Bakgrund: Outsourcing är inget nytt fenomen då transaktionskostnadsteorin formades 1937 som beskrev att företag bör vända sig till marknaden i de fall detta gynnade företaget ekonomiskt. Sedan dess har teorier kring outsourcing förändrats och i dag handlar outsourcing om att kunna fokusera på företagets kärnkompetens och vilka möjligheter och risker outsourcing medför. Läkemedelsbranschen har på senare år börjat outsourca forskning och produktutveckling, vilka ses som kärnprocesser. Det råder därför delade meningar om branschen faktiskt har en kärnprocess. Syfte: Syftet med denna uppsats är att förstå hur och varför läkemedelstillverkningsbranschen outsourcar, om de outsourcade processerna har koppling till företags kärnprocesser och hur outsourcing faktiskt påverkar företaget, både monetärt och icke-monetärt. Metod: Det empiriska materialet insamlades med både kvantitativ och kvalitativ metod. En enkätundersökning genomfördes för att få en generell bild av hur läkemedelstillverkningsbranschen outsourcar för att sedan genomföra tre intervjuer för att få djupare kunskap om varför företag gjort de angivna val kring outsourcing. De intervjuade företagen valdes ut genom ett typiskt urval där företag valdes som svarat utifrån vissa bestämda kriterier. Slutsats: Uppsatsen har belyst att den vanligaste processen att outsourca är tillverkning, men att även forskning och produktutveckling outsourcas till viss del. Detta berodde på att företag upplevde resurs- och kunskapsbrist inom de outsourcade processerna. Studien fann även att sambandet mellan anledningen till och utfallet av outsourcing var svagt. Däremot hamnade den ökade lönsamheten sist inom båda kategorierna. Det påvisades också att det är svårt att definiera en kärnprocess till branschen med anledning av den diversifiering som i dag karaktäriserar branschen. Däremot framkom produktutveckling som den vanligaste kärnprocessen inom företag, där det visade sig att företag inte tenderar att outsourca sin kärnprocess. / Background: Outsourcing is not a new phenomenon. Transaction cost theory was formed in 1937, which described that companies should transfer activities externally when this benefited companies financially. Since then, theories of outsourcing have changed and today, it has been switched to outsourcing of core competencies and a discussion of both opportunities and risks. In recent years the pharmaceutical industry has started to outsource their research and product development, which is considered a core process. Due to this there is a debate whether or not the industry has a core process. Purpose: The purposes of this thesis are to understand how and why the pharmaceutical manufacturing industry is outsourcing, how the outsourced processes relate to their core processes and how outsourcing affects the companies, both monetary and non-monetary. Method: The empirical evidence was gathered with both quantitative and qualitative methods. Firstly, a survey was conducted to get a general picture of how the pharmaceutical manufacturing industry outsources which was then followed by three interviews to gain an in-depth knowledge of why companies have made specified decisions regarding outsourcing. The companies were selected according to a number of specific criteria. Conclusion: The thesis has highlighted that manufacturing is the most common process of outsourcing, but also that research and product development is outsourced to some extent. This was due to the fact that companies experienced resource and knowledge shortage in the outsourced processes. The study also found that the relation between the reason and the outcome of outsourcing was weak. However, the increased profitability ended last in both categories. It was also found that it is difficult to define a core process within the industry due to the diversification that today characterizes the industry. On the other hand, product development appear to be the most common core process within companies, where it also shows that companies tend not to outsource their core process.

