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Computational Studies of ThDP-Dependent EnzymesPaulikat, Mirko 18 December 2018 (has links)
No description available.
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Análise de parâmetros eletromiográficos e cinemáticos durante teste incremental de corrida / Priscila de Brito Silva. -Silva, Priscila de Brito. January 2009 (has links)
Orientador: Mauro Gonçalves / Banca: Júlio Cerca Serrão / Banca: Camila Coelho Greco / Resumo: O presente estudo teve como objetivo verificar se as intensidades do LFEMG e do ponto de quebra são semelhantes e se há diferença no valor do índice, calculando-se o RMS em intervalos referentes a cinco segundos ou ao ciclo de passada e estudar o comportamento da freqüência de passada (FP), amplitude (RMS) e freqüência da atividade eletromiográfica nos período pré (RMS-PRE, FM-PRE) e pós contato (RMS-PRE, FM-POS) dos músculos íleocostal (IC), reto femoral (RF), vasto lateral (VL), vasto medial (VM), bíceps femoral (BF), tibial anterior (TA) e gastrocnêmio lateral (GL), bem como da co-ativação dos músculos RF/BF, VL/BF, VM/BF e GL/TA nos períodos pré (PRE) e póscontato (POS) ao longo de um teste incremental, considerando as intensidades absolutas e quatro intensidades relativas: inicial (IIN), equivalente ao LFEMG (ILF), 15% abaixo (IAB) e 15% acima (IAC) do LFEMG. Onze voluntários foram submetidos a um teste incremental de corrida até exaustão voluntária. Os valores de RMS foram obtidos de duas formas, a cada cinco segundos do intervalo de corrida e a cada ciclo de passada. O LFEMG e o ponto de quebra foram determinados. Não houve diferenças significantes entre os valores dos índices obtidos pelas duas formas de análise nem entre os músculos. Entretanto, foi evidenciado que os valores de LFEMG foram maiores do que os do ponto de quebra apenas quando determinados pelos valores de RMS obtidos nos ciclos de passada. As velocidades relativas obtidas foram 9,2±0,4 km.h-1 na IAB, 10,6±0,7 km.h-1 na LFEMG e 12,3±0,5 km.h-1 na IAC. A partir dos 11 km.h-1 a FP, a RMS-PRE para o músculo IC e a RMS-POS para os músculos VL e VM apresentaram aumento. Nas intensidades relativas, houve aumento dos valores da FP, da RMS-PRE para os músculos BF, TA e GL, da RMS-POS e FM-POS para o músculo GL a partir da ILF. As correlações foram significantes para FP e FM-PRE do VL... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: The aim of the present study was to verify whether eletromyographic fatigue threshold (EMGFT) and breakpoint intensities were similar and whether there is differences in the speed value between these indexes when calculated considering five seconds intervals or referent to stride cycle and study stride frequency (SF), amplitude and frequency of electromyographic activity behaviors on pre (PRE) and post (POS) contact periods for iliocostalis (IC), rectus femoris (RF), vastus lateralis (VL), vastus medialis (VM), biceps femoris (BF), tibialis anterior (TA) and gastrocnemius lateralis (GL), and co-activation ratio of RF/BF, VL/BF, VM/BF and GL/TA on PRE and POST periods during an incremental running protocol, considering absolute intensities and four relative intensities: initiail (IIN), equivalent to EMGFT (IFT), 15% below (IBE) and 15% above (IAB) EMGFT. Eleven males performed an incremental running test to exhaustion. RMS values were obtained every five seconds and during stride cycles of each running stage. EMGFT and breakpoint were determined for all muscles. There were no significant differences between two different indexes when calcula values obtained RMS calculation nor among different muscles. However, the EMGFT values were greater than breakpoint values when determined using RMS calculated for stride cycles, with no difference when obtained every five seconds. Relative intensities obtained were 9.2±0.4 km... (Complete abstract click electronic access below) / Mestre
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Cálculo rápido do operador de retroprojeção com aplicações em reconstrução tomográfica de imagens / Fast computation of the backprojection operator with applictions in tomographic image reconstructionLima, Camila de 09 June 2017 (has links)
