Limited clinical evidence exists regarding whether the single private room Neonatal Intensive Care Unit (NICU) environment of care delivery has a positive, negative, or neutral impact on health outcomes for the high risk neonate and on maternal stress as compared to the open room design. The study purpose was to examine whether a difference exists in health outcomes in the open room versus single private room NICU environment. The factors considered were weight gain, ventilator days, hospital length of stay, incidence and grade of intraventricular hemorrhage (IVH), the number of parental visits, and perceptions of maternal stress. Infants hospitalized in an open room environment (n=52) were matched by gestational age to infants in a single private room NICU (n=52). Mothers of the infants from the open room (n=26) and the single private room (n=20) groups completed the Parental Stress Scale: Neonatal Intensive Care Unit (PSS:NICU) survey instrument. The t-test for independent groups demonstrated a difference for the number of parent visits (t=6.672, df=60.13, p<.001) with a significant increase in visitation frequency for infants in the single private room NICU. Maternal perceptions of stress were not different (t=.154, df=44, p=.878), and high stress scores were reported for both groups regardless of the infant's environment of hospitalization. This study demonstrates that the single private room environment promotes increased parental access to their infants. The finding of high levels of maternal perception of stress in both the open room and single private room NICU's demonstrates that the environment did not impact the perception of maternal stress. This finding supports the implication that mothers of hospitalized infants need nursing support regardless of the type of NICU environment.

Mothers and siblings of children with autism incur stressors that impact their well-being more adversely than mothers of children with ADHD or normally developing children. In Study 1, twenty-six mothers of children with autism (Group 1) were compared to 24 mothers of children with ADHD (Group 2) and 24 mothers with normally developing children (Group 3). All families included a normally developing child (ages 4 to 12). Measures to delineate levels of maternal functioning were administered. Results for Study 1 indicated that mothers of children with autism had higher levels of psychological symptomatology, higher parenting stress, poorer perceptions of their family environment and their ability to parent the siblings, and higher perceptions of internalized problems of the siblings than mothers with normally developing children. These findings support the literature stating that mothers of children with autism may experience increased levels of maternal stress. The reciprocal nature of the parent-child relationship suggests that parents should be involved in meeting the needs of siblings in these families. A subgroup of Group 1 mothers participated in a parent group that occurred simultaneously with a sibling group. Mothers were randomly assigned to participate in a parent/sibling group, a sibling only group, or a wait-list group. Intervention efficacy was assessed using Study 1 measures plus measures designed specifically for the intervention. Overall results of study 2 indicated that mothers in the deluxe intervention perceived their parenting of the siblings to have improved after the intervention when compared to the standard and wait-list groups. This suggested that concurrent mother/sibling intervention provided the mothers with beneficial information and contributed to their enhanced sense of competence about parenting the siblings. In addition, mothers in the deluxe intervention perceived their family environment and the behaviors of the sibling to get worse at post-intervention, but return to baseline over time. This suggests that the intervention may have initially brought some difficulties to the surface that were resolved over time. Results will be discussed with their implications for further research and clinical intervention.