4 Summary Altogether, the six most common bee viruses which infect the honey bee (Apis mellifera) were monitored in the territory of the Czech Republic between 2006 and 2009. Parallel infections of viruses (DWV, ABPV and BQCV) in bee adults and parallel co- infection of viruses with fungal diseases caused by Nosema apis and Nosema ceranae were confirmed by PCR tests. A new sensitive method of detection of the originator of the American foulbrood (Paenibacillus larvae) from bee debris was developed for the practical use of detection of AFB disease in bee populations. Various approaches for the extraction of spores from bee debris and lyses of spores were compared. The sensitivity of PCR tests for the presence of Paenibacillus larvae in debris was compared with the classic cultivation method. The PCR method for the detection American foulbrood was further studied and developed to be more efficient. A new method, based on a matrix-like sample re-arrangement and a use of pooled samples, has been developed for testing 1000 samples in 35 PCR reactions. Another goal was to develop a robust and fast screening method for American foulbrood based on the cultivation test using paper sheets RIDA®COUNT with a specific cultivation medium, specific selection conditions for Paenibacillus larvae and chromogen visualization...

I will look at what impact big data have had on the managerial strategic decisions in the food and beverage industry. This in order to understand the complexity and theory of organizational strategic management, an effort to define the contemporary strategic theory into a holistic conceptual model is done through a literature review on organizational strategy. This literature explicitly proposes four distinctly different types of strategies that management need to consider in the organizational context. Namely, long-term strategy, internal business strategy, external corporate strategy, and competitive strategy. The study analyzed the food and beverage industry over a decade (2005-2014), where the three of the largest actors in the industry were selected, Nestlé S.A, PepsiCo Inc, and Unilever. The choice of method was content analysis, where three structured categorization matrixes were developed which each analyzed parts of the annual reports. The study propose the role of big data as a strategic tool for managerial decision from a theoretical standpoint. The content analysis show that hypothesis 1, could be confirmed, big data have an impact on all the proposed four managerial strategic decisions. Second hypothesis could not be confirmed, since decentralization does only occur for one of the organizations, but increased external environment turbulence could be concluded for the industry in general. The third hypothesis could be confirmed, which show that there is an increase in individualization due to increased customer involvement and demand. The analysis discovered three distinct time periods during the last decade, namely pre- economic instability period (2005-2007), economic instability period (2008-2011) and finally the post-paradigm period (2012-2014). Where the year 2011 was the most turbulent in terms of economy and technology for the industry. The study clearly show that customers are now involved in the production process, customers are co-creators of the products. There is now a two-way communication and increased social responsibility awareness. This study shows that the old traditional approach of looking at markets in order to position yourself to stay competitive are obsolete as this study predicted. customers demand to be a part of the organizational culture. This conclude that big data is an important tool for all strategic managerial decisions.

Background: Globalization, technological advancement and opportunity of capturing new markets have pushed business organizations to expand their business in the inter- national market. As a result, companies have established their subsidiaries in the host country and control their business from headquarters. Moreover, headquarters provide all the support such as training, strategies and knowledge to their subsidiary to perform better and help to build competitive advantage. The importance of knowledge transfer has increased in recent decades because knowledge is considered as an asset. Aim: The aim of the study is to analysis the method of knowledge transfer (explicit and tacit) from multinational companies headquarter to their subsidiaries. Methodology: In this paper, qualitative research approach has been followed with con- tent analysis technique. Primary data has been collected through interviews and Conve- nience sampling technique were used. Findings: Findings of the study shows that MNCs are using agency theory and knowl- edge base theory to transfer knowledge to their subsidiary. Most of the cases it has been observed that headquarters appeared as a knowledge creator whereas subsidiaries only utilize that knowledge. Moreover, manufacturing based companies transfer more explicit knowledge and service based companies transfer more tacit knowledge. Almost every MNCs use training, seminars, creating social groups and written instructions to transfer explicit and tacit knowledge to their subsidiaries. Study also found that there are some internal (hoarding behavior, non-invented here syndrome) and external factors (culture, language, location) which affect the knowledge transfer process of MNCs. Contribution of the study: This study will help managers around the world to under- stand the core concept of knowledge transfer, knowledge transfer method and factors affecting knowledge transfer. On the other hand, it will also help to design flawless channels to transfer knowledge. Scope of further studies: More interviews can be added including managers from the subsidiaries to get a more broader perspective. Also the studies can be done with com- paring different industries since knowledge is different depending on the industry. For example, the service Industry has more tacit knowledge than in the manufacturing indus- try.

