Experiments and simulations were performed to examine the complex processes that occur in Rayleigh�Taylor driven mixing. A water channel facility was used to examine a buoyancy-driven Rayleigh�Taylor mixing layer. Measurements of �uctuating den- sity statistics and the molecular mixing parameter were made for Pr = 7 (hot/cold water) and Sc 103 (salt/fresh water) cases. For the hot/cold water case, a high- resolution thermocouple was used to measure instantaneous temperature values that were related to the density �eld via an equation of state. For the Sc 103 case, the degree of molecular mixing was measured by monitoring a di�usion-limited chemical reaction between the two �uid streams. The degree of molecular mixing was quanti- �ed by developing a new mathematical relationship between the amount of chemical product formed and the density variance 02. Comparisons between the Sc = 7 and Sc 103 cases are used to elucidate the dependence of on the Schmidt number. To further examine the turbulent mixing processes, a direct numerical simu- lation (DNS) model of the Sc = 7 water channel experiment was constructed to provide statistics that could not be experimentally measured. To determine the key physical mechanisms that in�uence the growth of turbulent Rayleigh�Taylor mixing layers, the budgets of the exact mean mass fraction em1, turbulent kinetic energy fE00, turbulent kinetic energy dissipation rate e 00, mass fraction variance gm002 1 , and mass fraction variance dissipation rate f 00 equations were examined. The budgets of the unclosed turbulent transport equations were used to quantitatively assess the relative magnitudes of di�erent production, dissipation, transport, and mixing processes. Finally, three-equation (fE00-e 00-gm002 1 ) and four-equation (fE00-e 00-gm002 1 -f 00) turbulent mixing models were developed and calibrated to predict the degree of molecular mix- ing within a Rayleigh�Taylor mixing layer. The DNS data sets were used to assess the validity of and calibrate the turbulent viscosity, gradient-di�usion, and scale- similarity closures a priori. The modeled transport equations were implemented in a one-dimensional numerical simulation code and were shown to accurately reproduce the experimental and DNS results a posteriori. The calibrated model parameters from the Sc = 7 case were used as the starting point for determining the appropri- ate model constants for the mass fraction variance gm002 1 transport equation for the Sc 103 case.

Transistor aging through negative bias temperature instability (NBTI) has become a major lifetime constraint in VLSI circuits. We propose a technique that uses antifuses to widen PMOS transistors later in a circuit?s life cycle to combat aging. Using HSPICE and 70nm BPTM process numbers, we simulated the technique on four circuits (a ring oscillator, a fan-out four circuit, an ISCAS c432 and c2670). Over the lifetime of the circuit, our simulations predict a 8.89% and a 13% improvement in power in the c432 and c2670 circuits respectively when compared to similarly performing traditional circuits.

This study, explores the use of an iterative solution approach for the linearized Euler equations formulated in the frequency domain for fan tone noise propagation and radiation through bypass jets. The aim is to be able to simulate high frequency propagation and radiation phenomena with this code, without excessive computational resources. All computations are performed in parallel using MPI library routines on a computer cluster. The linearized Euler equations support the Kelvin-Helmholtz type convective physical instabilities in jet shear flows. If these equations are solved directly in frequency domain, the unstable modes may be filtered out for the frequencies of interest. However, direct solutions are memory intensive and the reachable frequency is limited. Results provided shown that iterative solution of LEE is more efficient when considered memory requirement and might solve a wider scope of frequencies, if the instabilities are controlled.

Purpose of this work is to provide a comprehensive picture of thin film (interconnect) and solid droplet surface evolution under the several external applied forces with anisotropic physical properties so that one can eventually be able to predict main reasons and conditions under which stability of surface is defined. A systematic study based on the self-consistent dynamical simulations is presented for the spontaneous surface evolution of an thin film and isolated thin solid droplet on a rigid substrate, which is driven by the surface drift diffusion induced by the anisotropic diffusivity, the anisotropic capillary forces (surface stiffness) and mismatch stresses under electron winding. The effect of surface free energy anisotropies (weak and strong (anomalous)) on the development kinetics of the Stranski-Krastanow island type morphology are studied. Although, various tilt angles and anisotropy constants were considered during simulations, the main emphasis was given on the effect of rotational symmetries associated with the surface Helmholtz free energy topography in 2D space. The investigations of dynamics of surface roughness on concurrent actions of the appliedelasto- and electro- static fields clearly indicate that applied misfit stress level is highly important effect on resultant surface form which may be smooth wave like or crack like. The droplet simulations revealed the formation of an extremely thin wetting layer during the development of the bell-shaped Stranski-Krastanow island through the mass accumulation at the central region of the droplet via surface drift-diffusion. The developments in the peak height, in the extension of in the wetting layer beyond the domain boundaries, and the change in triple junction contact angle, one clearly observes that these quantities are reaching certain saturation limits or plateaus, when the growth mode turned-off. Islanding differences for weak anisotropy constant levels and the strong (anomalous) anisotropy constant domains are discussed.

