INTRODUCTION: Celiac disease is a chronic immune disorder for which the only treatment is strict life-long adherence to a gluten-free diet (GFD). Collaborative management through regular follow-up with a care team that includes physicians and dietitians may improve long-term outcomes. However, many individuals with celiac disease are lost to follow-up. OBJECTIVE: This primary objective of this study was to identify factors associated with pediatric celiac disease patients being lost to follow-up. Secondary aims included identifying adherence to recommended care practices by both patients and providers. METHODS: A chart review of 250 randomly selected children with biopsy-confirmed celiac disease diagnosed between 2010 and 2014 at Boston Children’s Hospital (BCH) was conducted. Follow-up records were reviewed from diagnosis to 2017. Eligible children were diagnosed prior to age 18 and did not attend BCH solely for a second opinion. Demographics, medical history, visit information, and lab results were collected using an online database. RESULTS: Of the 241 eligible subjects (64% female, 1-17 years, median 9.7 years) the median time until lost to follow-up was 2.8 years from diagnosis (IQR, 1.0-4.7 years) with 22 subjects (9%) not attending any follow-up visits with their pediatric gastroenterologist (GI) after diagnosis and an additional 37 subjects (14%) lost within the first year. A majority of subjects (83%) attended a GFD education visit with a registered dietitian, although this was not associated with follow-up adherence (P>0.5). Excluding those who had aged out of the clinical practice, children who were adherent to follow-up had a younger mean age of diagnosis (95% CI 0.5-3.1, P<0.01). Children who were insured under Medicaid/CHIP (N=20) were more likely to be lost within one year compared to those with private health insurance (P<0.01). Celiac serologies taken at time of last clinical visit were abnormal in 25% of the subjects with available results (N=141) and the median time since diagnosis in this positive serology subgroup was 20 months (IQR, 12-29 months). DISCUSSION: The present study illustrates that children with celiac disease are not being followed-up adequately and that identifiable disparities exist in the pediatric celiac disease population. Within three years of diagnosis, 50% of the cohort was lost to follow-up with the majority of subjects lost within the first year of diagnosis. Children diagnosed at a younger age were more adherent to follow-up compared to those diagnosed during adolescence. Factors associated with decreased adherence included reliance on public medical insurance and older age at diagnosis. Improvement in long-term management of celiac disease may be achieved by increased outreach and education.

Orientador: Maria Cecilia Marconi Pinheiro Lima / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas / Made available in DSpace on 2018-08-23T03:43:36Z (GMT). No. of bitstreams: 1 Frederico_Michele_M.pdf: 1609671 bytes, checksum: 303c1622acace9483b0babc7d0f4dbcf (MD5) Previous issue date: 2013 / Resumo: O monitoramento do desenvolvimento auditivo e de linguagem, no primeiro ano de vida, possibilita a identificação precoce de uma perda auditiva e o encaminhamento da criança para os serviços especializados, caso o problema se confirme. Os objetivos do presente estudo foram os de analisar a utilização de estratégias de comunicação com mães de crianças com indicadores de risco para perda auditiva na adesão a um Programa de Monitoramento do Desenvolvimento Auditivo e de Linguagem, conhecer o perfil das mães que retornam para o monitoramento e a concepção que as mães possuem sobre as conseqüências de uma perda auditiva na infância. Os participantes do estudo foram mães encaminhadas de um hospital público, que compareceram para a realização da triagem auditiva do lactente realizada no seu primeiro mês de vida. Os lactentes que na triagem auditiva tiveram resultado normal, mas que possuíam algum indicador de risco era agendado para o Programa. As mães receberam informações, por meio de folder explicativo, sobre o desenvolvimento auditivo e as consequências de uma perda auditiva tardia, além de ligação telefônica dois dias antes da data agendada. A pesquisa caracterizou-se do tipo prospectivo longitudinal com análise quantitativa e qualitativa. Os dados foram coletados no período de agosto de 2011 a fevereiro de 2012, obtidos por meio do número de comparecimentos no livro de registros dos lactentes e entrevista semi-estruturada com as mães. Foram utilizados dados dos anos de 2009 e 2010 para comparação da freqüência de retornos das mães. Em 2009, 121 (49,19%) mães aderiam ao Programa; em 2010, 148 (50,17%) e em 2011, com as estratégias do telefonema e do uso do folder explicativo, 195 (58,38%) mães aderiram. Foram entrevistadas 53 mães, sendo que 38 (71,69%) disseram não ter dificuldades em comparecer às avaliações, embora alguns fatores tenham dificultado o comparecimento, tais como: dispensa no trabalho e uso do transporte coletivo. As principais razões de adesão foram: preocupação quanto à audição, presença de indicador de risco e retorno agendado. Com