Esta dissertação visa analisar o uso no português brasileiro, doravante PB, da pista prosódica de duração de sílabas na produção e percepção de sentenças ambíguas do tipo SN1-V-SN2-Atributo, tais como A mãe encontrou a filha suada. Tais sentenças apresentam contextos em que pode haver reestruturação de frases fonológicas a depender da interpretação escolhida. Um dos trabalhos que guiaram esta pesquisa foi o de MAGALHÃES & MAIA (2006), no qual os autores também observaram sentenças com ambiguidade devido à presença de um atributo que pode se referir ao sujeito ou ao objeto da oração. Fonologicamente, tais leituras podem ser explicadas pelo fato de o atributo poder ou não se juntar a seu núcleo na construção do domínio da frase fonológica, em que, se há fronteira, um alongamento é esperado (NESPOR & VOGEL, 1996). ANGELO & SANTOS (2012, 2015) concluíram que os falantes não realizaram alongamento significativo, porém, observaram uma tendência a produzir sentenças de aposição não local mais longas. O que se propõe, então, é que o alongamento é um fenômeno existente na língua, mas é opcional. Se isto é verdade, sempre que ele for feito, a sentença deve ser interpretada como não local. Caso contrário, haveria uma variação nas respostas perceptuais ou preferência por aposição local (Princípio da Aposição Local verificado por MAGALHÃES & MAIA (2006) no PB com base no Princípio de Late Closure apontado por FRAZIER (1979)). Dois testes foram realizados: No de produção, além dos 30 falantes de Angelo & Santos, mais 20 foram escolhidos e outros 10 recuperados para que lessem ambas as versões de cada uma das 9 sentenças em meio a histórias que guiavam a um ou outro significado, totalizando 720 dados. No de percepção, foram selecionadas as 3 versões mais longas (de aposição não local) e as 3 mais curtas (de aposição local) do teste de produção para cada sentença, em um teste onde 30 ouvintes selecionaram através de imagens qual a interpretação obtida, totalizando 1620 dados. Primeiramente, os resultados apontaram para diferenças significativas observando o tipo de estrutura (os falantes alongaram e acertaram as não locais). Por tipo de sentença, a diferença foi significativa na maioria delas, confirmando a predição de que, ainda que o alongamento seja opcional na produção, uma vez realizado, ele serve como condutor para uma interpretação não local. Para as sentenças locais, o Princípio de Aposição Local verificado no PB por MAGALHÃES & MAIA (2006) também foi observado em nosso experimento. Por fim, os resultados apontam para 2 tipos de estruturas que podem interferir no processo de alongamento: Sentenças em que o atributo é formado por adjetivos deverbais (geração de uma fronteira CP) e sentenças que permitem construções de small clause (bloqueio da reestruturação). / The aim of this thesis is to analyze the use of syllable duration in Brazilian Portuguese (henceforth BP) as a prosodic cue in the perception and production of syntactically ambiguous sentences with a NP1-V-NP2-attribute structure (lit. The mother has found her daughter sweating). This type of sentence is produced in contexts where phonological phrases may be restructured, depending on how the sentences are interpreted. A reference for the present research was the study by MAGALHÃES & MAIA (2006), who also found sentences which ambiguity was due to the presence of an attribute that may refer to either the subject or the object of the clause. Phonologically, interpretations of the above-mentioned structure can be explained by the fact that attributes may or may not join the head in the construction of the phonological phrase domain, because lengthening is expected when there is a boundary (NESPOR & VOGEL, 1996). ANGELO & SANTOS (2015) found that the speakers in their study did not make significant lengthening; however, they tended to produce high attachment in longer sentences. It is suggested, therefore, that although lengthening exists in BP as a phenomenon, it is optional. If this is actually true, sentences should be interpreted as having high attachment whenever lengthening is produced. Otherwise, it is assumed that there is variation in perceptual responses or preference for low attachment (Low Attachment Principle, found in PB by MAGALHÃES & MAIA (2006), based on the Late Closure Principle proposed by Frazier (1979)). Data were collected with two tests. In the sentence-reading production test, 30 speakers from the study by ANGELO & SANTOS (2015)) and 20 new speakers read one version of each sentence, while 10 out of the former 30 read two versions, thus the corpus was made of a total of 720 sentences. The perception test used the three longest versions (with high attachment) and the three shortest versions (with low attachment) of each sentence. The informants who took the test chose the image that best represented the meaning that they assigned to each sentence. A total of 1620 data were produced. Overall results showed significant differences for type of structure (the informants lengthened and identified high attachments correctly). For sentence type, there were significant differences in most sentences, thus confirming the hypothesis that lengthening is optional in production and, once it has been performed, it can lead a sentence to be interpreted as having high attachment. For sentences with low attachment, the Low Attachment Principle suggested by MAGALHÃES & MAIA (2006) also occurred in our experiment. The findings signal two types of structures that may interfere with the lengthening process: sentences whose attribute is formed by deverbal adjectives (generation of a CP phrasal boundary) and sentences that allow small clause constructions (restructuring is blocked).