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A computer program is developed for the dynamic analysis of a spar platform coupled with mooring lines and risers in waves, winds, and currents. The new multi-contact analysis program is developed for the nonlinear multi-contact coupling between vertical risers and guide frames inside of the spar moon-pool. The program extends capability of the current coupled dynamic analysis program, WINPOST, by adding the capability of analyzing riser effects caused by the contact forces and moments from buoyancy-cans inside the spar moon-pool on the global spar motions. The gap between the buoyancy can and riser guide frames are modeled using three different types of nonlinear gap springs. The new riser model also considers the Coulomb damping between the buoyancy-cans and riser guide frames, and it also calculates the impact force on risers for use in fatigue analysis. The spar platform generally uses vertical risers with dry trees. However, as the water depth increases, the size of the buoyancy-can increases, and it makes installation more difficult. The pneumatic riser support system does not use buoyancy-cans and is an alternative solution to the buoyancy-can approach. The dynamic characteristics of pneumatic riser support system are studied by using the newly developed numerical analysis program. The damped Mathieu instability diagram for the damped Mathieu's equation is developed. Due to spar heave and pitch coupling, Mathieu's instability may become excited in long period waves. In the numerical analysis program, pitch and roll hydrostatic stiffness are recalculated for heave motion in every time step to check Mathieu's instability for the spar platform. Simplified vortex-induced vibration effects on the spar platform are considered in newly developed numerical analysis program, and the results are systematically compared with those of the original program WINPOST. The results in this paper show that the buoyancy-can effect significantly reduces the spar pitch motion, and the Coulomb damping effect also significantly reduces the spar heave motion. The buoyancy-can effect also plays an important role in Mathieu instability. The results also show that a pneumatic riser support system increases the spar heave motion and payload.

Interpretation of 900 km of a closely spaced grid of high-resolution seismic profiles over the northwestern margin of South Caspian Basin (SCB) allows recognition and study of six late Pleistocene - Holocene depositional sequences. Sequence stratigraphy analysis of sedimentary strata from 117,000 years B.P. to present led to the identification of a highstand systems tract, two transgressive systems tracts and six lowstand systems tracts. Each systems tract is characterized by specific seismic facies. Diverse depositional processes on the northwestern margin of the SCB are suggested by the thirteen seismic facies patterns recognized in the study area. Two distinct progradational complexes were interpreted within Sequence III and Sequences IV and V in the northeastern and northwestern parts of the study area, respectively. Stratigraphic interpretation of the sequences provided important information on parameters that control depositional architectures, such as lake level fluctuations, tectonic dynamics, and sediment supply. High sedimentation rates combined with a series of high-frequency and high-amplitude lake-level fluctuations, abrupt changes at the shelf edge, abnormally high formation pressure, and high tectonic activity during Quaternary time resulted in the development of a variety of complex geologic drilling hazards. I distinguished three types of hazards as a result of this study: mud volcanoes, sediment instability, and shallow gas. The 2D high-resolution seismic dataset from the northwestern margin of the SCB allowed more detailed seismic sequence stratigraphic analysis in the study area than has previously been attempted. In particular, it has a clear application in deciphering sediment supply and relative lake level changes as well as tectonic relationship of the northwestern shelf margin of the SCB. Results of this work led us towards better understanding of recent depositional history, improved our knowledge of the nature of the basin tectonics, climate history and styles of and controls on sedimentation processes within a sequence stratigraphic framework during the late Pleistocene-Holocene time.