Os métodos incrementais pertencem a uma classe de métodos iterativos que divide o conjunto de dados em subconjuntos ordenados, e que atualiza a imagem ao processar cada subconjunto (sub-iterações). Isso acelera a convergência das reconstruções, e imagens de qualidade são obtidas em menos iterações. No entanto, a cada sub-iteração é necessário calcular os operadores de projeção e retroprojeção, resultando no custo computacional de ordem O(n3) para a reconstrução de imagens de dimensão × . Por outro lado, algumas alternativas baseadas na interpolação em uma grade regular no espaço de Fourier ou em transformadas rápidas não-uniformes, dentre outras ideias, foram desenvolvidas a fim de aliviar esse custo computacional. Além disso, diversas abordagens foram bem sucedidas em acelerar o cálculo das iterações de algoritmos clássicos, mas nenhuma havia sido utilizada em conjunto com os métodos incrementais. Neste trabalho é proposta uma nova abordagem em que a técnica de transformada rápida de Fourier não uniforme (NFFT) é utilizada nas sub-iterações de métodos incrementais com o objetivo de efetuar de forma eficiente os cálculos numericamente mais intensos: a projeção e a retroprojeção, resultando em métodos incrementais com complexidade O(n2 log n ). Os métodos propostos são aplicados à tomografia por radiação síncrotron e os resultados da pesquisa mostram um bom desempenho. / Incremental methods belong to a class of iterative methods that divide the data set into ordered subsets, and which update the image when processing each subset (sub-iterations). It accelerates the reconstruction convergence and quality images are obtained in fewer iterations. However, it is necessary to compute the projection and backprojection operators in each sub-iteration, resulting in the computational cost of O(n3) flops for × images. On the other hand, some alternatives based on interpolation over a regular grid on the Fourier space or on nonequispaced fast transforms, among other ideas, were developed in order to alleviate the computational cost. In addition, several approaches substantially speed up the computation of the iterations of classical algorithms, but the incremental methods had not been benefited from these techniques. In this work, a new approach is proposed in which the nonequispaced fast Fourier transform (NFTT) is used in each subiteration of incremental methods in order to perform the numerically intensive calculations efficiently: the projection and backprojection, resulting in incremental methods with complexity O(n2 log n ). The proposed methods are applied to the synchrotron radiation tomography and the results show a good performance.
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Influência do treinamento de força sobre a estratégia de prova e o desempenho de corredores de longa distância em um teste contrarrelógio de 10 km / Influence of strength training on pacing strategy and performance in long distance runners in a 10-km running time trialDamasceno, Mayara Vieira 16 October 2015 (has links)
O objetivo do presente estudo foi analisar o impacto de oito semanas de um programa de treinamento de força sobre a estratégia de prova e o desempenho de corredores de longa distância durante uma prova contrarrelógio de 10 km. Antes e após a fase de intervenção com o programa de treinamento de força, dezoito corredores recreacionais divididos nos grupos treinamento (GT) (n = 9) e controle (GC) (n = 9) foram submetidos aos seguintes testes: a) antropometria e teste progressivo até a exaustão voluntária, b) teste com velocidade submáxima constante, c) simulação de uma prova de 10 km para análise da estratégia de prova, d) teste de drop jump, e) teste de wingate, f) teste de uma repetição máxima (1RM) e g) teste de tempo limite. A atividade eletromiográfica dos músculos vasto medial e bíceps femoral foi medida durante o teste de 1RM. No GT, a magnitude de melhora para o 1RM (23,0 ± 4,2%, P = 0,001), drop jump (12,7 ± 4,6%, P = 0,039), e velocidade de pico na esteira (2,9 ± 0,8%, P = 0,013) foi significativamente maior em relação ao GC. Este aumento do 1RM para o GT foi acompanhado por uma tendência a uma maior atividade eletromiográfica (P = 0,080). A magnitude de melhora no desempenho na prova de 10 km foi maior (2,5%) no GT que no GC (-0,7%, P = 0,039). O desempenho foi melhorado principalmente devido a velocidades mais elevadas durante as últimas sete voltas (últimos 2800 m) da prova de 10 km. No entanto, não houve diferenças significativas antes e após o período de treinamento para o padrão de estratégia de prova utilizada, consumo máximo de oxigênio, ponto de compensação respiratória, economia de corrida e desempenho anaeróbio para ambos os grupos (P > 0,05). Em conclusão, estes