 12 months. Additional outcome measures included socio-demographic characteristics, a range of health services measures, psychosocial and health risk factors. Geographical variation in outcome measures was assessed using the Accessibility and Remoteness Index of Australia (ARIA). The data were analysed using SPPS and Stata statistical programs and weighted by region, age, sex and probability of selection in the household, using the 1999 total estimated resident population (ERP) figures supplied by the Australian Bureau of Statistics. Direct age-sex standardisation was applied to prevalence rates of mental illness, socio-demographic and health service utilisation data. Results Overall age-sex adjusted mental illness prevalence estimates were similar using the three measures of psychological distress (10.5%), depression (12.9%) and self-reported medically-confirmed mental illness (12.9%). For each measure, there was no significant variation in prevalence across ARIA categories, except for a lower than expected prevalence of depression (7.7%) in the accessible category. There was also no significant difference in the median number of uses of four types of health services across ARIA categories. Significantly fewer residents of highly accessible areas reported never using primary health care services (14.4% vs. 22.2% in very remote areas), and significantly more reported high use (6 visits, 29.3% vs. 21.5%). Fewer residents of remote areas reported never attending hospital (65.6% vs. 73.8% in highly accessible areas). Frequency of use of mental health services was low and not significantly different across ARIA categories. Very remote residents were more likely to spend at least one night in a public hospital (15.8%) than were residents of other areas (eg 5.9% for highly accessible areas). After controlling for the joint effects of stressful life events, perceived control of life events, socio-demographic characteristics and health risk factors, odds of mental illness did not vary by ARIA category (highly accessible: reference category; accessible: OR 0.9, 95% CI 0.60-1.31; moderately accessible: OR 0.80, 95% CI 0.45-1.43; remote/ very remote: 0.70, 95% CI 0.44-1.03). The most important predictors of mental illness in the multivariate logistic model were female sex; smoking; low consumption of vegetables; low exercise; a physical condition; perceived lack of control with: life in general, personal life, job security or health; and major stressful events such as family or domestic violence and the death of someone close. Conclusions Prevalence rates of psychological distress, depression and medically-confirmed mental illness in SA were high. However, there was no evidence that the prevalence of these conditions varied substantially across ARIA categories. The frequency of use of a range of health services was also broadly similar across the state. Remoteness per se was not associated with mental illness, either directly or indirectly as an important confounder in stressful life event/mental illness associations. Psychosocial factors were more important determinants of mental illness. The data do not support existing stereotypes of a rural – urban mental health differential in SA and point to potential mechanisms that may be responsible for poorer mental health outcomes.

RESUME<p>La Trypanosomiase Humaine Africaine (THA) appelée également « maladie du sommeil» est une maladie parasitaire provoquée par un protozoaire du genre Trypanosoma dont deux sous-espèces (T. brucei gambiense et T. brucei rhodesiense) sont pathogènes à l’homme. La stratégie de lutte contre cette maladie est essentiellement basée sur le dépistage précoce et le traitement des malades, complété avec le contrôle du vecteur. Cependant, l’utilisation du service de dépistage de la THA par les communautés exposées représente un défi majeur. L’adhésion aux campagnes de dépistage actif avec des équipes mobiles spécialisées était en-dessous de 50% dans certains villages endémiques fin des années nonante. De surcroît, l’utilisation des services de santé fixes en RDC est si faible que ceci compromet le dépistage passif dans les formations sanitaires fixes. Notre hypothèse est que cette faible utilisation des services de santé pourrait elle-même être due à un problème d’acceptabilité du dépistage et traitement de la THA par les communautés vivant dans les zones de transmission de la THA. Tout ceci compromet l’élimination de la THA comme problème de santé publique, un but que s’est fixé la communauté internationale d’ici 2020.<p>Ce travail a comme objectif d’explorer cette dimension socioculturelle de la maladie qui est souvent négligée dans le contrôle de la THA et générer une meilleure connaissance de ces aspects.<p><p>Nous avons réalisé cinq études en total pour adresser la question de la sous-utilisation des services de dépistage et traitement de la THA par les communautés et sa relation avec l’acceptabilité des services. Nous avons d’abord développé une première étude qui évalue les résultats du traitement de la THA en analysant rétrospectivement les données de routine du programme de contrôle de la THA pour l’année 2006 à 2008. Ensuite, nous avons réalisé trois études qualitatives par focus group (groupe focalisé) et entretiens individuels pour documenter la dimension socioculturelle de la lutte contre la THA. D’abord une étude qui a exploré les perceptions sur la THA dans la communauté, suivi par une étude qui explore les perceptions sur le traitement de la THA et une autre qui se concentre sur les pratiques diagnostics des professionnels de santé face à un syndrome neurologique en contexte de ressources limitées. <p><p>Une cinquième étude combine une enquête-ménage avec des focus groups et des entretiens individuels pour explorer les perceptions de la communauté sur la santé en général et les services de santé. <p>Nous avons comparé les obstacles à l’utilisation des services de dépistage et traitement de la THA identifiés dans ce travail avec les messages de sensibilisation sur la THA utilisés au programme de contrôle de la THA en RDC et nous avons développé des recommandations stratégiques.