Submitted by SBI Biblioteca Digital (sbi.bibliotecadigital@puc-campinas.edu.br) on 2017-04-12T13:26:24Z No. of bitstreams: 1 ALEXANDRA APARECIDA DOS REIS.pdf: 2254046 bytes, checksum: bf0291b84101fecae5af414bf1032ff7 (MD5) / Made available in DSpace on 2017-04-12T13:26:24Z (GMT). No. of bitstreams: 1 ALEXANDRA APARECIDA DOS REIS.pdf: 2254046 bytes, checksum: bf0291b84101fecae5af414bf1032ff7 (MD5) Previous issue date: 2017-02-21 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / INTRODUCTION: Psoriasis, chronic inflammatory skin disease, Characterized by pink or reddish lesions, covered by whitish and dry scales,Its plaque format is the most common type.In all forms of psoriasis, nail involvement may be present in about 50% of cases.Individuals with psoriasis have nail deformities and a tendency to develop psoriatic arthritis.Psoriatic arthritis inflammatory disease of the joints in a divergent way involves the spine and peripheral joints, can affect up to 30% of people with psoriasis between 5 to 12 years after their development as dactylitis, enthesitis and peripheral joints.This complicates the diagnosis because the involvement of the skin can affect before the joint involvement. There is an immunological development in the pathogenesis of this disease immunized by Th1 and Th17 cells.Recently there is evidence that plays a crucial role in the pathology of psoriatic arthritis.The prevalence of 06% to 42% of patients with psoriasis develop a joint disease. Some studies have been analyzing these items in detail, thus giving rise to methods for measuring quality of life, since to obtain a quality life it is necessary to evaluate the individual as a whole in psychological, social and physical aspects. The questionnaires are instruments, in which they collect information and characterize a composite research technique, in the objective form of questions presented in writing in the research, in application of the knowledge of the researcher.PASE-P: developed as a screening tool for PAs more effectively in individuals with Ps and validated by Husni, et al.2007. Its sensitivity is 76% and specificity is 82%. NAPSI instrument that evaluates each nail by dividing them into four quadrants, to be evaluated for the presence of any alteration coming from both the nail matrix and nail bed. PASI: An instrument developed in 1978 to quantify the severity of Ps in order to evaluate the body surface and was segmented into 04 regions of the head, trunk, lower limbs and upper limbs evaluated on a scale of 0 to 72.DLQI: Questionnaire aiming to obtain detailed data on the quality of life of patients with psoriasis.And it consists of 10 questions about symptoms and feelings, daily activities, leisure, work and school, personal relationships and treatment. CASPAR: Investigates the presence of joint manifestations, dermatological diseases or family history, typical nail changes, the existence of joint swelling and radiological changes. OBJECTIVES: To evaluate the presence of arthritis in male and female patients with Ps, aged between 18 and 80 years using a specific questionnaire to evaluate the severity of psoriasis, using PASE-P, NAPSI, PASI, DLQI AND CASPAR. And determine by means of laboratory variables the PCR and FR. OBJECTIVE: To compare and correlate the severity parameters of psoriasis PASE-P, NAPSI, PASI, DLQI and CASPAR in a screening with patients from the dermatology outpatient clinic to identify psoriatic arthritis, seeking correlations with literature content.METHOD: The study used a cross-sectional, longitudinal and prospective study, approved by the Research Ethics Committee (CEP) of the Celso Pierro Hospital and Maternity Hospital (HMCP) in Campinas-SP. RESULTS: During the study, 63 patients did not present withdrawal, 57.1% were men and 42.9% were women. We obtained a statistically significant correlation between PASE-B, which depicts the functionality and the CRP that characterizes the inflammatory activity.Patients with a PASE-P score greater than 44, defined as suspected APs, 15.9% of arthritis. Correlations for PASE-P greater than 44 obtained the following statistically significant correlations PASE-B with PASI r = 0.736, p = 0.037, DLQI with PCR r = 0.900, p = 0.037, PASE-B with