Global ETD Search

1	Development and characterization of a three-dimensional in vitro embryo implantation model Ye, Tianmin., 叶天民. January 2011 (has links) published_or_final_version / Obstetrics and Gynaecology / Doctoral / Doctor of Philosophy Endometrium. Human embryo - Transplantation.
2	A study of annexin A2 and implantation Wang, Bing, 王冰 January 2014 (has links) Implantation is a critical step in reproduction. It is complicated and well-coordinated consisting of apposition, attachment and invasion of embryo into the endometrium. The mechanism of implantation is unclear. Our previous proteomic study showed an increase of annexin A2 in the endometrium during the implantation window of mice, consistent with the increased annexin A2 expression in the receptive human endometrium. The hypothesis of this project was that annexin A2 mediatedthe embryo-endometrium attachment. The first objective was to study the spatio-temporal expression of endometrial annexin A2 immunoreactivities in humans and mice. The cyclical change in annexin A2 expression in the mouse and human reproductive cycle suggested the involvement of a steroid regulatory mechanism. Interestingly, annexinA2 was transiently expressed on the membrane between the mouse uterine luminal epithelium and the implanting embryos from Day 4 (pre-implantation) to Day 5 (post-implantation) of pregnancy. No such signal change was observed at the inter-implantation sites, showing that the implanting embryos partially regulated annexin A2 expression. These observations and the high expression of the molecule in the luminal epithelium of human endometrium in the mid-and late luteal phase were consistent with a role of annexin A2 in implantation. The second objective was to verify the action of steroids on annexin A2 expression. It was found that a combination of 6675 pmol/L of estrogen and 429.8nmol/L of progesterone increased the total and apical surface expression of annexin A2. In mice, estrogen but not progesterone, increased annexin A2 expression in the uterine luminal epithelium of ovariectomized mice. The third objective was to study the function of annexin A2 in embryo-endometrium attachment using an Ishikawa (endometrial epithelial cells)-JEG-3 trophoblast spheroids (embryo surrogate) coculture model. Knockdown of the expression of annexin A2 in either or both cell lines significantly decreased the attachment rate of the spheroids onto the endometrial cells. The suppressive action on the two cell lines was additive. The attachment was also suppressed in the presence of anti-annexin A2 antibody during coculture. Annexin A2 was also involved in mouse implantation as demonstrated by a significant decrease in implantation sites after injection of anti-annexin A2 antibody into the mouse uterine horn. The final objective was to study the action of annexin A2 as an adhesive molecule in embryo attachment. It was found that loss of P11, the binding partner of annexin A2, reduced the attachment rate of the JEG-3 spheroids probably by decreasing the translocation of annexin A2 to the surface of the endometrial cells. Recombinant P11 and annexin A2 protein failed to bind significantly to the Ishikawa cells and the JEG-3 cells. In summary, this study demonstrates the involvement of annexin A2 as an adherent molecule in the embryo-endometrium interaction. / published_or_final_version / Obstetrics and Gynaecology / Doctoral / Doctor of Philosophy Human embryo - Transplantation Lipocortins
3	Role of embryo quality in a randomised comparison of laser assisted hatching on the implantation rate of frozen thawed embryo transfercycles Naveed, Fatima. January 2004 (has links) published_or_final_version / Medical Sciences / Master / Master of Medical Sciences Frozen human embryos Human embryo - Transplantation Pregnancy
4	Cell adhesion and signalling at implantation Kang, Youn-Jung January 2012 (has links) No description available.
5	Endometrial assessment by ultrasonography, Doppler velocimetry and morphometry in women undergoing assisted reproduction treatment Basir, Ghazala Sikandar. January 1999 (has links) published_or_final_version / Obstetrics and Gynaecology / Master / Master of Philosophy Doppler ultrasonography Endometrium. Ultrasonics in obstetrics. Pregnancy. Human embryo - Transplantation.
6	The ethical implications of human ectogenesis Coleman, Stephen,1968- January 2001 (has links) Abstract not available Abortion -- Moral and ethical aspects
7	Embryo Adoption: Implications of Personhood, Marriage, and Parenthood McMillen, Brooke Marie 14 April 2008 (has links) Indiana University-Purdue University Indianapolis (IUPUI) / One’s personal claims regarding personhood will influence his moral belief regarding embryo adoption. In Chapter One, I consider the personhood of the human embryo. If the human embryo is a person, we are morally obligated to permit the practice of embryo adoption as an ethical means to save human persons. However, for those who do not claim that an embryo is a person at conception, embryo adoption is not a necessary practice because we have no moral obligation to protect them. There are still others who claim that personhood is gained at some point during gestation when certain mental capacities develop. I offer my own claim that consciousness and sentience as well as the potential to be self-conscious mark the beginning of personhood. Embryo adoption raises several questions surrounding the institution of marriage. Due to its untraditional method of procreation, embryo adoption calls into question the role of procreation within marriage. In Chapter Two, I explore the nature of the marriage relationship by offering Lisa Cahill’s definition of marriage which involves both a spiritual and physical dimension, and then I describe the concept of marriage from different perspectives including a social, religious, and a personal perspective. From a personal perspective, I explore the relationship between marriage and friendship. Finally, I describe how the concept of marriage is understood today and explore the advantages to being married as opposed to the advantages of being single. Embryo adoption changes the way we customarily think about procreation within a family because in embryo adoption, couples are seeking an embryo from another union to be implanted into the woman. This prompts some philosophers to argue that embryo adoption violates the marriage relationship. In Chapter Three, I further consider the impact of embryo adoption on the family as an extension of the marital relationship as well as the impact of embryo adoption on the traditional roles of motherhood and fatherhood. I examine motherhood by looking at how some philosophers define motherhood and when these philosophers claim a woman becomes a mother. After considering these issues regarding motherhood, I examine the same issues surrounding fatherhood. Peg Brand, PhD., Chair Embryo adoption Embryo rescue Embryo Adoption Rescue Motherhood Fatherhood Marriage Personhood Gestation Conception Reproductive technology Reproduction Surrogacy Conscious Consciousness Sentience Person Self-conscious Self-consciousness Procreation Conjugal union Marriage relationship Procreate Pregnancy Genetic motherhood Gestational motherhood Social motherhood Genetic father Social father Mother Motherhood Father Fatherhood IVF In vitro In vitro fertilization Pregnancy Postnatal adoption Althaus Aquinas Conee Crosby DeGrazia Finnis Ford Locke Lovering McMahan Parfit Quinn Singer Sumner Thomson Tooley Warren Cahill Moller Landau Mill Catholic Lutheran Calvinist Calvinism Aristotle Catholicism Kant Parsons Primoratz Feldman Firestone Tonti-Filippini Watt Geach Human embryo -- Transplantation Adoption -- Religious aspects Motherhood Fatherhood Marriage

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