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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
51

Tanscriptional regulation of human UDP-glucuronosyltransferases

Gardner-Stephen, Dione A. January 2008 (has links)
Thesis (Ph.D.)--Flinders University, School of Medicine, Dept. of Clinical Pharmacology. / Typescript bound. Includes bibliographical references: (leaves 334-391) Also available electronically.
52

AN EVALUATION OF THE NEWBORN MOUSE AS A POTENTIAL MODEL FOR THE BIOASSAY OF LIVER CARCINOGENESIS USING HISTOLOGICAL AND HISTOCHEMICAL MARKERS.

Cater, Kathleen Carmelle. January 1982 (has links)
No description available.
53

Identification and characterization of tumorigenic liver cancer stem/progenitor cells

Ma, Kwai-yee, Stephanie., 馬桂宜. January 2007 (has links)
Li Ka Shing Prizes for best PhD theses in the Faculties of Dentistry, Engineering, Medicine and Science, 2006-2007 / published_or_final_version / abstract / Pathology / Doctoral / Doctor of Philosophy
54

Melatonin receptors in mouse hepatocytes: binding characteristics and the effects of blood glucose

蔡孝柔, Choy, Hou-yau, Evelyn. January 1999 (has links)
published_or_final_version / Physiology / Master / Master of Philosophy
55

A study into the inhibitory effects of omega-3 fatty acids upon hepatocyte and macrophage mediated inflammation

Wong, Yun-en, Olive., 王韻恩. January 2009 (has links)
published_or_final_version / Surgery / Master / Master of Medical Sciences
56

THE DISPOSITION AND BIOTRANSFORMATION OF POLYCHLORINATED BIPHENYL CONGENERS IN ISOLATED RAT HEPATOCYTES.

VICKERS, ALISON ELIZABETH MARY. January 1983 (has links)
The metabolism and distribution of three commonly occurring PCB congeners, 4,4'-dichlorobiphenyl (4-DCB), 2,2',3,3',6,6'-hexachlorobiphenyl (236-HCB) and 2,2',4,4',5,5'-hexachlorobiphenyl (245-HCB), each displaying different structural features, were investigated at their principal metabolic site, the hepatocyte. Hepatocytes, isolated from male Sprague-Dawley rats (200-250 g) by collagenase perfusion, were suspended in medium 199 and maintained at 37°C in a gyratory shaker. The radiolabeled ¹⁴C-PCB congeners were added to the hepatocyte suspensions as a DMSO-albumin mixture. Each congener was rapidly taken up by the cells with less than 10% of the congener remaining in the medium. The congeners accumulated within the hepatocytes without being fully metabolized. Metabolism followed first order Michaelis-Menten kinetics for 20 min and plateaued by 90 min at which point only 32% of 4-DCB (0.01-100 uM) and 60% of 236-HCB (0.01-100 uM) was metabolized, while 245-HCB (0.1-200 uM) was not metabolized. Readdition of congener once metabolism had plateaued resulted in a reinitiation of metabolism with the same proportion of metabolites produced indicating that product inhibition was not the cause for the plateau. A partitioning of the PCB congeners within subcellular compartments and binding to cytosolic proteins influenced the extent of metabolism by decreasing the availability of congener for the drug metabolizing enzymes, cytochrome P-450. Spectral binding studies further revealed that the ability of a PCB congener to bind to the cytochrome P-450 system correlated with the extent of metabolism observed, with 236-HCB 4-DCB 245-HCB. The metabolic potential of the PCB congeners was influenced by both the affinity of the congener for cytochrome P-450 and the partitioning of congener within the hepatocyte, and not by product inhibition.
57

The influence of copper deficiency on the binding and uptake of high-density lipoprotein by rat hepatic parenchymal cells

Zhang, Jin, 1960- January 1988 (has links)
This study was designed to examine the influence of Cu deficiency on the binding, uptake, and degradation of apolipoprotein E-free high density lipoproteins (apo E-free HDL) in cultured rat hepatic parenchymal cells. The binding of apo E-free HDL during time course studies was slightly but significantly increased in cells derived from Cu-deficient rats. In saturation studies, the amount of surface-bound apo E-free HDL appeared to be saturable, although no difference was observed between Cu-deficient and adequate animals. The amount of total and specific cell-associated uptake of apo E-free HDL was significantly increased in hepatic parenchymal cells of Cu-deficient animals. The present data suggest that hepatic uptake of the HDL protein moiety may be increased in rats fed a diet deficient in copper.
58

Effect of cellular redox and energy states on benzo[a]pyrene induced modes of death in the hepa and the HepG2 cell lines