PCR; R = 0.360, p-0.021, PASI with NAPSI ML, r = 0.353. There was a statistically significant correlation between PASE-B which depicts functionality and the CRP that characterizes inflammatory activity. DISCUSSION: The choice of PASE-P, NAPSI, DLQI, PASI and CASPAR instruments in psoriasis was to evaluate their applicability in clinical practice. PASE-P has proved to be relevant, since it is a simple and quick and practical resource, and so far there are few studies with the publication in the Portuguese language version. The questionnaire PASS a recent tool to evaluate psoriatic arthritis, developed by Husni, et al, 2007. CONCLUSION: PASE-P as a specific instrument has been shown to be effective in the detection of some PA patients in a group of patients with psoriasis, as seen in the literature. Each case should be individualized and treated according to the association of disease severity parameters. It can be emphasized, therefore, that the association of PASE, CASPAR, NAPSI and DLQI can be of great assistance in clinical practice for both evolutionary follow-up and therapeutic decision-making. Taking into account that according to what was shown in this study the PASE-P is a specific instrument and that in a dynamic and effective way when detecting PAs in patients. / INTRODU??O: Psor?ase doen?a inflamat?ria cr?nica da pele, caracterizada por les?es r?seas ou avermelhadas, recobertas por escamas esbranqui?adas e secas, seu formato em placas ? o tipo mais comum. Em todas as formas de psor?ase o envolvimento ungueal pode estar presente em cerca de 50% dos casos. Os indiv?duos com psor?ase apresentam deformidades nas unhas e tend?ncia a desenvolver artrite psori?sica. A artrite psori?sica doen?a inflamat?ria das articula??es de maneira divergente envolve a coluna vertebral e articula??es perif?ricas, pode afetar at? 30% das pessoas portadoras da psor?ase entre 5 a 12 anos ap?s seu desenvolvimento como dactilite,entesite e articula??es perif?ricas. O que dificulta o diagn?stico pois os envolvimento cut?neo pode acometer antes do comprometimento articular. Existem um desenvolvimento imunol?gico na patog?nese desta doen?a imunodiada por c?lulas Th1 e Th17. Recentemente h? evidencias que desempenham um papel crucial na patologia da artrite psori?sica. A preval?ncia de 06% a 42% dos pacientes com psor?ase desenvolvem uma doen?a articular. Alguns estudos vem analisando minuciosamente estes itens, surgindo assim m?todos para mensurar a qualidade de vida, pois para obter uma vida com qualidade ? necess?rio avaliar o indiv?duo como um todo em aspectos psicol?gicos, social e f?sico. Os question?rios s?o instrumentos, nos quais coletam informa??es e caracterizam uma t?cnica de investiga??o composta, na forma objetiva de quest?es apresentadas por escrito na pesquisa, em aplica??o do conhecimento do pesquisador. PASE-P: desenvolvidos como uma ferramenta de triagem para APs de forma mais eficaz em indiv?duos com Ps e validados por Husni, et al.2007.Sua sensibilidade e de 76% e especificidade de 82%. NAPSI instrumento que avalia cada unha dividindo as em quatro quadrantes, para ser avaliada quanto a presen?a de qualquer altera??o provenientes tanto da matriz da unha quanto leito ungueal. PASI: Instrumento desenvolvido em 1978, para quantificar a gravidade da Ps, com o objetivo de avaliar a superf?cie corporal e para isto foi segmentado em 04 regi?es cabe?a, tronco, membros inferiores e membros superiores, avaliado em uma escala de 0 a 72.DLQI: Question?rio com intuito em obter dados de forma detalhada sobre a qualidade de vida dos portadores da psor?ase. E composto por 10 quest?es sobre sintomas e sentimentos, atividades di?rias, lazer, trabalho e escola, rela??es pessoais e tratamento. CASPAR: Investiga a presen?a de manifesta??es articulares, doen?as dermatol?gicas ou hist?rico familiar, mudan?as ungueais de forma t?pica, exist?ncia de incha?o articular e altera??es radiol?gicas. OBJETIVOS: Avaliar a presen?a da artrite em pacientes do g?nero masculino e feminino com Ps, com idade entre 18 a 80 anos atrav?s de question?rio espec?fico para avalia??o da gravidade da psor?ase, atrav?s de instrumentos de avalia??o e classifica??o PASE-P, NAPSI, PASI, DLQI E CASPAR. E determinar por meio de vari?veis