Greater trochanteric pain (GTP) is a regional pain syndrome characterized by lateral hip pain and tenderness. Its incidence after total hip arthroplasty (THA) is variable. Bursal inflammation, degenerative changes of the attachment of the gluteal muscles, direct operative trauma and biomechanical disturbance of the operated hip have been discussed as being related to GTP. The diagnosis is purely clinical because radiological and laboratory investigations show no definite pathology. Although most treatment modalities are conservative, some patients may develop refractory complaints leading to surgical intervention. In study I we studied the incidence of GTP in 172 consecutive patients who underwent THA during 2002 at Sundsvall Hospital. Patients with GTP (n=21, incidence 12%) were matched with controls from the same cohort. The THA outcome was assessed using the Western Ontario and McMaster Universities Arthrosis (WOMAC) Index. Trochanteric tenderness was studied using an electronic pressure algometer. We found an association between the occurrence of GTP and postoperative uncorrected lengthening of the operated limb of ≥ one centimetre. The WOMAC index revealed a reduction of the clinical outcome in the GTP group. In Study II we tested the value of using an algometer in the diagnosis of GTP after THA. We measured the pressure-pain threshold (PPT) over the greater trochanter and ilio-tibial band in 18 patients and 18 matched controls. Both groups were evaluated using the visual analogue scale (VAS). We found the algometer to have a good predictive validity and reproducibility. However, there was large inter-individual variability across subjects. The PPT ratio of 0.8 (affected vs. unaffected side) can be used as a cutoff ratio to establish GTP. There was no correlation between PPT measurements and VAS. Because of a low positive predictive value and large inter-individual variability, the pressure algometer has a limited value as a screening tool. In study III we proposed a new surgical treatment for refractory GTP after THA consisting of distal lengthening of the ilio-tibial band (ITB) by Z-plasty under local anaesthesia. This method was used in 12 women between March 2004 and June 2006. The patients were followed up by phone interview 3-4 months postoperatively and by an EQ-5D questionnaire and clinical examination including evaluation with the algometer at 1-3 years postoperatively. We found that the patients‘ quality of life was markedly improved following the operation (EQ-5D = 0.26 preoperatively vs. 0.67 postoperatively; p <0.005). There were no postoperative complications. In study IV we evaluated the accuracy of a commonly used clinical method of LLD measurement (anterior superior iliac spine-medial malleolus) by comparing it to a reliable radiological method (tear drop-lesser trochanter) in 139 patients before and after THA. We found the correlation between the clinical and radiological methods to be weak preoperatively (r=0.21, ICC= 0.33) while the correlation was moderate postoperatively (r= 0.45, ICC=0.62). It is therefore recommended that the radiological method be used to measure leg length discrepancy in patients who undergo THA.

