In rapid wireless communication technology development environment, antennas, the interface among many wireless communications, are an indispensable component for wireless systems. Miniaturization and functionality stability (high tolerance to environmental variations) of the antenna are fast becoming the design trends in research and development of wireless communication systems. They are also the main objectives of this thesis. In the first part of this thesis, we designed two highly stable antennas, which can be used in notebook computers or tablet PCs. The antenna has self-balanced characteristics, where the environmental interference is minimized, in its performance/functionality and patterns. The first antenna design, which can be easily integrated into an RF front-end board, employed capacitive coupling, differential feed printed loop configurations. Comparing to the existing differentially fed antenna design, our designs are much more miniaturized: the antenna size was 13 mm ¡Ñ 27 mm, the ground size was 4.5 mm ¡Ñ 4.5 mm. Implemented on a low-cost FR4 board, the antenna reduced the leakage current formed on coaxial transmission line, due to the advantage of being differentially fed. The second antenna design, fed by coaxial cable (single-ended fed), and without a ground plane, excited only self-balanced modes. The radiation patterns of higher modes in this antenna design are complete and without side lobes. This antenna design also has wide bandwidth characteristics: at 2.4 GHz it had 380 MHz, and at 5.2 GHz it had 1270 MHz bandwidths of high tolerance (stability). The actual measurement validated our simulation results. In the second part, MIMO antennas were designed for 802.11n wireless standards with maximum transfer rates of up to 300 Mbps. First, we designed two small single antennas, which were applied later in MIMO antenna designs. The size of our MIMO antenna designs was only 19 mm ¡Ñ 30.3 mm. In MIMO antenna designs, we employed two methods to increase the isolation between the two MIMO antennas: one manipulated the ground plane size, in which the isolation reached 18.9 dB; the other utilized a decoupling metal, where the overall isolation reached 24.6 dB in all of the operating frequencies, with the best isolation being 31.4 dB. The frequency of the coupling/decoupling for the decoupling metal can be adjusted independently; thus not affecting the original resonant frequency and the return loss of the two MIMO antennas. Actual measurements conducted in the microwave chamber (Reverberation Chamber) have verified the channel capacity were effectively increased, the total radiation efficiencies were about 60%, and the effective diversity gain was about 7dB. The MIMO antenna designs can practically and easily applied in the USB dongles.

No description available.

Digital microfluidics (DMF) has recently emerged as a popular technology for a wide range of applications. In DMF, nL-mL droplets containing samples and reagents are controlled(i.e., moved, merged, mixed, and dispensed from reservoirs) by applying a series of electrical potentials to an array of electrodes coated with a hydrophobic insulator. DMF is distinct from microchannel-based fluidics as it allows for precise control over multiple reagent phases (liquid and solid) in heterogeneous systems with no need for complex networks of microvalves. In this thesis, digital microfluidics has been applied to address key challenges in the fields of chemistry, biology and medicine. For applications in chemistry, the first two-plate digital microfluidic platform for synchronized chemical synthesis is reported. The new method, which was applied to synthesizing peptide macrocycles, is fast and amenable to automation, and is convenient for parallel scale fluid handling in a straightforward manner. For applications in biology, I present the first DMF-based method for extraction of proteins (via precipitation) in serum and cell lysate. The performance of the new method was comparable to that of conventional techniques, with the advantages of automation and reduced analysis time. The results suggest great potential for digital microfluidics for proteomic biomarker discovery. Furthermore, I integrated DMF with microchannels for in-line biological sample processing and separations. Finally, for applications in medicine, I developed the first microfluidic method for sample clean-up and extraction of estrogen from one-microliter droplets of breast tissue homogenates, blood, and serum. The new method is fast and automated, and features >1000x reduction in sample use relative to conventional techniques. This method has significant potential for applications in endocrinology and breast cancer risk reduction. In addition, I describe a new microfluidic system incorporating a digital microfluidic platform for on-chip blood spotting and processing, and a microchannel emitter for direct analysis by mass spectrometry. The new method is fast, robust, precise, and is capable of quantifying analytes associated with common congenital disorders such as homocystinuria, phenylketonuria, and tyrosinemia.