resultados sugerem que, embora um programa de treinamento de força não altere a estratégia de prova adotada, ele oferece um potente estímulo para combater a fadiga durante as últimas partes de uma corrida de 10 km, resultando em um melhor desempenho total / The aim of the present study was to analyze the impact of an 8-week strength-training program on performance and pacing strategy adopted by runners during a self-paced endurance running. Eighteen endurance runners were allocated into either strength training group (STG, n = 9) or control group (CG, n = 9) and performed the following tests before and after the training period: a) anthropometric measures and maximal incremental treadmill test, b) running speed-constant test, c) 10-km running time trial, d) drop jump test, e) 30-s Wingate anaerobic test, f) maximum dynamic strength test (1RM), g) time to exhaustion test. Electromyographic activity of vastus medialis and biceps femoris was measured during 1RM test. In the STG, the magnitude of improvement for 1RM (23.0 ± 4.2%, P = 0.001), drop jump (12.7 ± 4.6%, P = 0.039), and peak treadmill speed (2.9 ± 0.8%, P = 0.013) was significantly higher compared to CG. This increase in the 1RM for STG was accompanied by a tendency to a higher electromyographic activity (P = 0.080). The magnitude of improvement for 10-km running performance was higher (2.5%) for STG than for CG (-0.7%, P = 0.039). Performance was improved mainly due higher speeds during the last seven laps (last 2800 m) of the 10-km running. Nevertheless, there were no significant differences between before and after training period for pacing strategy, maximal oxygen uptake, respiratory compensation point, running economy, and anaerobic performance for both groups (P > 0.05). In conclusion, these findings suggest that, although a strength-training program does not alter the pacing strategy, it offers a potent stimulus to counteract fatigue during the last parts of a 10-km running, resulting in an improved overall running performance
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Etude expérimentale et modélisation de la mise en forme à chaud d'alliages d'aluminium innovants / Experimental study and modeling of hot forming for innovative aluminum alloys.Younes, Wael 08 December 2016 (has links)
La recherche permanente de solutions d’allègement des structures aéronautiques a conduit au développement de nouveaux alliages comme les Al-Cu-Li et les Al-Mg-Li qui se caractérisent par une densité inférieure aux alliages conventionnels et par des propriétés améliorées. De manière générale, la formabilité de ces alliages, que ce soit à froid ou à chaud est encore assez mal connue. Le projet « Formage avancé des alliages basses densité pour application aéronautique » se propose donc de caractériser précisément la plage de formabilité de ces nouveaux alliages et d’investiguer les voies de mise en œuvre les plus adaptées : procédé d’étirage conventionnel ou procédé de mise en forme pendant une étape de traitement thermique. Ce projet regroupe les entreprises AEROLIA SAS, ACB, AIRBUS Operation SAS et CONSTELLIUM.Ces développements seront destinés au fuselage métallique et plus particulièrement à la structure pointe-avant qui présente une géométrie en double courbure ; ils concernent à la fois les panneaux de fuselage et les profilés. / The ongoing researches to lighten aeronautical structures have led to the development of new materials like Al-Cu-Li and Al-Mg-Li alloys. These alloys exhibit lower density and higher mechanical properties than conventional alloys. However, their ability to be formed either by cold or hot forming process is not well known. The aims of this PhD research works are thus to characterize the formability of these new alloys and to suggest the most appropriate forming sequence to elaborate complex aeronautic parts. Various forming processes will be studied such as cold forming by stretching of sheet metal parts or hot forming by stamping of sheet metal parts after or during different heat treatments. An experimental as well as a numerical approach will be used to develop the forming process of these new alloys to elaborate fuselage panels with more or less complex shapes. These PhD research works are a component of a larger project led by IRT Jules Verne and entitled “Advanced forming of low density alloys for aeronautic applications”. This project includes several firms from aeronautic domain (AEROLIA SAS, ACB, AIRBUS SAS and CONSTELLIUM).