laboratoriais o PCR e FR. OBJETIVO ESPECIFICO: Comparar e correlacionar os par?metros de gravidade da psor?ase PASE-P, NAPSI, PASI, DLQI E CASPAR em uma triagem com pacientes do ambulat?rio de dermatologia afim de identificar a artrite psori?sica, buscando correla??es com conte?do da literatura. M?TODO: A pesquisa utilizou um estudo transversal, longitudinal e prospectivo, aprovado pelo Comit? de ?tica em Pesquisa (CEP) do Hospital e Maternidade Celso Pierro (HMCP) em Campinas-SP. RESULTADOS: Durante a pesquisa fizeram parte da popula??o 63 pacientes n?o havendo desist?ncia, sendo 57,1% eram homens e 42,9% eram mulheres. Obtivemos correla??o estatisticamente significativa entre o PASE-B, que retrata a funcionalidade e o PCR que caracteriza a atividade inflamat?ria. Pacientes com escore de PASE-P maior que 44, definiram se como suspeita de APs, 15,9% de artrite. Correla??es para o PASE-P maior que 44 obtivemos as seguintes correla??es estatisticamente significativas PASE-B com PASI r= 0,736, p=0,037, DLQI com PCR r=0,900, p=0,037, PASE-B com PCR; r=0,360, p- 0,021, PASI com NAPSI ML, r=0, 353.Houve correla??o estatisticamente significativa entre PASE-B que retrata funcionalidade e o PCR que caracteriza atividade inflamat?ria. DISCUSSAO: A escolha dos instrumentos PASE-P, NAPSI, DLQI, PASI E CASPAR, na psor?ase foram para avaliar suas aplicabilidades na pratica cl?nica. O PASE-P mostrou se relevante, pois e um recurso simples r?pido e pr?tico, e at? o momento h? poucos estudos com a publica??o na vers?o da l?ngua portuguesa. O question?rio PASE uma ferramenta recente em avaliar a artrite psori?sica, desenvolvido por Husni, et al,2007. CONCLUS?O: O PASE-P como instrumento especifico se mostrou eficaz na detec??o de alguns pacientes com APs em um grupo de pacientes com psor?ase, como visto na literatura. Cada caso deve ser individualizado e tratado de acordo com a associa??o dos par?metros de gravidade da doen?a. Pode-se ressaltar, portanto, que a associa??o do PASE, CASPAR, NAPSI e DLQI pode servir de grande aux?lio na pr?tica cl?nica tanto para o acompanhamento evolutivo, quanto para a tomada de decis?es terap?uticas. Levando em considera??o que de acordo com o que foi mostrado neste estudo o PASE-P ? um instrumento espec?fico e que de forma din?mica e eficaz ao detectar a APs em pacientes.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-02-23T00:12:01Z No. of bitstreams: 1 FabianaTenorioGomesDaSilva_DISSERT.pdf: 1184676 bytes, checksum: 9d03e59733d51511aa0eec704401ade1 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-02-26T22:56:55Z (GMT) No. of bitstreams: 1 FabianaTenorioGomesDaSilva_DISSERT.pdf: 1184676 bytes, checksum: 9d03e59733d51511aa0eec704401ade1 (MD5) / Made available in DSpace on 2016-02-26T22:56:55Z (GMT). No. of bitstreams: 1 FabianaTenorioGomesDaSilva_DISSERT.pdf: 1184676 bytes, checksum: 9d03e59733d51511aa0eec704401ade1 (MD5) Previous issue date: 2014-12-08 / Introdu??o: Estimula??o transcraniana por corrente continua (ETCC) tem sido usada em estudos voltados para o tratamento da dor perif?rica cr?nica em pessoas com les?o medular (LM), mas seus efeitos sobre o sistema nervoso auton?mico (SNA) nestes indiv?duos s?o inexistentes e, portanto a necessidade de estudos ? de fundamental import?ncia, pois estes indiv?duos apresentam desbalan?o auton?mico, e sua intensidade ? dependente do grau e n?vel da les?o. Objetivo: Investigar se a ETCC sobre o c?rtex motor prim?rio ir? modular o controle do SNA em pessoas com LM e se estas altera??es s?o dependentes do grau e n?vel de les?o. M?todos: Estudo randomizado, placebo controlado, aplicou ETCC an?dica ou sham sobre o c?rtex motor prim?rio (M1), bilateralmente, com o eletrodo de refer?ncia sendo colocado na protuber?ncia occipital. Dezenove sujeitos (les?o incompleta baixa (n=7), completa baixa (n=9) e completa alta (n=3)) visitaram o laborat?rio tr?s vezes e receberam ETCC ativa ou sham por 13min. A variabilidade da frequ?ncia card?aca (VFC) foi medida antes, durante e p?s-estimula??o. A VFC foi calculada usando a analise espectral batimento a batimento dos intervalos derivados das ondas r-r. Resultados: A ETCC modulou o sistema nervoso auton?mico de forma divergente nos grupos analisados. Nos indiv?duos com LM completa