京都大学 / 0048 / 新制・課程博士 / 博士(農学) / 甲第17905号 / 農博第2028号 / 新制||農||1018(附属図書館) / 学位論文||H25||N4801(農学部図書室) / 30725 / 京都大学大学院農学研究科応用生命科学専攻 / (主査)教授 植田 和光, 教授 加納 健司, 教授 小川 順 / 学位規則第4条第1項該当 / Doctor of Agricultural Science / Kyoto University / DGAM

京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第20801号 / 医博第4301号 / 新制||医||1025(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 松田 道行, 教授 山下 潤, 教授 宮本 享 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

The rehabilitation of the former Jaselská barracks aims to create a place with a clear identity within the city context. A green axis connects the urban-planning elements – the city house and dwellings in the park, and unites the newly built structure. The work elaborates on the park dwellings, which are characterised by a low-rise structure whilst keeping the density of a city block. Proportion suited to the human needs, simple spatial and architectural language and a gradient of public and private spaces are the key elements of this design.

To simulate crowds of people is of great social interest and is also believed to be useful when analyzing situations involving denser crowds. Many simulators seen over the years have however been struggling with simulating larger number of people, often due to a computationally expensive collision avoidance step. Furthermore, many simulators seems to forget the fact that people tend to stick together in smaller social groups rather than walking alone. A simulator for high density crowds has nevertheless been implemented through modeling crowds as a unilateral incompressible fluid. Together with an integration of groups onto this approach, the obtained solution allows for real time simulation of up to 3000 virtual people. The impact of having groups in simulations has furthermore been set as the overall goal of the thesis and has been analyzed through observing the effects of groups in various scenarios. A smaller user study has also been conducted in order to gain perceptual insights of groups in various crowd densities. These have shown that groups have a smaller impact on the crowd flow, and do not put a larger strain on the performance of the simulation. Groups are further proved to be perceived differently in different densities, with a possible difficulty for scenarios in higher density. / Att simulera folkmassor är av stort socialt intresse och tros även vara till nytta när man analyserar situationer som berör mer kompaktare folkmassor. Många tidigare simulationer har dock kämpat med att simulera större folkmassor, oftast på grund av höga beräkningskostnader mot förhindrandet av att två eller fler virtuella människor kolliderar in i varandra. Dessutom verkar många simulationer glömma bort att människor oftast går i mindre sociala grupper snarare än att gå var och för sig hela tiden. En simulering har trots detta gjorts genom att modellera folkmassor som en unilateral inkompressibel vätska. Tillsammans med en integration av grupper på detta tillvägagångssätt har lösningen visat sig alltsomallt ge simulation i realtid för uppemot 3000 virtuella människor. Effekten av att ha grupper i simulationer har vidare analyserats i en rad olika scenarion. En mindre användarstudie har också gett insikter i hur grupper uppfattas i olika kompakta folkmassor. Resultat har visat att grupper har en mindre effekt på folkmassor i det stora hela, och lägger inte en alltför stor påfrestning på simulationers prestanda. Det har också bevisats att grupper uppfattas annorlunda i olika kompakta folkmassor, med en viss möjlighet till svårare uppfattning i högre, mer kompakta folkmassor.

No

The physiological role of LCAT has been the subject of a number of recent articles (Glomset, 1979; Nilsson-Ehle et al., 1980). According to most current theories, the enzyme functions in combination with high-density lipoproteins in the reverse cholesterol transport pathway which presumably returns peripheral cholesterol to the liver where cholesterol catabolism takes place. Despite the exciting potential for studies on the catalytic function and the nature of the enzyme-substrate complex, the mechanism of action of LCAT remains largely unexplored. The relatively slow progress in the elucidation of the LCAT reaction mechanism is likely to be due to the difficulties in the isolation of the enzyme in sufficient quantities. Consequently, considerably less is known about the physical and chemical properties of the enzyme. Therefore, the first objective of this investigation was to isolate and purify sufficient amount of enzyme for subsequent characterization studies. The second objective of this investigation was to characterize the physical properties of the enzyme by techniques including analytical ultracentrifugation, ultraviolet spectroscopy, and circular dichroism and fluorescence spectroscopy. The third objective of this investigation was to characterize the chemical properties of the enzyme which deals with the amino acid and carbohydrate composition and with some basic structural features that are related to the chemical composition of LCAT.

No description available.

No description available.

No description available.

No description available.