This thesis explores the possibilities of doing mathematical problems involving algebra on a computer. A language is designed which allows names to occur as unknown quantities. This language has all the facilities of a general purpose language such as IMP, but is designed to be used inter-actively by a user at a console. The language also includes instructions which cause the usual algebraic operations to be applied to expressions. These operators include simplification, differentiation, but not integration. A brief survey is given of other languages in the field, with comments on their capabilities and restrictions. The second part of the thesis describes how the language is implemented. An interpreter is used. Statements of the language are analysed syntactically and then obeyed. Algebraic expressions are stored in byte arrays, using a type of prefix Polish notation. Finally the language is reviewed in the light of recent work done in the field, and suggestions are made for a further version.

Nowadays ERP system is crucial for management to improve internal process or SOP. The critical roles of ERP system are system user and MIS. This research is to discuss the main factors of MIS professional service quality based on IMP structures affecting user¡¦s satisfaction and behavior intention based on electronic manufacturing industry. A total 100 questionaries were filled out by system users and 76 were returned effectively. The data analysis goes to the conclusion as below. 1. The three dimensions ¡§social exchange¡¨¡B ¡§cooperation¡¨ and ¡§system quality¡¨ have significant effects on user satisfaction. 2. The two dimensions ¡§social exchange¡¨ and ¡§system quality¡¨ have significant effects on behavioral intention. The above conclusions are significant to the management as the following aspects. 1. Female user is willing to accept routine and paper work than male user. The satisfaction and behavior intention is also higher than male user. 2. The open and trust attitude between user, MIS and management is crucial to improve ERP system and internal process. 3. System quality and stability is key point for system user.

Abstract Deinococcus radiodurans is highly resistant to radiation when it grown in tryptone-glucose-yeast extraxt (TGY) medium. It oxidized glucose slowly mainly by the pentose phosphate pathway (PPP) and showed little glycolytic Embden-Meyerhof pathway (EMP) activity. The addition of 10 µM Mn(II) into the stationary phase cultures, could induced new round of cell division (Mn-CD effect) and the EMP activity. Glucose metabolized by Mn-CD cells at a EMP:PPP=6:1 ratio. In analyzing the metabolites for DNA repair, we found that after the addition of Mn(II) , the concentrations of PPP metabolites such as insione monophosphate (IMP)¡Buridine monophosphate (UMP) and NAD (nicotine adenine dinucleotide) were greatly reduced. This event is also occurred when replacing the glucose by fructose, sodium acetate, or removing glucose from the TGY culture medium. Besides, we also found that the TGY and TFY grown cells contained more PPP metabolites than those of TAY and TY cells. This finding suggested that glucose and fructose were metabolized by the PPP pathway in D. radiodurans. Finally, the concentrations of IMP¡BUMP and NAD in the cells were greatly decreased after UV irradiation. This indicated that these metabolites were probably employed to repair the DNA damage causing by UV irradiation.

No description available.