Digital microfluidics (DMF) has recently emerged as a popular technology for a wide range of applications. In DMF, nL-mL droplets containing samples and reagents are controlled(i.e., moved, merged, mixed, and dispensed from reservoirs) by applying a series of electrical potentials to an array of electrodes coated with a hydrophobic insulator. DMF is distinct from microchannel-based fluidics as it allows for precise control over multiple reagent phases (liquid and solid) in heterogeneous systems with no need for complex networks of microvalves. In this thesis, digital microfluidics has been applied to address key challenges in the fields of chemistry, biology and medicine. For applications in chemistry, the first two-plate digital microfluidic platform for synchronized chemical synthesis is reported. The new method, which was applied to synthesizing peptide macrocycles, is fast and amenable to automation, and is convenient for parallel scale fluid handling in a straightforward manner. For applications in biology, I present the first DMF-based method for extraction of proteins (via precipitation) in serum and cell lysate. The performance of the new method was comparable to that of conventional techniques, with the advantages of automation and reduced analysis time. The results suggest great potential for digital microfluidics for proteomic biomarker discovery. Furthermore, I integrated DMF with microchannels for in-line biological sample processing and separations. Finally, for applications in medicine, I developed the first microfluidic method for sample clean-up and extraction of estrogen from one-microliter droplets of breast tissue homogenates, blood, and serum. The new method is fast and automated, and features >1000x reduction in sample use relative to conventional techniques. This method has significant potential for applications in endocrinology and breast cancer risk reduction. In addition, I describe a new microfluidic system incorporating a digital microfluidic platform for on-chip blood spotting and processing, and a microchannel emitter for direct analysis by mass spectrometry. The new method is fast, robust, precise, and is capable of quantifying analytes associated with common congenital disorders such as homocystinuria, phenylketonuria, and tyrosinemia.

Superconducting microelectronics (SME) technology has the potential of realizing very high speed digital receivers capable of performing direct digitization of radio frequency signals with very low power consumption. The SME receiver is implemented on a single chip using Niobium based low temperature superconductive (LTS) Josephson Junction (JJ) technology by HYPRES. Analogue RF filters are still required at the receiver front end and are key components of the overall superconductor digital receiver. SME receivers usually require two types of RF filters; a wideband bandpass filter and a bandstop filter (a notch filter). The notch filter is required to eliminate interference and unwanted signals in the passband. In this thesis, design of highly miniaturized lumped element wideband and bandstop filters is investigated and some challenges are addressed. The filters are fabricated by the HYPRES process and therefore can be integrated with the SME receiver on the same chip. In a wideband filter, the coupling between the adjacent resonators is high. Achieving such a strong coupling is one of the challenges of designing wideband filters. The wideband filters realized with distributed elements usually suffer from very low spurious frequency. As the bandwidth of the filter becomes wider, the spurious peak of the second harmonic gets closer to the passband of the filter. In the first part of this work, the possibility of realizing lumped element superconducting bandpass filters (BPF) with a relative bandwidth of 80% is investigated. In the second part of the thesis, design and realization of lumped element superconducting bandstop filters (BSF) is discussed. The challenge for designing a bandstop filter is providing a good match over a wide frequency range. So narrowband inverters cannot be used. Instead, usually λ/4 matched transmission lines provide 90° phase shift between the resonators of a notch filter. The possibility of replacing the long transmission line with other means or eliminating the inverters and using both shunt and series resonators are investigated. Having both series and shunt resonators introduces some new challenges that are addressed in the thesis and discussed thoroughly. A tunable notch resonator is presented. The tunability is provided by a superconducting MEMS varactor that is realized in our group by doing some post processing on the device fabricated by HYPRES. The tunability range of the device at cryogenic temperatures is investigated. A 3-pole tunable BSF is also designed that uses the same tunable resonators. The tunability of the filter is investigated through simulation.