relação ao perfil das mães, a maioria possuía ensino médio completo, se encontrava em união estável, procedentes da cidade de Campinas e não possuíam vínculo empregatício. Do grupo entrevistado, 39 (73,58%) mães demonstraram ter algum conhecimento sobre a deficiência auditiva. A maioria das mães se preocupa com a audição do lactente, com a questão do aprendizado escolar e fazem relação entre fala e audição / Abstract: The monitoring of auditory and language development in the first year of life, enables early identification of hearing loss and referral of children to specialized services if the problem is confirmed. The objectives of this study were to examine the use of communication strategies with mothers of children with risk factors for hearing loss in adhesion to a Monitoring Program of Development of Auditory and Language, knowing the profile of mothers who return to monitoring and design that mothers have about the consequences of hearing loss in childhood. Study participants were mothers referred from a public hospital, who attended the hearing screening of infants performed in their first month of life. Infants with hearing screening results were normal but had some risk indicator, were booked into the program. Mothers received information through explanatory folder on auditory development and the consequences of hearing loss late addition to phone call two days before the scheduled date. The research was characterized with a prospective longitudinal quantitative and qualitative analysis. Data were collected from August 2011 to February 2012, obtained by the number of appearances in the book of records of infants and semi-structured interviews with mothers. Data from 2009 and 2010 to compare the frequency of returns of mothers. In 2009, 121 (49.19%) mothers adhered to the program, in 2010, 148 (50.17%) and in 2011, with the strategies of the call and the use of explanatory folder, 195 (58.38%) mothers joined. 53 mothers were interviewed, of which 38 (71.69%) said they had difficulties in attending assessments, although some factors have hampered attendance such as waiver at work and use of public transport. The main reasons for membership were: concern about hearing, presence of indicator of risk and return scheduled. Regarding the profile of mothers, the majority had completed high school, was in stable, coming from the city of Campinas and had no employment. The respondent group, 39 (73.58%) mothers were found to have some knowledge about hearing impairment. Most mothers worry about hearing the infant, with the issue of school learning and make the relationship between speech and hearing / Mestrado / Interdisciplinaridade e Reabilitação / Mestra em Saúde, Interdisciplinaridade e Reabilitação

Master of Public Health - MPH / Background: HIV/AIDS remains a major public health issue that is affecting all population groups and communities in Zambia. Among the most affected groups are key populations (KPs) such as female sex workers. KPs are considered at high risk of contracting HIV but have limited access to HIV services and retention in care due to internalized stigma, discrimination, criminalization, and negative attitudes towards HIV treatment. Under the USAID Open Doors project in Zambia, KPs access comprehensive HIV prevention, care and treatment services. The test and treat strategy is implemented by the project in support of the UNAIDS 90-90-90 targets by 2020 to diagnose 90% of people living with HIV, put 90% of them on treatment, and for 90% of them to have suppressed viral load. Aim: This study aimed to determine retention in care among female sex workers (FSWs) in the first six months after ART initiation using the HIV care cascade. Methodology: A retrospective cohort study was conducted of all new HIV positive female sex workers (FSWs) initiated on ART between October 2018 and June 2019 (9 months period) based on the electronic records. Data were extracted from SmartCare, an electronic health record system used by the ART clinic. Microsoft Excel and Epi-Info 7 software were used for data entry and analysis. Kaplan–Meier survival analysis was conducted to examine differences in retention rates. Results: A total of 205 FSWs were initiated on ART, out of which 180 were active on ART (36 youths and 144 adults) and 25 were lost to follow-up (four youths and 21 adults) during the 9 months study period. Of the 180 FSWs active on ART, 36 were FSWs aged 18 – 24 years (youths) representing 90% retained in care while 144 were FSWs aged 25 – 42 years (adults) with 87% being retained on ART treatment. Retention in ART care was not significantly different in the survival curves between the age groups of FSW youths and FSW adults during the study period (p-value = 0.637). Retention in ART care was not statistically significant for education (p-value = 0.481), marital status (p-value = 0.545), and occupation (p-value = 0.169). Conclusion: Retention in ART care among FSWs was 88%. However, there were no significant differences by age group identified in this study. While this study shows 88% retention rate among FSWs, it will be used as a baseline in meeting the UNAIDS 90-90-90 goals.

