No description available.

No description available.

Purpose: The aims of these studies were to examine the effects of wearing different grades of graduated compression stockings (GCS) on performance, physiological, and perceptual measures before, during, and after exercise in well-trained runners. Method: Two separate running studies were conducted where participants wore different grades of GCS compared with a placebo control stocking in random, counter-balanced order: (1) a field study focussed on a series of 10-km running performances on a 400m track; (2) a laboratory study that examined the effects of 40-min treadmill running on physiological, perceptual, and muscle function responses. Changes in muscle function and damage were determined pre- and post-run by measuring creatine kinase (CK) and myoglobin (Mb) concentrations, counter-movement jump (CMJ) height, muscle soreness, and pressure sensitivity. Physiological measurements of heart rate (HR), oxygen uptake (V&O2), blood lactate concentration [La], and ratings of perceived exertion (RPE) were measured during running. Pre- and post-run perceptual scales assessed comfort, tightness and pain associated with wearing GCS. Results: There were no significant differences in 10-km run time, mean HR, V&O2, [La], and RPE for participants wearing different GCS in (1) and (2) (P<0.05). Con and Low were rated most comfortable (P<0.05) and Hi were tightest (P<0.05) and induced more pain (P<0.05) when GCS were compared in both studies. CMJ was better in participants wearing Low and Med GCS post-run compared with Con in (1) and for Con and all GCS at 0 h post-exercise in (2). CK and Mb levels were higher (P<0.05) and pressure sensitivity was more pronounced (P<0.05) at 0 h post-run for Con and all GCS (2). Few participants (4/10) reported muscle soreness at any one location in (2). Conclusions: Well-trained runners did not experience improved performance, physiological, or perceptual responses when wearing different grades of GCS during 10- km track or 40 min treadmill running compared with a control garment. 40 min treadmill running at 80% V&O2 max may not be strenuous enough to elicit a loss of muscle function in well-trained runners. Runners felt more comfortable wearing GCS that had less compression.

Background: Pseudoephedrine (PSE) is a mild central nervous system stimulant that when consumed at a high dosage has the potential to alter physiological and psychophysical responses. PSE is widely accessible as over-the-counter medication and despite limited research into PSE at high dosages or its effects on prolonged exercise (>2 hours) is no-longer on the World Anti-Doping Association’s banned substance list. Currently unrestricted in sport and with no real understanding of the abovementioned responses during endurance exercise there is a high potential for abuse in sport. A recent study performed in our laboratory found PSE to improve self-paced cycling performance in some individuals, however no physiological measurements were taken Purpose: The primary purpose of this study was to determine the physiological effects of PSE at a dosage previously shown to improve performance (2.5 mg/kg) in some individuals during prolonged cycling. A secondary purpose of this study was to assess the effect on endurance cycling performance. Methods: In a randomized, double-blind and counter-balanced design, ten welltrained cyclists participated in two trials, consisting of 120 min of fixed-intensity cycling at 65% VO2max followed by a set work, self-paced time-trial (TT) of ~30 min, following ingestion of either 2.5 mg/kg PSE or visual-matched glucose placebo. Venous blood samples were collected before and during exercise, along with body temperatures and heart rate. Perceived effort and expired gas samples were collected during exercise. Exercise and diet was controlled ~48-hours prior to the trials. Results: Mean heart rate was significantly higher with PSE (P = 0.028) during fixed-intensity exercise. Blood glucose concentrations were significantly lower with PSE (P <0.001) for the first 40 min of fixed-intensity exercise. Respiratory exchange ratio was lower in the final 20-min of fixed-intensity and TT with PSE. Blood lactate, perceived effort, ventilation, and body temperatures were not significantly different between conditions during exercise, nor was TT performance; however individual response was variable. Conclusions: PSE ingestion increased heart rate during endurance cycling and initially suppressed carbohydrate release into the bloodstream while increasing fat oxidation in the later stages of exercise. Despite individual responses, endurance cycling performance remained unchanged with PSE ingestion.