Amostras com pequenos volumes e matrizes complexas, como sistemas biológicos, necessitam de preparação criteriosa. Muitas dessas amostras são melhor analizadas em estruturas miniaturizadas devido à necessidade de detectar células e microorganismos em diferentes matrizes. Por essa razão, equipamentos capazes de detectar e destruir microorganismos e estruturas para prévia retenção desses se faz necessários na vida moderna. Chicanas, constrições usadas para reduzir velocidade de fluxo, que podem ser utilizadas para reter compostos, são estruturas macroscópicas para remover resíduos de lagos, fazendas e etc. e chicanas miniaturizadas foram usadas para a adsorção de compostos orgânicos do ar e da água. Assim, esse trabalho tem dois diferentes objetivos: 1) Produção de um equipamento de baixo custo, para teste de partículas ou eliminação de microorganismos e 2) O desenvolvimento de estruturas miniaturizadas para retenção e/ou seleção de partículas e substâncias viscosas de um fluido líquido. A metodologia utilizada foi: 1) Dois software foram escolhidos para esse trabalho. O LabVIEW® 7.0 foi utilizado como plataforma para o desenvolvimento do software do equipamento e o FemLAB® 3.1 para a simulação de estruturas. O equipamento produzido usou Microbalança de Quartzo como detector e um sistema de admissão baseado em uma bomba e tubos. 2) O desenho da estrutura foi otimizado por simulação do comportamento do fluxo. A estrutura otimizada foi feita desmontável, e usinada em polimetilmetacrilato ? acrílico, com ferramentas convencionais. Acrílico foi usado devido à sua transparência óptica, que permite testes com microsocpia óptica. As simulações consideraram N2 e Água como fluidos gasoso e líquido, respectivamente. Avaliou-se o comportamento das partículas (50?m and 13?m) em fluxo gasoso e polidimetilsiloxano (silicone, com viscosidade de 350 cSt) e partículas em fluxo líquido. As estruturas foram caracterizadas quanto à adsorção e retenção de partículas usando equipamento desenvolvido e por microscopia óptica. As estruturas foram, também, continuamente fotografadas durante a execução do experimento e fotos foram utilizadas para determinar o comportamento do fluxo. Os reagentes foram injetados na estrutura em pequenos pulsos. O equipamento mostrou boa performance para detecção de adsorção em fluxo líquido e reprodutibilidade no monitoramento do aquecimento de estruturas. As chicanas mostraram boa capacidade de reter partículas grandes (50?m), mas não pequenas (13?m), tanto para fluxos gasosos como líquidos. Contudo, a estrutura tem pequena capacidade de carga para fluidos líquidos (? 1mg); além disso, a retenção de amostras de silicone na estrutura, utilizando fluido líquido, ocorreu devido à diferença de velocidade entre os fluidos. A simulação e os resultados experimentais apresentam boa correlação. Assim, a chicana mostrou a possibilidade de, seletivamente, separar partículas em fluxos gasosos e líquidos ou reter substâncias viscosas em fluxo líquido. Esses resultados apontam para diversas aplicações, como por exemplo, pré-tratamento para análises biológicas e retenção ou eliminação de microorganismos. / Samples with small volume and complex matrix, such as biological systems, require careful preparation. Many of these samples are better analyzed in miniaturized structures owing to the need of detect cells and microorganisms in different arrays. Therefore equipment able to detect and destroy microorganisms and structures to previously retain them are require in the modern life. Chicanes, i.e. constrictions used to reduce flow velocity, can be useful to retain compounds, are macroscopic devices to remove waste removal from lakes, farms, etc. and miniaturized chicane was used to adsorption of organic compounds from air and water. Thus, this work has two different targets: 1) Production of a low-cost equipment useful for tests of particle or microorganisms elimination and 2) The development of miniaturized structures useful for retention and/or selection of particles and viscous substances from a liquid flow. The methodology used was: 1) Two software were chosen to this work. The LabVIEW® 7.0 was used for development of equipment software and FemLAB® 3.1 for structures simulation. The equipment production used Quartz Crystal Microbalance as detector and an admission system based on simple pumps and plumbing. 2) The design of the structure design was optimized using flow simulation. The optimized design was manufactured in poly(methyl methacrylate) -acrylic, with conventional tools. Acrylic was used due to the optical transparency that allows photographic tests and the structures can be easily disassembled. The simulations considered nitrogen and water for gaseous and liquid flow, respectively. It was evaluated the behavior of particles (50?m and 13?m) on gaseous flow and polydimethylsiloxane (silicone, viscosity of 350 cSt) and particles on liquid flow. The structures were characterized using equipment produced to measure adsorption and optical microscopy to evaluate particle retention. The structures were also continuously photographed during the experiments and the photos were analyzed to determine flow behavior. The reactants were inserted in the structure in small pulses. The equipment shows good performance for detection of adsorption in liquid flows and reproducibility on monitoring heated structures. Chicanes showed good ability to retain big particles (50 ?m) but not small ones (13 ?m) for both liquid and gaseous flow. However, the structure has small load capacity for liquids (? 1 mg). Moreover, the retention of silicone samples in the structure on liquid flow occurs due to the difference in the fluid velocity. The simulation and experimental results are in good agreement and also chicane structure shows the possibility of selectively separate particles from gaseous and liquid flow or retain viscous substances from a liquid flow. These results point out to several applications, such as sample pretreatment for biological analysis and microorganism retention or elimination.