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Child-directed speech (CDS) differs from adult-directed speech (ADS) in several respects whose possible facilitating effects for language acquisition are still being studied. One such difference concerns articulation rate --- the number of linguistic units by the number of time units, excluding pauses --- which has been shown to be generally lower than in ADS. However, while it is well-established that ADS exhibits an inverse relation between articulation rate and information-theoretic surprisal --- the amount of information encoded in a linguistic unit --- this measure has been conspicuously absent in the study of articulation rate in CDS. Another issue is if the lower articulation rate in CDS is stable across utterances or an effect of local variation, such as final lengthening. The aim of this work is to arrive at a more comprehensive model of articulation rate in CDS by including surprisal and final lengthening. In particular, one-word utterances were studied, also in relation to word-length effects (the phenomenon that longer words generally have a higher articulation rate). To this end, a methodology for large-scale automatic phoneme-alignment was developed, which was applied to two longitudinal corpora of Swedish CDS. It was investigated i) how articulation rate in CDS varied with respect to child age, ii) whether there was a negative relation between articulation rate and surprisal in CDS, and iii) to what extent articulation rate was lower in CDS than in ADS. The results showed i) a weak positive effectof child age on articulation rate, ii) a negative relation between articulation rate and surprisal, and iii) that there was a lower articulation rate in CDS but that the difference could almost exclusively be attributed to one-word utterances and final lengthening. In other words, adults seem to adapt how fast they speak to their children's age, speaking faster to children is correlated with a reduced amount of information, and the difference in articulation rate between CDS and ADS is most prominent in isolated words and final lengthening. More generally, the results suggest that CDS is well-suited for word segmentation, since lower articulation rate in one-word utterances provides an additional cue.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico / On the growth evaluation of the open-grown trees was selected 57 samples, of which were mensuration many morphometric variables from digital photographs in software AutoCAD and dendrometrics variables in bole increment extracted in diameter breast height (DBH). The development of this research was to described the singular dimensions and recover crown and bole growth from open-grown Cedrela fissilis, corresponding to period 2007-2011, and build mathematical equations to described the growth of variable crown diameter (CD), mantle of the crown (MC), crown diameter in relative heights (CDrh) and periodic annual increment in basal area (PAIb). In the annual lengthening (AL) were observed minimum, maximum and median annual values of 3.0, 91.0 and 32.4 cm, respectively. As well as, serie correlations, determined by Pearson (r = 0.76 a 0.86; Pr<.0001), with higher lengthening connected to the lower orders of branching. In periodic lengthening (PL), corresponding to the period of 2007-2011 there were values of up to 1.82 m, found in diameter class 30-40, with a coefficient of variation (CV) up to 67.67%, checked in diametric class > 60. To model growth construction 35 trees were selected from 57 initially sampled considering it crown and bole conditions, having been discarded sample of the > 60 diametric class. To the mantle of the crown variable the model NLMC=b0+b1*(1/DBH)+b2*(DBH²) has good adjust (R²adj.=0.92; VC=6.12%). The equation to annual lengthening of the crown, ALC=b0+b1*(NLCAI)+b2*(DBH) showed adjustment and precision (R²adj.=0.50; VC=35.95%), it explaining until 50% total variance, but with higher percent residual. With similar precision, the model adjusted to crown growth in diameter, CGD=b0+b1*(NLCAI), had statistical precision defined to R²adj= 0.44 and VC=36.25%, with higher VC resulted from the higher variance in samples. To the CDrh the adjust was represented to R²adj.=0.58 and VC=52.41%, had been defined the model NLCDrh=b0+b1*(NLDBH)+b2*(1/hi²)+b3*(DBH²), with the results of residual evaluations didn t submit normality distribution and homogeny variance. The adjust to CAIb equation showed good statistical precision (R²adj.