Magister Public Health - MPH / Background: HIV/AIDS remains a major public health issue that is affecting all population groups and communities in Zambia. Among the most affected groups are key populations (KPs) such as female sex workers. KPs are considered at high risk of contracting HIV but have limited access to HIV services and retention in care due to internalized stigma, discrimination, criminalization, and negative attitudes towards HIV treatment. Under the USAID Open Doors project in Zambia, KPs access comprehensive HIV prevention, care and treatment services. The test and treat strategy is implemented by the project in support of the UNAIDS 90-90-90 targets by 2020 to diagnose 90% of people living with HIV, put 90% of them on treatment, and for 90% of them to have suppressed viral load. Aim: This study aimed to determine retention in care among female sex workers (FSWs) in the first six months after ART initiation using the HIV care cascade. Methodology: A retrospective cohort study was conducted of all new HIV positive female sex workers (FSWs) initiated on ART between October 2018 and June 2019 (9 months period) based on the electronic records. Data were extracted from SmartCare, an electronic health record system used by the ART clinic. Microsoft Excel and Epi-Info 7 software were used for data entry and analysis. Kaplan–Meier survival analysis was conducted to examine differences in retention rates. Results: A total of 205 FSWs were initiated on ART, out of which 180 were active on ART (36 youths and 144 adults) and 25 were lost to follow-up (four youths and 21 adults) during the 9 months study period. Of the 180 FSWs active on ART, 36 were FSWs aged 18 – 24 years (youths) representing 90% retained in care while 144 were FSWs aged 25 – 42 years (adults) with 87% being retained on ART treatment. Retention in ART care was not significantly different in the survival curves between the age groups of FSW youths and FSW adults during the study period (p-value = 0.637). Retention in ART care was not statistically significant for education (p-value = 0.481), marital status (p-value = 0.545), and occupation (p-value = 0.169). Conclusion: Retention in ART care among FSWs was 88%. However, there were no significant differences by age group identified in this study. While this study shows 88% retention rate among FSWs, it will be used as a baseline in meeting the UNAIDS 90-90-90 goals.

Made available in DSpace on 2014-12-17T14:13:51Z (GMT). No. of bitstreams: 1 MariaLCS_TESE.pdf: 740512 bytes, checksum: d109f443eb2da08401d2bbd676359e7c (MD5) Previous issue date: 2013-11-27 / The aim of the present study was to analyze cardiovascular risk of women with a history of preeclampsia, as well as its follow-upin the National Health System.This is a cross-sectional quantitative research conducted at the Janu?rio Cicco Maternity School. The study population was composed of 573 women selected from a databank belonging to the Women s Health Research Group of the Gynecology Department at Universidade Federal do Rio Grande do Norte, with a history of preeclampsia, and normotensives who gave birth at this institution five years before. The final sample consisted of 147 women, 64 in the group with a history of PE and 83 normotensives. Data were collected on a questionnaire containing the following: sociodemographic aspects, anthropometric measures, life habits, personal and family history of pregnancy-induced hypertension, family history of cardiovascular diseases and frequency of measuring current blood pressure levels. In relation to the association between cardiovascular risk and altered blood pressure (&#8805;130x85 mmHg), the likelihood of exhibiting the latter condition was significantly higher in women with a history of preeclampsia (CI 95% 4.12-38.92), the overweight and obese (CI 95% 1.70-20.75), and in those with a family historyof CVD and personal history of PIH (CI 95% 0.78-47.07 and CI 95% 3.20-25.39) respectively. Likewise, the probability of having altered blood pressure was higher in women with fasting glycemia &#8805;100mg/dL (CI 95% 2.09-24.73), as well as in those with