Thesis (doctoral)--Katholieke Universiteit te Nijmegen.

Chung Mei-lan. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2000. / Includes bibliographical references (leaves 118-124). / Abstracts in English and Chinese. / Abstract --- p.i / Declaration --- p.v / Acknowledgment --- p.vi / Abbreviations --- p.viii / List of Figures --- p.x / List of Tables & Graphs --- p.xi / Chapter 1. --- Background --- p.1 / Chapter Chapter 1: --- Age-Associated Changes in Nutritional Status in the Elderly --- p.1 / Chapter 1.1. --- Body Composition --- p.1 / Chapter 1.2. --- Nutritional Requirements --- p.2 / Chapter 1.2.1. --- Energy requirement in the elderly --- p.3 / Chapter 1.2.2. --- Protein requirement in the elderly --- p.3 / Chapter 1.2.3. --- Vitamin and minerals requirement in the elderly --- p.4 / Chapter 1.3. --- Food Intake --- p.4 / Chapter 1.3.1. --- Biobehavioral factors --- p.5 / Chapter 1.3.2. --- Social factors --- p.9 / Chapter 1.3.3. --- Psychological factors --- p.9 / Chapter 1.3.4. --- Physical factors --- p.10 / Chapter 1.3.5. --- Medical factors --- p.10 / Chapter 1.4. --- Age-Related Changes in Gastrointestinal Tract --- p.10 / Chapter Chapter 2: --- Energy Expenditure in the Elderly --- p.12 / Chapter 2.1. --- Total Daily Energy Expenditure (TEE) --- p.13 / Chapter 2.2. --- Basal Metabolic Rate (BMR) --- p.14 / Chapter 2.2.1. --- Mechanisms Leading to a Decrease in FFM Adjusted BMR --- p.15 / Chapter (i) --- Sex --- p.15 / Chapter (ii) --- Sympathetic Nervous System (SNS) Activity --- p.16 / Chapter (iii) --- Physical Activity --- p.17 / Chapter (iv) --- Body Weight --- p.17 / Chapter (v) --- Hormones --- p.18 / Chapter 2.3. --- Diet-Induced Thermogenesis (DIT) --- p.18 / Chapter 2.4. --- Energy Costs of Physical Activity --- p.20 / Chapter Chapter 3: --- Methods for the Measurements of Energy Expenditure --- p.22 / Chapter 3.1. --- Direct Calorimetry --- p.22 / Chapter 3.1.1. --- Principle of Direct Calorimetry --- p.22 / Chapter 3.1.2. --- Isothermal calorimetry --- p.23 / Chapter 3.1.3. --- Gradient-layer direct calorimetry --- p.23 / Chapter 3.1.4. --- Advantages and Disadvantages of Direct Calorimetry --- p.24 / Chapter 3.2. --- Indirect Calorimetry --- p.25 / Chapter 3.2.1. --- Principle of Indirect Calorimetry --- p.25 / Chapter 3.2.2. --- Whole body indirect calorimetry --- p.25 / Chapter 3.2.3. --- "Indirect calorimetry: ventilated hood system, a face mask, or mouthpiece" --- p.26 / Chapter 3.2.4. --- Advantages and Disadvantages of Indirect Calorimetry --- p.27 / Chapter 3.3. --- The Doubly-Labeled Water Method --- p.27 / Chapter 3.3.1. --- Principle --- p.27 / Chapter 3.3.2. --- Advantages and Disadvantages --- p.28 / Chapter 3.4. --- The Labeled Bicarbonate Method --- p.29 / Chapter 3.4.1. --- Principle of Isotope Dilution Method --- p.29 / Chapter 3.4.2. --- Principle of Traditional Labeled HC03 Method --- p.32 / Chapter 3.4.3. --- Labeled Bicarbonate-Urea Method --- p.34 / Chapter I. --- Calculations --- p.35 / Chapter A. --- Determination of energy