INTRODUÇÃO: Exposição a fatores ambientais e estresse durante o período intrauterino estão associados com alterações da trajetória do neurodesenvolvimento de forma sexo-dependente. Mecanismos epigenéticos estão envolvidos a esta associação. OBJETIVOS: Analisar de acordo com a exposição ao estresse na gestação o impacto do sexo e de alterações de metilação do DNA no sangue de cordão umbilical nas medidas antropométricas do neonato. MÉTODOS: Foram recrutadas 94 gestantes e aplicados questionários de medidas exposição ao estresse e fatores de risco durante a gravidez. A coleta de sangue do cordão umbilical seguiu protocolo padronizado. Para analisar o estresse foi utilizada análise de componentes principais (ACP) dos fatores de exposição avaliados: status socioeconômico, educação, ganho de peso, índice de massa corporal pré-gravídico, presença de doença psiquiátrica, estresse psicossocial durante a gravidez. Após o ACP fizemos análise de agrupamento por K-means. As análises de metilação foram realizadas utilizando Illumina Infinium Human Methylation450 (450K) BeadChip. Os dados foram analisados pelos pacotes Minfi e ChAMP (Chip Analysis Methylation Pipeline). A partir das posições diferencialmente metiladas (PDMs) foi feito análise de enriquecimento de processos biológicos com a ferramenta WebGestalt. Para avaliar impacto do sexo e alterações de metilação no desfecho antropométrico do neonato usamos modelos de análise linear de regressão múltipla. RESULTADOS: A coorte final para a avaliação do estresse foi composta por 89 pares mãe/recém-nascidos, sendo 50 meninas e 39 meninos. A ACP mostrou que os primeiros 3 componentes explicaram 60% da variabilidade da amostra. Sendo o primeiro componente (CP1) estresse psíquico, o segundo CP estresse social e o CP3 exposição a tóxicos. O biplot dos primeiros dois componentes sugeriu a separação das mães em dois grupos, confirmados pela análise de agrupamentos. Usando o ponto de corte de p-valor < 0,01 e deltabeta-valor>5%, encontramos 110 posições PDMs entre os grupos e restringindo este valor para p-valor < 0,01 e delta beta valor > 10% encontramos 13 PDMs. Usando apenas as crianças adequadas para idade gestacional fizemos análise de metilação diferencial entre os sexos. Foram encontradas 426 PDMs. Nenhuma das 13 PDMs encontradas entre os dois grupos pertenciam ao conjunto das PDMs entre sexos. No modelo de regressão linear multivariada controlando para sexo da criança e idade da mãe não encontramos nenhuma PDM associada aos desfechos antropométricos do neonato. Na análise estratificada por grupos os sítios cg24702040 (MAP3K21), cg21550016 (PAX8) foram estatisticamente significantes para perímetro abdominal e cg18706028 (CCKBR) e cg21550016 (PAX8) foram estatisticamente significantes para índice do perímetro cefálico para a idade. Este estudo sugere que o estresse materno independente do sexo pode afetar o crescimento fetal, mediado por respostas epigenéticas em genes relacionados à resposta ao estresse, regulação negativa da via de sinalização do receptor do fator de crescimento epidérmico, biogênese da sinapse e processo apoptótico / BACKGROUND: Exposure to environmental factors and stress during the intrauterine period are associated with changes in the neurodevelopmental trajectory in a sex-dependent manner. Epigenetic mechanisms are involved in this association. OBJECTIVES: Analyze according to exposure to stress during pregnancy the impact of sex and DNA methylation alterations on umbilical cord blood in the anthropometric measurements of the neonate METHODS: A total of 94 pregnant women were recruited and questionnaires were used to measure stress exposure and risk factors during pregnancy. Umbilical cord blood collection followed a standardized protocol. In order to analyze the stress, the principal components analysis (PCA) of the exposure factors evaluated were: socioeconomic status, education, weight gain, pre-gravid body mass index, presence of psychiatric illness, and psychosocial stress during pregnancy. After the PCA we did group analysis by k-means. Methylation analyzes were performed using Illumina Infinium Human Methylation 450 (450K) BeadChip. The data were analyzed by the Minfi and ChAMP (Chip Analysis Methylation Pipeline) packages. From the differentially methylated positions (DMPs) was made analysis of enrichment of biological processes with the tool WebGestalt. To evaluate gender impact and methylation alterations in the neonatal anthropometric outcome we used multiple regression linear analysis models. RESULTS: The final cohort for the evaluation of stress was composed of 89 mother/newborn pairs, being 50 girls and 39 boys. The PCA showed that the first 3 components accounted for 60% of the variability of the sample. Being the first component (PC1) psychic stress, the second PC social stress and PC3 exposure to toxic. The biplot of the first two components suggested the separation of the mothers into two groups, confirmed by cluster analysis. Using the cutoff point of p-value < 0.01 and delta beta-value > 5%, we found 110 DMPs between the groups and restricting this value to p-value < 0.01 and delta beta-value > 10 % we found 