=0.66; VC=11%), it explaining until 66% total variance from model NLCAIb=b0+b1*(DBH)+b2*(h/d). On the increment descriptive analyses it observed high periodic annual increment in diameter (PAId) and PAIb in the 25, 35 and 45 cm diameter class. The PAId medium, minimum and maximum values correspond to 3.6 cm, 0.7 cm and 7.3 cm. At the 35 and 45 cm class it observed 95.6 and 75.5 PAIb average, respectively. All of the diameter classes it was observed current annual increment in diameter (CAId) higher 2.5 cm. The crown growth reviews from the open-grown trees demonstrated that the crown growth rhythmic and its correlation with the bole increments it turn possible to build growth models characterized to good adjust and statistical efficiency, wherever, it should be stratification methods based in site informations. The methodology analyses with digital photography also showed good precision and practicality, it can be widely used to review singular and open-grown trees. / Na avaliação do crescimento de árvores isoladas foram selecionadas 57 amostras, das quais se mensurou variáveis morfométricas em fotos digitalizadas no software AutoCAD e dendrométricas a partir de rolos de incremento coletados na altura do DAP. O desenvolvimento desta pesquisa teve como objetivo descrever as dimensões individuais e reconstituir o crescimento da copa e fuste de árvores isoladas de Cedrela fissilis, avaliado de 2007 a 2011, e construir equações matemáticas para descrever o crescimento da variável diâmetro da copa (DC), manto de copa (MC), diâmetro da copa em alturas relativas (DChi) e incremento periódico anual em área basal (IPAg). Nos alongamento anuais (ALG) foram verificados valores mínimo, máximo e médio anual de 3,0, 91,0 e 32,4 cm, respectivamente. Assim como correlações em série, determinada por r = 0,76 a 0,86 (Pr<.0001), tendo sido observados maiores alongamentos nas menores ordens de ramificação. Nos alongamentos periódicos (ALGP), correspondente ao período 2007-2011, verificaram-se valores médios de até 1,82 m, observado na classe diamétrica 30-40 cm, com coeficiente de variação (CV) máximo de 67,67%, verificado na classe > 60 cm. Para a construção dos modelos de crescimento foram selecionadas 35 árvores de acordo com sua condição de copa e fuste, sendo descartada a classe diamétrica > 60 cm devido a pouca amostragem. Para o manto de copa o modelo LNMC = b0+b1*(1/DAP)+b2*(DAP²) apresentou bom ajuste (R²aj.= 0,92 e CV = 6,12%). A equação da variável alongamento anual da copa, ALG=b0+b1*(LNICA)+b2*(DAP), apresentou o ajuste comprometido pelo alto erro percentual (R²aj. = 0,50; CV = 35,95%), descrevendo até 50% da variância total. Com precisão semelhante à ALG, o modelo ajustado para a variável crescimento da copa em diâmetro, CCD=b0+b1*(LNICA), apresentou altas taxas de erro percentual, com precisão estatística definida por CV = 36,25%; R²aj. = 0,44. Para o modelo DChi o ajuste foi descrito por R²aj.=0,58 e CV=52,41%, tendo sido definido o modelo LNDChi=b0+b1*(LNDAP)+b2*(1/hi²)+b3*(DAP²), tendo o mesmo não apresentado distribuição normal e heterogeneidade na variância dos resíduos. O ajuste da equação apara o IPAg apresentou boa precisão estatística (R²aj.=0,66; CV=11%), descrevendo até 66% da variância total a partir do modelo LNIPAg=b0+b1*(DAP)+b2*(h/d). Na avaliação descritiva dos incrementos observaram-se elevadas taxas de incremento periódico anual em diâmetro (IPAd) e IPAg nas classes diamétricas 25, 35 e 45 cm. Os valores de IPAd médio, mínimo e máximo foram de 3,6 cm, 0,7 e 7,3 cm, respectivamente. Nas classes 35 e 45 cm verificou-se taxa de IPAg média de 95,6 e 75,5 cm², respectivamente. Em todas as classes de diâmetro foram encontradas taxas de incremento corrente anual em diâmetro (ICAd) superior a 2,5 cm. As análises do crescimento da copa de árvore isoladas demonstraram que o crescimento rítmico da mesma e sua correlação com os incrementos do fuste possibilitam a construção de modelos de crescimento com boa eficiência estatística, porém, devendo se aperfeiçoar a estratificação fazendo uso de informações que descrevam as condições dos sítios. A metodologia de avaliação a partir de fotos digitalizadas também apresentou boa precisão e praticidade, podendo ser amplamente utilizada na avaliação de árvores singulares ou isoladas.

