No description available.

No description available.

Syfte: Syftet med studien var att kartlägga förekomst och undersöka samband mellan stress och depression hos patienter som genomgått en hjärtinfarkt. Syftet var även att undersöka eventuella skillnader mellan män och kvinnors upplevelser av stress och depression vid hjärtinfarkt. Metod: Patienter som vårdats på en hjärtavdelning för hjärtinfarkt i Mellansverige och är svensktalande inkluderades i studien. Enkäterna Vardagslivets Stress och MADRS-S användes som mätinstrument. Resultat: Antalet inkluderade deltagare i studien var 20 stycken. Förekomsten av självskattad depression uppgick till 5 % efter en hjärtinfarkt. Förekomst av självskattad stress sågs hos totalt 20 % av deltagarna, av dessa var det 5 % som hamnade i den högsta kategorin av stress. Inget samband konstaterades mellan depression och stress (r=0,15), signifikans (p=0,52). Skillnader mellan män och kvinnors upplevelser av stress och depression vid hjärtinfarkt kunde ej bestämmas i denna studie. Slutsats: Denna studie är relativt liten och omfattar endast 20 deltagare. För att kunna dra giltiga slutsatser, krävs en mer omfattande studie som inkluderar fler deltagare och har en jämnare könsfördelning. / Purpose: The purpose of this study was to evaluate the prevalence and to examine the correlation between stress and depression among patients that have had a myocardial infarction. The purpose was also to examine differences between men and women and their experiences of stress and depression due to myocardial infarction. Methods: Patients who received treatment at a cardiac department in the central parts of Sweden and spoke the Swedish language were included in the study. The questionnaires Everyday Life Stress and MADRS-S were used as measurements. Results: 20 participants were included in the study. The prevalence of self-rated depression was 5 %. Self-rated stress was found among 20 % of the participants, and of these 5 % fell into the highest category of stress. No correlation could be found between depression and stress (r=0.15), significance (p=0,52). Differences in experiences between men and women regarding stress and depression due to myocardial infaction could not be determined. Conclusion: This study is relatively small and covers only 20 participants. In order to reach valid conclusions, a more comprehensive study should be made that includes more participants and with better gender balance.

Syftet med föreliggande litteraturstudie var att beskriva vad som framkommer om socialt stöd och livsstilsförändringar efter hjärtinfarkt. Studien är en beskrivande litteraturstudie som innefattar tio vetenskapliga artiklar vilka har granskats av författarna och därefter kvalitetsbedömts. Resultatet visade att livsstilsförändringar inte var lätta att genomföra. Det sociala stödet var viktigt för att de olika livsstilsförändringarna skulle klaras av och att stödets utformning skulle vara anpassat efter den hjärtinfarktdrabbades behov. För mycket eller för litet stöd hade negativ inverkan på hur patienten lyckades med livsstilsförändringarna. Personalen på sjukhuset hade stor inverkan på hur lyckad livsstilsförändringarna skulle bli. Sjukvårdspersonalen behövde stödja både hjärtinfarktdrabbade och anhöriga för att rehabiliteringen skulle bli lyckad. De slutsatser som dragits från föreliggande studie är, att socialt stöd påverkar hjärtinfarktdrabbades möjlighet att genomföra livsstilsförändringar. Det sociala stödet kan få både en positiv och negativ inverkan på livsstilsförändringar. Det har visat sig vara viktigt att sjuksköterskan samarbetar med den hjärtinfarktdrabbade. Att anpassa situationen och informationen till respektive individ kan förbättra stödet från sjukvården. / The purpose of this study was to describe what is found about social support and lifestyle changes after a myocardial infarction. The study is a descriptive literature review that includes ten scientific articles that have been reviewed and qualitatively evaluated by the authors. The results showed that lifestyle changes were not easy to conduct. Social support was essential to cope with lifestyle changes and it was important that the aid was designed to match each individual. Too much or too little support had adverse effects on the lifestyle changes that needed to be made. The hospital staff had a major impact on how successful lifestyle changes would be. The hospital staff needed to support both myocardial infarction victims and relatives to make the rehabilitation a success to assure a full recovery. The conclusions drawn from this study is that social support affects myocardial infarction victims and their opportunity to conduct lifestyle changes. Social support can have both positive and negative effects on lifestyle changes. It has also proved to be of great importance that the nurse is collaborating with the myocardial infarction victim. Adjustment to the situation and information to each individual could change the support from the healthcare.