13 DMPs. Using only children suitable for gestational age we did differential methylation analysis between genders. There were 426 DMPs found. None of the 13 DMPs found between the two groups belonged to the pool of DMPs between the sexes. In the multivariate linear regression model controlling for child sex and age of the mother we did not find any DMP associated with the anthropometric outcomes of the neonate. In group-stratified analysis the cg24702040 (MAP3K21), cg21550016 (PAX8) sites were statistically significant for abdominal perimeter and cg18706028 (CCKBR) and cg21550016 (PAX8) were statistically significant for head cephalic circumference for age. This study suggests that maternal stress independent of sex can affect fetal growth, mediated by epigenetic responses in genes related to stress response, negative regulation of the epidermal growth factor receptor signaling pathway, biogenesis of the synapse and apoptotic process

INTRODUÇÃO: Exposição a fatores ambientais e estresse durante o período intrauterino estão associados com alterações da trajetória do neurodesenvolvimento de forma sexo-dependente. Mecanismos epigenéticos estão envolvidos a esta associação. OBJETIVOS: Analisar de acordo com a exposição ao estresse na gestação o impacto do sexo e de alterações de metilação do DNA no sangue de cordão umbilical nas medidas antropométricas do neonato. MÉTODOS: Foram recrutadas 94 gestantes e aplicados questionários de medidas exposição ao estresse e fatores de risco durante a gravidez. A coleta de sangue do cordão umbilical seguiu protocolo padronizado. Para analisar o estresse foi utilizada análise de componentes principais (ACP) dos fatores de exposição avaliados: status socioeconômico, educação, ganho de peso, índice de massa corporal pré-gravídico, presença de doença psiquiátrica, estresse psicossocial durante a gravidez. Após o ACP fizemos análise de agrupamento por K-means. As análises de metilação foram realizadas utilizando Illumina Infinium Human Methylation450 (450K) BeadChip. Os dados foram analisados pelos pacotes Minfi e ChAMP (Chip Analysis Methylation Pipeline). A partir das posições diferencialmente metiladas (PDMs) foi feito análise de enriquecimento de processos biológicos com a ferramenta WebGestalt. Para avaliar impacto do sexo e alterações de metilação no desfecho antropométrico do neonato usamos modelos de análise linear de regressão múltipla. RESULTADOS: A coorte final para a avaliação do estresse foi composta por 89 pares mãe/recém-nascidos, sendo 50 meninas e 39 meninos. A ACP mostrou que os primeiros 3 componentes explicaram 60% da variabilidade da amostra. Sendo o primeiro componente (CP1) estresse psíquico, o segundo CP estresse social e o CP3 exposição a tóxicos. O biplot dos primeiros dois componentes sugeriu a separação das mães em dois grupos, confirmados pela análise de agrupamentos. Usando o ponto de corte de p-valor < 0,01 e deltabeta-valor>5%, encontramos 110 posições PDMs entre os grupos e restringindo este valor para p-valor < 0,01 e delta beta valor > 10% encontramos 13 PDMs. Usando apenas as crianças adequadas para idade gestacional fizemos análise de metilação diferencial entre os sexos. Foram encontradas 426 PDMs. Nenhuma das 13 PDMs encontradas entre os dois grupos pertenciam ao conjunto das PDMs entre sexos. No modelo de regressão linear multivariada controlando para sexo da criança e idade da mãe não encontramos nenhuma PDM associada aos desfechos antropométricos do neonato. Na análise estratificada por grupos os sítios cg24702040 (MAP3K21), cg21550016 (PAX8) foram estatisticamente significantes para perímetro abdominal e cg18706028 (CCKBR) e cg21550016 (PAX8) foram estatisticamente significantes para índice do perímetro cefálico para a idade. Este estudo sugere que o estresse materno independente do sexo pode afetar o crescimento fetal, mediado por respostas epigenéticas em genes relacionados à resposta ao estresse, regulação negativa da via de sinalização do receptor do fator de crescimento epidérmico, biogênese da sinapse e processo apoptótico / BACKGROUND: Exposure to environmental factors and stress during the intrauterine period are associated with changes in the neurodevelopmental trajectory in a sex-dependent manner. Epigenetic mechanisms are involved in this association. OBJECTIVES: Analyze according to exposure to stress during pregnancy the impact of sex and DNA methylation alterations on umbilical cord blood in the anthropometric measurements of the neonate METHODS: A total of 94 pregnant women were recruited and questionnaires were used to measure stress exposure and risk factors during pregnancy. Umbilical cord blood collection followed a standardized protocol. In order to analyze the stress, the principal components analysis (PCA) of the exposure factors evaluated were: socioeconomic status, education, weight gain, pre-gravid body mass index, presence of psychiatric illness, and psychosocial stress during pregnancy. After the PCA we did group analysis by k-means. Methylation analyzes were performed using Illumina Infinium Human Methylation 450 (450K) BeadChip. The data were analyzed by the Minfi and ChAMP (Chip Analysis