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THE EFFECTS OF NATURAL RESOURCE DEPENDENCE AND DEMOCRACY ON THE INCREMENTAL BUDGETING THEORY AND PUNCTUATED EQUILIBRIUM WITHIN A BUDGETARY CONTEXTAlgharabali, Barrak Ghanim 01 January 2019 (has links)
I contribute to the literature by providing additional factors that could affect the incremental budgeting theory and punctuated equilibrium theory (PET) within a budgetary context. Because of the fluctuation in the price of natural resources, I argue that dependence on natural resources could lead to less stable budgets than ones not dependent on natural resources. I also argue that democracy is another source that leads to stability in the budget, relative to countries that are not democratic. I theorize that countries with no democracy and heavy dependence on natural resources will have budgets with more volatility than the rest of the countries. Most of the extant literature focuses on countries that are democratic and not dependent on natural resources. My theory expects these to have the most stable budgets. I extend the literature by comparing the Kuwaiti National Budget (dependent on natural resources and not democratic) to the U.S. Federal Budget (democratic and not dependent on natural resources). The results of all tests are consistent with the expectations of the theory that countries with no democracy and heavy dependence on natural resources have less incremental budgets than nations that are democratic and not dependent on natural resources.
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Méthodologie de dimensionnement d’un assemblage collé pour application aérospatiale / Design methodology applied to bonded structure for space applicationLe Pavic, Jérémy 26 April 2018 (has links)
Les lanceurs spatiaux sont des structures complexes associant une multitude de composants. L’assemblage de ces éléments doit répondre à un niveau de performance élevé. Le collage structural demeure un bon candidat en raison des nombreux avantages qu’il présente. Cependant, cette technologie montre des inconvénients. En raison des changements brusques de géométrie et de propriétés matériaux, des concentrations de contraintes apparaissent aux extrémités du joint de colle. Ce phénomène appelé effets de bords est néfaste pour la tenue mécanique de l’assemblage collé. La présence des effets de bords exclut l’utilisation de critères en contrainte utilisés classiquement. Le dimensionnement d’assemblages collés requiert des outils fiables prenant en compte ces effets de bords. Dans cette étude, un modèle de ruine incrémentale, associant une approche en contrainte et en énergie, est utilisé. L’utilisation de cet outil dans un cadre industriel, impose de répondre aux besoins d’un Bureau d’Études, notamment en termes de coût de calculs. Afin de le diminuer, une implémentation semi-analytique, est tout d’abord développée. Puis, une seconde méthode d’implémentation, basée sur la méthode des Eléments Finis, permet une prévision plus précise de la ruine d’un assemblage. La pertinence de ces deux approches a été vérifiée pour plusieurs configurations de joints collés. Des campagnes d’essais, destinées à confronter les résultats expérimentaux aux prévisions numériques, ont été réalisées. Dans le cadre de ce travail, un montage de collage et d’essai pour assemblages tubulaires a en particulier été développé. L’objectif du pré-dimensionnement est d’identifier une zone d’intérêt dans l’ensemble du domaine d’étude. Aussi, une étude paramétrique peut être requise afin de réaliser cette tâche. Afin de réduire le coût de calcul, une méthode d’interpolation spatiale appelée Krigeage a été mise en œuvre, et permet la construction efficace d’une surface de réponse. / Space Launchers are complex structures composed of a large number of elements. The assembling of these components must show a high level of reliability. The use of adhesive bonding technology is an interesting solution since it presentsseveral assets compared to “classical” joint techniques (such as riveting, bolting and welding), mainly because it can help to construct lighter and less energy consuming systems However„ the implementation of adhesives also has somedrawbacks. Due to the strong variations of geometrical and material properties, stress concentrations appear at the extremities of the joint. This phenomenon; called edge effects; has a great influence on the failure of the bond. As a result, the simple use of a classical stress or energetic criteria is not appropriate to predict the fracture of such structures. Therefore, it is obvious that the design of bonded assemblies requires reliable tools to take the edge effects into account. In this work an incremental failure model, which combines the stress and energetic criteria, is used. In order to decrease the computational cost, a semi-analytical application of this model is proposed. This is intended to make the approach more interesting to be implemented in an industrial environment. The accuracy of the prediction of the failure load is enhanced by means of the Finite Element method. The reliability of both the semi-analytical and Finite Element approaches is verified by comparing the model predictions with experimental data issued from double-notched Arcan and tubular specimen geometries. The aim of the pre-design phase is to identify the critical area in the whole range of the application of the studied geometry. Therefore, the realization of a parametric study is required in order to build a response surface. In the present study, this has been achieved by means of spatial interpolation using the Kriging model.