equivalent of CO2 --- p.35 / Chapter B. --- Relationship between specific activity of urea and specific activity of CO2 --- p.35 / Chapter C. --- Fixation of infused label in the body --- p.36 / Chapter D. --- Calculation of CO2 production from the specific 3 activity of urinary urea --- p.6 / Chapter E. --- Two assumptions in labeled bicarbonate-urea method --- p.36 / Chapter 3.4.4. --- Advantages and Disadvantages of Labeled Bicarbonate-Urea Method --- p.37 / Chapter 3.5. --- Heart Rate Monitoring --- p.37 / Chapter 3.5.1. --- Principle --- p.37 / Chapter 3.5.2. --- Advantages and Disadvantages --- p.38 / Chapter 3.6. --- Activity Monitoring --- p.39 / Chapter 3.6.1. --- Principle --- p.39 / Chapter 3.6.2. --- Advantages and Disadvantages --- p.39 / Chapter 3.7. --- Activity Diaries --- p.40 / Chapter 3.7.1. --- Retrospective activity questionnaires --- p.40 / Chapter I. --- Principle --- p.40 / Chapter II. --- Advantages and Disadvantages --- p.40 / Chapter 3.7.2. --- Current diary method --- p.41 / Chapter I. --- Principle --- p.41 / Chapter II. --- Advantages and Disadvantages --- p.42 / Chapter 3.7.3. --- Time-and-motion study --- p.42 / Chapter I. --- Principle --- p.42 / Chapter II. --- Advantages and Disadvantages --- p.43 / Chapter Chapter 4: --- Nutritional Status and Energy Expenditure in Chronic Obstructive Pulmonary Disease (COPD) Patients --- p.44 / Chapter 4.1. --- Nutritional Status --- p.44 / Chapter 4.1.1. --- Body weight --- p.44 / Chapter 4.1.2. --- Fat-free mass (FFM) --- p.44 / Chapter 4.2. --- REE --- p.46 / Chapter 4.3. --- DIT --- p.47 / Chapter 4.4. --- TEE --- p.47 / Chapter 4.5. --- Nutrition Repletion by Caloric Supplement --- p.48 / Chapter 2. --- Objectives --- p.50 / Chapter 3. --- Subject and Method --- p.51 / Chapter 3.1. --- Part A: Subject and Methods I --- p.51 / Chapter 3.1.1. --- Subjects --- p.51 / Chapter 3.1.2. --- Methods --- p.51 / Chapter I. --- Anthropometric Assessment --- p.51 / Chapter II. --- Nutrient Intake --- p.52 / Chapter III. --- Clinical Assessment --- p.52 / Chapter IV. --- Energy Expenditure --- p.53 / Chapter V. --- Mini Nutritional Assessment Questionnaire --- p.53 / Chapter VI. --- Statistical Analysis --- p.54 / Chapter 3.2. --- Part B: Subject and Methods II --- p.55 / Chapter 3.2. --- Subjects --- p.55 / Chapter I. --- Patients --- p.55 / Chapter II. --- Control subjects --- p.55 / Chapter 3.2.2. --- Methods --- p.56 / Measurement of TEE by Labeled Bicarbonate-Urea Method --- p.56 / Chapter I. --- Study Protocol --- p.56 / Chapter Figure 6: --- Study protocol in Hospital --- p.57 / Chapter II. --- Clinical Protocol --- p.58 / Chapter A. --- Preparing the infusion --- p.58 / Chapter B. --- "Inserting the subcutaneous cannula, and starting the infusion" --- p.58 / Chapter C. --- Urine collection --- p.59 / Chapter D. --- Blood sample --- p.59 / Chapter III. --- Laboratory Procedures --- p.60 / Chapter A. --- Measuring the radioactivity of the infused bicarbonate solution --- p.60 / Chapter B. --- Measuring of