Methylation Pipeline) packages. From the differentially methylated positions (DMPs) was made analysis of enrichment of biological processes with the tool WebGestalt. To evaluate gender impact and methylation alterations in the neonatal anthropometric outcome we used multiple regression linear analysis models. RESULTS: The final cohort for the evaluation of stress was composed of 89 mother/newborn pairs, being 50 girls and 39 boys. The PCA showed that the first 3 components accounted for 60% of the variability of the sample. Being the first component (PC1) psychic stress, the second PC social stress and PC3 exposure to toxic. The biplot of the first two components suggested the separation of the mothers into two groups, confirmed by cluster analysis. Using the cutoff point of p-value < 0.01 and delta beta-value > 5%, we found 110 DMPs between the groups and restricting this value to p-value < 0.01 and delta beta-value > 10 % we found 13 DMPs. Using only children suitable for gestational age we did differential methylation analysis between genders. There were 426 DMPs found. None of the 13 DMPs found between the two groups belonged to the pool of DMPs between the sexes. In the multivariate linear regression model controlling for child sex and age of the mother we did not find any DMP associated with the anthropometric outcomes of the neonate. In group-stratified analysis the cg24702040 (MAP3K21), cg21550016 (PAX8) sites were statistically significant for abdominal perimeter and cg18706028 (CCKBR) and cg21550016 (PAX8) were statistically significant for head cephalic circumference for age. This study suggests that maternal stress independent of sex can affect fetal growth, mediated by epigenetic responses in genes related to stress response, negative regulation of the epidermal growth factor receptor signaling pathway, biogenesis of the synapse and apoptotic process

Many parents experience high levels of stress after the birth of a premature infant admitted to a neonatal intensive care unit (NICU) given the often fragile status of their infant and the numerous medical interventions necessary to stabilize the infant. Previous research has found that parents of very preterm (VPT; <32 weeks‟ gestation) infants often experience high levels of stress, particularly in relation to feelings of having lost their parental role. Of particular concern are findings which suggest that such symptoms may last beyond the immediate hospitalization period to have an adverse effect on the parental ability to provide quality infant care-giving at home. However, little is known about the paternal NICU stress response, the role of stressors external to the NICU environment and the perceptions of NICU staff. Against this background, aims of this thesis were: 1) to describe and compare sources of NICU stress for mothers and fathers of VPT infants, 2) to identify key predictors of parental NICU stress, 3) to describe staff perceptions of parental NICU stress, and 4) to identify parental stressors external to the NICU. Two cohorts of parents of VPT infants were studied: 11 mothers and 10 fathers of VPT infants (<32 weeks' gestation) admitted to a level III NICU, Christchurch Women's Hospital; and 68 mothers and 68 fathers of VPT infants (<30 weeks' gestation) who participated in the Victorian Infant Brain Studies, admitted to the Royal Women‟s Hospital NICU, Melbourne. Twenty-three NICU nurses from Christchurch Women‟s Hospital, level III NICU were also interviewed. The Parental Stressors Scale: NICU (PSS: NICU) determined sources of stress among parents. NICU nurses completed an adapted version of the PSS: NICU that measured nursing staffs‟ perceptions of parental NICU stress. Parents also completed the Life Events Scale on upsetting life events from the previous 12 months. An external stressors scale which measured stress relating to finances, transport and childcare was developed and completed by parents and staff. Familial demographic and infant clinical information was collected from birth records and hospital databases. Results showed across both cohorts studied that mothers reported significantly higher levels of NICU stress than fathers on the “sights and sounds”, “infant appearance”, and “loss of parental role” subscales on the PSS: NICU (p < .05). The number of upsetting life events (B = .33, p = .01)) and paternal level of NICU stress predicted maternal NICU stress (B = .23, p = .03). Maternal NICU stress also predicted paternal NICU stress (B = .37, p = .01). Staff consistently overestimated parental stress levels (p < .05). The most stressful item on the external stressors scale reported by parents and staff was “fitting in everything else I have to do”. Findings emphasize the need for increased awareness of NICU-specific and NICU-external factors contributing to parental stress. Research into the extent to which staff perceptions of parent experiences may affect the quality of staff-parent relations in the NICU is also warranted. These findings contribute to our understanding of the parental experience of having a preterm infant in the NICU and implications for practice and future research are discussed.