Syftet med den föreliggande litteraturstudien var att beskriva kvinnors respektive mäns livskvalitet efter insjuknande i hjärtinfarkt och de copingstrategier som användes i hanteringen av vardagen. En deskriptiv litteraturstudie genomfördes utifrån sex kvalitativa samt åtta kvantitativa studier med övervägande delen hög kvalitet. Publikationsåren för de inkluderade artiklarna var mellan 2000 och 2010. Artikelsökningen genomfördes i databaserna MedLine (PubMed) samt Cinahl med följande sökord: Hjärtinfarkt, anpassning, psykologisk, livskvalitet och coping. Sammanfattningsvis var vanligt förekommande problem under den första tiden efter insjuknande i hjärtinfarkt fysiska symtom och emotionell utmattning där tillfredsställande behandling och god sjukdomsinsikt kunde leda till välbefinnande. Följande faktorer såsom stress, oro, ångest, nedstämdhet, depression samt kronisk trötthet hade negativ inverkan på den upplevda livskvaliteten, liksom alltför omfattande livsstilsförändringar. Att återgå till sitt arbete hade däremot positiva effekter ur de fysiska och psykologiska aspekterna på livskvaliteten. Likaså hade det sociala nätverket inverkan på välbefinnandet där män i huvudsak sökte stöd från sin partner medan kvinnor även sökte sympati från övriga anhöriga. Optimistiska copingstrategier var vanligast bland både kvinnor och män, dock använde sig kvinnor av fler copingstrategier och hade svårare att hantera sin vardag än vad män hade. För ytterligare evidens i copingstrategier och genusskillnader krävs ytterligare forskning av komparativ design. / The purpose of this study was to describe perceived quality of life and used coping in daily life of women and men after myocardial infarction, which is described in the literature review included studies and methodological quality. A descriptive literature review was conducted based on six qualitative and eight quantitative studies of high quality nature. In conclusion, the year of publication of the studies was between the years of 2000 and 2010. The databases MedLine (Pubmed) and Cinahl were used in the searching of scientific articles with the following keywords: Myocardial infarction, Adaptation, Psychological, Quality of life and Coping. Furthermore, the findings in satisfaction of treatment and good insight in illness was increased in terms of well-being. Return to work appeared to bring positive outcomes of the physical and psychological aspects in quality of life. By the same token, social network had an impact in terms of well-being, since men mainly perceived available support trough their partner as women in larger extension perceived available support from other relatives than men did. Optimistic coping was the most frequently used strategy by both women and men, however, women practiced several strategies of coping. Also, difficulties were found in women managing their daily life compared to men. Regarding coping strategies as well as gender differences, further research is to claim.

No description available.

