The central nervous system (CNS) develops in a temporally and spatially organised manner. Any adverse events happening during the critical periods of early brain formation may lead to arrest in the process or injury to specific developed structures. Infants born at less than 30 weeks of gestation and those with intra-partum asphyxia are at risk of motor delay. The cause of this delay may be related to injuries in the brain such as the motor cortex, basal ganglia and cerebellum, all of which are essential in controlling movements. According to the dynamical systems theory of motor development, other than the CNS, body systems within the infant such as the musculoskeletal system, and external to the infant such as environmental enrichment and supportive child-rearing practice also have a decisive role in motor development in infants. / Paediatric physiotherapists have been involved in the management of these infants since birth. A number of well-established assessment tools are used to assess these infants’ motor functions. Most of these tools typically do not describe the movement patterns of infants but emphasise the achievement of age-specific motor milestones. The Alberta Infant Motor Scale (AIMS) is one of the few tools that acknowledge the importance of movement quality. / The overall aim of the present research was to examine the impact of adverse events in early infancy, including birth prior to 30 weeks of gestation and intra-partum asphyxia, on motor development of infants during the first two years of (corrected) age. One hundred and twenty infants were recruited, including 58 preterm infants, 10 infants with post-asphyxia neonatal encephalopathy (NE) and 52 term born infants as the control group. All the infants were assessed using the AIMS at 4, 8, 12 and 18 months of (corrected) age. / The preterm group scored significantly lower on various sub-scores of the AIMS at all age levels than the control group. Uneven progression in the sit subscale from 4 to 8 months corrected age (CA) was found in the preterm infants, possibly due to a dominant extensor strength, inadequate tonus and postural control in the trunk. At 12 and 18 months CA, limited variations in movements were evident in some preterm infants in the crawling, sitting and standing positions. The ten infants with post-asphyxia NE showed scattered motor development, related mostly to the severity of their NE. The moderate NE group had the most varied motor outcomes ranging from normal to suspected mild cerebral palsy. / The AIMS was shown to be a valid assessment tool in the preterm population although limitations in its use were found at 4 months CA and when the infants walked or were close to independent ambulation. The present results show that motor performance of typically and non-typically developing infants should be investigated longitudinally as variations are the characteristic of early development. The dynamical systems theory provides a more satisfactory explanation of the motoric differences in infants in this study. All these findings have great implications for the clinical management of these at risk infants.

Thesis (M. P. A.)--University of Hong Kong, 2007. / Title proper from title frame. Also available in printed format.

<p>A control system for a BLDC (Brushless Direct Current) motor has been developed in Labview 2009. This report explains how it works, conclusions and some information about things that could have been done differently. This report is also a good introduction to Labview including its advantages and disadvantages. It also explains how a FOC (Field Oriented Control) works.</p><p>This is the public version of the report which does not include any results or information about the implementation. This information can be found in the original report which only authorized persons have access to.</p>

No description available.

Interest in gesture production has considerably increased in recent decades, yet few studies have examined the preschool population. Even fewer studies have examined the intriguing interaction between motor skills and gesture. The original intent of this study was to investigate the relationship of gesture and motor skills in individuals who stutter. However due to recruitment limitations the enrolled sample consists solely of typically developing preschoolers, 3:8 to 6:6 years. Data are presented on gestures and disfluencies during spontaneous speech, a cartoon narration, and a video narration. Additionally, disfluencies were observed during a procedural description task with restricted hand use and hand tapping. Data indicated that higher frequencies of gestures and disfluencies were seen during the cartoon narration. A greater frequency of disfluencies was also experienced with restricted hand use. Relationships between the variables were also explored. Limitations and implications of these results are discussed from both theoretical and clinical perspectives. / Rangos School of Health Sciences / Speech-Language Pathology (SLP) / MS / Thesis

We review some computational aspects of motor control. The problem of trajectory control is phrased in terms of an efficient representation of the operator connecting joint angles to joint torques. Efficient look-up table solutions of the inverse dynamics are related to some results on the decomposition of function of many variables. In a biological perspective, we emphasize the importance of the constraints coming from the properties of the biological hardware for determining the solution to the inverse dynamic problem.

Thesis (M.A. (Industrial Psychology))--North-West University, Vaal Triangle Campus, 2007.

Thesis (Ph. D.)--University of Washington, 2006. / Vita. Includes bibliographical references (leaves 107-112).

Amyotrophic Lateral Sclerosis (ALS) is a fatal disease characterized by the progressive degeneration of motor neurons. Although there has been some progress in the identification of genes linked to inherited cases of ALS, the etiology of this disease remains largely unknown. Clinical progression of motor neuron diseases is associated with the degeneration of the axon preceding cell death. Elucidating novel mechanisms important for motor axon maintenance will help gain greater insight into disease pathogenesis. Here, I report that mutations in ras-opposite (rop), which encodes the Drosophila homologue of mammalian Sec1/Munc18, cause progressive degeneration of motor axons while sensory axons are largely unaffected. While mutations in mammalian munc18-1 have been linked to degeneration of the spinal cord, the mechanisms by which this occurs are unknown. Using Drosophila, I found that RNAi-induced knockdown of rop leads to severe motor deficits in adult flies. In addition, I discovered that motor axon degeneration in rop mutants could be delayed by overexpression of the neuronal maintenance factor Nmnat. Interestingly, I found that Rop is localized with Nmnat at the neuromuscular junction and that Rop physically interacts with Nmnat in vivo. These data indicate a novel role for Rop in motor axon maintenance and provide insight into the pathogenesis of neurodegenerative diseases targeting motor neurons, such as ALS.

Previous studies found that providing infants with repeated opportunities for reaching improved the emergence and quality of the behavior, presumably via exploratory and selective processes (Bojczyk & Corbetta, 2004; Lobo et al., 2008). Here we further examined the effects of opportunities for reaching by exposing infants to multimodal objects that were activated either continuously by a hidden motor or contingently by hand-toy contact. We asked if such objects would motivate infants to try to reach for them even more than still and silent objects. Forty-four pre-reaching infants were recruited within the week prior to turning three months of age and were seen for 16 consecutive days. Three groups received daily exposure to objects that either moved and made noise continuously (continuous), moved and made noise only on hand-object contact (contingent), or did not move or make noise when touched (repeated task exposure). A control group received no daily experience. On day 1, all infants were assessed in the laboratory to ensure they were not reaching. From days 2-15, an experimenter tested the repeated groups in the home. On day 16, all infants’ reaching was reassessed in our laboratory. Arm kinematics were recorded during laboratory visits. All testing was the same: infants were seated in an infant chair behind a table and an experimenter placed 1 toy on the table at midline for one minute. Infants received ten trials per day. We measured amount of intentional reaches, hand-toy distance, and peak movement speed. Intentional reaching significantly increased for all repeated groups. Examination of infants that improved showed that the contingent group displayed a significantly higher gain in reaching over time relative to the repeated task exposure and continuous groups. Kinematic measures indicated that these young infants modulated the speed of their reaching movements to match task demands. Specifically, infants in the continuous group displayed increased peak speeds of their movements in order to contact a moving object. Results suggest that repeated opportunities to reach for objects underlies the emergence of reaching; however this process may be aided by providing a salient, multimodal link that highlights the effects of successful action.