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Las membranas celulares contienen un canal de Cl- (Maxi-Cl-) que es modulado por estrógenos y antiestrógenos. El trabajo experimental de mi tesis doctoral ha consistido en el estudio de la modulación de este canal y su identidad molecular. El resultado de mi trabajo ha demostrado que la base molecular del canal Maxi-Cl- es una isoforma de la proteína mitocondrial VDAC y que la activación del canal por los antiestrógenos y su inhibición por los estrógenos implica procesos de defosforilación y fosforilación, respectivamente. / Cellular membranes contain a Maxi-Cl- channel that is modulated by oestrogen and antioestrogens. The experimental work of my PhD Thesis has focussed in the study of the molecular identity of the Maxi-Cl- channel and its regulation. My results demonstrated that an isoform of the mitochondrial protein VDAC is the molecular correlate of the Maxi-Cl- channel and that the activation of the channel by antioestrogens and its inhibition by oestrogen requires a dephosphorylation and phosphorylation process, respectively.

Submitted by Valquíria Barbieri (kikibarbi@hotmail.com) on 2017-05-24T21:15:58Z No. of bitstreams: 1 DISS_2014_Kátia Cristina Carse Alcover.pdf: 1770353 bytes, checksum: 48d69624f92fd5e01f056041e4ebf5c4 (MD5) / Approved for entry into archive by Jordan (jordanbiblio@gmail.com) on 2017-05-25T14:51:50Z (GMT) No. of bitstreams: 1 DISS_2014_Kátia Cristina Carse Alcover.pdf: 1770353 bytes, checksum: 48d69624f92fd5e01f056041e4ebf5c4 (MD5) / Made available in DSpace on 2017-05-25T14:51:50Z (GMT). No. of bitstreams: 1 DISS_2014_Kátia Cristina Carse Alcover.pdf: 1770353 bytes, checksum: 48d69624f92fd5e01f056041e4ebf5c4 (MD5) Previous issue date: 2014-03-21 / CAPES / A presente dissertação de mestrado tem por objetivo compreender como foi o processo de adoção da política de currículo apostilado de uma rede privada de ensino pela rede pública municipal de educação de Primavera do Leste – MT. Tivemos como questões centrais do estudo: Que interesses entram em disputa e influenciam o sistema público de ensino do município de Primavera do Leste na adoção do currículo apostilado de um sistema privado de ensino? O que a equipe técnica e os professores das escolas dizem sobre suas experiências pedagógicas com os currículos apostilados do Sistema Maxi de Ensino? A metodologia adotada para esta pesquisa é qualitativa com a abordagem do ciclo de políticas de Ball e Bowe (1992; 1994). Foram analisadas, no contexto de influência, as negociações realizadas para que este sistema privado de ensino fosse adotado e posteriormente, retirado das escolas do município; no contexto da produção dos textos foram analisados documentos dos sites da prefeitura, do Sistema Maxi de Ensino e alguns documentos fornecidos pelo Conselho Municipal de Educação e no contexto da prática foi investigado como os professores trabalhavam com os currículos apostilados em sala de aula. O lócus da pesquisa foram duas escolas da rede municipal de ensino de Primavera do Leste – MT. Os sujeitos da pesquisa foram: a secretária municipal de educação do ano de 2005-2006 e 02 (duas) técnicas que trabalharam na secretaria de educação na época da adoção das apostilas, 01 (uma) conselheira do Conselho Municipal de Educação, a atual secretária municipal de educação que participou das negociações para a retirada das apostilas, 02 (duas) diretoras, 01 (uma) coordenadora pedagógica e 09 (nove) professoras. A fundamentação teórica pautou-se principalmente nos estudos de Apple (1989; 1997; 2005), Ball (2001; 2010), Bianchetti (1996), Freitas (2002; 2012), Gentili (1995), Goodson (1995), Freitas (2002), Gentili (1995), Paraskeva (2008), Santos (2002), Sacristán (1998), Silva, T. (2011), Lopes e Macedo (2011), Bernstein (1996; 2003), Giroux (1992), Moreira (2008), Mainardes (2007), Tyler (1977) entre outros que contribuíram de forma significativa para a compreensão do estudo. Os estudos destes teóricos foram utilizados para discutirmos principalmente os conceitos de: globalização, mercado educacional, mercantilização da educação, qualidade da educação, currículo, currículo apostilado e recontextualização. Dos dados coletados uma das indicações é de que o currículo apostilado foi adotado no município de Primavera do Leste com a intenção de melhorar a qualidade do ensino e a escolha pelo Sistema Maxi de Ensino foi baseada em experiências pessoais e profissionais de alguns gestores do macro sistema. Esses dados nos revelaram também que interesses políticos e econômicos se fizeram presentes durante as negociações dos momentos de adoção e retirada desse currículo apostilado das escolas municipais, evidenciando que as decisões políticas dependeram de quem estava no poder nesses momentos para a tomada dessas decisões. Os dados também revelaram que, apesar deste currículo prescrito ter sido imposto e tido como padrão de currículo na política pedagógica do município, os professores recriavam e reinterpretavam sua prática, rompendo deste modo com as prescrições, porém uns com maior ênfase e outros mais timidamente. / This dissertation aims to understand about the adoption process of a booklet learning method policy from a private school used by the municipal education system of Primavera do Leste - MT. We had some central questions of this study: What interests are in dispute and influence the public education system of the city of Primavera do Leste in adopting a booklet learning method from a private school system? What the crew and the school teachers say about their teaching experiences with Maxi Learning System? The methodology adopted for this research is qualitative with the policy cicle approach formulated by Ball and Bowe (1992, 1994). They were analyzed, on the influence context, the negotiations to adopt this private school system and subsequently withdrawn from the schools in the city; in the context of text production, Town Hall website documents were analyzed, the Maxi Learning System, Mato Grosso court and some documents provided by the City Board of Education and in the context of the practice was investigated how the teachers worked with booklet learning method in the classroom. The research locus were two municipal schools of Primavera do Leste - MT. The research subjects were: the municipal secretary of education during 2005-2006 and two (02) techniques that have worked in the Department of Education at the time of the adoption of handouts, one (01) Councilor City Board of Education, the current secretary municipal education who participated in the negotiations for the withdrawal of handouts, two (02) directors, one (01) educational coordinator and nine (09) teachers. The theoretical framework was based primarily on studies of Apple (1989, 1997 , 2005 ), Ball (2001, 2010 ), Bianchetti (1996) , Freitas (2002, 2012), Gentili (1995), Goodson (1995), Freitas (2002), Gentili (1995) Paraskeva (2008) , Santos (2002) , Sacristan (1998) , Smith, T. (2011) , Lopes and Macedo (2011) Bernstein (1996, 2003), Giroux (1992), Moreira (2008), Mainardes (2007), Tyler (1977) among others that have contributed significantly to the understanding of the study. The studies of these theoretical were used primarily to discuss the concepts of globalization, educational market, commercialization of education, quality of education, curriculum, booklet learning method and re-contextualization. Of the collected data is one of the indications that the booklet learning method was adopted in the city of Primavera do Leste with the intention of improving the quality of education and the choice of Maxi Learning System was based on personal and professional managers of some of the macro system experiences. These data also revealed in which political and economic interests were present during the negotiations of the times of adoption and withdrawal of such booklet curriculum of municipal schools, showing that political decisions depended on who was in power at these times foresee decisions. The data also revealed that, despite this prescribed curriculum had been imposed and regarded as a standard curriculum in educational policy of the municipality, that teachers recreated and reinterpreted their practice, thereby breaking with the norm, but some with a greater emphasis and others more timidly.