specific activity of urea --- p.60 / Chapter (i) --- Titration of hyamine hydroxide solution --- p.60 / Chapter (ii) --- Urine radioactivity quantification --- p.61 / Chapter (1) --- Removal of dissolved CO2 from urine --- p.61 / Chapter (2) --- Determination of specific activity of C02 --- p.62 / Chapter (a) --- Principle --- p.62 / Chapter (b) --- Laboratory procedures for the determination of specific activity of urea --- p.62 / Chapter IV. --- Measurement in Hospital --- p.63 / Chapter A. --- Anthropometry --- p.63 / Chapter B. --- Indirect calorimetry --- p.63 / Chapter (i) --- Principle --- p.63 / Chapter (ii) --- Measurement of REE --- p.64 / Chapter (iii) --- Measurement of DIT --- p.65 / Chapter C. --- Food supply and dietary record during the study --- p.65 / Chapter D. --- Record of physical activity in rehabilitation program --- p.66 / Chapter E. --- Mini Nutritional Assessment Questionnaire --- p.67 / Chapter V. --- Statistical Analysis --- p.67 / Chapter 4. --- Results --- p.68 / Chapter 4.1. --- Results of Part A Study --- p.68 / Chapter 4.1.1. --- Anthropometry --- p.68 / Chapter 4.1.2. --- Nutrient Intake --- p.69 / Chapter 4.1.3. --- Caloric Balance --- p.71 / Chapter 4.1.4. --- Mini Nutritional Assessment Questionnaire --- p.72 / Chapter 4.2. --- Results of Part B Study --- p.73 / Chapter 4.2.1. --- Anthropometric Data --- p.73 / Chapter 4.2.2. --- REE --- p.74 / Chapter 4.2.3. --- DIT --- p.75 / Chapter 4.2.4. --- Nutrient Intake --- p.75 / Chapter 4.2.5. --- TEE --- p.76 / Chapter 4.2.6. --- Caloric Balance --- p.77 / Chapter 4.2.7. --- Mini Nutritional Assessment Questionnaire --- p.77 / Chapter 4.3. --- Table 1-1 --- p.78 / Chapter 4.4. --- Table 2-1 --- p.89 / Chapter 4.5. --- Graph1 --- p.100 / Chapter 5. --- Discussion --- p.103 / Chapter 5.1. --- Anthropometry in COPD patients --- p.103 / Chapter 5.2. --- Caloric and Nutrient intake in COPD patients --- p.105 / Chapter 5.3. --- Resting Energy Expenditure (REE) --- p.107 / Chapter 5.4. --- Diet-Induced Thermogenesis (DIT) --- p.108 / Chapter 5.5. --- Total Daily Energy Expenditure (TEE) --- p.108 / Chapter 5.6. --- Caloric Balance --- p.109 / Chapter 5.7. --- Limitation of this Study --- p.112 / Chapter 5.7.1. --- 24-hrs dietary recall --- p.112 / Chapter 5.7.2. --- Bicarbonate-urea method --- p.113 / Chapter 5.7.3. --- Anthropometry of community healthy elderly --- p.113 / Chapter 5.8. --- Recommendations --- p.114 / Chapter 5.8.1. --- Anthropometry monitoring in COPD patients --- p.114 / Chapter 5.8.2. --- Caloric supplements --- p.114 / Chapter 5.8.3. --- Physical activity in COPD patients --- p.115 / Chapter 6. --- Conclusions --- p.117 / Chapter 7. --- References --- p.118 / Chapter 8. --- Appendix I --- p.125 / Chapter A. --- Calculation of Total Energy Expenditure (TEE) --- p.125 / Chapter B. --- Sample of Calculation of Total Energy Expenditure (TEE) in Part B of the Study --- p.129 / Chapter 9. --- Appendix II - Equations --- p.133 / Chapter 10. --- Appendix III - Flow Calibration --- p.136