alta a ETCC n?o alterou a VFC. Para os indiv?duos com LM incompleta baixa a ETCC alterou a VFC no sentido de aumentar o simp?tico e reduzir o parassimp?tico e para os indiv?duos com LM completa baixa a ETCC reduziu o simp?tico e aumentou o parassimp?tico. Conclus?o: O presente estudo observou que a ETCC an?dica aplicada sobre o c?rtex motor prim?rio de forma bilateral, conseguiu modular o balan?o do SNA em pessoas com les?o medular e este efeito ? dependente do grau e n?vel de les?o. Palavras-chave: Estimula??o Transcraniana; Sistema nervoso auton?mico; Variabilidade da frequ?ncia card?aca; Les?o medular. / Introduction: Transcranial Direct Current Stimulation (tDCS) has been used in studies for the treatment of chronic pain, but their effects on the autonomic nervous system (ANS) are non-existent. Therefore, the need for studies is of fundamental importance, as these individuals have autonomic imbalance and the intensity of this is dependent on the degree and level of injury. Objective: We investigated the effect of tDCS on the ANS in people with spinal cord injury (SCI) with different degrees and levels of injury. Methods: Randomized, placebo-controlled, double-blind, applied anodal tDCS or sham on the primary motor cortex (M1), bilaterally. The subjects (lower incomplete injury, n = 7; lower complete injury, n = 9; and high complete thoracic injury, n = 3) visited the laboratory three times and received active or sham tDCS for 13min. The heart rate variability (HRV) was measured before, during and after stimulation and analyzed the variables LF, HF and LF / HF. Results: The tDCS modulated the ANS in different ways among the groups. In individuals with SCI high complete thoracic the tDCS did not change the HRV. However, for individuals with SCI low incomplete, tDCS changed the HRV in order to increase sympathetic (LF, p = 0.046) and reduced parasympathetic (HF, p = 0.046). For individuals SCI low complete to tDCS changed the HRV reduction sympathetic (LF, p = 0.017) and increased parasympathetic (HF, p = 0.017). Conclusions: The present study suggests that anodal tDCS applied on the motor cortex bilaterally could modulate the ANS balance in people with spinal cord injury and that this effect is dependent on the degree and level of injury.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-07-11T17:13:30Z No. of bitstreams: 1 MaraLuanaBatistaSevero_DISSERT.pdf: 1279812 bytes, checksum: d55a74719b46a51718b7399d61a2a556 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-07-15T18:45:17Z (GMT) No. of bitstreams: 1 MaraLuanaBatistaSevero_DISSERT.pdf: 1279812 bytes, checksum: d55a74719b46a51718b7399d61a2a556 (MD5) / Made available in DSpace on 2016-07-15T18:45:17Z (GMT). No. of bitstreams: 1 MaraLuanaBatistaSevero_DISSERT.pdf: 1279812 bytes, checksum: d55a74719b46a51718b7399d61a2a556 (MD5) Previous issue date: 2016-02-25 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / Objetivo desse estudo foi analisar a imunoexpress?o de receptores de calcitonina (CTRs) e glicocorticoides (GCRs) em les?es centrais de c?lulas gigantes (LCCGs) agressivas e n?o agressivas. Trata-se de um estudo imuno-histoqu?mico (t?cnica da imunoperoxidase), quantitativo e descritivo de 52 casos de LCCGs dos ossos maxilares, nos quais 13 pacientes portadores de LCCG foram tratados com triancinolona intralesional ou calcitonina spray intranasal. A m?dia de imunomarca??o foi comparada entre os tipos celulares e subtipo cl?nico da les?o. O teste de Mann-Whitney foi realizado para essas compara??es. Dos 52 casos de LCCGs, 53.8% eram do g?nero feminino, com uma m?dia de idade de 25.69 anos. A mand?bula foi o s?tio anat?mico mais acometido. Trinta casos (57.7%) foram de LCCGs agressivas e 22 (42.3%) de n?o agressivas. A cirurgia foi o tratamento de escolha em 75% das LCCGs estudadas. Em 56.7% das LCCGs agressivas foi realizada cirurgia, enquanto 43.4% foram submetidas ao tratamento conservador. Dos submetidos ao tratamento conservador, a maioria (n = 8; 61.5%) respondeu bem ao tratamento. A express?o de CTR foi evidenciada em 67.3% da amostra e para o GCR em 96.15% dos casos. N?o houve diferen?a estatisticamente significante entre a express?o de CTRs e GCRs em c?lulas mononucleares e multinucleadas das LCCGs em rela??o ? agressividade, em rela??o ao tratamento realizado para os casos de les?es agressivas e em rela??o ? resposta ao tratamento conservador realizado nos casos de LCCGs agressivas (p>0.05). Os resultados da nossa pesquisa sugerem que a imunoexpress?o dos CTRs e GCRs n?o influenciou na resposta ao tratamento cl?nico com calcitonina ou triancinolona na amostra estudada e exibiu uma express?o variada independente da agressividade da les?o. / The aim of this study was to analyze the immunoexpression of calcitonin (CTR) and glucorticoid (GCR) receptors in aggressive and non-aggressive central giant cell lesions (CGCL). This is an immunohistochemistry study (immunoperoxidase technique) of 52 cases of CGCL of the jaws, in which 12 patients were treated with intralesional triamcinolone injections and one with calcitonin nasal spray. The mean of immunostaining was compared between the cell types and clinical subtype of the lesion. The correlations among means were analyzed by Mann-Whitney test. Of the 52 cases studied, 53.8% were females, with a mean of 25.69 years. Most lesions were located in the mandible. Thirty patients (57.7%) had aggressive lesions and 22 (42.3%) of the cases consisted of non-aggressive lesions. Surgery was the treatment of choice in 75% of the cases. In 56.7% of the aggressive CGCL surgery was performed, while 43.4% of patients were submitted to conservative treatment. Among cases submitted to conservative treatment, the majority (n = 8; 61.5%) responded well to treatment. CTR expression was observed in 67.3% and GCR in 96.15% of cases. There was no significant statistical difference between the expression of CTRs and GCRs in mononuclear and multinucleated CGCLscells, regarding aggressiveness, treatment performed for aggressive lesions and the response to conservative treatment (p>0.05). The results of our research suggest that the immunoreactivity of CTRs and GCRs did not influence the response to clinical treatment with calcitonin or triamcinolone in the sample studied and it exhibited a varied expression regardless of the aggressiveness of the lesion.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-06-02T21:45:30Z No. of bitstreams: 1 VictorHugoRezendeDuarte_DISSERT.pdf: 944081 bytes, checksum: b102ccdae8dc58e29f3c26819c75b9c6 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-06-07T21:07:26Z (GMT) No. of bitstreams: 1 VictorHugoRezendeDuarte_DISSERT.pdf: 944081 bytes, checksum: b102ccdae8dc58e29f3c26819c75b9c6 (MD5) / Made available in DSpace on 2017-06-07T21:07:26Z (GMT). No. of bitstreams: 1 VictorHugoRezendeDuarte_DISSERT.pdf: 944081 bytes, checksum: b102ccdae8dc58e29f3c26819c75b9c6 (MD5) Previous issue date: 2017-04-26 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / As prote?nas da fam?lia triggering receptor expressed on myeloid cells (TREM) s?o associados com o risco e progress?o da aterosclerose. Em resultados pr?vios observamos que a alta express?o do TREML4est? relacionada com fase inicial da S?ndrome Coronariana Aguda (SCA).Neste estudo, investigamos a rela??o dos polimorfismos e a express?o do RNAm do TREML4 em leuc?citos de pacientes estratificados de acordo com a extens?o das les?es das atr?rias coron?rias. Foram inclu?dos pacientes com doen?a arterial coronariana (DAC) (n=151), com idades entre 30 e 74 anos, submetidos ? angiografia coron?ria eletiva. A extens?o da les?o coronariana foi avaliada atrav?s do ?ndice de Friesinger. Os polimorfismosrs2803495 (A> G), rs2803496 (T> C) e aexpress?o do RNAm do TREML4 em leuc?citos foram analisadas por qRT-PCR. A express?o de TREML4 foi maior em pacientes com les?es coronarianas graves em rela??o aos sem les?o, baixas e intermedi?rias, (p <0.05). Indiv?duos portadores do alelo G do rs2803495 (gen?tipos AG / GG) e do alelo C do rs2803496(gen?tipos TC / CC) apresentaram uma express?o de RNAm de TREML4 positiva (Alelo G: OR = 2.4, 95% CI 1.0-5.7, p < 0.05; e Alelo C: OR = 7.8, 95% CI = 2.9-20.9, p < 0.01, respectivamente).Entretanto, os polimorfismos do TREML4 n?o foram associados com as extens?es das les?es coron?rias. Em conclus?o, a express?o aumentada de mRNA de TREML4 nos leuc?citos ? influenciada por polimorfismos e est? associada a les?es mais graves das art?rias coron?rias, sugerindo seu papel