A água doce é um recurso mineral finito e essencial para sustentar a vida na terra. Para um bom gerenciamento dos recursos hídricos em uma bacia hidrográfica é importante que se conheça a curva Cota-Área-Volume (CAV) dos reservatórios. Concessionárias de energia e empresas públicas se pautam nesta relação em suas tomadas de decisões considerando os usos múltiplos que os reservatórios apresentam atualmente. Devido ao processo de assoreamento que o reservatório apresenta, é necessário que esta relação seja atualizada com certa frequência, tendo como base os levantamentos batimétricos atualizados. Entretanto, quanto maior o espaçamento entre as seções batimétricas maiores são as falhas que a modelagem do terreno apresenta e maiores os erros que as curvas CAV apresentam. Este estudo visa aprimorar os procedimentos realizados para modelagem de dados batimétricos em reservatórios, apresentando o método denominado Inserção de Malha de Pontos (IMP), que gera uma malha de pontos entre as seções levantadas corrigindo os efeitos de borda gerados pelo interpolador TIN. Com o intuito de otimizar e reduzir o tempo de obtenção dos resultados também é apresentada a ferramenta computacional CAV-NH, desenvolvida em linguagem Python, que utiliza a biblioteca do Arcgis 9.3 para realizar a modelagem do terreno e calcular a curva CAV como resultado final. Para a avaliação e validação do método foi realizada uma batimetria detalhada do reservatório do Lobo-SP, com intervalos entre as seções batimétricas de 10 metros, a qual foi comparada com diferentes espaçamentos até o intervalo de 600 metros. O método também foi aplicado aos reservatórios de Bariri e Ibitinga para a verificação de sua eficácia. Para todos os 1830 casos analisados houve uma melhora significativa na precisão, tendo uma redução no erro do volume calculado maior que 50% para o caso do distanciamento de 200 metros entre as seções, para a cota 703 metros. As análises indicam que o método IMP provê uma modelagem mais condizente com o relevo do terreno de fundo, obtendo-se uma maior acurácia e possibilitando a diminuição do trabalho de coleta de dados em campo sem prejudicar o cálculo do volume do reservatório. O CAV-NH foi utilizado em todas as simulações e se mostrou uma ferramenta de fácil utilização, proporcionando uma maior agilidade em todo processo. Conclui-se que o método IMP juntamente com a ferramenta computacional CAV-NH são importantes contribuições para a definição de uma curva Cota-Área-Volume de qualidade, sendo esta de grande importância para sistemas de suporte à decisão e para um bom gerenciamento dos recursos hídricos. / Freshwater is a finite mineral resource and essential for sustaining life on earth. For proper water resource management in the watershed, it is important to know the reservoirs Elevation-Area-Volume (EAV) curve. Energy companies and government agencies use this curve for their decision-making, considering the multiple uses of the reservoirs. Due to the reservoir sedimentation process, it is necessary to update this curve frequently, based on the bathymetric surveys. However, a greater space between transects causes failures in the terrain model and also in the EAV curve. This study aims to improve the procedures used for modeling reservoir survey data, introducing the method called Insertion of Mesh Points (IMP), that generates a mesh of points between transects correcting the edge effects caused by TIN interpolation. In order to optimize and reduce work time for obtaining the results, a computational tool CAV-NH, which was developed in Python language, is also presented. It employs the Arcgis 9.3 library to generate the terrain model and obtain the EAV table. For the evaluation and validation of the method, a detailed bathymetry of the Lobo reservoir was carried out, with 10 meter intervals of survey lines, which was compared with different survey lines spacing up to 600 meters. To verify its effectiveness the method was also applied to Bariri and Ibitinga reservoirs. For all 1830 cases analyzed there was a significant accuracy improvement. For the case of 200 meter line spacing and 703 meters elevation, the error of volume obtained was reduced by more than 50%. The analysis showed that the IMP method provides a terrain model more suited, resulting in greater accuracy and allowing the work reduction of reservoir survey without affecting the volume calculation. The CAV-NH was used in all simulations and proved an easy tool to use, providing greater agility in the whole process. It is concluded that the IMP method and the computational tool CAV-NH are important contributions to achieve a quality relationship of elevation-area-volume.