Made available in DSpace on 2016-04-25T16:44:59Z (GMT). No. of bitstreams: 1 Gilmar Lima Hilario.pdf: 4391683 bytes, checksum: 9b2bffb0c354d5d73021c08c4604cee2 (MD5) Previous issue date: 2007-10-24 / The recognition that internal factors of the organization, among them knowledge, can act much more on its performance than the external factors, is collaborating to consolidate the use of new approaches for enterprise administration. Among these, are pointed out in this paper the Knowledge-Based View (KBV) and the Resource-Based View (RBV). In the information technology (IT) sector, in which the knowledge is used in an intensive way, the adoption of those approaches can be expressed through the increasing of the knowledge to the condition of an important asset for the company. Consequently, the adoption of knowledge management practices aims at producing better performance results and quality in the processes of products generation and services offerings. In this paper - drewed out from a Case Study with a Research-Action carried through in a business unit of a company supplier of specialized IT services the evaluation was focused on the potential contributions and main challenges for the adoption of knowledge management practices. As result, a knowledge management method was produced, whose application can contribute for knowledge mapping and dissemination in projects of same scope / O reconhecimento de que fatores internos da organização, entre eles o conhecimento, exercem uma influência significativamente maior sobre seu desempenho do que os fatores externos estão colaborando para consolidar a utilização de novas abordagens para gestão empresarial. Entre estas abordagens destacam-se neste trabalho a Visão da Empresa Baseado no Conhecimento (KBV Knowledge-Based View) e a Visão da Empresa Baseada em Recursos (RBV Resource-Based View). No setor de tecnologia da informação TI, em que o conhecimento é utilizado de maneira intensiva, a adoção dessas abordagens podem se traduzir na elevação do conhecimento à condição de importante ativo da empresa. Por conseqüência, a adoção de praticas de gestão do conhecimento tem como objetivo produzir melhores resultados de desempenho e qualidade nos processos de geração de produtos e prestação de serviços. Neste trabalho a partir de um estudo de caso com pesquisa ação - realizada em uma unidade de negócios de uma empresa prestadora de serviços especializados de TI busca-se avaliar as potenciais contribuições e principais desafios inerentes a adoção de práticas de gestão do conhecimento. Como resultado, produziu-se um método para gestão do conhecimento cuja aplicação pode trazer contribuições para mapeamento e disseminação de conhecimentos em projetos de mesmo teor

Made available in DSpace on 2016-04-25T16:44:37Z (GMT). No. of bitstreams: 1 Antonio Thomaz Pacheco Lessa Neto.pdf: 3151767 bytes, checksum: d39f096f36e24de37a2e846d245fa19e (MD5) Previous issue date: 2013-11-05 / Knowledge flows, especially in subsidiaries of multinational corporations, now have an increasing importance in organizations and therefore the discussion of research in the field. The aim of this work is to analyze flows not only through transfers, but also conversions of knowledge between the three families of intangible assets (external structure, internal structure and individual competence), since, for the creation of value, the key lies in the fact that such transfers and conversions be effective (SVEIBY, 2001). Concerning the method, this dissertation presents an empirical study through a survey applied along the Brazilian subsidiaries of multinational corporations, from a theoretical construct Knowledge-based view (KBV) where makes an analysis of the assets of individual competence, internal structure and external structure, and having for its object of study brazilian companies in Brazil listed in data collection known as the best and biggest from business magazine EXAME covering the year 2012. The study indicates, for the sample data (nine respondents) removed of the universe effectively researched (140 companies and not the initial 565), that there is the maximization of value creation from knowledge flows in two directions only by knowledge transfers and conversions of Individual Competencies for External Structure, within the Internal Structure, of Internal Structure for Individual Competencies and within the External Structure / Os fluxos de conhecimento, de modo especial em subsidiárias de corporações multinacionais, passam a ter uma importância crescente nas organizações e por consequência nas discussões de pesquisas no campo. O objetivo deste trabalho é a análise dos fluxos, não somente através das transferências, mas também das conversões, de conhecimento entre as três