como potencial biomarcador para investigar a extens?o da les?o coronariana em pacientes com DAC. / The members of the triggering receptor expressed on myeloid cells (TREM) family are associated with the risk and progression of atherosclerosis. We previously reported the upregulation of TREML4 in the early phase of theacute coronary syndrome. Here, we investigated the relationship of TREML4 polymorphisms and mRNA expression in blood leukocytes of patients stratificate accordingto the extension of coronary artery lesion. Patients with coronary artery disease (CAD) (n = 151), aged 30 to 74 years and undergoing elective coronary angiography,were selected. The extension of coronary lesion was assessed by the Friesinger index.TREML4 rs2803495 (A>G) and rs2803496 (T>C) variants andleukocyte mRNA expression were analyzed by qRT-PCR. TREML4 expression was higher in patients with major coronary artery lesions compared to subjects without or with low and intermediate lesions, (p < 0.05). Subjects carrying rs2803495 G allele (AG/GG genotypes) and rs2803496 C allele (TC/CC genotypes) were more prone to have positive TREML4 mRNA expression (Allele G: OR = 2.4, 95% CI 1.0-5.7, p < 0.05; allele C: OR = 7.8, and 95% CI = 2.9-20.9, p < 0.01, respectively).However, TREML4 polymorphisms were not associated with the extent of coronary lesion.In conclusion, increased TREML4 mRNA expression in blood leukocytes is influenced by gene polymorphisms and it is associated with more severe coronary artery lesions, suggesting its role as potential biomarker to investigate the extent of coronary lesion in CAD patients.

Made available in DSpace on 2014-12-17T14:13:33Z (GMT). No. of bitstreams: 1 FabioBR.pdf: 720183 bytes, checksum: 1313bd8e73f55a8bcc3e2f4c1f5d52a7 (MD5) Previous issue date: 2007-12-20 / Despite the observation of an increase in life expectancy in individuals with Spinal cord injury (SCI), it is lower than that of the general population. Studies have shown that affected individuals have a sedentary lifestyle that reflects negatively on health and quality of life. Studies have demonstrated that HDL cholesterol (HDL-C) levels, a high-density lipoprotein and important predictor of cardiovascular disease, are lower in this population exposing these people to a greater incidence of heart disease from atherosclerotic process In the general population, exercise increases HDL-C serum levels, but this phenomenon is not very clear in people with spinal cord injury (SCI). The present study examined the effect of both swimming and wheelchair basketball in the lipid profile of eleven men and seven women with SCI. The subjects included in regular exercise programs showed increases in HDL-C levels and decreases in CT/HDL-C and LDL-C/HDL-C ratios. We found better results mainly in men with lower levels of SCI and in those that sustained exercise intensities above 60% of the heart rate reserve. The duration of training sessions can be an essential factor in these results. The results suggest that both the exercise prescription and the personal characteristics of people with SCI influence changes in the lipid profile mediated through exercise. The elaboration of this work is an attempt to clarify uncertainties about health and the longevity of people with SCI generated in discussion of all members of the interdisciplinary rehabilitation team, especially the physiotherapists, nutritionists, nurses and physicians that contributed considerably in all phases of the research / Apesar do aumento da expectativa de vida das pessoas com les?o medular (LM), esta ? ainda inferior ? da popula??o em geral. Pesquisas demonstram que os indiv?duos acometidos pela LM levam um estilo de vida sedent?rio, o que repercute negativamente na sa?de e na qualidade de vida. Os n?veis do colesterol HDL (HDL-C), cada vez mais se consolidam como importantes preditores de doen?a cardiovascular. Na popula??o com LM, os n?veis destas lipoprote?nas encontram-se significativamente diminu?dos, expondo estes indiv?duos a uma maior incid?ncia de doen?as cardiovasculares ligadas ao processo ateroscler?tico. Estudos na popula??o geral assinalam que o exerc?cio f?sico regular eleva os n?veis s?ricos de HDL-C. Por?m, este fen?meno n?o ? muito claro para