Background: Pseudoephedrine (PSE) is a mild central nervous system stimulant that when consumed at a high dosage has the potential to alter physiological and psychophysical responses. PSE is widely accessible as over-the-counter medication and despite limited research into PSE at high dosages or its effects on prolonged exercise (>2 hours) is no-longer on the World Anti-Doping Association’s banned substance list. Currently unrestricted in sport and with no real understanding of the abovementioned responses during endurance exercise there is a high potential for abuse in sport. A recent study performed in our laboratory found PSE to improve self-paced cycling performance in some individuals, however no physiological measurements were taken Purpose: The primary purpose of this study was to determine the physiological effects of PSE at a dosage previously shown to improve performance (2.5 mg/kg) in some individuals during prolonged cycling. A secondary purpose of this study was to assess the effect on endurance cycling performance. Methods: In a randomized, double-blind and counter-balanced design, ten welltrained cyclists participated in two trials, consisting of 120 min of fixed-intensity cycling at 65% VO2max followed by a set work, self-paced time-trial (TT) of ~30 min, following ingestion of either 2.5 mg/kg PSE or visual-matched glucose placebo. Venous blood samples were collected before and during exercise, along with body temperatures and heart rate. Perceived effort and expired gas samples were collected during exercise. Exercise and diet was controlled ~48-hours prior to the trials. Results: Mean heart rate was significantly higher with PSE (P = 0.028) during fixed-intensity exercise. Blood glucose concentrations were significantly lower with PSE (P <0.001) for the first 40 min of fixed-intensity exercise. Respiratory exchange ratio was lower in the final 20-min of fixed-intensity and TT with PSE. Blood lactate, perceived effort, ventilation, and body temperatures were not significantly different between conditions during exercise, nor was TT performance; however individual response was variable. Conclusions: PSE ingestion increased heart rate during endurance cycling and initially suppressed carbohydrate release into the bloodstream while increasing fat oxidation in the later stages of exercise. Despite individual responses, endurance cycling performance remained unchanged with PSE ingestion.

Background: Due to the unique demands of the sport, athletes playing football perform a variety of differing training methods to improve physiological performance. These include strength, endurance and sprint training. While the effects of strength and endurance training have been well researched, the effects of repeated-sprint training on blood and muscle variables in well trained males and females are not well known. An understanding of changes to the blood and muscle during and following an exercise bout are important, so to gain an understanding of the type of stress and resulting adaptations that may occur. Also, while a large volume of research in training adaptations has been performed on males; little has been done on females. To date, some research indicates metabolism during moderateintensity exercise may differ between males and females; however, no study has compared repeated-sprint exercise. Therefore, it is unclear as to whether males and females would have a differing physiological response to repeated-sprint training. Purpose: The purpose of this study was to determine the effects of a repeated-sprint bout on molecular signalling in muscle and blood measures and heart rate in well-trained footballers. Additionally, we compared running times and sprint decrement (%). Research Design: Eight female senior University football players (Mean ± SD, age, 19 ± 1 y, VO ? 2peak 53.0 ± 5.1 ml·kg-1min-1) and seven male senior University football players (Mean ± SD, age, 19 ± 3 y, VO ? 2peak 59.0 ± 6.6 ml·kg-1min-1) volunteered to participate in this study. Participants performed four bouts of 6 x 30 m maximal sprints spread equally over a 40 min period. Sprint time was measured (at 30 m) for each sprint and sprint decrement was also calculated for all bouts. Muscle biopsies were taken from the vastus lateralis muscle at rest, 15 min following exercise and 2 h into recovery. Venous blood samples were taken at the same time points as the biopsies while capillary blood lactate was measured at rest and 3 min following each sprint bout. Repeated measures ANOVA and Post hoc t-tests were performed to determine significant differences between the two groups (male vs. female) and time points. Findings: Both groups had a significant (P<0.05) increase in blood lactate (mM) after the first bout of repeated sprints, with no differences between females (pre 0.9 ± 0.4 mM – post 10.0 ± 1.6 mM) and males (pre 0.8 ± 0.3 mM – post 10.0 ± 3.5 mM). Blood lactate remained elevated compared to rest (P<0.05) following bouts 2, 3 and 4 for both females (12.0 ± 3.6, 12.0 ± 3.3, 12.2 ± 3.8 mM respectively) and males (11.9 ± 2.9, 11.6 ± 2.3, 