Les troubles anxieux apparaissent très tôt chez les jeunes. Les études corrélationnelles suggèrent que plusieurs facteurs, tels que le stress prénatal maternel (SPM) et la surimplication maternelle contribueraient à leur développement et à leur maintien. L’objectif de l’étude est de mieux comprendre si la surimplication maternelle est une cause ou une conséquence de l’anxiété chez l’enfant, le tout dans un contexte de stress prénatal maternel causé par un désastre naturel. L’échantillon fait partie d’un projet plus grand dans lequel les stress objectif et subjectif ont été mesurés chez les femmes enceintes lors de l’inondation en 2011 à Queensland en Australie. L’échantillon de l’étude inclut 72 dyades mère-enfant, ayant complété une tâche difficile de casse-tête, d’une durée de 5 minutes, lorsque les enfants étaient âgés de 4 ans. À partir des vidéos, les observateurs ont évalué le comportement maternel (la surimplication) et le comportement de l’enfant (l’anxiété) en continu. Des techniques d’analyse séquentielle ont été utilisées pour déterminer la probabilité qu’un comportement maternel de surimplication se produise avant ou après un comportement anxieux et vice versa. Les corrélations obtenues entre le SPM (objectif et subjectif), le comportement anxieux de l’enfant et le comportement de surimplication maternelle n’ont pas été significatives. Le comportement de surimplication n’est pas un médiateur entre le SPM (objectif et subjectif) et le comportement anxieux de l’enfant. Toutefois, les chances qu’un comportement maternel de surimplication suive un comportement anxieux chez l’enfant étaient plus grandes que les chances qu’un comportement anxieux suive un comportement maternel de surimplication. Nos résultats suggèrent que le stress prénatal maternel n’est pas associé avec le comportement de surimplication maternelle, ni avec le comportement anxieux de l’enfant. La surimplication maternelle est plutôt une réaction au comportement anxieux de l’enfant. Il est essentiel, pour de futures recherches, de se rappeler que l’enfant est un participant actif dans la relation mère-enfant et qu’il est important d’étudier la bidirectionnalité de la relation pour mieux comprendre et pour mieux intervenir. / Anxiety disorders start very early in young people and several factors, such as prenatal maternal stress (PNMS) and maternal overinvolvement are believed to contribute to their development and maintenance. The objective of this study is to better understand if the overinvolvement of the mother is a cause or a consequence of the child’s anxiety, all in a context of prenatal maternal stress due to a natural disaster. The sample is part of a larger project that assessed the objective hardship and the subjective distress in women who were pregnant during the 2011 Queensland flood in Australia. The current sample included 72 mother-child dyads, completing a 5-minute puzzle task when the children were 4 years old. Observers rated maternal (overinvolved) and child (anxious) behaviors from videos continuously. Sequential analysis techniques were used to determine the likelihood of a maternal overinvolved behavior occurring before or after a child anxious behavior and vice versa. The correlations between PNMS (objective and subjective) and the child's anxiety and maternal over-involvement were not significant. Maternal overinvolvement did not mediate the relationship between PNMS (objective and subjective) and anxiety in children. However, the odds of maternal overinvolvement following child anxiety, was stronger than the odds of child anxiety following maternal overinvolvement. Our results suggest that prenatal maternal stress is not associated with maternal overinvolvement nor with child anxiety. It also suggests that maternal overinvolvement is a reaction to the child’s anxious behavior rather than a cause of it. Future research needs to keep in mind that the child is an active participant in the mother-child relationship and that it is important to study the bidirectionality of the relationship to better understand it and intervene.

Background: Antenatal Psychosocial Assessment (APA) has recently been introduced into routine antenatal care, but the ways in which maternity service providers assess and respond to maternal stress are subject of debate. There is a lack of consensus on the instrument(s) of choice and lack of evidence regarding appropriate interventions. Further, national guidelines have not kept apace with the conceptual shift from ‘postnatal depression’ to ‘perinatal anxiety and depression’. Adopting the Medical Research Council Complex Interventions Framework, the ARMS research aimed to inform the development of interventions that support women who are experiencing, or at risk of, mild-moderate mental health disorder in pregnancy. Methods: A mixed methods approach was adopted. In the quantitative element (Study Part 1) participants (n=191) completed a questionnaire when attending for their first formal antenatal appointment, using a procedure and materials that had been previously tested in a pilot study. Details including mental health assessment and referrals were obtained from their health records, following delivery. In the qualitative element (Study Part 2) a sub-sample of women (n=22) experiencing high levels of maternal stress took part in up to three serial in-depth interviews during pregnancy and the early postnatal period.Findings: Maternal stress was found to be common. Using the Edinburgh Postnatal Depression Scale (EPDS) threshold of ≥10, approximately 1 in 4 women were classed as high depression (halving to 1 in 8 at the more conservative threshold of ≥13). Almost 1 in 3 women were classed as high anxiety, using the state scale of the State-Trait Anxiety Inventory (STAI-S, threshold ≥41), compared with 1 in 5 using the two-item GAD (threshold ≥3). Fewer than half of the women identified as high anxiety were identified by both measures. Factor analyses of the symptom measures were consistent with wider literature suggesting a three-item anxiety component of the EPDS; however, concurrent validation using regression analyses did not indicate that the EPDS could be used as an anxiety case finding instrument. Women reported that maternal stress had significant impact on their lives that may not be captured with existing clinical approaches. Women commonly found it difficult to self-assess severity of maternal stress and the assessment process could itself act as an intervention. The research provided the first validation of the depression case finding questions in UK clinical practice. The Whooley items completed in clinical practice identified only half of the possible cases identified by the EPDS, at both commonly adopted EPDS thresholds. Inclusion of the Arroll 'help' question as a criterion improved specificity of the assessment completed in clinical practice but substantially compromised sensitivity, missing 9 in 10 possible cases. Women’s mental health history and treatment history were similarly under-reported, particularly concerning anxiety. APA was introduced into routine clinical practice without attention to topics of relevance to women, context of disclosure or to provision of adequate resources for consistently responding to identified need. Women experiencing, or at risk of, mild-moderate disorder were thus usually ineligible for further support. Implications: Care pathways are needed that encompass both assessing and responding to maternal stress, where communication with health professionals, subsequent referral and management are addressed. The development, implementation and evaluation of low-cost resources embedded in such pathways are a priority and the research presented in the thesis offers a foundation on which to build.