triglycerides &#8805;150mg/dl (CI 95% 1.72-9.66). After fitting the logistic model, diagnosis previous preeclampsia and altered triglycerides remained as explanatory variables.The women with a history of preeclampsia five years before exhibited altered blood pressure levels, clinical and laboratory manifestations suggestive of elevated risk for cardiovascular disease, as well as family and personal history of hypertension. There is no differential treatment or adequate outpatient follow-up for this population in basic health care units / O estudo teve como objetivo analisar o risco cardiovascular atual em mulheres com hist?rico de pr?-ecl?mpsia havia cinco anos e oseu seguimento no Sistema ?nico de Sa?de. Trata-se de pesquisa quantitativa do tipo transversal, realizada na Maternidade Escola Janu?rio Cicco. Avaliaram-se 147 mulheres, sendo 64 com hist?rico de pr?-eclampsia, comparadasa 83 com gesta??o normal. A pesquisa foi realizada atrav?s de busca ativa com coleta de sangue para mensura??o bioqu?mica de marcadores cardiovasculares e verifica??o da press?o arterial. Averiguaram-se aspectos sociodemogr?ficos, medidas antropom?tricas, h?bitos de vida, antecedentes pessoais e familiares para hipertens?o na gesta??o e antecedentes familiares de doen?a cardiovascular. Utilizou-se pacote estat?stico para as an?lises considerando n?vel de signific?ncia de 5%. O estudo foi aprovado pelo Comit? de ?tica em Pesquisa da Universidade do Federal do Rio Grande do Norte. No que se refere ? associa??o entre condi??es de risco cardiovascular e presen?a de n?veis press?ricos alterados (&#8805;130x85 mmHg), observa-se que a chance de ter press?o arterial alterada foi significativamente maior nas mulheres com hist?rico de pr?-ecl?mpsia (P< 0,001), nas com sobrepeso e obesas (P= 0,002), e ainda entre as com antecedente familiar de doen?a cardiovascular (P= 0,039) e com antecedente pessoal de doen?a hipertensiva da gesta??o (P< 0,001). Da mesma forma, a chance de ter press?o arterial alterada foi maior nas mulheres com glicemia de jejum &#8805;100mg/dL (P= 0,002), bem como nas com triglicer?deos &#8805;150mg/dl (P= 0,001). Conclui-se que as mulheres com hist?rico de pr?-ecl?mpsia havia cinco anos apresentavam atualmente manifesta??es sugestivas de risco elevado para doen?a cardiovascular, antecedentes familiares e pessoais de hipertens?o, bem como n?o h? atualmente atendimento diferenciado, nem seguimentoambulatorial adequado nas redes de aten??o prim?ria para essa popula??o

Submitted by Erika Demachki (erikademachki@gmail.com) on 2015-05-11T21:18:50Z No. of bitstreams: 2 Dissertação - Valéria Costa Peres - 2014.pdf: 1086390 bytes, checksum: d7d4f057f959093aea29c55a320a2f26 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) / Approved for entry into archive by Erika Demachki (erikademachki@gmail.com) on 2015-05-11T21:26:32Z (GMT) No. of bitstreams: 2 Dissertação - Valéria Costa Peres - 2014.pdf: 1086390 bytes, checksum: d7d4f057f959093aea29c55a320a2f26 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) / Made available in DSpace on 2015-05-11T21:26:32Z (GMT). No. of bitstreams: 2 Dissertação - Valéria Costa Peres - 2014.pdf: 1086390 bytes, checksum: d7d4f057f959093aea29c55a320a2f26 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Previous issue date: 2014-04-11 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES / INTRODUCTION: Breast cancer is the leading cause of women’s death in many countries and the cancer type of highest incidence among Brazilian women. It is important to strengthen public health policies for women's health through multidisciplinary teamwork to identify the best interventions aiming early detection of the disease recurrence and suiting follow-up after the treatment has begun. OBJECTIVE: To evaluate the association between relapse and survival of women with breast cancer staging and follow-up for five years after diagnosis. METHODOLOGY: retrospective cross-sectional study made in a specialized cancer institute in the state of Goiás. The study population consisted of 460 records of women diagnosed with breast cancer in 2008 and treated in this institution. Data collection