famílias de ativos intangíveis (estrutura externa, estrutura interna e competência individual), uma vez que, para a criação de valor, a chave reside no fato de tais transferências e conversões serem eficazes (SVEIBY, 2001). Quanto ao método, esta dissertação apresenta um estudo empírico desenvolvido através de uma survey aplicada junto às subsidiárias brasileiras de corporações multinacionais, a partir de um construto teórico da visão baseada no conhecimento (VBC) - ou Knowledge-based View (KBV) - onde se faz uma análise dos ativos de competência individual, de estrutura interna e de estrutura externa, e tendo por objeto de estudo as empresas do Brasil listadas no levantamento de dados conhecido como Melhores e Maiores da Revista EXAME referente ao ano de 2012. O estudo indica, para a amostra dos dados (nove respondentes) retirada do universo efetivamente pesquisado (140 empresas e não as 565 iniciais), que existe a maximização de criação de valor a partir dos fluxos de conhecimento em duas direções somente pelas transferências e conversões de conhecimento de Competências Individuais para a Estrutura Externa, dentro da Estrutura Interna, da Estrutura Interna para as Competências Individuais e dentro da Estrutura Externa

Submitted by PEDRO MESQUITA (pedrovmesquita@gmail.com) on 2016-01-26T13:59:53Z No. of bitstreams: 1 Dissertação MSc Pedro Mesquita.pdf: 333112 bytes, checksum: 19c620f913bea534bc0c66b9eab0c763 (MD5) / Approved for entry into archive by ÁUREA CORRÊA DA FONSECA CORRÊA DA FONSECA (aurea.fonseca@fgv.br) on 2016-01-27T18:52:08Z (GMT) No. of bitstreams: 1 Dissertação MSc Pedro Mesquita.pdf: 333112 bytes, checksum: 19c620f913bea534bc0c66b9eab0c763 (MD5) / Approved for entry into archive by Marcia Bacha (marcia.bacha@fgv.br) on 2016-02-01T11:55:48Z (GMT) No. of bitstreams: 1 Dissertação MSc Pedro Mesquita.pdf: 333112 bytes, checksum: 19c620f913bea534bc0c66b9eab0c763 (MD5) / Made available in DSpace on 2016-02-01T11:56:05Z (GMT). No. of bitstreams: 1 Dissertação MSc Pedro Mesquita.pdf: 333112 bytes, checksum: 19c620f913bea534bc0c66b9eab0c763 (MD5) Previous issue date: 2015-12-07 / Extant literature examined the benefits of relational embeddedness in facilitating collaboration between organizations, as well as the necessity of firms to balance their knowledge generation into exploration and exploitation activities. However, the effects of relational embeddedness in the specific outputs of firm-university collaborations, as well as the elements that affect the exploratory nature of such outcomes remain underexplored. By examining fine grained data of more than 4.000 collaborative research and development projects by a firm and universities, 5.000 patents, and 300.000 scientific publications, it was proposed that relational embeddedness would have a positive effect on resource commitment and on joint scientific publications, but a negative effect on joint patents and exploratory outcomes resulting of such collaborations. Additionally, it was proposed that knowledge similarity would have a negative impact in exploratory endeavors made in such projects. Although some of the propositions were not supported by the data, this study revealed that relational embeddedness increases resource commitment and the production of joint scientific publications in such partnerships. At last, this study presents interesting opportunities for future research. / A literatura existente examinou os benefícios de intensidade da relação como facilitador de colaborações entre organizações, assim como a necessidade de empresas balancearem a geração de conhecimento em ações exploratórias e de aplicação. Todavia, os efeitos da intensidade da relação nos resultados específicos das parcerias entre empresas e universidades, assim como os elementos que afetam a natureza exploratória desses resultados, permanecem subexplorados. Examinando dados detalhados de mais de 4.000 projetos de pesquisa e desenvolvimento em colaboração entre uma empresa e universidades, 5.000 patentes e 300.000 publicações científicas, foi proposto que a intensidade da relação teria um efeito positivo no investimento de recursos e na produção de artigos científicos conjuntos, porém um efeito negativo na geração de patentes conjuntas e nos empreendimentos exploratórios resultantes dessas colaborações. Adicionalmente, foi proposto que semelhança entre conhecimentos teria um efeito negativo nas iniciativas exploratórias realizadas nesses projetos. Apesar de algumas proposições não terem sido confirmadas pelos dados, esse estudo revelou que a intensidade da relação tem efeito positivo no investimento de recursos e na produção de artigos científicos conjuntos nessas parcerias. Por fim, o estudo apresenta oportunidades interessantes para pesquisas futuras.

