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Genetic and genomic studies of histone H3 methylation and acetylationJin, Yi. January 2008 (has links) (PDF)
Thesis (Ph. D.)--Washington State University, December 2008. / Title from PDF title page (viewed on Feb. 18, 2010). "Department of Molecular Plant Sciences." Includes bibliographical references.
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Analysis of Gcn5 function in His3 expression in Saccharomyces cerevisiaeAlmy, David James. January 2006 (has links)
Thesis (M.S.)--Michigan State University. Dept. of Biochemistry and Molecular Biology, 2006. / Title from PDF t.p. (viewed on Nov. 20, 2008) Includes bibliographical references (p. 100-101). Also issued in print.
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Histone acetylation in gynaecological malignanciesMan, Pui-sum, Ellen. January 2004 (has links)
Thesis (M.Med.Sc.)--University of Hong Kong, 2004. / Also available in print.
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The interaction of the adenovirus E1B-55K protein with a histone deacetylase complex : its importance in regulation of P53 protein functions /Punga, Tanel, January 2003 (has links)
Diss. (sammanfattning) Uppsala : Univ., 2004. / Härtill 3 uppsatser.
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The effects of histone acetylation on the maize allele PL1-blotchedLadipo, Paul B. January 2007 (has links)
Thesis (M.A.)--University of Missouri-Columbia, 2007. / The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on September 29, 2008) Includes bibliographical references.
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Histone acetylation in Saccharomyces cerevisiae proliferation /Choy, John Sing. January 2001 (has links)
Thesis (Ph. D.)--University of Chicago, Department of Molecular Genetics and Cell Biology, 2001. / Includes bibliographical references. Also available on the Internet.
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Rôle de Hda1 dans la régulation de l'expression gènes par les longs ARN / Role of Hda1 in gene regulation mediated by long RNATisseur, Mathieu 20 June 2013 (has links)
Les ARNnc sont impliqués dans la régulation de l’expression de gènes chez les Procaryotes, les Archées et les Eucaryotes. Cette régulation peut être effectuée au niveau transcriptionnel ou post-transcriptionnel. Elle fait parfois intervenir des modifications des histones comme la méthylation ou l’acétylation. J’ai étudié le gène TIR1 dont l’expression est fortement réduite lorsqu’un ARNnc codant antisens nommé TIR1axut est stabilisé. J’ai montré que cette régulation est dépendante de l’histone déacétylase Hda1. De plus, j’ai montré que l’acétylation de H3K14 et H3K18 ne sont pas directement impliquées dans la régulation de TIR1 mais qu’un résidu polaire est nécessaire pour la répression de TIR1 en présence de l’ARNnc antisens. En outre, j’ai mis en évidence que la répression de TIR1 par son XUT est en parti post-transcriptionnel, mais ne fait pas varier la stabilité de l’ARNm. Finalement, j’ai tenté en vain de comprendre le ciblage de l’activité histone déacétylase de Hda1 le long de TIR1 en cherchant la présence d’hybride ARN/ADN grâce à un anticorps reconnaissant ce type de structure. / NcRNAs are involved in gene regulation in Prokaryotes, Eukaryotes and Archaea. This regulation could be transcriptional or post-transcriptional. Histone modifications could be involved such as methylation or acetylation. I studied TIR1 gene whose expression is highly reduced when an antisense ncRNA called TIR1axut is stabilized. I showed that this regulation is Hda1-dependant. In addition to that, I showed that H3K14ac and H3K18ac are not directly responsible for TIR1 repression but a polar residue is required for a proper silencing of TIR1 in a XUT depending manner. Moreover, I showed that TIR1 repression is due to a post-transcriptional effect but does not affect mRNA stability. Finally, I tried in vain to understand Hda1 targeting on TIR1 searching for RNA/DNA hybrids using an antibody that recognizes such structures.
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Genome-wide analysis of epigenetics and alternative promoters in cancer cellsWu, Jiejun, January 2007 (has links)
Thesis (Ph. D.)--Ohio State University, 2007. / Title from first page of PDF file. Includes bibliographical references (p. 129-159).
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