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Analyse de Flux de Trames AFDX en Réception et Méthode d’Optimisation Mémoire / AFDX Frame Flow Analysis in Reception and Memory Optimization MethodBaga, Yohan 03 May 2018 (has links)
L’essor des réseaux AFDX comme infrastructure de communication entre les équipements de bord des aéronefs civils motive de nombreux travaux de recherche pour réduire les délais de communication tout en garantissant un haut niveau de déterminisme et de qualité de service. Cette thèse traite de l’effet des accolements de trames sur l’End System de réception, notamment sur le buffer interne afin de garantir une non perte de trames et un dimensionnement mémoire optimal. Une modélisation pire cas du flux de trames est réalisée selon une première méthode pessimiste, basée sur un flux de trames périodiques ; puis une seconde, plus optimiste, basée sur des intervalles de réception et un placement de trames itératif. Une étude probabiliste met en œuvre des distributions gaussiennes pour évaluer les probabilités d’occurrences des pires cas d’accolements et apporte un éclairage qui ouvre une discussion sur la pertinence de ne considérer que la modélisation pire cas pour dimensionner le buffer de réception. Un gain mémoire supplémentaire peut être obtenu par la mise en œuvre de la compression sans perte LZW. / The rise of AFDX networks as a communication infrastructure between on-board equipment of civil aircraft motivates many research projects to reduce communication delays while guaranteeing a high level of determination and quality of service. This thesis deals with the effect of the back-ot-back frame reception on the reception End System, in particular, on the internal buffer, in order to guarantee a non-loss of frames and optimal memory dimensioning. A worst-case modeling of the frame flow is carried out according to a first pessimistic method, based on a periodic frame flow. Then a more optimistic method is presented based on the reception intervals and an iterative frame placement. A probabilistic study implements Gaussian distributions to evaluate the occurrence probabilities of the worst back-to-back frames and provides an illumination that opens a discussion on the relevance of not considering the worst-case modeling to size the reception buffer. Additional memory gain can be achieved by implementing LZW lossless compression.
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Techniques for VLSI Circuit Optimization Considering Process VariationsVenkataraman, Mahalingam 23 March 2009 (has links)
Technology scaling has increased the transistor's susceptibility to process variations in nanometer very large scale integrated (VLSI) circuits. The effects of such variations are having a huge impact on performance and hence the timing yield of the integrated circuits. The circuit optimization objectives namely power, area, and delay are highly correlated and conflicting in nature. The inception of variations in process parameters have made their relationship intricate and more difficult to optimize. Traditional deterministic methods ignoring variation effects negatively impacts timing yield. A pessimistic worst case consideration of variations, on the other hand, can lead to severe over design. In this context, there is a strong need for re-invention of circuit optimization methods with a statistical perspective.
In this dissertation, we model and develop novel variation aware solutions for circuit optimization methods such as gate sizing, timing based placement and buffer insertion. The uncertainty due to process variations is modeled using interval valued fuzzy numbers and a fuzzy programming based optimization is proposed to improve circuit yield without significant over design. In addition to the statistical optimization methods, we have proposed a novel technique that dynamically detects and creates the slack needed to accommodate the delay due to variations.