Horizontal Directional Drilling (HDD) is used around the world when traditional open cut methods are not practical or impossible for installing pipelines. Maxi-sized drill rigs are the largest and most powerful directional drills and are more common in the field than ever before with over 5,000 rigs in operation world wide. The complexity of installations and the design associated with them continues to increase. This research has two main objectives. 1. Develop a real time data acquisition system for monitoring pullback forces on the product pipe; and, 2. Compare data gathered using maxi-sized drill rigs with current modelling methods using BoreAid. The first portion of the research, as listed above, required attaching multiple pressure transducers to the drilling display panel in an American Auger DD-1100 drill rig and recording, in real time, the carriage, rotation, and mud pressure as seen by the operator. This research also describes the various challenges and issues associated with developing real time in-the-bore data acquisition processes. Finally, future recommendations for further development of the in-the-bore data acquisition are discussed. The second portion of this research describes how the gathered data was processed into a workable data set. The field data was then compared to theoretical models by using the drill assistant tool BoreAid. The results of this comparison show that these models are appropriate for all size drill rigs, although some limitations are present.

Horizontal Directional Drilling (HDD) is used around the world when traditional open cut methods are not practical or impossible for installing pipelines. Maxi-sized drill rigs are the largest and most powerful directional drills and are more common in the field than ever before with over 5,000 rigs in operation world wide. The complexity of installations and the design associated with them continues to increase. This research has two main objectives. 1. Develop a real time data acquisition system for monitoring pullback forces on the product pipe; and, 2. Compare data gathered using maxi-sized drill rigs with current modelling methods using BoreAid. The first portion of the research, as listed above, required attaching multiple pressure transducers to the drilling display panel in an American Auger DD-1100 drill rig and recording, in real time, the carriage, rotation, and mud pressure as seen by the operator. This research also describes the various challenges and issues associated with developing real time in-the-bore data acquisition processes. Finally, future recommendations for further development of the in-the-bore data acquisition are discussed. The second portion of this research describes how the gathered data was processed into a workable data set. The field data was then compared to theoretical models by using the drill assistant tool BoreAid. The results of this comparison show that these models are appropriate for all size drill rigs, although some limitations are present.