Made available in DSpace on 2014-06-11T19:24:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-07-23Bitstream added on 2014-06-13T20:12:10Z : No. of bitstreams: 1 carnier_le_me_bauru.pdf: 1982119 bytes, checksum: b4ab862bfa7521b0f63af29532202451 (MD5) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / A hospitalização infantil para realização de cirurgia envolve uma sobrecarga emocional tanto para as crianças quanto para sua família. Sabendo que adultos e crianças são atingidos de modo semelhante pelo stress, este estudo avaliou o nível de stress de acompanhantes e crianças em situação pré-cirúrgica e as estratégias de enfrentamento (coping) das crianças nesta situação. Participaram 63 crianças, com idade entre 7 e 12 anos, hospitalizadas para cirurgias eletivas, e seus acompanhantes. Para verificar as variáveis sociodemográficas e de hospitalização das crianças, um Questionário de Levantamento de Informações, elaborado para este estudo, foi aplicado nos acompanhantes. Para avaliar a presença de stress nas crianças, foi aplicada a Escola de Stress Infantil (ESI) e, nos acompanhantes, o Inventário de Sintomas de Stress para adultos de Lipp (ISSL). Aplicou-se o Instrumento de Avaliação das Estratégias de Enfrentamento da Hospitalização (AEH) para identificar as estratégias de enfrentamento utilizadas pelas crianças para lidar com a hospitalização. Observou-se que cerca de 12,7% das crianças apresentaram stress e 23,8% possibilidade de stress, especialmente para sintomas psicológicos (33%), relacionados às variáveis: idade (sete a oito anos), sexo feminino, não ter experiência anterior com cirurgia e receber pouca informação acerca do período perioperatório. As crianças informadas pelo médico e com informação sobre o procedimento cirúrgico, apresentaram menor nível de stress. A maioria dos acompanhantes (76%) foram diagnosticados como estressados, com prevalência da fase de resistência e sintomas psicológicos principalmente as do sexo feminino. As crianças pontuaram mais comportamentos facilitadores da hospitalização como: tomar medicação, assistir TV e conversar. Meninas, crianças com idade igual ou superior a 11 anos e crianças... / Children's hospitalization for surgery may involve an emotional burden for both, the child and for his family. Knowing that adults and children alike are affected by stress, this study evaluated the stress level of caregivers and children in pre-surgical situation and the coping strategies of children in this situation. Participated in this study 63 children aged between seven and 12 years hospitalized for elective sugery and their carers. To determine the sociodemographic variables and hospitalizationn of children, a questionnaire survey of information prepared for this study was applied in companions. To evaluate the the presence of stress in children, was applied the Escala de Stress Infantil (ESI) and, in accompanying the Inventário de Sintomas de Stress para adultos de Lipp (ISSL). To identify the coping strategies used bu children to cope with hospitalization was applied the Instrumento de Avaliação das Estratégias de Enfrentamento da Hospitalização (AEH). It was observed that approximately 12.7% of children showed stress and 23.8% possibility of stress, especially for psychological psychological symptoms (33%), related to the variables age (seven to eight years), female, have no previous experience with surgery and receive little information about the perioperative period. The children reported by the physician and the surgical procedure had a lower level of stress. The most caregivers (76%) were diagnosed as stressed, with a prevalecence of resistance phase and psychological symptons. The fact that a woman companion and chief caregiver, in addition to being a companion of young children with no previous surgical experience and female was related with higher stress. The children scored more facilitative behaviors of hospitalization as taking medication, watching TV and chatting. Girls, children aged less than 11 years and children ... (Complete abstract click electronic access below)