A água doce é um recurso mineral finito e essencial para sustentar a vida na terra. Para um bom gerenciamento dos recursos hídricos em uma bacia hidrográfica é importante que se conheça a curva Cota-Área-Volume (CAV) dos reservatórios. Concessionárias de energia e empresas públicas se pautam nesta relação em suas tomadas de decisões considerando os usos múltiplos que os reservatórios apresentam atualmente. Devido ao processo de assoreamento que o reservatório apresenta, é necessário que esta relação seja atualizada com certa frequência, tendo como base os levantamentos batimétricos atualizados. Entretanto, quanto maior o espaçamento entre as seções batimétricas maiores são as falhas que a modelagem do terreno apresenta e maiores os erros que as curvas CAV apresentam. Este estudo visa aprimorar os procedimentos realizados para modelagem de dados batimétricos em reservatórios, apresentando o método denominado Inserção de Malha de Pontos (IMP), que gera uma malha de pontos entre as seções levantadas corrigindo os efeitos de borda gerados pelo interpolador TIN. Com o intuito de otimizar e reduzir o tempo de obtenção dos resultados também é apresentada a ferramenta computacional CAV-NH, desenvolvida em linguagem Python, que utiliza a biblioteca do Arcgis 9.3 para realizar a modelagem do terreno e calcular a curva CAV como resultado final. Para a avaliação e validação do método foi realizada uma batimetria detalhada do reservatório do Lobo-SP, com intervalos entre as seções batimétricas de 10 metros, a qual foi comparada com diferentes espaçamentos até o intervalo de 600 metros. O método também foi aplicado aos reservatórios de Bariri e Ibitinga para a verificação de sua eficácia. Para todos os 1830 casos analisados houve uma melhora significativa na precisão, tendo uma redução no erro do volume calculado maior que 50% para o caso do distanciamento de 200 metros entre as seções, para a cota 703 metros. As análises indicam que o método IMP provê uma modelagem mais condizente com o relevo do terreno de fundo, obtendo-se uma maior acurácia e possibilitando a diminuição do trabalho de coleta de dados em campo sem prejudicar o cálculo do volume do reservatório. O CAV-NH foi utilizado em todas as simulações e se mostrou uma ferramenta de fácil utilização, proporcionando uma maior agilidade em todo processo. Conclui-se que o método IMP juntamente com a ferramenta computacional CAV-NH são importantes contribuições para a definição de uma curva Cota-Área-Volume de qualidade, sendo esta de grande importância para sistemas de suporte à decisão e para um bom gerenciamento dos recursos hídricos. / Freshwater is a finite mineral resource and essential for sustaining life on earth. For proper water resource management in the watershed, it is important to know the reservoirs Elevation-Area-Volume (EAV) curve. Energy companies and government agencies use this curve for their decision-making, considering the multiple uses of the reservoirs. Due to the reservoir sedimentation process, it is necessary to update this curve frequently, based on the bathymetric surveys. However, a greater space between transects causes failures in the terrain model and also in the EAV curve. This study aims to improve the procedures used for modeling reservoir survey data, introducing the method called Insertion of Mesh Points (IMP), that generates a mesh of points between transects correcting the edge effects caused by TIN interpolation. In order to optimize and reduce work time for obtaining the results, a computational tool CAV-NH, which was developed in Python language, is also presented. It employs the Arcgis 9.3 library to generate the terrain model and obtain the EAV table. For the evaluation and validation of the method, a detailed bathymetry of the Lobo reservoir was carried out, with 10 meter intervals of survey lines, which was compared with different survey lines spacing up to 600 meters. To verify its effectiveness the method was also applied to Bariri and Ibitinga reservoirs. For all 1830 cases analyzed there was a significant accuracy improvement. For the case of 200 meter line spacing and 703 meters elevation, the error of volume obtained was reduced by more than 50%. The analysis showed that the IMP method provides a terrain model more suited, resulting in greater accuracy and allowing the work reduction of reservoir survey without affecting the volume calculation. The CAV-NH was used in all simulations and proved an easy tool to use, providing greater agility in the whole process. It is concluded that the IMP method and the computational tool CAV-NH are important contributions to achieve a quality relationship of elevation-area-volume.

Nowadays a new businesses form, online business occurred, which helps companies to improve their working efficiency in managing risks and allocating resources. Relationship and network are essential for understanding online business, which can help firms to reduce costs by outsourcing, and to increase efficiency by sharing information with cooperators. That leads to the purpose of this study, is to investigate how do the relationship and network between firms influence the cooperation of product developing and server operating companies within online business. In order to study this topic, the concepts from IMP group of characteristics of relationship, relationship development stages and the model of managing in networks are applied. Furthermore qualitative research method was employed for interviewing five companies in two types: 1) product developing companies 2) server operating companies.     The relationship and network are perceived by interviewed companies are dynamic, fast changing and high technology focused. To cope with this phenomenon, most of companies choose to put their efforts on developing products and advancing technology rather than communicating with partners. In conclusion, the cooperation between firms in online business is influenced by fast changing and short-term relationships, high competition and the risk of plagiarism, which leads to competition focus in their business.