L’abeille domestique (Apis mellifera) est un insecte qui contribue à l’agriculture par sa pollinisation. Le taux élevé des mortalités hivernales des colonies est préoccupant depuis des décennies au Canada. Plusieurs facteurs sont impliqués, particulièrement Varroa destructor; un parasite qui se nourrit du corps gras de l’abeille. Le développement d’outils adaptés permettrait un meilleur suivi des colonies. Le projet consiste à corréler l’infestation de varroa avec les concentrations en sucres sériques et les co-infections (virales et bactériennes). Cette étude compare dans le temps six ruches fortement infestées et six ruches traitées (témoins). Un prélèvement d’hémolymphe a été effectué pour mesurer les concentrations en sucres en utilisant un glucomètre humain préalablement validé. Les concentrations en sucres (glucose et tréhalose) dans l’hémolymphe étaient significativement plus faibles (p<0.001) dans les ruches fortement infestées que les témoins en septembre. L’analyse RT-PCR multiplexe de six virus (DWV A/B, BCQV, KBV, IAPV et ABPV) a démontré que les ruches fortement infestées présentent une infection simultanée virale avec des charges plus élevées que chez les ruches témoins (p<0.05) pour la majorité des virus, sauf pour ABPV. Chez les ruches fortement parasitées, les charges virales pour DWVA et BQCV sont plus élevées en septembre qu’en juillet (p≤0.0001). Serratia marcescens a été seulement détectée dans une ruche infestée et une ruche témoin. Une exposition continue et élevée à varroa occasionne, en automne, une augmentation des charges virales et une diminution des sucres, suggérant une altération de l’immunité, du métabolisme et des réserves. Ces paramètres provoquent une faiblesse et une mortalité des colonies. / The European honeybee (Apis mellifera) contributes to the agriculture by its pollination; however, the mean overwintering loss rate of colonies over the last decades in Canada is worrisome. Varroa destructor, which feeds on the fat bodies of honeybees, is considered one of the most important causes of bee colony declines. The development of adapted diagnostic tools would improve the monitoring of honeybee health. This project aims to correlate the infestation by varroa to the hemolymph sugar concentrations (trehalose and glucose) and bacterial and viral coinfections. Six highly infested and six treated hives were compared over time. Pooled hemolymph of honeybees was collected for sugar concentration measurements using a previously validated portable glucometer. The hemolymph samples were also submitted for bacteriology. Multiplex RT-PCR analyses were performed on pooled honeybees for six viruses: Deformed wing virus A and B (DWV-A/B), Bee Queen Cell Virus (BQCV), Acute Bee Paralysis Virus (ABPV), Kashmere Bee Virus (KBV), Israeli Acute Paralysis Virus (IAPV). The results show that, in September, sugar concentrations in hemolymph were significantly lower in highly infested hives (p<0.001). Infested hives showed markedly higher viral loads (p<0.05), except for ABPV. Viral loads were significantly higher (p≤0.0001) in September than in July for DWV-A and BQCV. Serratia marcescens was only detected in one infested hive and one control. Overall, a continued and severe exposure to varroa leads to increased viral charges and decreased sugar concentrations, suggesting alterations in immunity, metabolism and reserve mobilization. All these parameters contribute to the weakening and mortality of the colonies.