11.5 ± 4.0 mM respectively), with no differences between groups or time points (P>0.05). There were no differences (P>0.05) between the female and male athletes in mean heart rate attained at the end of each bout of repeated sprints (187 ± 2 v 190 ± 2 bpm respectively) or during recovery between sprints (140 ± 2 v 130 ± 2 bpm respectively). There were no differences between groups or time points in blood insulin (P>0.05). Fastest 30 m sprint time and mean 30 m sprint time during the repeated-sprint bout was faster for the males than females (4.58 ± 0.12 v 5.26 ± 0.27 s respectively; (P>0.05)). However, there were no differences in running velocity during the sprints between the males and females (165 ± 0.4 % vs. 155 ± 0.05 %; P>0.05) when expressed relative to velocity at VO ? 2peak (vVO ? 2peak). Also, mean % decrement during the repeated-sprint bout was lower in the males then females (4.9 ± 1.3 v 7.1 ± 1.9 % respectively; P<0.05). No changes were observed in total or phosphorylated Akt at any time-point or between genders. However, while total 4E-BP1 was lower, the ratio of total to phosphoryalated 4E-BP1 at rest was greater in males than females (P<0.05). Finally, there was also a significant decrease in 4E-BP1 phosphorylation post-exercise in males (P<0.05), but not females. Conclusions: There were no sex differences in blood lactate or heart rate throughout the repeated-sprint bout. These findings suggest that there were no cardio respiratory or lactate production/clearance differences in the response to a repeated-sprint-training bout between sexes. However, while males were faster than their female counterparts, the average relative speed was similar between sexes, suggesting a similar relative volume of work was performed during the sprint bouts. However, the females did have a greater decrement in sprint performance indicating a greater ability to recover sprint performance in the males. Sex differences in resting total and phosphorylated 4E-BP1 may indicate greater potential for muscle growth in the male athletes during basal conditions. However, differences could be due to factors other than sex, including previous training history. There was a lack of change in plasma insulin or Akt, but, similar to resistance exercise, a significant decrease in post-exercise 4E-BP1 phosphorylation for the males, but not females. The sex differences in the 4E-BP1 phosphorylation response post-exercise could be due to differences in the metabolic disturbance in the muscle during and following maximal sprints. Keywords: blood lactate, heart rate, muscle

Background: Due to the unique demands of the sport, athletes playing football perform a variety of differing training methods to improve physiological performance. These include strength, endurance and sprint training. While the effects of strength and endurance training have been well researched, the effects of repeated-sprint training on blood and muscle variables in well trained males and females are not well known. An understanding of changes to the blood and muscle during and following an exercise bout are important, so to gain an understanding of the type of stress and resulting adaptations that may occur. Also, while a large volume of research in training adaptations has been performed on males; little has been done on females. To date, some research indicates metabolism during moderateintensity exercise may differ between males and females; however, no study has compared repeated-sprint exercise. Therefore, it is unclear as to whether males and females would have a differing physiological response to repeated-sprint training. Purpose: The purpose of this study was to determine the effects of a repeated-sprint bout on molecular signalling in muscle and blood measures and heart rate in well-trained footballers. Additionally, we compared running times and sprint decrement (%). Research Design: Eight female senior University football players (Mean ± SD, age, 19 ± 1 y, VO ? 2peak 53.0 ± 5.1 ml·kg-1min-1) and seven male senior University football players (Mean ± SD, age, 19 ± 3 y, VO ? 2peak 59.0 ± 6.6 ml·kg-1min-1) volunteered to participate in this study. Participants performed four bouts of 6 x 30 m maximal sprints spread equally over a 40 min period. Sprint time was measured (at 30 m) for each sprint and sprint decrement was also calculated for all bouts. Muscle biopsies were taken from the vastus lateralis muscle at rest, 15 min following exercise and 2 h into recovery. Venous blood samples were taken at the same time points as the biopsies while capillary blood lactate was measured at rest and 3 min following each sprint bout. Repeated measures ANOVA and Post hoc t-tests were performed to determine significant differences between the two groups (male vs. female) and time points. Findings: Both groups had a significant (P<0.05) increase in blood lactate (mM) after the first bout of repeated sprints, with no differences between females (pre 0.9 ± 0.4 mM – post 10.0 ± 1.6 mM) and males (pre 0.8 ± 0.3 mM – post 10.0 ± 3.5 mM). Blood lactate remained elevated compared