No description available.

Diss. (sammanfattning) Stockholm : Karol. inst., 2005. / Härtill 5 uppsatser.

Thesis (Ph. D.)--University of Oklahoma. / Bibliography: leaves 116-150.

This study was designed to gain an understanding of the family experience when an adult member has chronic obstructive pulmonary disease (COPD). It is recognized that illness within the family affects the well-being of the family unit and the health of all members. To understand the impact of COPD upon the family, however, the literature provides only knowledge of the experience of the individual who has COPD and the spouse, not that of the family unit. Thus, the purpose of this study was to describe and explain the COPD experience from the perspective of the family unit. A qualitative method, phenomenology, was chosen for this investigation. Data were collected through semi-structured interviews with eight families who shared their experiences. From the content analysis of these data, three themes that were common throughout the families' accounts were identified and developed to describe and explain family life with COPD. The first theme, disease-dictated family life, describes four aspects of a common lifestyle that is imposed on the family by the characteristics of COPD. The second theme, isolation, describes the isolation that accompanies the illness experience, for the family group and the individual members within the group. The final theme, family work, describes the four primary challenges the families face and the coping strategies they use to deal with them. These findings revealed that COPD acts as an intense stressor within the family, requiring extensive family work to cope with COPD in a way that maintains the well-being of the family unit. Furthermore, it was found that living with COPD in many ways inhibits the resources within the family and those external sources of support that foster the family's ability to manage the stress associated with living with COPD. The implications for nursing practice and nursing research were delineated in light of the research findings. / Applied Science, Faculty of / Nursing, School of / Graduate

Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 6 uppsatser.

O propósito da presente investigação foi avaliar o papel da atividade física no desenvolvimento de enfisema induzido por papaína em ratos. Para tanto, ratos Wistar foram randomicamente divididos em quatro grupos (n = 10 para cada grupo) que receberam, respectivamente, infusão intra-traqueal de papaína (6 mg em 1 mL de NaCl 0,9%) ou veículo e foram submetidos ou não ao protocolo de exercício em uma esteira ergométrica. Os ratos exercitaram-se a 13,3 m/min, 6 dias por semana, durante 9 semanas (o tempo de exercício foi aumentado gradualmente, de 10 a 35 min). Foram medidas a elastância e a resistência do sistema respiratório (Ers e Rrs, respectivamente), o peso e tamanho do coração, volume das câmaras cardíacas, diâmetro médio das fibras cardíacas e diâmetro alveolar médio. Após 9 semanas de atividade física não houve diferença para os valores de Ers e Rrs entre os quatro grupos experimentais. Houve um aumento estatisticamente significativo do peso do coração preenchido por solução de formaldeído nos grupos de animais submetidos à atividade física comparados aos grupos de animais sedentários (P = 0,007). Não houve diferenças significativas entre os dois grupos que fizeram exercício físico (tendo ou não recebido papaína) ou entre os dois grupos sedentários. O volume das câmaras cardíacas direita e esquerda não foram diferentes entre os diferentes grupos. O diâmetro médio das fibras do ventrículo esquerdo foi significativamente maior nos grupos submetidos à atividade física quando comparados aos grupos sedentários (P = 0,006). O diâmetro alveolar médio foi significativamente maior em ratos que receberam papaína quando comparados aos ratos que receberam salina intratraqueal (P = 0,025). Entretanto o diâmetro alveolar médio foi significativamente maior nos animais que receberam instilação intratraqueal de papaína e que foram submetidos à atividade física, quando comparados aos animais que foram instilados com papaína, mas não foram submetidos ao condicionamento físico. Concluímos que a atividade física pode aumentar à lesão alveolar induzida pela infusão de papaína / The purpose of the present study was to evaluate the role of exercise training on the development of papain-induced emphysema in rats. Wistar rats were randomly assigned to four groups (n = 10 for each group) that received, respectively, intratracheal infusion of papain (6 mg in 1 mL NaCl 0.9%) or vehicle and were submitted or not to a protocol of exercise on a treadmill. Rats exercised at 13.3 m/min, 6 days per week, for 9 weeks (increasing exercise time, from 10 to 35 min). We measured respiratory system elastance (Ers) and resistance (Rrs), the size and weight of the heart and mean alveolar diameter (Lm). After 9 weeks of exercise training, there were no differences in Rrs and Ers values among the four experimental groups. There was a significant increase in the heart weight filled with formaldehyde solute in animals submitted to exercise training compared to the sedentary groups (P = 0.007). There were no differences between the two groups submitted to exercise training (receiving or not papaine) or between the sedentary groups. There were no differences in cardiac chambers volume between all groups. The left ventricule fibers mean diameter was significantly greater in rats submitted to exercise training compared to sedentary rats (P = 0.006). Lm was significantly greater in rats that received papain compared to saline-infused rats (P = 0.025). However, Lm was significantly greater in papain + exercise rats compared to rats that received papain and were not submitted to exercise. We conclude that exercise training can increase alveolar damage induced by papain infusion