The sense of taste is one of the most important factors in regulating ingestive decisions. This is central to a number of disease conditions including but not limited to obesity, diabetes, anorexia, hypertension, coronary artery diseases and malnutrition. The detection of the molecules eliciting taste qualities in food is mediated by the coordinated actions of distinct types of taste sensory cells (TSCs) housed in taste buds within specialized papillae throughout the oral cavity. Taste receptors in the taste sensory cells that detect food molecules are the key players in selecting dietary nutrients. One such example is L-amino acids, a critical part of one's diet. L-glutamate is the prototypical umami compound and is known to increase palatability of food. A unique characteristic of umami taste is the response potentiation of glutamate by 5' ribonucleotide monophosphates, such as inosine 5' monophosphate (IMP), which is also capable of eliciting an umami taste. Candidate receptors for umami taste include a heterodimer T1r1+T1r3, brain variants of mGluR1 and mGluR4, and the truncated variants of mGluR1 and mGluR4. Studies using heterogeneous expression of T1r1+T1r3 suggest it is an umami and a broadly tuned L-amino acid receptor. While much attention is devoted to understanding glutamate transduction, the detection mechanisms for other L-amino acids by TSCs are less well understood. Here calcium imaging of isolated TSCs and taste cell clusters from the circumvallate and foliate papillae of C57BL/6J and T1r3 knockout mice was performed to determine if other receptors are involved in the detection of L-amino acids and IMP. Ratiometric imaging with Fura-2 was used to study calcium responses to IMP and four L-amino acids (monopotassium L-glutamate, L-serine, L-arginine, and L-glutamine) with and without IMP. The results of these experiments showed that the response patterns elicited by L-amino acids varied significantly across TSCs. Only a small subset of cells responded to all stimuli. Interestingly, L-amino acids other than glutamate elicited synergistic responses in a subset of TSCs. Additionally IMP alone elicited a response in a large number of TSCs. Our data indicate that synergistic and non-synergistic responses to L-amino acids and IMP are mediated by multiple receptors or possibly a receptor complex. Next the roles of mGluR1 and mGluR4 in the detection of the IMP and L-amino acids were investigated. Selective agonists for mGluR1, (RS)-3, 5-dihydroxyphenylglycine (DHPG; a group I mGluR agonist), and mGluR4, L-(+)-2-amino-4-phosphonobutyric acid (L-AP4; a group III mGluR4 agonist) elicited responses in TSCs. In addition, TSCs responsive to these agonists were also responsive to L-amino acids and IMP. More importantly, selective antagonists against different mGluRs such as (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA; a group I mGluR antagonist), and (RS)-α-methylserine-O-phosphate (MSOP; a group III mGluR antagonist) significantly suppressed L-amino acid- and IMP-mediated responses in TSCs of T1r3 knockout mice. Collectively, these data provide evidence for the involvement of taste and the brain variants of mGluR1 and mGluR4 in L-amino acid and IMP taste responses in mice, and support the hypothesis that multiple receptors contribute to the IMP and L-amino acid tastes.

BARROS, Francisco Ferreira do Rego. Análise da pobreza unidimensional e multidimensional no Nordeste do Brasil em 2009 e 2012. 2014. 37f. Dissertação (Mestrado Profissional) - Programa de Pós Graduação em Economia, CAEN, Universidade Federal do Ceará, Fortaleza-CE, 2014. / Submitted by Mônica Correia Aquino (monicacorreiaaquino@gmail.com) on 2014-10-30T12:36:29Z No. of bitstreams: 1 2014_dissert_ffrbarros.pdf: 532253 bytes, checksum: 9f2a7cbac33572c37156c4af34e567c3 (MD5) / Approved for entry into archive by Mônica Correia Aquino(monicacorreiaaquino@gmail.com) on 2014-10-30T12:36:46Z (GMT) No. of bitstreams: 1 2014_dissert_ffrbarros.pdf: 532253 bytes, checksum: 9f2a7cbac33572c37156c4af34e567c3 (MD5) / Made available in DSpace on 2014-10-30T12:36:46Z (GMT). No. of bitstreams: 1 2014_dissert_ffrbarros.pdf: 532253 bytes, checksum: 9f2a7cbac33572c37156c4af34e567c3 (MD5) Previous issue date: 2014 / This dissertation aims to analyze poverty on the one-dimensional and multidimensional aspect in the Northeast, from the approach to Multivariate Poverty Index ( IMP ) proposed by Asselin (2002 ) . Specifically , we use the multivariate technique of Multiple Correspondence Analysis ( MCA) , which estimates the IMP . Based on this indicator it is possible to find the ratio of the Poor - FGT ( 0 ) , intensity Poor - FGT ( 1 ) and Severity of Poverty - FGT ( 2 ) . Information PNADs were used in 2009 and 2012 . The results showed that the proportion of measured poverty , using multidimensional analysis for the region and the northeastern states in 2009 and 2012 is higher than the results obtained by dimensional analysis , using the same data , but based it is only in equities , as commonly underlie the criteria of one-dimensional technique. Thus , it became evident to be more objective use of the multidimensional method for the analysis of the problem , which , based on a larger common to the object number of variables analyzed , showed strongest results for the definition of the real level of poverty in that population. / A presente Dissertação tem como objetivo analisar a pobreza sobre o aspecto unidimensional e Multidimensional no Nordeste, a partir da abordagem do Índice Multivariado de Pobreza (IMP) proposto por Asselin (2002). Especificamente, utiliza-se a técnica multivariada de Análise de Correspondência Múltipla (ACM), que permite calcular o IMP. Com base nesse indicador é possível encontrar a proporção de Pobres - FGT(0), Intensidade de Pobres - FGT(1) e Severidade da Pobreza - FGT(2). Foram utilizadas informações das PNADs em 2009 e 2012. Os resultados permitiram concluir que a proporção de pobreza mensurada, empregando-se a análise multidimensional para a região e os estados nordestinos, em 2009 e 2012, é superior aos resultados obtidos através da análise unidimensional, utilizando-se os mesmos dados, mas, baseando-se, apenas, na variável renda, conforme comumente, fundamentam-se os critérios da técnica unidimensional. Desse modo, ficou evidenciado ser mais objetiva a utilização do método multidimensional, para a análise do problema, o qual, fundamentado em um número maior de variáveis comuns ao objeto analisado, apresentou resultados mais contundentes para a definição do nível real de pobreza naquela população.

