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Real-world evidence (RWE) plays a crucial role in understanding the impact of medical interventions and uncovering disparities in clinical practice. However, confounding bias, especially unmeasured confounding, poses challenges to inferring causal relationships from observational data, such as estimating treatment effects and treatment responses. Various methods have been developed to reduce confounding bias, including methods specific for detecting and adjusting for unmeasured confounding. However, these methods typically rely on assumptions that are either untestable or too strong to hold in practice. Some methods also require domain knowledge that is rarely available in medicine. Despite recent advances in method development, the challenge of unmeasured confounding in observational studies persists. This dissertation provides insights in adjusting for unmeasured confounding by exploiting correlations within electronic health records (EHRs). In Aim 1, we demonstrate a novel use of probabilistic model for inferring unmeasured confounders from drug co-prescription pattern. In Aim 2, we provide theoretical justifications and empirical evidence that adjusting for all (pre-treatment) covariates without explicitly selecting for confounders, as implemented in the large-scale propensity score (LSPS) method, offers a more robust approach to mitigating unmeasured confounding. In Aim 3, we shift focus to the problem of evaluating fairness of treatment allocation in clinical practice from a causal perspective. We develop a causal fairness algorithm for assessing treatment allocation. By applying this fairness analysis method to a cohort of patients with coronary artery disease from EHR data, we uncover disparities in treatment allocation based on gender and race, highlighting the importance of addressing fairness concerns in clinical practice. Furthermore, we demonstrate that social determinants of health, variables that are often unavailable in EHR databases and are potential unmeasured confounders, do not significantly impact the estimation of treatment responses when conditioned on clinical features from EHR data, shedding light on the intricate relationship between EHR features and social determinants of health. Collectively, this dissertation contributes valuable insights into addressing unmeasured confounding in the context of evidence generation from EHRs. These findings have significant implications for improving the reliability of observational studies and promoting equitable healthcare practices.

As a result of our heavy reliance on internet usage and running online transactions, authentication has become a routine part of our daily lives. So, what happens when we lose or cannot use our digital credentials? Can we securely recover our accounts? How do we ensure it is the genuine user that is attempting a recovery while at the same time not introducing too much friction for the user? In this dissertation, we present research results demonstrating that account recovery is a growing need for users as they increase their online activity and use different authentication factors. We highlight that the account recovery process is the weakest link in the authentication domain because it is vulnerable to account takeover attacks because of the less secure fallback authentication mechanisms usually used. To close this gap, we study user behavior-based machine learning (ML) modeling as a critical part of the account recovery process. The primary threat model for ML implementation in the context of authentication is poisoning and evasion attacks. Towards that end, we research randomized modeling techniques and present the most effective randomization strategy in the context of user behavioral biometrics modeling for account recovery authentication. We found that a randomization strategy that exclusively relied on the user’s data, such as stochastically varying the features used to generate an ensemble of models, outperformed a design that incorporated external data, such as adding gaussian noise to outputs. This dissertation asserts that account recovery process security posture can be vastly improved by incorporating user behavior modeling to add resiliency against account takeover attacks and nudging users towards voluntary adoption of more robust authentication factors.

The immaculate control of atoms and molecules with light is the defining trait of modern experiments in ultracold physics. The rich internal degrees of freedom afforded by molecules enrich the toolbox of precision spectroscopy for fundamental physics, and hold great promise for applications in quantum simulation and quantum information science. A vibrational molecular lattice clock with systematic fractional uncertainty at the 14th decimal place is demonstrated for the first time, matching the performance of the earliest optical atomic clocks. Van der Waals dimers of strontium are created at ultracold temperatures and levitated by an optical standing wave, whose wavelength is finely tuned to preserve the delicate molecular vibrational coherence. Guided by quantum chemistry theory refined by highly accurate frequency-comb-assisted laser spectroscopy, record-long Rabi oscillations were demonstrated between vibrational molecular states that span the entire depth of the ground molecular potential. Enabled by the narrow molecular clock linewidth, hertz-level frequency shifts were resolved, facilitating the first characterization of molecular hyperpolarizability in this context. In a parallel effort, deeply bound strontium dimers are coherently created using the technique of stimulated Raman adiabatic passage. Ultracold collisions of alkaline-earth metal molecules in the absolute ground state are studied for the first time, revealing inelastic losses at the universal rate. This thesis reports one of the most accurate measurement of a molecule's vibrational transition frequency to date, which may potentially serve as a secondary representation of the SI unit of time in the terahertz (THz) band where standards are scarce. The prototypical molecular clock lays the important groundwork for future explorations into THz metrology, quantum chemistry, and fundamental interactions at atomic length scales.