Abstract The aim of this study was to follow 8 to 36- month old children's communicative development and its' associations with social-emotional skills (the Brief Infant Toddler Social-Emotional Assessment, BITSEA) and behavioural problems. This study is the first study using the Finnish version of the BITSEA. A total of 50 children participated in the Oulu region (first phases at year 2006 and 2007). At the age of 8 months (at year 2006, n&#160;= &#160;31), child participants were grouped into two conditions: 1) children possibly needing support for deficiencies in communicative and interaction skills and 2) children without noted areas of need of support in communicative and interaction skills. Through random sampling, three groups were formed and included children from both the above mentioned conditions. The groups met fortnightly for five months for a directed song-play session (enrichment intervention). The sample size was increased at year 2007 (n&#160;= &#160;19) and follow-up questionnaires were sent to all of the participating families (N&#160;= &#160;50) at the child's age of 18, 24 and 36 months. The sample during the year 2007 did not receive any intervention. Results suggest, that the children's communicative and social-emotional development may be linked to each other. Children who scored higher in the assessments in communicative skills were also more successful on assessments measuring social interaction and social-emotional competence. Children with better communication skills demonstrated higher scores after enrichment-intervention. Scores on the BITSEA demonstrated an association with other indicators of children's development employed in the study suggesting the utility of the BITSEA as a follow-up assessment in Finnish sample. Mothers, who rated high maternal stress (measured at the child's age of 8 months) also rated higher levels of social-emotional and behavioural problems in their children, especially when a child was 18 months. This effect appeared to decrease over time. Results indicate the clinical importance of directly measuring not only a child's linguistic and social-emotional development, but also including assessment of a child's immediate environment, such as parents and siblings. / Tiivistelmä Tutkimuksen tarkoituksena oli seurata 8-36 kuukauden ikäisten lasten kielellistä kehitystä ja sen yhteyttä sosioemotionaaliseen kehitykseen (Brief Infant Toddler Social-Emotional Assessment, BITSEA-lomake) sekä käyttäytymisen ongelmiin. Tämä oli ensimmäinen tutkimus Suomessa, jossa käytettiin BITSEAn suomenkielistä versiota. Tutkimukseen osallistui 50 perhettä (aloitus vuosina 2006 ja 2007) Oulun alueelta. Kahdeksan kuukauden iässä täytettyjen lomakkeiden perusteella (vuonna 2006, n&#160;= &#160;31) lapset luokiteltiin vuorovaikutus- ja kommunikaatiotaitojen mukaan kahteen joukkoon: 1) Vuorovaikutus- ja kommunikaatiotaitojen tukea mahdollisesti tarvitsevat lapset ja 2) Lapset, joilla ei todennäköisesti ollut tuen tarvetta vuorovaikutus- ja kommunikaatiotaidoissa. Satunnaisotannalla muodostettiin kolme pienryhmää (rikastuttamisryhmät), joihin kuului sekä mahdollista tukea tarvitsevia että tukea tarvitsemattomia lapsia. Ryhmät kokoontuivat joka toinen viikko viiden kuukauden ajan ohjattuun laulu-leikkituokioon. Tutkimusta laajennettiin syksyllä 2007 (n&#160;= &#160;19) ja kaikille tutkimukseen osallistuneille perheille (N = 50) lähetettiin seurantalomakkeita, jotka vanhempien tuli täyttää lapsen ollessa 18, 24 ja 36 kuukauden ikäinen. Vuoden 2007 otoksen perheille ei tarjottu perheinterventiota. Tutkimuksessa kävi ilmi, että lapset, jotka saivat korkeat pisteet sosioemotionaalista kompetenssia kuvaavissa kartoituksissa, menestyivät paremmin myös vuorovaikutus- ja kommunikaatiotaitoja kuvaavissa