Les rhabdomyosarcomes embryonnaires et aléolaires (RMS) appartiennent aux tumeurs des tissus mous les plus fréquentes chez les enfants dont elles représentent 2/3 des cas. Plusieurs données suggèrent que la dérégulation des cellules progénitrices du muscle squelettique pourrait jouer un rôle dans l'émergence des cellules de RMS qui ont aussi bien perdu le contrôle de la régulation de la prolifération cellulaire que la capacité à se différencier.Néanmoins les mécanismes de développement des RMS restent à caractériser. La famille des IMPs et notamment IMP-2, protéines liant les ARN, sont à la fois fortement exprimées dans le muscle en régénération in vivo mais aussi dans les cellules de RMS.Au cours de ma thèse, j’ai pu mettre en évidence le rôle d’IMP-2 dans la motilité des cellules de RMS et dans les cellules musculaires ainsi que dans le contrôle de l’intégrité du cytosquelette de microtubules (MTs) et dans le remodelage des adhésions focales. En effet, IMP-2 est impliqué à la fois dans la régulation de l’expression de MuRF-3, une protéine lié àla stabilisation des MTs et de Pinch-2, un important médiateur de l’adhésion cellulaire. / The RNA-binding proteins IMPs (IGF-II mRNA binding protein) first discovered in rhabdomyosarcoma cells (RMS) are expressed during embryonic development but their expression is decreased in adult tissues.We showed that IMPs and particularly IMP-2 are strongly expressed in mouse myoblatsts, during early regeneration of skeletal muscle in vivo and in and RMS. IMP-2 loss of function experiments using siRNA have shown that IMP-2 is necessary for microtubules stability(MTs), cell motility and invasion of myoblasts and RMS.Expression of IMP-2 specifically increases MTs stability by an enrichment of detyrosinated tubulin Glu-tubulin. Detyrosination is indispensable for myogenic differentiation and plays substantial role in tumor growth. Additionaly, MTs stabilization play an important role in focal adhesion remodeling, in cytoskeleton integrity, cell adhesion and cell motility.To get new insight into molecular mechanism underlying the function of IMP-2 in MTs stability and cell motility, full ranscriptome analysis was performed between IMP-2 knockdown (KD) myoblasts and control myoblatsts. We have further shown that IMP-2 controls the mRNA levels of many important mediators of cell adhesion such as PINCH-2, as well as multiple cytoskeleton remodeling, such as MuRF-3.We have identified a number of functionally relevant protein partners of IMP-2.Moreover subsequent RNAi screens have revealed the importance of IMP-2 regulated transcripts involved in cell motility and cell adhesion In conclusion, we show that IMP-2 dependent regulation of mRNA such as MuRF3 and PINCH2 largely contributes to the motility –deficient in IMP-2 KD cells. Moreover these results indicate clearly, that further analysis of IMP2 protein partners and RNA targets regulated by IMP-2 will help to characterized the function of IMP-2 and to propose a model of IMP-2 transcriptional regulation of gene expression in myoblasts and RMS cells.