The past decade has seen tremendous growth in potential applications of language technologies in our daily lives due to increasing data, computational resources, and user interfaces. An important step to support emerging applications is the development of algorithms for processing the rich variety of human-generated text and extracting relevant information. Machine learning, especially deep learning, has seen increasing success on various text benchmarks. However, while standard benchmarks have static tasks with expensive human-labeled data, real-world applications are characterized by dynamic task specifications and limited resources for data labeling, thus making it challenging to transfer the success of supervised machine learning to the real world. To deploy language technologies at scale, it is crucial to develop alternative techniques for teaching machines beyond data labeling. In this dissertation, we address this data labeling bottleneck by studying and presenting resource-efficient frameworks for teaching machine learning models to solve language tasks across diverse domains and languages. Our goal is to (i) support emerging real-world problems without the expensive requirement of large-scale manual data labeling; and (ii) assist humans in teaching machines via more flexible types of interaction. Towards this goal, we describe our collaborations with experts across domains (including public health, earth sciences, news, and e-commerce) to integrate weakly-supervised neural networks into operational systems, and we present efficient machine teaching frameworks that leverage flexible forms of declarative knowledge as supervision: coarse labels, large hierarchical taxonomies, seed words, bilingual word translations, and general labeling rules. First, we present two neural network architectures that we designed to leverage weak supervision in the form of coarse labels and hierarchical taxonomies, respectively, and highlight their successful integration into operational systems. Our Hierarchical Sigmoid Attention Network (HSAN) learns to highlight important sentences of potentially long documents without sentence-level supervision by, instead, using coarse-grained supervision at the document level. HSAN improves over previous weakly supervised learning approaches across sentiment classification benchmarks and has been deployed to help inspections in health departments for the discovery of foodborne illness outbreaks. We also present TXtract, a neural network that extracts attributes for e-commerce products from thousands of diverse categories without using manually labeled data for each category, by instead considering category relationships in a hierarchical taxonomy. TXtract is a core component of Amazon’s AutoKnow, a system that collects knowledge facts for over 10K product categories, and serves such information to Amazon search and product detail pages. Second, we present architecture-agnostic machine teaching frameworks that we applied across domains, languages, and tasks. Our weakly-supervised co-training framework can train any type of text classifier using just a small number of class-indicative seed words and unlabeled data. In contrast to previous work that use seed words to initialize embedding layers, our iterative seed word distillation (ISWD) method leverages the predictive power of seed words as supervision signals and shows strong performance improvements for aspect detection in reviews across domains and languages. We further demonstrate the cross-lingual transfer abilities of our co-training approach via cross-lingual teacher-student (CLTS), a method for training document classifiers across diverse languages using labeled documents only in English and a limited budget for bilingual translations. Not all classification tasks, however, can be effectively addressed using human supervision in the form of seed words. To capture a broader variety of tasks, we present weakly-supervised self-training (ASTRA), a weakly-supervised learning framework for training a classifier using more general labeling rules in addition to labeled and unlabeled data. As a complete set of accurate rules may be hard to obtain all in one shot, we further present an interactive framework that assists human annotators by automatically suggesting candidate labeling rules. In conclusion, this thesis demonstrates the benefits of teaching machines with different types of interaction than the standard data labeling paradigm and shows promising results for new applications across domains and languages. To facilitate future research, we publish our code implementations and design new challenging benchmarks with various types of supervision. We believe that our proposed frameworks and experimental findings will influence research and will enable new applications of language technologies without the costly requirement of large manually labeled datasets.

Piezoelectricity crystal is used in different area in industry, such as downhole oil, gas industry, and ballistics. The piezoelectricity crystals are able to create electric fields due to mechanical deformation called the direct piezoelectric effect, or create mechanical deformation due to the effect of electric field called the indirect piezoelectric effect. In this thesis, piezoelectricity effect is the core part. There are 4 parts in the frequency output pressure transducer: two crystal oscillators, phase-locked loop (PLL), mixer, frequency counter. Crystal oscillator is used to activate the piezoelectricity crystal which is made from quartz. The resonance frequency of the piezoelectricity crystal will be increased with the higher pressure applied. The signal of the resonance frequency will be transmitted to the PLL. The function of the PLL is detect the frequency change in the input signal and makes the output of the PLL has the same frequency and same phase with the input signal. The output of the PLL will be transmitted to a Mixer. The mixer has two inputs and one output. One input signal is from the pressure crystal oscillator and another one is from the reference crystal oscillator. The frequency difference of the two signal will transmitted to the frequency counter from the output of the mixer. Thus, the frequency output pressure transducer with a frequency counter is a portable device which is able to measure the pressure without oscilloscope or computer.