was conducted in the period of June and October of 2013 through semi-structured script prepared by the researcher and validated by an expertise of the area. The data were transferred to an excel spreadsheet and analyzed in Statistical Package for Social Science (SPSS) 19.0. Categorical variables were presented as absolute value (f) and percentage value (%) and continuous variables were presented as average ± standard deviation. Fisher’s exact test was used to verify the association among categorical variables. It was considered statistically significant if p <0.05. The Kaplan Meier estimator was also used to identify the survival of women in a period of five years. The project was approved by the ethics research committee and complied with the ethical and legal aspects set out in Resolution No. 466 / 012. RESULTS: It was identified a rate of 14% of deaths, 6% of local/regional recurrence and 25% of metastatic within five years. It was pointed that 26% of women missed follow-up, from these, 45% were diagnosed at stage III, 35% had cancer recurrence and 77% of women did not have consultation with the nurse during the period. CONCLUSION: It is noticed an improvement in survival of women with breast cancer in five years, but there are still a significant number of women being diagnosed in advanced stages. Among women who lost follow-up, a considerable number of them were identified as relapsed before leaving the following, which confirms the need for effective strategies to ensure follow-up of these women in the health service during the recommended period. / INTRODUÇÃO: O câncer de mama se apresenta como a principal causa de morte em mulheres em diversos países e como o tipo de câncer de maior incidência entre as mulheres brasileiras. É importante consolidar políticas públicas de saúde voltadas à saúde da mulher com atuação da equipe multidisciplinar para análise das melhores intervenções que visem a detecção precoce de recidivas da doença e o seguimento adequado após instituição do tratamento. OBJETIVO: Avaliar a associação entre recidiva e sobrevida de mulheres com câncer de mama com estadiamento e seguimento durante cinco anos após o diagnóstico. METODOLOGIA: estudo de coorte transversal do tipo retrospectivo realizado em uma instituição especializada em oncologia do estado de Goiás. A população foi constituída de prontuários de mulheres diagnosticadas com câncer de mama no ano de 2008 atendidas nessa instituição, perfazendo o total de 460 prontuários. A coleta de dados foi realizada no período entre junho e outubro de 2013 por meio de roteiro semiestruturado elaborado pela pesquisadora e validado por expertise da área. Os dados foram transferidos para uma planilha do excel e analisados em Statistical Package for Social Science (SPSS) 19.0. As variáveis categóricas foram apresentadas como valor absoluto (f) e valor percentual (%) e as variáveis contínuas apresentadas como média±desvio padrão. O teste Exato de Fisher foi usado para verificar a associação entre as variáveis categóricas. Considerou-se estatisitcamente significativo p<0,05. Foi utilizado ainda a curva de Kaplan Meier a fim de identificar a sobrevida das mulheres em um período de cinco anos. O projeto foi aprovado pelo comitê de ética em pesquisa e atendeu aos aspectos ético-legais enunciados na Resolução nº466/012. RESULTADOS: Identificou-se uma taxa de 14% de óbitos, de 6% de recidiva locorregional e de 25% de metástase à distância em cinco anos. Detectou-se que 26% das mulheres apresentaram perda de seguimento, destas, 45% foram diagnosticadas no estágio III, 35% apresentaram recidiva da doença e 77% das mulheres não realizaram consulta com o enfermeiro durante o período. CONCLUSÃO: Percebe-se uma melhora da sobrevida de mulheres com câncer de mama em cinco anos, porém ainda há um número considerável de mulheres diagnosticadas em estágios avançados. Entre as mulheres que perderam o seguimento, um número considerável apresentou recidiva antes de abandonar o seguimento, o que confirma a necessidade de estratégias eficazes na garantia de acompanhamento dessas mulheres no serviço de saúde durante o período recomendado.