aqueles com LM. O presente estudo analisou o efeito da nata??o e do basquetebol em cadeira de rodas no perfillip?dico de 11 homens e sete mulheres com LM inclu?dos em um programa regular de atividade f?sica. Os participantes mostraram modifica??es entre a primeira e a segunda coleta que sugerem aumento nos n?veis de HDL-C e diminui??es nas rela??es CT/HDL-C e LDL-C/HDL-C. Verificaram-se melhores resultados nos homens com LM em n?veis mais baixos e que se submeteram a intensidade de esfor?o superior a 60% da freq??ncia card?aca de reserva. O tempo de dura??o da sess?o de treinamento pode ser uma vari?vel fundamental nestes resultados. Estes resultados sugerem que tanto a prescri??o do exerc?cio quanto caracter?sticas individuais das pessoas com LM influenciam modifica??es no perfil lip?dico mediadas pelo exerc?cio. A elabora??o deste trabalho ? uma tentativa de esclarecer questionamentos relacionados ? sa?de e a longevidade de pessoas com LM gerados atrav?s da discuss?o de todos integrantes da equipe interdisciplinar de reabilita??o, especialmente os fisioterapeutas,nutricionistas,enfermeiros e m?dicos, que contribu?ram consideravelmente em todas as fases da pesquisa

Made available in DSpace on 2014-12-17T15:16:03Z (GMT). No. of bitstreams: 1 MariaINN.pdf: 1641471 bytes, checksum: 418fb1ddb8d49afec9041cfbd9871221 (MD5) Previous issue date: 2009-03-18 / Background: Several studies emphasize the importance of assessing the knee function after anterior cruciate ligament (ACL) reconstruction. The influence of several variables on the function of these patients has been analyzed, but there is no consensus in the science literature. Purpose: To evaluate the correlation between the torque and balance on the knee function after ACL reconstruction. Methods: 23 males patients with ACL reconstruction were tested. The procedures of the study included analysis of concentric peak torque at 60o/s and 180o/s of quadriceps femoris and hamstring muscle with a isokinetic dynamometer. The balance in single-limb stance was measured with stabilometry. The functional performance were performed by two hop tests. To estimate the subjective function of the patients was applied Lysholm Knee Scoring Scale and a Global Rating scale. Results: The analysis of data showed a moderate positive correlation between knee extensor torque and functional performance tests (r= 0,48; p=0,02). A moderate negative correlation was found between the two variables of the stabilometry center of pressure and average speed of centre of pressure and the Global Rating scale (r = -0.4, p = 0,04 and r = -0,49, p = 0 ,02, respectively). No correlation was found between peak torque and balance in single-limb stance. Conclusion: The results of the present study suggest that knee extensor strength and postural balance have some influence on knee function in patients after ACL reconstruction / Introdu??o: Diversos estudos ressaltam a import?ncia de avaliar a fun??o do joelho ap?s a reconstru??o do Ligamento Cruzado Anterior (LCA). A influ?ncia de diversas vari?veis sobre a fun??o desses pacientes tem sido analisada, por?m ainda n?o ? encontrado um consenso na literatura. Objetivo: avaliar correla??o entre o torque e o equil?brio postural sobre a fun??o do joelho ap?s a reconstru??o do LCA. M?todos: Foram avaliados 23 pacientes do sexo masculino. Os procedimentos do estudo inclu?ram an?lise do torque conc?ntrico a 60o/s 180 o/s dos m?sculos quadr?ceps e ?squiostibiais no dinam?metro isocin?tico. O equil?brio est?tico em apoio unipodal foi avaliado sobre um baropod?metro computadorizado. A avalia??o do desempenho funcional foi feita por dois testes de salto e para estimar a fun??o subjetiva dos pacientes foi aplicado o question?rio Lysholm e uma escala de avalia??o global. Resultados: A an?lise dos dados mostrou uma correla??o positiva moderada entre o pico de torque extensor e os testes de desempenho funcional (r= 0,48; p= 0,02) e uma correla??o negativa moderada entre as vari?veis do equil?brio oscila??o do centro de press?o e velocidade m?dia do centro de press?o e a escala de avalia??o global (r= - 0,4; p= 0,04 e r= -0,49; p= 0,02, respectivamente). Nenhuma correla??o foi encontrada entre pico de torque e equil?brio em apoio unipodal. Conclus?o: Os resultados encontrados no presente estudo sugerem que a for?a extensora e o equil?brio postural t?m alguma influ?ncia na fun??o do joelho de pacientes ap?s reconstru??o de LCA