Esta dissertação visa analisar o uso no português brasileiro, doravante PB, da pista prosódica de duração de sílabas na produção e percepção de sentenças ambíguas do tipo SN1-V-SN2-Atributo, tais como A mãe encontrou a filha suada. Tais sentenças apresentam contextos em que pode haver reestruturação de frases fonológicas a depender da interpretação escolhida. Um dos trabalhos que guiaram esta pesquisa foi o de MAGALHÃES & MAIA (2006), no qual os autores também observaram sentenças com ambiguidade devido à presença de um atributo que pode se referir ao sujeito ou ao objeto da oração. Fonologicamente, tais leituras podem ser explicadas pelo fato de o atributo poder ou não se juntar a seu núcleo na construção do domínio da frase fonológica, em que, se há fronteira, um alongamento é esperado (NESPOR & VOGEL, 1996). ANGELO & SANTOS (2012, 2015) concluíram que os falantes não realizaram alongamento significativo, porém, observaram uma tendência a produzir sentenças de aposição não local mais longas. O que se propõe, então, é que o alongamento é um fenômeno existente na língua, mas é opcional. Se isto é verdade, sempre que ele for feito, a sentença deve ser interpretada como não local. Caso contrário, haveria uma variação nas respostas perceptuais ou preferência por aposição local (Princípio da Aposição Local verificado por MAGALHÃES & MAIA (2006) no PB com base no Princípio de Late Closure apontado por FRAZIER (1979)). Dois testes foram realizados: No de produção, além dos 30 falantes de Angelo & Santos, mais 20 foram escolhidos e outros 10 recuperados para que lessem ambas as versões de cada uma das 9 sentenças em meio a histórias que guiavam a um ou outro significado, totalizando 720 dados. No de percepção, foram selecionadas as 3 versões mais longas (de aposição não local) e as 3 mais curtas (de aposição local) do teste de produção para cada sentença, em um teste onde 30 ouvintes selecionaram através de imagens qual a interpretação obtida, totalizando 1620 dados. Primeiramente, os resultados apontaram para diferenças significativas observando o tipo de estrutura (os falantes alongaram e acertaram as não locais). Por tipo de sentença, a diferença foi significativa na maioria delas, confirmando a predição de que, ainda que o alongamento seja opcional na produção, uma vez realizado, ele serve como condutor para uma interpretação não local. Para as sentenças locais, o Princípio de Aposição Local verificado no PB por MAGALHÃES & MAIA (2006) também foi observado em nosso experimento. Por fim, os resultados apontam para 2 tipos de estruturas que podem interferir no processo de alongamento: Sentenças em que o atributo é formado por adjetivos deverbais (geração de uma fronteira CP) e sentenças que permitem construções de small clause (bloqueio da reestruturação). / The aim of this thesis is to analyze the use of syllable duration in Brazilian Portuguese (henceforth BP) as a prosodic cue in the perception and production of syntactically ambiguous sentences with a NP1-V-NP2-attribute structure (lit. The mother has found her daughter sweating). This type of sentence is produced in contexts where phonological phrases may be restructured, depending on how the sentences are interpreted. A reference for the present research was the study by MAGALHÃES & MAIA (2006), who also found sentences which ambiguity was due to the presence of an attribute that may refer to either the subject or the object of the clause. Phonologically, interpretations of the above-mentioned structure can be explained by the fact that attributes may or may not join the head in the construction of the phonological phrase domain, because lengthening is expected when there is a boundary (NESPOR & VOGEL, 1996). ANGELO & SANTOS (2015) found that the speakers in their study did not make significant lengthening; however, they tended to produce high attachment in longer sentences. It is suggested, therefore, that although lengthening exists in BP as a phenomenon, it is optional. If this is actually true, sentences should be interpreted as having high attachment whenever lengthening is produced. Otherwise, it is assumed that there is variation in perceptual responses or preference for low attachment (Low Attachment Principle, found in PB by MAGALHÃES & MAIA (2006), based