Inaug.-Diss.--Philosophie--Köln, 1981. / Bibliogr. p. 280-290.

京都大学 / 0048 / 新制・課程博士 / 博士(理学) / 甲第20179号 / 理博第4264号 / 新制||理||1613(附属図書館) / 京都大学大学院理学研究科物理学・宇宙物理学専攻 / (主査)准教授 上田 佳宏, 教授 嶺重 慎, 教授 長田 哲也 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DFAM

As many buying decision are made in retail stores, it is interesting to investigate which factors, such as noise, lighting, music, colour, layout or visual communication have a significant influence on customers’ behaviour in a supermarket. Since only a few studies have been conducted among customers in Sweden, this paper examined their behaviour in the supermarket. The purpose of this study was to examine the role of the various environmental factors in the supermarket as well as how the perceived servicescape influences customers’ behaviour in the store. The research approach used was that of a single case study, based on survey instrument (personal interviews and electronic collection) in order to collect data on facets in regards to the perceived servicescape and customers’ behaviour in the supermarket. A supermarket chain – the ICA group, precisely ICA MAXI in Jönköping was used for this purpose. The collected data was analysed with the means of factor analysis and multiple regression methods in order to obtain factors that can influence customers’ behaviour in the supermarket. The conducted study showed that lighting, noise, colours, signs and symbols as well as space/function conditions such as layout and equipment are the factors that create emotionally pleasant environment in the supermarket. Thus, these factors influence customers’ moods, attitudes or certain beliefs about the supermarket. Moreover, customers may feel happier, more satisfied or relaxed in the supermarket, which lead to arousal – stimulation or excitement. Furthermore, the environmental factors explain the approach behaviour such as exploring the supermarket, spending more time on browsing the products which, consequently, refer to an increased number of items bought.

Background: Leadership can be understood from the perspective of corporate leaders and employees in two retail organizations such as ICA Maxi and IKEA in Sweden. Research to date has tended to pay little attention to the study of leadership and its related issues in retail organizations. Hence this study attempted to fill the gap by exploring the specified aims and objectives. Aims and Objectives: The aim and objective of this study are to offer new and profound insights into how corporate leaders engage employees when leading organizational change, and the rest. Additionally, to provide a deeper understanding with respect to the key challenges facing corporate leaders when leading organizational change in ICA Maxi and how they address these challenges. Method: By employing qualitative modes of inquiry and by using a case study approach, this paper sought to help illuminate the research questions and objectives in detail. This research was exploratory, interpretative, and inductive in nature and the empirical data were collected through a semi-structured and face-to-face interview from six corporate leaders/managers and six employees in ICA Maxi and IKEA in Sweden.      Findings: In addition to several other findings, this empirical research found that corporate leaders engage the employees by creating question and answer time in a way that demonstrates leadership in action. Furthermore, the corporate leaders not only engage the employees in a way that enables them to mobilize the support of the employees; but also, the corporate leaders engage the employees by voluntarily relinquishing leadership to them for the short-term. This research paper also found that corporate leaders who align themselves with vertical leadership tend to support vertical-participatory leadership in practice and both vertical-participatory leadership and participatory leadership can be problematic when leading organizational change. The corporate leaders in the retail organizations, ICA Maxi and IKEA could face challenges of adaption, a barrage of why questions from the employees, and a situation where the employees can become afraid of taking responsibility for wrongdoing. Finally, this study found that corporate leaders tend to address the challenges they face when leading organizational change by means of providing the right information and by joint consultation with the employees. Contributions: Theoretically, this research has contributed to filling the gap in the literature by adding to the growing body of research with respect to the phenomenon of leadership in retail organizations such as ICA Maxi and IKEA. Practically, this qualitative study has contributed to our understanding of how daily routines could be improved between the corporate leaders and employees in these retail organizations, ICA Maxi and IKEA. In terms of managerial contribution, this exploratory study has contributed to reminding the corporate leaders about the need to accelerate their leadership roles by implementing important policies with respect to selling products that are environmentally sound. As regards societal contribution, this thesis has contributed in creating awareness by highlighting different ways that corporate leaders could engage the employees appropriately and inappropriately.

I set out to make a lighthearted comedy punctuated with some scary moments. I wanted this story to come from a seven-year-old girl's point of view and match fantastic visuals with equally fantastic sounds. I will discuss the entire creative process in this book such as preproduction, writing, direction, cinematography, editing, and the sound design process, as well as many of my own personal experiences on this set and in my life. I have included the influence of unbiased audience members to determine whether or not I was successful in making a competent movie. This entire process, including all of the work done, rests entirely on my audience. I have done my best to include both people who are affluent in film production, as well as those who are not.