Global ETD Search

1	Corrosion Inhibitive Properties of Metal-Gluconate Coatings on Al Substrates Jain, Aman Vinay January 2017 (has links) No description available. Materials Science Corrosion Inhibtion Coatings Metal-Gluconates Potentiodynamic Measurement SEM Mass-spec
2	Characterization of two unique pathways for wyosine biosynthesis in Kinetoplastids Sample, Paul J. 09 September 2014 (has links) No description available. Microbiology Molecular Biology Bioinformatics trypanosomes wyosine wybutosine hydroxywybutosine mitochondria organelle tRNA transfer RNA tRNA modification modified nucleic acids modified nucleotides rna mass spec de novo sequencing mass spectrometry robooligo
3	The metabolic sequelae of oesophago-gastric resection Roberts, Geoffrey Peter January 2019 (has links) Bypass or resection of the stomach and oesophagus, has long been recognised to result in profound changes in the handling of ingested nutrients. This results in significant morbidity after radical surgery for oesophago-gastric cancer, in particular post-prandial hypoglycaemia, altered appetite, early satiety and noxious post-prandial symptoms. By profiling and challenging the gut hormone axis in healthy volunteers and patients who had undergone total or subtotal gastrectomy, or oesophagectomy, this thesis explores the possible causative mechanisms for the challenges faced by this patient population. In the surgical groups, an oral glucose tolerance test (OGTT) resulted in enhanced secretion of satiety and incretin gut hormones (GLP-1, GIP, PYY) and insulin, followed by hypoglycaemia in a cohort of patients. Continuous glucose monitoring of gastrectomy participants over two weeks of normal lifestyle identified an increased incidence of day and night time hypoglycaemia. RNAseq and mass spectrometry based peptidomics of human and murine enteroendocrine cells in the pre- and post-operative populations revealed no significant change in the underlying cellular pathways for nutrient sensing and gut hormone secretion, indicating that the altered hormone secretion is primarily driven by accelerated nutrient transit, rather than adaptive changes in the gut. Finally, specific blockade of the GLP-1 receptor in post-gastrectomy patients using Exendin 9-39 normalised insulin secretion and prevented reactive hypoglycaemia after an OGTT. In conclusion, profound changes in gut hormone secretion as a result of enhanced nutrient transit after foregut surgery likely underlie the early and late post-prandial symptoms seen in this group, and therapies specifically targeting the gut hormone axis, and GLP-1 in particular, could be the first targeted treatments for post-gastrectomy syndromes.
4	Structure Elucidation of Bioactive Compounds Isolated from Endophytes of Alstonia scholaris and Acmena graveolens Hundley, Nicholas James 02 September 2005 (has links) (PDF) Alstonia scholaris is an evergreen tree native to Southeast Asia and Australia. It is commonly used as a medicinal plant throughout these regions. In the present study, an endophyte of the genus Xylaria was isolated from a stem of Alstonia scholaris, its mycelia and exudate extracted, and the extract assayed for growth inhibition of HeLa cancer cells in vitro. Several known compounds were isolated and identified based on NMR, infrared, and mass spectral data. The compounds identified are 19,20-epoxycytochalasin C; 19,20epoxycytochalasin D; and xylobovide. Two other compounds, fusaric acid and dehydrofusaric acid, were discovered in an endophyte of the Hypocreales family inhabiting the plant Acmena Graveolens. endophtye endophytes endophytic (endophyt) fungi fungal symbiosis rDNA ribosomal DNA fungal taxonomy ITS cytochalasins cytochalasans xylobovide fusaric acid dehydrofusaric acid xylaria xylariaceae rosellinia necatrix taxol HPLC NMR GC gas chromatography MS mass spectrometry (mass spec) IR infrared spectroscopy PCR natural products ethnobotany ethnomedicine COSY HMQC HMBC Biochemistry Chemistry

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