To, Wing Shu 01 January 2010 (has links)
No description available.
59

Effects of gambogic acid on human hepatoma cells. / 藤黃酸對肝癌細胞的作用 / Teng huang suan dui gan ai xi bao de zuo yong

January 2008 (has links)
Lee, Ngan Hon. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2008. / Includes bibliographical references (leaves 120-133). / Abstracts in English and Chinese. / Acknowledgements --- p.IV / Abstract --- p.V / 論文摘要 --- p.VII / Table of Contents --- p.IX / List of Figures --- p.XI / List of Abbreviations --- p.XIII / Chapter 1 Introduction --- p.1 / Chapter 1.1 --- Hepatocellular carcinoma (HCC) --- p.1 / Chapter 1.1.1 --- Risk factors --- p.1 / Chapter 1.1.2 --- Molecular mechanism of HCC --- p.4 / Chapter 1.1.3 --- Treatment of HCC --- p.7 / Chapter 1.2 --- Gambogic acid (GA) - a compound derived from Tradition Chinese Medicine (TCM) --- p.9 / Chapter 1.2.1 --- Traditional Chinese Medicine (TCM) --- p.9 / Chapter 1.2.2 --- Gambogic acid --- p.13 / Chapter 1.3 --- Molecular mechanism of apoptosis --- p.18 / Chapter 1.3.1 --- Overview of apoptosis --- p.18 / Chapter 1.3.2 --- Caspases cascade --- p.18 / Chapter 1.3.3 --- Bcl-2 family --- p.20 / Chapter 1.3.4 --- Mitochondria in apoptosis --- p.23 / Chapter 1.4 --- Apoptosis as a strategy for cancer therapies --- p.26 / Chapter 1.5 --- Aims of study --- p.29 / Chapter Chapter 2 --- Materials and Methods --- p.30 / Chapter 2.1 --- Cell culture and treatment --- p.30 / Chapter 2.1.1 --- Cell lines used --- p.30 / Chapter 2.1.2 --- Gambogic acid (GA) --- p.31 / Chapter 2.1.3 --- Chemicals and reagents --- p.31 / Chapter 2.1.4 --- Preparation of solutions --- p.32 / Chapter 2.1.5 --- Procedures --- p.33 / Chapter 2.2 --- Apoptotic detection --- p.35 / Chapter 2.2.1 --- Chemicals and reagents --- p.35 / Chapter 2.2.2 --- Preparation of solutions --- p.35 / Chapter 2.2.3 --- Procedures --- p.37 / Chapter 2.3 --- Effects of GA on gene expression in HepG2 --- p.41 / Chapter 2.3.1 --- Chemicals and Reagents --- p.41 / Chapter 2.3.2 --- Preparation of solutions --- p.41 / Chapter 2.3.3 --- Procedures --- p.43 / Chapter 2.4 --- Protein expression in GA-induced apoptotic cells --- p.51 / Chapter 2.4.1 --- Chemicals and Reagents --- p.51 / Chapter 2.4.2 --- Preparation of solution --- p.51 / Chapter 2.4.3 --- Procedures --- p.54 / Chapter 2.5 --- Caspase cascade study in GA-induced apoptosis --- p.60 / Chapter 2.5.1 --- Chemicals and reagents --- p.60 / Chapter 2.5.2 --- Procedures --- p.60 / Chapter 2.6 --- Downregulation of mRNA using siRNA vector --- p.62 / Chapter 2.6.1 --- siRNA expression vector --- p.62 / Chapter 2.6.2 --- Chemicals and Reagents --- p.63 / Chapter 2.6.3 --- Preparation of solution --- p.63 / Chapter 2.6.4 --- Procedures --- p.64 / Chapter Chapter 3 --- Results --- p.71 / Chapter 3.1 --- GA induces apoptosis in hepatocellular cells --- p.71 / Chapter 3.2 --- Effects of gene expression in HCC --- p.80 / Chapter 3.3 --- Caspase cascade studies in GA-induced apoptosis --- p.83 / Chapter 3.4 --- Caspase 8 activation in GA-treated cells lead to Bid cleavage --- p.89 / Chapter 3.5 --- GA induces Bax conformational changes and cytochrome c release --- p.95 / Chapter 3.6 --- Levels of protein players involved in apoptosis and cell cycle --- p.101 / Chapter Chapter 4 --- Discussion --- p.106 / References --- p.120
60

Investigations into mechanisms of paracetamol-induced toxicity using ìn vitro' systems

Bruschi, Sam A. (Sam Anthony) January 1987 (has links) (PDF)
Bibliography: leaves 116-138.

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