<p>In a mouse model of ischemic stroke, infarct volume is highly variable and strain dependent, but the natural genetic determinants responsible for this difference remain unknown. To identify genetic determinants regulating ischemic neuronal damage and to dissect apart the role of individual genes and physiological mechanisms in infarction in mice, we performed forward genetic mapping analyses of surgically induced cerebral infarct volume. We have identified multiple quantitative trait loci (QTL) that modulate infarct volume, with a major locus (<italic>Civq1 </italic>) on chromosome 7 accounting for over 50% of the variation, with a combined LOD score of 21.7. Measurement of infarct volume in chromosome substitution strains (CSS) and two additional intercrosses validate that <italic>Civq1</italic> on chromosome 7 is present in multiple inbred strains. Interval-specific ancestral SNP haplotype analysis for <italic>Civq1</italic> results in 5 candidate genes. A causative gene underlying <italic>Civq1</italic> may regulate collateral artery formation and genetic variations in the gene may result in the differential outcome of cerebral infarction. Additionally, we have identified a locus of large effect, <italic>Civq4</italic>, modulating infarct volume through a mechanism different from collateral circulation. In conclusion, the extent of ischemic tissue damage after distal middle cerebral artery occlusion (MCAO) in inbred strains of mice is regulated by genetic variation mapping to at least 4 different loci. A single locus on chromosome 7 determines the majority of the observed variation in the trait in multiple mouse strains. <italic>Civq1</italic> appears to be identical to <italic>Lsq1</italic>, a locus conferring limb salvage and reperfusion in hindlimb ischemia. The identification of the genes underlying these loci may uncover novel genetic and physiological pathways that modulate cerebral infarction and provide new targets for therapeutic intervention in ischemic stroke, and possibly other human vascular occlusive diseases.</p> / Dissertation

Background: Evidence-based medicine (EBM) receives significant attention worldwide. Many studies have used questionnaires to discuss the factors obstructing the practice of EBM. There has however been no large-scale data analysis on who and when to practice EBM. This study aims to fill this gap in research by applying nationally representative data to analyze EBM practice after the provision of new evidence regarding rosiglitazone prescription. Methods: We used the National Health Insurance Database in Taiwan to analyze the changes in the prescription of rosiglitazone after meta-analysis found the drug to increase the risk of myocardial infarction. The study period was 18 months from the second quarter of 2007 to the fourth quarter in 2008. Two models of doctors¡¦ prescription behaviors were analyzed in the study. We conducted univariate analyses to distinguish significant differences in the variable and applied multivariate logistic analyses to predict the probability of physicians ceasing to prescribe rosiglitazone. Results: We found a significant improvement in EBM practice from specialists and experienced physicians. When compared to other specialists, endocrinologists were four times more likely to change rosiglitazone prescription (OR: 4.129, 95% CI: 2.484-6.863). Doctors with more than 10 years of specialist experience performed better in EBM practice than younger doctors. The hospital level that a physician worked at was not a significant factor. Local urbanization and economic status did not affect the practice of EBM by physicians in clinics either. Conclusions: Our study found that the EBM was still not well practiced among doctors in Taiwan. The practice of new evidence depended on the specialty or professional experience. Younger doctors and doctors working in medical centers seemed not to practice EBM well. In clinics, patients did not have enough influence to modify the doctor¡¦s prescription behavior. There was a significant time lag between the EBM emergence and EBM practice. This suggests that setting up an authoritative organization to provide timely EBM recommendations is very important. Further improvements to the practice of EBM are still urgently needed within the medical community.