to rest (P<0.05) following bouts 2, 3 and 4 for both females (12.0 ± 3.6, 12.0 ± 3.3, 12.2 ± 3.8 mM respectively) and males (11.9 ± 2.9, 11.6 ± 2.3, 11.5 ± 4.0 mM respectively), with no differences between groups or time points (P>0.05). There were no differences (P>0.05) between the female and male athletes in mean heart rate attained at the end of each bout of repeated sprints (187 ± 2 v 190 ± 2 bpm respectively) or during recovery between sprints (140 ± 2 v 130 ± 2 bpm respectively). There were no differences between groups or time points in blood insulin (P>0.05). Fastest 30 m sprint time and mean 30 m sprint time during the repeated-sprint bout was faster for the males than females (4.58 ± 0.12 v 5.26 ± 0.27 s respectively; (P>0.05)). However, there were no differences in running velocity during the sprints between the males and females (165 ± 0.4 % vs. 155 ± 0.05 %; P>0.05) when expressed relative to velocity at VO ? 2peak (vVO ? 2peak). Also, mean % decrement during the repeated-sprint bout was lower in the males then females (4.9 ± 1.3 v 7.1 ± 1.9 % respectively; P<0.05). No changes were observed in total or phosphorylated Akt at any time-point or between genders. However, while total 4E-BP1 was lower, the ratio of total to phosphoryalated 4E-BP1 at rest was greater in males than females (P<0.05). Finally, there was also a significant decrease in 4E-BP1 phosphorylation post-exercise in males (P<0.05), but not females. Conclusions: There were no sex differences in blood lactate or heart rate throughout the repeated-sprint bout. These findings suggest that there were no cardio respiratory or lactate production/clearance differences in the response to a repeated-sprint-training bout between sexes. However, while males were faster than their female counterparts, the average relative speed was similar between sexes, suggesting a similar relative volume of work was performed during the sprint bouts. However, the females did have a greater decrement in sprint performance indicating a greater ability to recover sprint performance in the males. Sex differences in resting total and phosphorylated 4E-BP1 may indicate greater potential for muscle growth in the male athletes during basal conditions. However, differences could be due to factors other than sex, including previous training history. There was a lack of change in plasma insulin or Akt, but, similar to resistance exercise, a significant decrease in post-exercise 4E-BP1 phosphorylation for the males, but not females. The sex differences in the 4E-BP1 phosphorylation response post-exercise could be due to differences in the metabolic disturbance in the muscle during and following maximal sprints. Keywords: blood lactate, heart rate, muscle

abstract: The data explosion in the past decade is in part due to the widespread use of rich sensors that measure various physical phenomenon -- gyroscopes that measure orientation in phones and fitness devices, the Microsoft Kinect which measures depth information, etc. A typical application requires inferring the underlying physical phenomenon from data, which is done using machine learning. A fundamental assumption in training models is that the data is Euclidean, i.e. the metric is the standard Euclidean distance governed by the L-2 norm. However in many cases this assumption is violated, when the data lies on non Euclidean spaces such as Riemannian manifolds. While the underlying geometry accounts for the non-linearity, accurate analysis of human activity also requires temporal information to be taken into account. Human movement has a natural interpretation as a trajectory on the underlying feature manifold, as it evolves smoothly in time. A commonly occurring theme in many emerging problems is the need to \emph{represent, compare, and manipulate} such trajectories in a manner that respects the geometric constraints. This dissertation is a comprehensive treatise on modeling Riemannian trajectories to understand and exploit their statistical and dynamical properties. Such properties allow us to formulate novel representations for Riemannian trajectories. For example, the physical constraints on human movement are rarely considered, which results in an unnecessarily large space of features, making search, classification and other applications more complicated. Exploiting statistical properties can help us understand the \emph{true} space of such trajectories. In applications such as stroke rehabilitation where there is a need to differentiate between very similar kinds of movement, dynamical properties can be much more effective. In this regard, we propose a generalization to the Lyapunov exponent to Riemannian manifolds and show its effectiveness for human activity analysis. The theory developed in this thesis naturally leads to several benefits in areas such as data mining, compression, dimensionality reduction, classification, and regression. / Dissertation/Thesis / Doctoral Dissertation Electrical Engineering 2016