Made available in DSpace on 2014-12-17T15:32:29Z (GMT). No. of bitstreams: 1 KaruzaMAP_Tese.pdf: 829792 bytes, checksum: 60cd145c0f060b54f7dfbb5463648200 (MD5) Previous issue date: 2010-02-25 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / The Giant Cell Lesions, both the Central Giant Cells Lesions (CGCL) as the Peripheral Giant Cells Lesions (PGCL), correspond to a group of oral lesions that are histologically similar entities; however they show a variable clinical behaviour. The purpose of this study was to compare the immunohistochemical expression of bone resorption factors RANK (Receptor Activator of Nuclear Factor kappa B), RANKL (Receptor Activator of Nuclear Factor kappa B Ligand) and OPG (Osteoprotegerin) between CGCL and PGCL. Additionally, these bone resorption factors were examined in terms of aggressiveness of these lesions. The sample consisted of 61 cases, 30 cases of PGCL and 31 CGCL (16 non-aggressive and 15 aggressive). The analysis was performed by quantification of mononuclear cells (MO) and giant multinucleated cells (CG) immunopositive to anti-RANK, anti-RANKL and anti-OPG antibodies in 10 fields. Moreover, according to the proportion between the amount of cells positive for RANKL and OPG, the cases were categorized into: RANKL>OPG, OPG>RANKL e RANKL=OPG. CGCL showed a higher amount of MO (p=0.002) and total cells (p=0.003) both positives to RANKL compared with the PGCL. Additionally, the CGCL revealed a significant association with the ratio of RANKL>OPG (p=0.001). Analysis of the bone resorption factors revealed no significant differences between aggressive and non-aggressive CGCL (p>0.05). It was observed a positive correlation between the markers themselves, and a negative correlation between lesion size and quantity of OPG positive MO cells (p=0,004) and total cells (p=0,009). Through these results, we suggest that the greatest CGCL resorptive potential compared to the PGCL, may have occurred to the high expression of RANKL. Furthermore differences in the biological behavior of aggressive and non-aggressive CGCL appear to be related to the expression of these bone resorption factors / As Les?es de C?lulas Gigantes, tanto as Les?es Centrais (LCCG) quanto as Perif?ricas (LPCG), correspondem a um grupo de les?es orais que apresentam-se histologicamente semelhantes, por?m demonstram um comportamento cl?nico vari?vel. O prop?sito deste estudo foi comparar a express?o imuno-histoqu?mica dos fatores de reabsor??o ?ssea RANK (Receptor Ativador do Fator Nuclear kappa B), RANKL (Ligante do Receptor Ativador do Fator Nuclear kappa B) e OPG (Osteoprotegerina) entre LCCG e LPCG. Adicionalmente, esses fatores foram analisados nas LCCG quanto ? agressividade destas. A amostra consistiu de 61 casos, sendo 30 casos de LPCG e 31 de LCCG (16 n?o-agressivos e 15 agressivos). A an?lise foi realizada por meio da quantifica??o das c?lulas mononucleadas (MO) e c?lulas gigantes multinucleadas (CG) imunopositivas aos anticorpos anti-RANK, anti-RANKL e anti-OPG, em 10 campos. Al?m disso, de acordo com a propor??o entre quantidade total de c?lulas positivas para RANKL e para OPG, os casos foram categorizados em: RANKL>OPG, OPG>RANKL e RANKL=OPG. As LCCG apresentaram maior quantidade de MO (p=0,002) e c?lulas totais (p=0,003) positivas para RANKL, em compara??o com as LPCG. As LCCG ainda revelaram uma associa??o significativa com a propor??o de RANKL>OPG (p=0,001). A an?lise dos fatores de reabsor??o ?ssea n?o revelou diferen?as significativas entre LCCG agressivas e n?o-agressivas (p>0,05). Foi constatada correla??o positiva dos marcadores entre si, bem como uma correla??o negativa entre o tamanho das les?es e a quantidade de MO (p=0,004) e c?lulas totais (p=0,009) positivas para OPG. Diante desses resultados, concluise que o maior potencial reabsortivo das LCCG frente ?s LPCG pode ser decorrente da elevada express?o de RANKL. Al?m disso, as diferen?as nos comportamentos biol?gicos de LCCG agressivas e n?o-agressivas parecem n?o estar relacionadas com a express?o desses fatores de reabsor??o ?ssea.