<p>Successful treatment of myocardial infarction requires anearly and accurate diagnosis. Recent studies have shown thatacute myocardial scintigraphy has a high predictive value forprognosis of myocardial events. Three dimensional (3D)perfusion data obtained with SPECT are however very rare in theemergency department (ED).</p><p>We have developed a mobile tomographic system for myocardialscintigraphy, which can be used in the ED. The objectives ofthe studies presented were:</p><p>    To develop software and hardware for a mobile tomographicgamma camera system: the Cardiotom</p><p>    To demonstrate that a mobile tomographic system can beused in a clinical situation</p><p>    To evaluate the limitations of Ectomography when usingfiltered back projection for reconstruction</p><p>    To develop a method of reconstruction that compensatesfor the incomplete data acquisition associated with theacquisition geometry of Ectomography</p><p>Three prototypes of a mobile tomographic gamma camera systemhave been designed and built at the Division of MedicalEngineering, which all have been used in a clinical setting.The systems are based on Ectomography, a limited view anglemethod, also developed by us. Instead of rotating the entiregamma camera detector around the patient as in SPECT, a slanthole collimator is rotated in front of a stationary detector.Since short imaging times are important in the ED and the heartonly occupies a small area of the detector, system sensitivityhas been increased by dividing the collimator into segmentswith different projection directions. In myocardial imaging, 4segments are used and within 10 minutes from the start ofacquisition, reconstructed short axis view sections areavailable for interpretation.</p><p>Using the Cardiotom in an experimental animal study, weverified that the system could be used to quantify myocardialarea at risk and final infarct size. This conclusion was madefrom a comparison of images obtained from the Cardiotom andpathological staining of the myocardium, analysedpost-mortem.</p><p>Inherent limitations of Ectomography were evaluated withboth phantom studies and computer simulated data, reconstructedusing filtered back-projection Results show that moderatedeviation from optimal position of the detector with respect tothe myocardium will have little or no influence on thediagnostic information when assessed from short axis sectionimages and polar tomograms. However, long axis section imagesappear elongated when reconstructed using filteredback-projection.</p><p>We have shown that this elongation distortion can besuppressed using iterative reconstructions techniques, and wehave implemented such an algorithm, called three-dimensionalTotal Variation Expectation Maximisation (3DTV-EM). Resultswere that elongation distortion was reduced and depthresolution improved. The reconstruction technique was alsoevaluated for SPECT reconstruction and was found to decreasethe noise in reconstructed images, when compared to thetwo-dimensional TV-EM algorithm. Noise pattern were also foundto be more uniform for the 3DTV-EM algorithm compared totwo-dimensional TV-EM.</p><p>In conclusion, we have shown that the Cardiotom may beuseful in a clinical acute setting, providing valuablediagnostic information. Rapid positioning is possible, sincemoderate deviation from optimal positioning will cause few orno artefacts. Image quality can be improved if iterativetechniques are used for image reconstruction instead offiltered back-projection.</p><p><b>Keywords</b>: acute studies, myocardial infarction,scintigraphy, mobile gamma camera, tomography.</p>

Es werden in einer kumulativen Dissertationsschrift zwei wissenschaftliche Arbeiten zusammengefasst. Die erste Arbeit beschreibt die Etablierung der Kontrastmittelechokardiografie zur Charakterisierung des Herzinfarktmodells an der Ratte im zeitlichen Verlauf. Es wird der Ablauf der geometrischen Änderungen am linken Herz nach Herzinfarkt gezeigt. Zusätzlich wird die Methode mit anderen etablierten echokardiografischen Methoden verglichen. Hier wird die Messung der linksventrikulären Querschnittsfläche der Volumenbestimmung nach der modifizierten Simpson-Methode gegenübergestellt. Es wird gezeigt, dass die Flächenmessungen, bei Nichtverfügbarkeit der Kontrastmittelechokardiografie eine valide Methode zur Verlaufsbeobachtung im Modell darstellt. Die zweite Arbeit untersucht im Rattenversuch den Einfluss von mesenchymalen Vorläuferzellen aus Nabelschnurblut auf die Entwicklung des Herzversagens nach Herzinfarkt. Die Injektion der Zellen erfolgt direkt in das Herzmuskelgewebe am Rand des Infarktareals. Zusätzlich zur Phänotypisierung mittels Echokardiografie wurden hämodynamische Messungen, sowie immunhistochemische und molekularbiologische Untersuchungen vorgenommen. Es konnte in einem Multigruppendesign gezeigt werden, dass im vorliegenden Versuch durch die Injektion von Vorläuferzellen kein Einfluss auf die geometrischen und biomechanischen Änderungen nach Herzinfarkt genommen werden konnte. Es konnten jedoch zusätzlich Differenzen zwischen den Versuchsgruppen in der Genexpression von Signalmolekülen der extrazellulären Matrix gezeigt werden, welche Spekulationen über den Einfluss der Zellen auf parakrine Mechanismen im Herzgewebe zulassen.