<p><p>L’évaluation des indicateurs de performances sur l’issue de traitement montre que le taux de suivi post-thérapeutique est faible dans son ensemble :25 % pour le premier suivi de six mois et moins d’un pourcent des patients revient pour la dernière visite de contrôle au mois 24. Nous avons aussi observé dans cette étude un taux d’échec au mélarsoprol et à la pentamidine respectivement de 30% et de 22 % au Kasaï Oriental qui sont cependant difficilement interprétables, car le dénominateur est incomplet. Comme très peu de patients reviennent au contrôle post-thérapeutique, cette proportion est probablement biaisée vers ceux qui sont en échec de traitement.<p><p>L’étude de perception de la THA montre que la maladie est bien connue dans les communautés vivant dans les zones à risque. Par contre, plusieurs obstacles au dépistage et traitement de la THA ont été identifiés. Les plus importants sont :la toxicité des médicaments de la THA, les obstacles financiers, l’inadéquation entre le programme de dépistage des équipes mobiles et les occupations des communautés, les interdits qui accompagnent le traitement de la THA, le manque de confidentialité et la peur de la ponction lombaire. <p>L’étude sur la perception du traitement de la THA a montré que le mélarsoprol est perçu comme un médicament toxique et est surnommé « médicament des interdits ». Par contre, le régime NECT est perçu comme un nouveau médicament moins toxique qui a rendu les interdits liés au mélarsoprol obsolètes sauf un seul, celui de ne pas avoir de rapport sexuel pendant la période de traitement et de suivi post thérapeutique qui est de 6 mois. Les interdits ont été instaurés de manière empirique par les professionnels de santé et les communautés pour mitiger les effets indésirables du mélarsoprol. Leur violation pourrait entrainer des conséquences graves et mortelles. Ces interdits sont fortement ancrés dans les croyances de la communauté et constituent aujourd’hui un obstacle au dépistage et traitement. <p><p>L’étude sur les pratiques diagnostiques des professionnels de santé en matière de syndrome neurologique en contexte de ressources limitées a montré qu’en zone rurale le diagnostic est principalement clinique. Les obstacles perçus au diagnostic de confirmation sont essentiellement d’ordre financier puisque le patient doit tout financer de sa poche. Autres obstacles évoqués sont le manque d’outils de diagnostic et la perception de la communauté qui voit le clinicien comme un devin (petit dieu) ou oracle capable de « deviner » directement la maladie sans passer par un processus diagnostique de laboratoire.<p>L’étude sur les perceptions de la santé et des services de santé a montré que les capacités de travailler (82%) et les capacités de se mouvoir (66%) sont les signes de bonne santé les plus perçus. 90% des responsables des ménages perçoivent positivement la santé de leur ménage. Les opinions sur le service de santé sont partagées.<p><p>Les études présentées dans ce travail ont généré des nouvelles connaissances sur la dimension socioculturelle de la THA. L’analyse des messages de sensibilisation sur la THA utilisés par le programme de contrôle de la THA en RDC en termes de comparaison avec les obstacles au dépistage et traitement de la THA identifiés dans ce travail montre que ces aspects socioculturels bien qu’étant des véritables goulots d’étranglements dans la dynamique de la lutte contre la THA ne sont pas bien ciblés par la communication sur la THA. <p>Les perspectives des communautés exposées au risque de la THA doivent être adressées par un dialogue continu entre professionnels de santé et communautés adapté aux réalités locales. Ainsi il sera possible d’améliorer de manière opérationnelle les stratégies d’information, éducation et communication, et de façon plus large, le dépistage et traitement de la THA en intégrant la dimension socioculturelle de la THA dans la politique de lutte contre la THA. <p><p>SUMMARY<p>Human African Trypanosomiasis (HAT), also known as “sleeping sickness” is a parasitic disease caused by protozoa of the species Trypanosoma. There are two types that infect humans, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense. The strategy used to control sleeping sickness consists of early case detection and treatment of patients, together with vector control. Meanwhile, utilization/access to HAT screening by the affected communities remains a major challenge. Adherence to active screening programs with mobile units was below 50% in certain endemic villages end of the 90’s. Moreover, utilization of fixed health facilities in DRC is so low that it compromises passive case finding. Our hypothesis is that this low utilization of health services is caused by a problem of acceptance of case detection and treatment of HAT by the communities living in the HAT transmission zones. This compromises the target of the international community to eliminate HAT as a public health problem by 2020. This thesis wants to explore and tries to generate more knowledge on the socio-cultural aspect that is often neglected in the control of HAT. <p><p>We conducted five studies to address the lack of community participation in HAT screening and treatment activities and the relation with acceptance of these services. <p>The first study evaluated the results of HAT treatment by retrospectively analyzing data of the routine HAT control program for the period 2006-2008. <p><p>Afterwards we performed three qualitative studies consisting of focus group discussions and individual interviews to document the socio-cultural dimension of the fight against HAT. The first study explored the community perceptions regarding sleeping sickness. The second study explored the perceptions regarding HAT treatment and a third study focused on diagnostic practices of health professionals in low-resource settings facing a neurological syndrome. <p><p>The fifth study consists of a household survey, focus group discussions and individual interviews to explore community perception regarding health in general and health services. We compared the identified barriers to screening and treatment of HAT with awareness messages on sleeping sickness used by the HAT control program in DRC and we developed strategic recommendations. The evaluation of performance indicators for treatment showed that compliance with post-treatment follow-up is very poor: 25% for the first post-treatment follow-up examination at six months and less than 1% of the patients returns for the final examination at 24 months. In this study we also observed a treatment failure rate of respectively 30% and 22% for melarsoprol and pentamidine in Kasai-Oriental. However, these date are difficult to interpret because of an incomplete denominator. As only few patients return for follow-up visits, this proportion is probably biased towards those in treatment failure.