O propósito da presente investigação foi avaliar o papel da atividade física no desenvolvimento de enfisema induzido por papaína em ratos. Para tanto, ratos Wistar foram randomicamente divididos em quatro grupos (n = 10 para cada grupo) que receberam, respectivamente, infusão intra-traqueal de papaína (6 mg em 1 mL de NaCl 0,9%) ou veículo e foram submetidos ou não ao protocolo de exercício em uma esteira ergométrica. Os ratos exercitaram-se a 13,3 m/min, 6 dias por semana, durante 9 semanas (o tempo de exercício foi aumentado gradualmente, de 10 a 35 min). Foram medidas a elastância e a resistência do sistema respiratório (Ers e Rrs, respectivamente), o peso e tamanho do coração, volume das câmaras cardíacas, diâmetro médio das fibras cardíacas e diâmetro alveolar médio. Após 9 semanas de atividade física não houve diferença para os valores de Ers e Rrs entre os quatro grupos experimentais. Houve um aumento estatisticamente significativo do peso do coração preenchido por solução de formaldeído nos grupos de animais submetidos à atividade física comparados aos grupos de animais sedentários (P = 0,007). Não houve diferenças significativas entre os dois grupos que fizeram exercício físico (tendo ou não recebido papaína) ou entre os dois grupos sedentários. O volume das câmaras cardíacas direita e esquerda não foram diferentes entre os diferentes grupos. O diâmetro médio das fibras do ventrículo esquerdo foi significativamente maior nos grupos submetidos à atividade física quando comparados aos grupos sedentários (P = 0,006). O diâmetro alveolar médio foi significativamente maior em ratos que receberam papaína quando comparados aos ratos que receberam salina intratraqueal (P = 0,025). Entretanto o diâmetro alveolar médio foi significativamente maior nos animais que receberam instilação intratraqueal de papaína e que foram submetidos à atividade física, quando comparados aos animais que foram instilados com papaína, mas não foram submetidos ao condicionamento físico. Concluímos que a atividade física pode aumentar à lesão alveolar induzida pela infusão de papaína / The purpose of the present study was to evaluate the role of exercise training on the development of papain-induced emphysema in rats. Wistar rats were randomly assigned to four groups (n = 10 for each group) that received, respectively, intratracheal infusion of papain (6 mg in 1 mL NaCl 0.9%) or vehicle and were submitted or not to a protocol of exercise on a treadmill. Rats exercised at 13.3 m/min, 6 days per week, for 9 weeks (increasing exercise time, from 10 to 35 min). We measured respiratory system elastance (Ers) and resistance (Rrs), the size and weight of the heart and mean alveolar diameter (Lm). After 9 weeks of exercise training, there were no differences in Rrs and Ers values among the four experimental groups. There was a significant increase in the heart weight filled with formaldehyde solute in animals submitted to exercise training compared to the sedentary groups (P = 0.007). There were no differences between the two groups submitted to exercise training (receiving or not papaine) or between the sedentary groups. There were no differences in cardiac chambers volume between all groups. The left ventricule fibers mean diameter was significantly greater in rats submitted to exercise training compared to sedentary rats (P = 0.006). Lm was significantly greater in rats that received papain compared to saline-infused rats (P = 0.025). However, Lm was significantly greater in papain + exercise rats compared to rats that received papain and were not submitted to exercise. We conclude that exercise training can increase alveolar damage induced by papain infusion

Diss. Linköping : Univ., 2003.