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Pixel-Based Algorithms for Data Analysis in Digital Pathology : Data Analysis of the BOMI2 Redox Dataset, A Step Away From Cell Segmentation Dependant MethodsWallgren Fjellander, Michael January 2019 (has links)
In this project report a novel pixel-based approach to digital pathology is proposed. The algorithm directly decides the class of single pixels in an image without needing the larger context of neighbouring pixels. This allows researchers to circumvent complications that might arise from using classical cell segmentation methods based around counting cells - which then relies on the cell segmentation being close to perfect. Such issues are avoided by pixel-based approaches by instead directly measuring total area. The algorithm is tested on the BOMI2 Redox dataset consisting of 79 samples of multi-spectral images from lung cancer patients. The results of the algorithm are compared against ground truth data in the form of RNA sequencing data from the same patient cores as the images are taken. The algorithm achieves Spearman correlations in the range of R = [0.4,0.6], thereby serving as an initial testament to the validity of pixel-based methods. Furthermore an automatic method for deciding biomarker threshold values is proposed, based around finding the knee point of the biomarker histogram. The threshold values found by the algorithm on the BOMI2 Redox data set are reasonable. The method opens up for a standardised way of deciding thresholds in digital pathology, allowing easier comparison between research results from different researchers.
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Dimenzování přístrojových transformátorů pro digitální ochrany / Design of instrument transformers for digital protection relaysSouček, Jan January 2009 (has links)
Master’s thesis is concerned with instrument transformers, which are used in conjunction with numerical protection relays. Therefore mainly with protective transformers of class P and transformers dimensioned for transient effects, which are important e.g. for fast differential or distance protections. The introduction includes fundamental notions, quantities and equations, which refers to instrumental current and voltage transformers. Below are mentioned connection diagrams of these transformers applied to specific electrical network types and faults, of which identification is required. These diagrams and faults are supplied with math equations and eventually with phasor diagrams. Noted informations corresponds to the present standards. Task of the next part is to compile requirements for dimensioning of current transformers, which imposes digital protections from ABB, AREVA and Siemens companies. These requirements, which mostly defines the minimal accuracy limit factor or the knee-point voltage of current transformer, are specified for individual protection terminals, eventually for specific protective functions. Part of the thesis is computer program developed as macro in the Microsoft Office Excel program via Visual Basic for Applications programming language. Program uses equations noted in this work and it can be used for quick dimensioning of current transformers for protective terminals from manufactures mentioned above.
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Berechnungsansatz für Strukturbauteile aus Holzfurnierlagenverbundwerkstoff – WVC / Calculation approach of structures made from Wood Veneer Composite – WVCEichhorn, Sven 15 February 2013 (has links) (PDF)
Es wird ein einfacher Berechnungsansatz für ein Baukastensystem aus Kastenprofilen verschiedener Querschnittsabmessungen erarbeitet. Diese Profile bestehen aus WVC (Wood Veneer Composites, Holzfurnierlagenverbundwerkstoffen). Der Ansatz bildet den statischen Lastfall und das Ermüdungsverhalten unter schwellende Dreipunktbiegung ab. Am Beispiel eines ausgewählten Strukturbauteils aus handelsüblichen Birkensperrholz wird der Berechnungsansatz konkretisiert und durch Versuche evaluiert. Aufbauend auf dem Kraft-Verformungsverhalten der analysierten Einzelbauteile und der kapillarporösen Struktur des Holzes wird bei dem Berechnungsansatz auf eine Analyse der Spannungen verzichtet. Stattdessen wird als Berechnungskriterium die kritische Normaldehnung in der Randfaser der Strukturbauteile genutzt. Weiterhin wird eine Methode vorgestellt um mittels niederzyklischen Ermüdungsversuchs (LCF, ca. 1e+03 Lastwechsel) den „Knickpunkt“ der Zeitfestigkeitslinie eines einstufigen Ermüdungsversuchs bei hohen Lastspielzahlen (HCF, 1e+06 bis 1e+07 Lastwechsel) für diese Strukturbauteile zu bestimmen. / It was developed a simple approach for the calculation of a modular construction system for box sections (profile structures) of different cross-sectional dimensions. These profile structures consists of WVC (Wood Veneer Composites). The approach maps the static load case and the fatigue behavior under pulsating three-point bending. By using a structural component made from commercial birch plywood, the calculation approach is specified and verified. Based on the force-deformation behavior of the analyzed single components in connection with the capillary-porous structure of the wood, the calculation approach dispense on an analysis of the tensions. Instead, a criterion, which calculates the critical normal strain in the outer fibers of the structural components, is used. Furthermore, a method of a low-cycle fatigue test (LCF, abbr. 1e+03 cycles) is presented. This method detects the “knee point" of the fatigue limit line for the profiles. That point is usually determined by the use of a high-cycle fatigue tests (HCF, 1e+06 until 1e+07 cycles).
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Berechnungsansatz für Strukturbauteile aus Holzfurnierlagenverbundwerkstoff – WVC: Berechnungsansatz für Strukturbauteile ausHolzfurnierlagenverbundwerkstoff – WVCEichhorn, Sven 19 December 2012 (has links)
Es wird ein einfacher Berechnungsansatz für ein Baukastensystem aus Kastenprofilen verschiedener Querschnittsabmessungen erarbeitet. Diese Profile bestehen aus WVC (Wood Veneer Composites, Holzfurnierlagenverbundwerkstoffen). Der Ansatz bildet den statischen Lastfall und das Ermüdungsverhalten unter schwellende Dreipunktbiegung ab. Am Beispiel eines ausgewählten Strukturbauteils aus handelsüblichen Birkensperrholz wird der Berechnungsansatz konkretisiert und durch Versuche evaluiert. Aufbauend auf dem Kraft-Verformungsverhalten der analysierten Einzelbauteile und der kapillarporösen Struktur des Holzes wird bei dem Berechnungsansatz auf eine Analyse der Spannungen verzichtet. Stattdessen wird als Berechnungskriterium die kritische Normaldehnung in der Randfaser der Strukturbauteile genutzt. Weiterhin wird eine Methode vorgestellt um mittels niederzyklischen Ermüdungsversuchs (LCF, ca. 1e+03 Lastwechsel) den „Knickpunkt“ der Zeitfestigkeitslinie eines einstufigen Ermüdungsversuchs bei hohen Lastspielzahlen (HCF, 1e+06 bis 1e+07 Lastwechsel) für diese Strukturbauteile zu bestimmen. / It was developed a simple approach for the calculation of a modular construction system for box sections (profile structures) of different cross-sectional dimensions. These profile structures consists of WVC (Wood Veneer Composites). The approach maps the static load case and the fatigue behavior under pulsating three-point bending. By using a structural component made from commercial birch plywood, the calculation approach is specified and verified. Based on the force-deformation behavior of the analyzed single components in connection with the capillary-porous structure of the wood, the calculation approach dispense on an analysis of the tensions. Instead, a criterion, which calculates the critical normal strain in the outer fibers of the structural components, is used. Furthermore, a method of a low-cycle fatigue test (LCF, abbr. 1e+03 cycles) is presented. This method detects the “knee point" of the fatigue limit line for the profiles. That point is usually determined by the use of a high-cycle fatigue tests (HCF, 1e+06 until 1e+07 cycles).
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