<p> <p>The study on the perception of sleeping sickness shows that the disease is well known amongst the communities living in the endemic areas. However, several screening and treatment barriers were identified. The most important are: drug toxicity, financial barriers, the incompatibility between the itineraries of the mobile screening teams and the local communities’ activities, the prohibitions related to HAT treatment, lack of confidentiality and fear of lumbar punctures. The study on the perceptions regarding HAT treatment show that melarsoprol is perceived as a toxic drug and is nicknamed the ‘taboo drug’. On the other hand the NECT regime is perceived as the new drug that is less toxic and that has abolished all the taboos of melarsoprol with the important exception of sexual intercourse during the treatment period and the post-treatment follow-up period of six months. <p><p>The prohibitions have been established empirically by healthcare providers and communities to mitigate the side effects of the melarsoprol regimen. Violating these restrictions is believed to cause severe and sometimes mortal complications. Communities adhere strictly to these prohibitions and this constitutes a barrier for HAT screening and treatment.<p><p>The study focusing on diagnostic work-up of neurological syndromes in low-resource settings by health care providers has shown that in rural areas diagnosis is usually clinical. Barriers to confirmation of diagnosis are mainly related to the purchasing power of the patient. Other reported barriers are a lack of diagnostic tools and the communities’ perceptions associated with the care provider. Clinicians are perceived as diviners being able to directly identify the cause of the illness without using laboratory tests. The study regarding the perceptions on health and health services has shown that ability to work (82%) and ability to move (66%) are the most perceived signs of good health. 90% of the household responsibles positively perceive the health of their family. The opinions on the health services are divided. <p><p>The studies presented in this thesis have generated new insights on the socio-cultural dimension of HAT. The analysis of the awareness messages on HAT in DRC compared with the reported HAT screening and treatment barriers have shown that <p>although these sociocultural aspects are real bottlenecks in the dynamic of the fight against HAT, they are not targeted by the communication on HAT. <p><p>The prospects for communities at risk of HAT should be addressed through continuous dialogue between health professionals and communities adapted to local realities.<p><p>It will thus be possible to operationally improve the information strategies, education and communication, and more broadly, screening and treatment of HAT by integrating the socio-cultural dimension in the fighting policy against sleeping sickness.<p> / Doctorat en Sciences / info:eu-repo/semantics/nonPublished

This study investigated the factors influencing the utilisation of PMTCT of HIV services and proposed measures to promote service utilisation by HIV positive pregnant women in the FCT, Abuja, Nigeria. Effective interventions exist that can reduce the transmission of HIV infection to the baby. The study is a quantitative descriptive one, with 190 HIV positive pregnant women from 20 health Centres in three area councils in Abuja, who were interviewed using structured questionnaire to get their opinion. The findings revealed that the majority (90.4%) of the respondents were aware of PMTCT and how HIV can be transmitted from mother-to-child. The respondents (95.9%) were of the opinion that all pregnant women should be tested. Notably, PMTCT services will be hindered by the following: permission from spouse before being tested, couple counselling not done, group post test counselling, non-incorporation of family planning and low support group enrolment. Recommendations made include emphasis on couple counselling, confidentiality and friendly environment / Health Studies / M.A. (Public Health)

This study investigated the factors influencing the utilisation of PMTCT of HIV services and proposed measures to promote service utilisation by HIV positive pregnant women in the FCT, Abuja, Nigeria. Effective interventions exist that can reduce the transmission of HIV infection to the baby. The study is a quantitative descriptive one, with 190 HIV positive pregnant women from 20 health Centres in three area councils in Abuja, who were interviewed using structured questionnaire to get their opinion. The findings revealed that the majority (90.4%) of the respondents were aware of PMTCT and how HIV can be transmitted from mother-to-child. The respondents (95.9%) were of the opinion that all pregnant women should be tested. Notably, PMTCT services will be hindered by the following: permission from spouse before being tested, couple counselling not done, group post test counselling, non-incorporation of family planning and low support group enrolment. Recommendations made include emphasis on couple counselling, confidentiality and friendly environment / Health Studies / M.A. (Public Health)