<p>Approximately 4.2 million Canadian adults suffer from a physical or psychological disability, of whom up to 30% suffer from depression. Those receiving disability benefits versus those not receiving benefits may be at greater risk of unsatisfactory outcomes because their circumstances or psychological status may interfere with successful implementation of standard therapies. This thesis addresses the effectiveness of therapies for depression in patients receiving disability benefits, using an individual patient data meta-analysis of all published randomized controlled trials evaluating Cognitive Behavioural Therapy and a secondary analysis of an administrative database from a large, private, Canadian insurer. Additionally, this thesis addresses an important methodological issue: assessing the impact of missing participant data for continuous outcomes in systematic reviews. Missing participant data may bias results of individual trials or systematic reviews of individual trials if participants with missing data have different expected outcomes from those with available data. No methods have been proposed for investigating the extent to which missing participant data for continuous outcomes might bias the results of systematic reviews, and this dissertation addresses that gap.</p> / Doctor of Philosophy (PhD)

Made available in DSpace on 2016-12-23T13:54:30Z (GMT). No. of bitstreams: 1 Regina Furbino Villefort Rocha.pdf: 5172514 bytes, checksum: a4a9d38bcac502c5c9c1fe6298995e29 (MD5) Previous issue date: 2012-07-04 / Ameloblastomas são tumores odontogênicos (TOs) de origem epitelial e etiologia desconhecida. Porém, estudos recentes identificaram alterações moleculares associadas ao desenvolvimento e progressão dos TOs, dentre elas as móleculas de adesão celular E-caderina e beta catenina. Objetivos: realizar um levantamento epidemiológico dos casos de ameloblastomas pertencentes ao arquivo do Serviço de Anatomia Patológica da Universidade Federal do Espírito Santo (SAPB-UFES), analisar suas características histopatológicas e a expressão de beta catenina nas diferentes variantes de ameloblastomas. Método: estudo retrospectivo dos casos de ameloblastomas registrados no SAPB-UFES, no período compreendido entre março de 2004 e dezembro de 2010. Foram coletados dados sociodemográficos, clinicorradiográficos, dados sobre acesso, diagnóstico, tratamento e seguimento desses pacientes. As análises histopatológicas foram baseadas nos critérios de Vickers e Gorlin, Waldron e El-Mofty e da Organização Mundial da Saúde. Para análise imuno-histoquímica foi utilizada a técnica indireta de imuno-peroxidase, com anticorpo primário anti beta catenina monoclonal de camundongo. Foram avaliados a intensidade e a localização da marcação. Para análise semiquantitativa foram adotados os escores: negativo, postividade focal, positividade variável e uniformidade positiva. Resultados: foram encontrados 13 ameloblastomas, classificados histopatologicamente como sólidos (06), unicísticos (03) e desmoplásicos (03). Todos foram imunomarcados. A intensidade de marcação variou de fraca a forte (1 a 3). A média de marcação variou de 10,82% a 13,38% no núcleo; de 39,93% a 47,61% na membrana; e de 90,01% a 98,53% no citoplasma. Entretanto não foi encontrada diferença significante de expressão de beta catenina entre os três diferentes tipos de ameloblastomas. Conclusão: os resultados epidemiológicos foram semelhantes a outros estudos. A expressão citoplasmática de beta catenina evidencia o acúmulo da mesma no citoplasma e sugere alteração na via de sinalização de Wnt. Por outro lado, a redução da expressão na membrana sugere alteração na adesão celular / Ameloblastomas are odontogenic tumors (OTs) derived from epithelium which etiology remains unknown. However, recent studies have identified molecular changes associated with the development and progression of OTs, including cell adhesion molecules like E-cadherin and beta-catenin. Objectives: to conduct an epidemiological investigation of ameloblastomas cases from files of the Anatomical Pathology Service at Federal University of Espírito Santo (SAPB-UFES), analyze their histopathological features and the expression of beta-catenin in different variants of ameloblastomas. Methods: a retrospective study of ameloblastomas registered at SAPB-UFES between March 2004 and December 2010. Sociodemographic, clinical and imaginological data were collected, as well as data about access, diagnosis, treatment and follow up of these patients. The histopathological analyzes were based on Vickers and Gorlin, Waldron and El-Mofty and the World Health Organization criteria. Primary antibody anti beta-catenin mouse monoclonal and indirect immuno-peroxidase technique was employed for immunohistochemical analysis. Intensity and location of the immunostaining were analysed. For semiquantitative analysis the scores were: negative, focal, variable and uniformity positivity. Results: there were 13 ameloblastomas, histopathologically classified as solid (06), unicystic (03) and desmoplastic (03). All of them were immunostained. The intensity of immunostaining ranged from weak to strong (1-3). The mean of immunostaining ranged from 10.82% to 13.38% in the nucleus; from 39.93% to 47.61% in the membrane; and from 90.01% to 98.53% in the cytoplasm. However, there was no significant difference in expression of beta-catenin between three different types of ameloblastomas. Conclusion: The results were similar to other epidemiological studies. The cytoplasmic expression of beta-catenin shows accumulation in the cytoplasm and suggests changes in the Wnt signaling pathway. Moreover, the reduction of membrane expression suggests changes in cell adhesion