This work aims to implement 3D microstructures that generate light with orbital angular momentum towards applications in Biophotonics. Over the past few decades, 3D printing has established itself as the most versatile technology with effortless adaptability. Parallel to this, the concept of miniaturiza tion has seen tremendous growth irrespective of the field and has become an estab lished trend motivated by the need for compact, portable and multi-function devices. Therefore, when these two concepts get together, i.e., 3D printing of miniaturized objects, it could lead to an exciting path with endless opportunities. When it comes to optics, miniaturized 3D printing offers the potential to create compact optical micro-systems and exhibits a way to manufacture freeform µ-optics. In particular, two-photon lithography (TPL) is a cutting edge 3D printing technology that has re cently demonstrated groundbreaking solutions for optics as it offers high resolution with a great degree of flexibility. With a TPL 3D printer, it is possible to fabricate complex µ-optical elements and employ them for compelling applications. In recent years, light with orbital angular momentum (OAM), or ”twisted” light, has captured the interests of several researchers due to its inspiring applications. Tra ditionally, to generate OAM beams, one would require bulk, table-top optics, restrict ing their applications to over-the-table setup. An alternative approach of OAM beam generation is through µ-structures over the fiber, as they can open up new opportu nities, especially in Bioscience, and facilitate in-vivo operations. In particular, this probe-like setup can be used for processes such as optical trapping, high-resolution microscopy, etc. Hence, I propose the development of a novel approach with un precedented capabilities for generating OAM beams right from single-mode optical fibers, by transforming its Gaussian-like output beam by using complex 3D printed microstructures. In this document, I will showcase designs and results on generating Bessel beams (both zeroth- and high-order) and high-NA converging beams (with and without OAM) for optical trapping from the fiber. Remarkably, I achieved the first-ever fiber-based high-order Bessel beam generation and the first-ever fiber optical tweezers with OAM.

The electrostatic ion beam trap (EIBT) was designed by D. Zajfman during the previous decade. This ion trap combines many properties of the Fourier-transform ion cyclotron resonance (FTICR) mass analyzer and time-of-flight (TOF) mass analyzer. There are several advantages for the electrostatic ion beam trap. First, large mass-to-charge particles in an electrostatic field could be easier to analyze. Second, there is a folded flight path, which could make the mass analyzer smaller compared to conventional TOF mass analyzer. This principle of operation of this ion trap is analogous to an optical resonator. The ions are trapped in a voltage valley and oscillate between the two parallel sets of mirror electrodes with high voltages. In this thesis, I first describe a new type of miniaturized electrostatic ion beam trap mass analyzer that consists of two printed circuit boards (PCBs). The facing surfaces of these boards are imprinted with copper electrodes. The center of the boards is field free and at ground potential with ion mirrors and Einzel lenses on either side. A charge detector is attached to the center for recording the time-dependant motion of the ions in the field. The PCB-based EIBT design is easier to construct than the original EIBT mass analyzer. The electrostatic fields are optimized by adjusting the potential on the mirror electrodes as well as the geometry of the electrodes. Although nondestructive charge detection is much less sensitive for small ions, this detection is ideal for analysis of large ions. The planar electrostatic ion beam trap is inexpensive, small, and simple to operate. The PCB EIBT device was designed, built, and tested using metal samples such as copper and nickel. The electric field of the PCB EIBT is not the same as that of the original EIBT. Unfortunately, there were no ion signals captured in image charge detector. Another new type of miniaturized electrostatic ion beam trap was made by depositing electrodes onto Kapton film. Seven thin tin/copper traces (1 mm wide by 0.015 mm thick) were deposited onto each side of a flat, flexible circuit board substrate (Kapton film 0.15 mm thickness). The film was rolled to form a cylinder. The flexible EIBT is small (4.5 cm × 8 cm), and lightweight (~1 g). This device was tested using laser ablation of CsI. The CsI signals were detected by the charge detector, amplified and sent to the oscilloscope. Fourier transformation was used to convert the data to the frequency domain spectrum. The resolution of Cs+ is around 1000 (m/Δm) from initial flexible EIBT test. The mass accuracy of the Cs+ peak is better than 0.1%.

No description available.

No description available.