Bibliography: leaves 149-178 / Anxiety Disorder is one of the most common disorders experienced by children and, if not managed, can extend into adulthood. Research has established a link between unintegrated primitive reflexes (UPR) and Learning Disorders. Learning Disorders are often co-morbid with symptoms of anxiety, however, the relationship between symptoms of anxiety and UPR have not been studied. This study aims to explore the relationship between the UPR and symptoms of anxiety in children between 10 – 13 years of age. No correlation was found between the total primitive reflex score and total symptoms of anxiety score; however, a significant relationship was found between symptoms of anxiety and the Moro, Plantar and Spinal Galant reflex. These UPR play an important role in balance. Research on balance dysfunction indicates a relationship with symptoms of anxiety. Prenatal maternal stress, common childhood illness and comorbidity with ADHD were also found to be factors in symptoms of anxiety in children. / Psychology / M.A. (Psychology)

Le stress prénatal est un sujet d'intérêt éthologique croissant en raison de ses effets sur la santé humaine et le bien-être des animaux. Cette thése de doctorat s’intéresse à la seiche Sepia officinalis, un modèle pratique dans lequel la progéniture en développement peut être séparée de leurs mères pour examiner diverses sources potentielles de stress en isolement expérimental. Plusieurs catégories de facteurs de stress ont été appliquées aux embryons et aux juvéniles et la progéniture résultante a été testée dans une série d'épreuves physiologiques et comportementales. L'objectif était de déterminer si différents types de stress prénatal affectent la seiche et, dans l'affirmative, comment ces effets se transmettent. Les données présentées démontrent que les stresseurs appliqués aux femelles reproductrices (stress maternel), ainsi que les stresseurs appliqués directement aux embryons (stress embryonnaire), affectent le comportement postnatal (y compris la structuration corporelle, la latéralisation cérébrale, la prédation et les schémas d'activité) la mémoire et / ou la neurobiologie (y compris les concentrations et le renouvellement de la monoamine, la taille des différents lobes cérébraux et la division cellulaire). Les résultats mettent en évidence la présence de trois voies par lesquelles le stress peut exercer des effets: sur le nombre de descendants produits par la femelle, la transmission de la femelle à sa progéniture et directement sur la progéniture elle-même. Les expériences ont également démontré qu'un facteur de stress complètement artificiel (lumière forte) affectait un éventail plus large de comportements chez la progéniture qu’un stress naturel (odeur de prédateur). Enfin, les données ont montré que l'environnement d'incubation et d’élevage peuvent également affecter la progéniture et méritent donc une attention particulière dans la formulation et l'interprétation des expériences avec cette espèce. Ces découvertes informent à la fois les pratiques de bien-être des seiches et d'autres céphalopodes (par exemple, réduisent la manipulation pour maximiser la reproduction) et élucident et renforcent les principes éthologiques qui s'appliquent au stress animal en général (par exemple la transmission des effets de stress de la mère à la progéniture). Compte tenu des informations fournies ici et dans de nombreuses autres études, la seiche et d'autres céphalopodes devraient continuer à servir de modèles comportementaux en éthologie et en biologie en général. / Prenatal stress is a subject of growing ethological interest due to its effects on human health and animal welfare. This Ph.D. thesis utilizes the cuttlefish Sepia officinalis, a convenient model in which developing offspring can be separated from their mothers to examine various potential sources of stress in experimental isolation. Several categories of stressors were applied to cuttlefish and cuttlefish eggs and the resulting offspring were tested in a range of physiological and behavioral tests. The goal was to determine if various types of prenatal stress affect cuttlefish, and if so, how these effects are transmitted. The data presented demonstrate that both stressors applied to reproducing females (maternal stress), as well as stressors applied directly to embryos (embryonic stress), affected post-natal behavior (including body patterning, brain lateralization, predation and activity patterns), learning, memory and/or neurobiology (including monoamine concentrations and turnover, the size of various brain lobes and cell division). The results highlight the presence of three pathways by which stress can exert effects: on the number of offspring produced by the female, transmission from the female to her offspring and directly on the offspring themselves. The experiments also demonstrated that a completely artificial stressor (bright light) affected a wider range of behaviors in offspring than a natural-occurring one (predator odor). Finally, the data showed that incubation and spawning environment can also affect offspring, and thus deserve attention in the formulation and interpretation of experiments with this species. These findings inform both welfare practices for cuttlefish and other cephalopods (e.g. reduce handling to maximize reproduction) as well as elucidating and reinforcing ethological principles that apply to animal stress in general (e.g. the transmission of stress effects from mother to offspring). Given the insight provided here and in numerous other studies, cuttlefish and other cephalopods should continue to serve as behavioral models in ethology and biology in general.