on the Late Closure Principle proposed by Frazier (1979)). Data were collected with two tests. In the sentence-reading production test, 30 speakers from the study by ANGELO & SANTOS (2015)) and 20 new speakers read one version of each sentence, while 10 out of the former 30 read two versions, thus the corpus was made of a total of 720 sentences. The perception test used the three longest versions (with high attachment) and the three shortest versions (with low attachment) of each sentence. The informants who took the test chose the image that best represented the meaning that they assigned to each sentence. A total of 1620 data were produced. Overall results showed significant differences for type of structure (the informants lengthened and identified high attachments correctly). For sentence type, there were significant differences in most sentences, thus confirming the hypothesis that lengthening is optional in production and, once it has been performed, it can lead a sentence to be interpreted as having high attachment. For sentences with low attachment, the Low Attachment Principle suggested by MAGALHÃES & MAIA (2006) also occurred in our experiment. The findings signal two types of structures that may interfere with the lengthening process: sentences whose attribute is formed by deverbal adjectives (generation of a CP phrasal boundary) and sentences that allow small clause constructions (restructuring is blocked).

No description available.

Skeletal muscle is prone to damage from a range of stimuli. The muscle repair process that ensues is complex, involving several phases and requiring the participation of many different cell types. Among the cells involved are various immune cells including neutrophils, macrophages, monocytes, and eosinophils. More recently, T cells were added to this list of immune cells known to participate in effective muscle repair from traumatic injuries in mice. We recently published data showing that T cells also accumulate in human muscle following contraction-induced damage. These data suggested that T cells might be involved an adaptation known as the repeated bout effect that renders muscle protected from future damage after an initial exposure. This document contains research on the role of the immune system, particularly T cells, in the "repeated bout effect."

Background: The risk of future injury appears to be influenced by agonist fascicle length (FL), joint range of motion (ROM) and eccentric strength. Biomechanical observations of the torque-angle-relationship further reveal a strong dependence on these factors. In practice, a longer FL improves sprinting performance and lowers injury risk. Classical stretching is a popular and evidenced-based training for enhancing ROM but does not have any effects on FL and injury risk. However, recent studies show that eccentric-only training (ECC) improves both flexibility and strength, and effectively lowers risk of injury. Objectives: To review the evidence on benefits of ECC for flexibility and strength. Methods: COCHRANE, PUBMED, SCOPUS, SPOLIT, and SPONET were searched for laboratory trials that compare ECC to at least one comparison group. Studies were eligible if they examined both strength and flexibility metrics in a healthy sample (<65 years) and met criteria for controlled or randomized clinical trials (CCT, RCT). 18 studies have been included and successfully rated using the PEDro scale. Results: 16 of 18 studies show strong evidence of strength and flexibility enhancements for the lower limb. While improvements between ECC and concentric training (CONC) were similar for eccentric (+19 ± 10% vs. +19 ± 11%) and isometric strength (+16 ± 10% vs. +13 ± 6%), CONC showed larger improvements for concentric strength (+9 ± 6% vs. +16 ± 7%). While for ROM ECC showed improvements (+9 ± 7%), no results could be found for CONC. The overall effectiveness of ECC seems to be higher than of CONC. Conclusion: There is clear evidence that ECC is an effective method for changes in muscle architecture, leading to both flexibility and strength improvements for the lower limb. Due to limited data no shoulder study could be included. Further research is needed for the upper body joints with a focus on functional and structural adaptions.