The variation aware gate sizing technique is formulated as a fuzzy linear program and the uncertainty in delay due to process variations is modeled using fuzzy membership functions. The timing based placement technique, on the other hand, due to its quadratic dependence on wire length is modeled as nonlinear programming problem. The variations in timing based placement are modeled as fuzzy numbers in the fuzzy formulation and as chance constraints in the stochastic formulation. Further, we have proposed a piece-wise linear formulation for the variation aware buffer insertion and driver sizing (BIDS) problem. The BIDS problem is solved at the logic level, with look-up table based approximation of net lengths for early variation awareness.In the context of dynamic variation compensation, a delay detection circuit is used to identify the uncertainty in critical path delay. The delay detection circuit controls the instance of data capture in critical path memory flops to avoid a timing failure in the presence of variations. In summary, the various formulation and solution techniques developed in this dissertation achieve significantly better optimization compared to related works in the literature. The proposed methods have been rigorously tested on medium and large sized benchmarks to establish the validity and efficacy of the solution techniques.
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營業而來的運用資金及現金流量增額資訊內涵之研究王毅偉 Unknown Date (has links)
本研究的目的在探討,盈餘中所包括的由營業而來的運用資金及現金流量相對於盈餘而言,是否具增額資訊內涵?動機來自於我國於民國78年12月28日公布現金流量表取代財務狀況變動表,前者之主要衡量指標為營業活動現金流量,後者則為營業而來之運用資金,而以前者取代後者的理由究竟是因營業活動現金流量較營業而來運用資金更具資訊內涵?抑或是營業而萊的運用資金與盈餘之相關性太高,導致該指標無增額資訊內涵,而須提供與盈餘相關性較低的現金流量資訊?還是財務狀況妥動表相對於損益表及現金流量表而言,已無法提供增額資訊內涵?由於相關研究結果分歧,故本論文試圖做一深入瞭解。
本研究採事件研究法(Event Study),藉由橫斷面分析,透過四階段進行測試:第一階段比較營業而來的運用資金及營業活動現金流量之相對資訊內涵;第二階段則加入稅後盈餘,測試第一階段之自變數相對於稅後盈餘而言,是否具增額資訊內涵,至於測試方法則採用可能比例測試法(Liklihood Ratio Test),測試全迴歸模式中,某一特定變數的估計值是否異於零的方式;第三階段則將異積異常報酬(CAR)分成高、中、低三組,重新檢視一、二階段之結果,看是否在三組間能獲得相同的結論。最後則測試重大非營業項目及土地重估增值之增額資訊內涵。
本研究以162家國內上市製造業為樣本,蒐集其民國八十年至八十四年之財務資料進行實證研究,獲致以下結論:
一、營業而來的運用資金及現金流量相對資訊內涵之比較以年度資料及Pooling結果觀之,除民國80年之營業而來運用資金及營業活動現金活動與股票報酬有顯著關聯性外,其餘年度(包括pooling)則否,故無法得出年度之一般化結論。但若將累積異常報酬之pooling結果依大小分為三組,結果發現高報酬組中,營業而來的運用資金與股票報酬關聯性大於營業活動現金流量,此項結果與前者為加計流動性應計項目之資訊有關,而另外兩組無法得出結論。
二、營業而來的運用資金及現金流量增額資訊內涵之比較以年度資料觀之,民國80年的營業而來運用資金有超越盈餘及營業活動現金流量之增額資訊內涵。而從分組結果得知,高報酬組中,盈餘及營業而來的運用資金皆具有增額資訊內涵。
三、重大非營業項目及土地重估增值資訊內涵之比較以分組結果觀之,在高報酬組中,迴歸模式主要解釋能力來自盈餘,而處分投資、固定資產利得及土地重估增值均無增額資訊內涵;但在中、低報酬組及Pooling,處分固定資產利益皆具增額資訊內涵。 / This study aims to examine the incremental information contents of working capitals and cash flows which is mainly motivated by the mandated accounting regulation in relation to statement of cash flows on December 28, 1989. The empirical analysis includes 162 samples covering from 1991 to 1995. The findings can be summarized as follows.
1. In addition to the samples of 1991, no significant association between cash flows from operations (including working capitals from operations) and stock returns can be detected. Among high returns sample group, the working capital from operations significantly associates with stock returns, if all samples are pooled.
2. In 1991, the working capitals from operations has significant incremental information contents. In addition, among high returns samples the working capital from operations has significant incremental information contents, if all samples are pooled.
3. Among high returns samples, the explanatory power of stock returns is mainly derived from earnings. In addition, gain on disposal of fixed asset has significant incremental information contents in medium and low return sample groups.
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