The main goal of this research is to understand molecular mechanisms of GAA/TTC-associated genetic instability in a model eukaryotic organism, S. cerevisiae. We demonstrate that expanded GAA/TTC repeats represent a threat to eukaryotic genome integrity by triggering double-strand breaks and gross chromosomal rearrangements. The fragility potential strongly depends on the length of the tracts and orientation of the repeats relative to the replication origin and to block replication fork progression. MutSbeta complex and endonuclease activity of MutLalpha play an important role in facilitation of fragility. In addition to GAA/TTC triplex forming repeats, non-GAA polypurine polypyrimidine mirror repeats that are prone to the formation of similar structures were found to be hotspots for rearrangements in humans and other model organisms. These include H-DNA forming sequences located in the major breakpoint cluster region at BCL2, intron 21 of PKD1, and promoter region of C-MYC. Lastly, we have investigated the effect of the triplex-binding small molecules, azacyanines, on GAA-mediated fragility using the chromosomal arm loss assay. We have found that in vivo, azacyanines stimulate (GAA/TTC)-mediated arm loss in a dose dependent manner in actively dividing cells. Azacyanines treatment enhances the GAA-induced replication arrest. We discovered that also, azacyanines at concentrations that induce fragility also inhibit cell growth. Over 60% of yeast cells are arrested at G2/M stage of the cell cycle. This implies an activation of DNA-damage checkpoint response.

<p>The problem of spatial disorientation during flight of aircraft is briefly described, as are definitions of the phenomenon. Traditional countermeasure efforts that are often directed towards changes in the central visual field are reconsidered in favour of presentation of information in the peripheral visual field. It is proposed to use optic flow to support spatial orientation, as well as to omit such information from the central visual field. An experiment was conducted, and results showed that forward visual flow gave very important spatial information. The flow could be cropped to a certain degree in the periphery (horizontally), as well as parts of the central presentation could be omitted without decreasing effects in the experiment. Implications relevant to possible implementations in aircraft are discussed.</p>

<p>Experimental findings show that transition from laminar toturbulent ow may occur also if the exponentially growingperturbations, eigensolutions to the linearised disturbanceequations, are damped. An alternative non-modal growthmechanism has been recently identi fied, also based on thelinear approximation. This consists of the transient growth ofstreamwise elongated disturbances, with regions of positive andnegative streamwise velocity alternating in the spanwisedirection, called streaks. These perturbation are seen toappear in boundary layers exposed to signi ficant levels offree-stream turbulence. The effect of the streaks on thestability and transition of the Blasius boundary layer isinvestigated in this thesis. The analysis considers the steadyspanwise-periodic streaks arising from the nonlinear evolutionof the initial disturbances leading to the maximum transientenergy growth. In the absence of streaks, the Blasius pro filesupports the viscous exponential growth of theTollmien-Schlichting waves. It is found that increasing thestreak amplitude these two-dimensional unstable waves evolveinto three-dimensional spanwiseperiodic waves which are lessunstable. The latter can be completely stabilised above athreshold amplitude. Further increasing the streak amplitude,the boundary layer is again unstable. The new instability is ofdifferent character, being driven by the inectional pro filesassociated with the spanwise modulated ow. In particular, it isshown that, for the particular class of steady streaksconsidered, the most ampli fied modes are antisymmetric andlead to spanwise oscillations of the low-speed streak (sinuousscenario). The transition of the streak is then characterisedby the appearance of quasi-streamwise vorticesfollowing themeandering of the streak.</p><p>Simulations of a boundary layer subjected to high levels offree-stream turbulence have been performed. The receptivity ofthe boundary layer to the external perturbation is studied indetail. It is shown that two mechanisms are active, a linearand a nonlinear one, and their relative importance isdiscussed. The breakdown of the unsteady asymmetric streaksforming in the boundary layer under free-stream turbulence isshown to be characterised by structures similar to thoseobserved both in the sinuous breakdown of steady streaks and inthe varicose scenario, with the former being the mostfrequently observed.</p><p><b>Keywords:</b>Fluid mechanics, laminar-turbulent transition,boundary layer ow, transient growth, streamwise streaks,lift-up effect, receptivity, free-stream turbulence, secondaryinstability, Direct Numerical Simulation.</p>