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Agradecemos a compreensão. on 2018-04-19T16:35:52Z (GMT) / Submitted by TIAGO PENEDO (tp37_harry@hotmail.com) on 2018-05-04T13:41:43Z No. of bitstreams: 1 Dissertação_final.pdf: 2290846 bytes, checksum: 55df0177b77cae283535bafcdcef98ad (MD5) / Approved for entry into archive by Lucilene Cordeiro da Silva Messias null (lubiblio@bauru.unesp.br) on 2018-05-07T17:07:09Z (GMT) No. of bitstreams: 1 penedo_t_me_bauru.pdf: 2008041 bytes, checksum: 672b9331fbf4c347f1107713c46e43d0 (MD5) / Made available in DSpace on 2018-05-07T17:07:09Z (GMT). No. of bitstreams: 1 penedo_t_me_bauru.pdf: 2008041 bytes, checksum: 672b9331fbf4c347f1107713c46e43d0 (MD5) Previous issue date: 2018-04-06 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / O aumento da oscilação do centro de massa causado pela fadiga muscular bilateral afeta o controle da postura em pé. Entretanto, ainda não é claro como a fadiga muscular afeta o controle postural, especialmente relacionado à estratégia motora e à assimetria. Assim, os objetivos deste estudo foram: i) analisar e comparar o uso de estratégias motoras para o controle postural de adultos jovens após fadiga muscular bilateral da região do tornozelo e do quadril, considerando a simetria no controle postural e; ii) analisar o efeito da fadiga muscular unilateral e bilateral de tornozelo na simetria dos membros inferiores durante postura bipodal estática. Para responder as questões da dissertação, dois estudos foram desenvolvidos. Participaram em cada estudo 20 adultos jovens com idade entre 20 e 35 anos. Os participantes realizaram avaliação postural sobre duas plataformas de força, antes e após fadiga muscular bilateral de tornozelo ou de quadril (estudo 1) e fadiga bilateral, fadiga unilateral do membro preferido e unilateral do membro não-preferido de tornozelo (estudo 2), sendo cada tipo de fadiga muscular realizado em um dia específico. A indução à fadiga foi realizada pela tarefa de flexão plantar e dorsiflexão do tornozelo (fadiga de tornozelo) sobre um step ou pela flexão e extensão do quadril (fadiga de quadril) sentado em uma cadeira, com frequência de movimento controlada. Em ambos os estudos os parâmetros do centro de pressão foram mensurados, sendo utilizado o índice de simetria para analisar o nível de assimetria no controle postural. Para responder os objetivos dos estudos, os parâmetros de interesse foram comparados através de ANOVAs e MANOVAs com fatores de acordo com as variáveis independentes de cada estudo. Os principais achados da dissertação foram que não houve alteração da estratégia motora após fadiga muscular e houve diminuição da assimetria entre os membros inferiores após fadiga muscular de tornozelo. Ainda, a fadiga bilateral de tornozelo não causou assimetria postural. Por outro lado, as fadigas unilaterais, tanto do membro preferido quanto do não-preferido, geraram assimetrias durante o controle da postura, na qual o membro preferido assumiu o papel de controlador principal da tarefa, mesmo depois de fadigado. / Bilateral muscle fatigue affects postural control while standing , increasing the sway of the center of mass . However, it is still unclear how muscle fatigue affects postural control, especially related to the motor strategy and asymmetry. Th us, th e objective s of this study were: i) to analyze and compare the use of motor strategies for the postural control of young adults after bilateral muscular fatigue of the ankle and hip, considering symmetry in postural control and; ii) to analyze the effect s of unilateral and bilateral ankle muscle fatigue on the symmetry of the lower limbs during bipodal standing . To answer the questions of the research project , two studies were develop ed. Participate in each study 20 young adults aged 20 to 35 years. Participants performed the postural task on two force platforms, before and after bilateral ankle or hip muscle fatigue (study 1) and bilateral, and unilateral of the preferred limb and uni lateral of the non - preferred limb ankle muscle fatigue (study 2). E ach type of muscle fatigue was performed on a specific day. Fatigue induction was performed by the plantar flexion and dorsiflexion of the ankle (ankle fatigue) task on a step or by flexion and extension of the hip (hip fatigue) sitting on a chair, with controlled movement frequency. In both studies the center of pressure parameters were measured, using the symmetry index to analyze the level of asymmetry in the postural control. In order to answer the objectives of the studies, the parameters of interest were compared through ANOVAs and MANOVAs with factors according to the independent variables of each study. The main findings of the dissertation were that there was no change in the motor s trategy after muscle fatigue and there was a decrease in the asymmetry between the lower limbs after ankle muscle fatigue. Moreover , bilateral ankle fatigue did not cause postural asymmetry. On the other hand, unilateral fatigue of both the preferred and t he non - preferred limb generated asymmetries during posture control, in which the preferred member assumed the role of main controller of the task, even after fatigue.

