Die Vorteile von Microlearning gegenüber langatmiger (Online-) Schulungen liegen auf der Hand: Sie führen schnell zu Lernerfolgen, unterbrechen den Alltag nur kurz und entsprechen der Kultur der „Net Generation“. Mit einem Blogeintrag stellte sich Gabi Reinmann [Rei10a] diesen Argumenten offen entgegen und sprach sich für die Notwendigkeit langer Lernphasen für eine umfassende Bildung aus. Dabei widersprechen sich die Lernkonzepte nicht, sondern können und müssen einander ergänzen. Auch die dafür benötigten Lernmaterialen sollten nicht isoliert voneinander erstellt werden: durch eine geeignete Strukturierung können Bestandteile umfassenderer Schulungen für Microlearning-Einheiten wiederverwendet werden.

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The Assessment System implemented in this research has three characteristics. First ItemBank standardization¡Afollow and import IMS QTI specifications. Then, we can reuse ItemBank resource in other platforms which follow IMS QTI specification. Second ItemBank maintainable¡Athrid feedback information for teacher and student . Both implemented in feedback design through the assessment analysis agent.

Die Vorteile von Microlearning gegenüber langatmiger (Online-) Schulungen liegen auf der Hand: Sie führen schnell zu Lernerfolgen, unterbrechen den Alltag nur kurz und entsprechen der Kultur der „Net Generation“. Mit einem Blogeintrag stellte sich Gabi Reinmann [Rei10a] diesen Argumenten offen entgegen und sprach sich für die Notwendigkeit langer Lernphasen für eine umfassende Bildung aus. Dabei widersprechen sich die Lernkonzepte nicht, sondern können und müssen einander ergänzen. Auch die dafür benötigten Lernmaterialen sollten nicht isoliert voneinander erstellt werden: durch eine geeignete Strukturierung können Bestandteile umfassenderer Schulungen für Microlearning-Einheiten wiederverwendet werden.

Many researchers have investigated ways to improve the separation power of conventional chromatography, most notable is the development of ultra-high performance liquid chromatography (UHPLC). However, only slight improvements in separation efficiency have been achieved up to this point, and unfortunately, modern reversed phase liquid chromatography (RPLC) methods do not have high enough resolving power to analyze complex proteomic mixtures.Uniformly sized silica particles from 10 nm to 1 micron are known to self-assemble into a highly ordered face centered cubic crystal. Silica colloidal crystals have shown recent promise in biological applications such as permselective nanoporous membranes, DNA sieving, reversed phase separation of small molecules on planar substrates, protein sieving, microarrays, total internal reflection fluorescence microscopy of live cells, and 3-D scaffolds for supported lipid films. In this work, silica colloidal crystals packed in capillaries are explored for their potential improvement in the efficiency of reversed phase chromatography.The silica colloidal crystal columns were chemically stabilized by with trichlorosilanes. The trichlorosilanes form chemical bonds between the particles and the particles and the substrate creating an increase in mechanical stability, and at the same time, providing an excellent chromatographic monolayer. After stabilization the fritless columns were able to withstand the pressure limit of the commercial UHPLC. Next, the columns were characterized using a small dye molecule, 1,1' - Didodecyl - 3,3,3',3' - tetramethylindocarbocyanine (DiIC12). The dye was run under capillary electrochromatography (CEC), and sub-micron plate heights were achieved. Further, a van Deemter plot of the dye molecule indicates that the plate height is largely due to the molecule's diffusion. This result suggests that the plate heights for proteins would be even smaller, since proteins have diffusion coefficients an order of magnitude smaller. The analysis of proteins by CEC yielded nanometer plate heights. Finally, pressure driven flow separations coupled with nano-electrospray ionization (n-ESI) MS have also been explored. The Poiseuille flow profile has been shown not to perturb the low plate heights. Gradient elution of peptides was also achieved, and the results demonstrate the highest chromatographic peak capacities for short analysis times to date.

Benzodiazepines (Benzos) and ketamine (K) are compounds that have been encountered in Drug-Facilitated Sexual Assault (DFSA) cases. Due to the intimate nature of these crimes, evidence collection is often postponed due to delays and/or reluctance in reporting these crimes. Further delays in analysis may be encountered in laboratories with large caseloads and/or backlogs. Drug identification in biological samples is important to determine whether victims knowingly or unknowingly took an impairing substance, however, the results could be negative due to chemical degradation over a long storage period. The purpose of this project was to study if degradation could be prevented with a new preservation method at the time of collection. Urine samples were prepared by the addition of K and metabolites and selected benzos and metabolites that were subjected to different sample pre-treatment techniques, and were analyzed after storage at room temperature (25°C), refrigerator (4°C) and freezer (-20°). The samples were either pre-treated with preservative (0.5% toluene) or filtration sterilization (sterile filter kit) within two hours after sample collection, and a control group with no pre-treatment was incorporated into the study for comparison. The changes in concentrations over 50 days (Benzos group) and 210 days (K group) were evaluated between different pre-treated methods and different temperature conditions. Sample that were treated with 0.5% toluene showed the most degradation: 44% of oxazepam and 96% of diazepam degraded over 10 days, and 80% of dehydronorketamine degraded after storage of 150 days regardless the temperature conditions. Clonazepam and flunitrazepam concentrations were reduced by 80% of the original concentration when stored at room temperature for 10 days. The major benzodiazepines evaluated in this study were stable when stored in the freezer. In K group, ketamine and norketamine that were stored at room temperature and refrigerated over 210 days were stable, however, degradation was observed after 150 days when the samples were stored in the freezer. There was no statistically different change observed among the samples pre-treated with or without filtration sterilization. Each sample pH was measured and it was determined that those stored at room temperature had an average pH of 8.5, while samples stored in the refrigerator and freezer had an average pH of 6.7 and 6.5, respectively. This finding revealed that pH could be the major factor affecting compound degradation rather than the bacterial contamination with high pH contributing to degradation, and low pH potentially preventing sample lost.

The goal of my master's thesis is a description of the Moodle learning management system, and demonstration of its usability in human resources supporting the whole process of systematical approach in training and further development of employees. In order to confirm its applicability I describe the real system implementation. My master's thesis also includes supporting objectives to support the main objectives. The purpose of their use is to introduce the reader to the problematic of training and further development. Supporting objectives are: to introduce the issue of training and further development of employees in organizations, introduction of systematical approach to training of employees in organizations, introduction of methods and forms of education with a focus on e-learning and blended learning and introduction of learning management systems and learning content management systems.

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