Les Artefacts de Tissus Mous (ATM) sont actuellement une des limitations principales pour la mesure du mouvement du membre supérieur avec les techniques actuelles d'analyse du mouvement. L'optimisation multi-segmentaire (OMS) a déjà prouvé son efficacité pour la mesure du mouvement du membre inférieur. Afin d'avoir la meilleure correction possible, il est nécessaire d'utiliser des modèles d'articulation proches de l'anatomie. L'objectif de cette thèse a donc été de développer et de valider un modèle du membre supérieur qui pourrait être utilisé pour la correction des ATM par OMS. De nouveaux modèles en boucle fermée de l'avant-bras et de la ceinture scapulaire ont ainsi été développés accompagnés d'un nouveau modèle de l'articulation scapulo-thoracique imposant à la scapula d'être tangente à un ellipsoïde modélisant le thorax. Ces nouveaux modèles ont été confrontés aux modèles courants de la littérature à travers une étude avec vis intra-corticales sur cadavre et in vivo sur sujets asymptomatiques. Des niveaux d'erreur similaires ont été observés pour tous les modèles quant à leur capacité de corriger les ATM et d'imiter la cinématique osseuse. Les nouveaux modèles semblent cependant beaucoup plus intéressants dans une perspective de développement d'un modèle musculo- squelettique. En effet, le modèle d'avant-bras autorise à la fois d'avoir le mouvement du radius et de l'ulna tandis que le modèle scapulo-thoracique représente mieux la contrainte existant entre le thorax et la scapula. En résumé, cette thèse a permis de développer un modèle complet proche de l'anatomie du membre supérieur permettant de corriger les ATM en utilisant une OMS. Bien que la correction des ATM obtenue n'est pas aussi satisfaisante qu'espérée, l'utilisation de cette approche pour le développement de futurs modèles musculo-squelettique a été validée / Soft Tissue Artefact (STA) is one of the most important limitations when measuring upper limb kinematics through marker-based motion capture techniques, especially for the scapula. Multi Body Optimisation (MBO) has already been proposed to correct STA when measuring lower limb kinematics and can be easily adapted for upper limb. For this purpose, the joint kinematic constraints should be as anatomical as possible. The aim of this thesis was thus to define and validate an anatomical upper limb kinematic model that could be used both to correct STA through the use of MBO and for future musculoskeletal models developments. For this purpose, a model integrating closed loop models of the forearm and of the scapula belt have been developed, including a new anatomical-based model of the scapulothoracic joint. This model constrained the scapula plane to be tangent to an ellipsoid modelling the thorax. All these models were confronted to typical models extracted from the literature through cadaveric and in vivo intracortical pins studies. All models generated similar error when evaluating their ability to mimic the bones kinematics and to correct STA. However, the new forearm and scapulothoracic models were more interesting when considering further musculoskeletal developments: The forearm model allows considering both the ulna and the radius and the scapulothoracic model better represents the constraint existing between the thorax and the scapula. This thesis allowed developing a complete anatomical upper limb kinematic chain. Although the STA correction obtained was not as good as expected, the use of this approach for a future musculoskeletal models has been validated