arvioinneissa. Lapset, joilla oli jo ennestään korkeammat pisteet vuorovaikutus- ja kommunikaatiotaitoja kuvaavissa lomakkeissa, näyttivät saavan korkeammat pisteet myös intervention jälkeen. Tutkimuksessa tuli esiin, että BITSEA -lomake korreloi hyvin muiden lasten kehityksen seurannassa käytettyjen mittareiden kanssa ja soveltuu siten hyvin tutkimuslomakkeeksi suomalaisessakin aineistossa. Lisäksi äidit, jotka arvioivat stressitasonsa korkealle (lapsen ollessa kahdeksan kuukauden ikäinen), arvioivat myöhemmin myös korkeampia pisteitä lasten sosioemotionaalisten ja käyttäytymisen ongelmien kyselylomakkeissa lapsen ollessa 18 kuukauden ikäinen. Tämä vaikutus kuitenkin väheni lapsen kasvaessa. Tutkimustulokset osoittavat, että perhe- ja neuvolatyössä on lapsen kehityksen kannalta tärkeää huomioida myös hänen kasvuympäristönsä; vanhempien hyvinvointi ja sisarusten määrä vaikuttavat lapsen kielelliseen ja sosioemotionaaliseen kehitykseen.

Orientador: Olga Maria Piazentin Rolim Rodrigues / Resumo: O objetivo geral deste trabalho foi descrever, comparar e correlacionar, de famílias nucleares e não nucleares, as práticas educativas parentais, a saúde emocional materna e problemas de comportamento das crianças. Quatro estudos foram realizados, a partir do relato de múltiplos informantes: 62 mães, 25 professoras e 62 crianças com faixa etária entre oito e 11 anos. Os instrumentos foram: Inventário de Estilos Parentais, Inventário de Depressão Beck, Inventário de Ansiedade Traço-Estado, Escala de Estresse Percebido, Questionário de Capacidades e Dificuldades e entrevista sobre dados sociodemográficos. O Estudo 1 analisou problemas de comportamento de crianças de famílias nucleares e não nucleares sob o ponto de vista de mães e professores. Os resultados apontaram que ambas informantes observaram comportamentos pró-sociais nas crianças, independente do grupo. Mães dos dois grupos perceberam de forma semelhante os problemas de comportamento dos filhos e, mais do que os professores e estes relataram significativamente mais problemas de comportamento das crianças do grupo não-nuclear. O Estudo 2 descreveu e comparou práticas educativas de mães de famílias não-nucleares e não nucleares associando-a a saúde emocional materna. Os resultados mostraram que a maioria das mães da amostra total foi classificada com estilo parental de risco, sem diferença significativa entre os grupos. As mães de famílias não nucleares utilizaram significativamente mais a prática de Abuso Físico. Quanto... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: The general objective of this study was to describe, compare and correlate, of nuclear and non-nuclear families, parental educational practices, maternal emotional health and behavior problems of children. Four studies were conducted based on the report of multiple informants: 62 mothers, 25 teachers and 62 children aged between eight and 11 years old. The instruments were: Parental Styles Inventory, Beck Depression Inventory, Dash-State Anxiety Inventory, Perceived Stress Scale, Capabilities and Difficulties Questionnaire and interview about sociodemographic data. The search 1 analyzed child behavior problems from nuclear and non-nuclear families from the point of view of mothers and teachers. The results showed that both informants observed prosocial behaviors in the children, regardless of the group. Mothers from both groups perceived similarly the behavior problems of their children and, more than teachers and these reported significantly more behavioral problems of children in the non-nuclear group. The search 2 described and compared educational practices of mothers from nuclear and non-nuclear families associating her with maternal emotional health. The results showed that the majority of mothers in the total sample were classified as at risk parental style, without significant difference between the groups. The Mothers from non-nuclear families used the practice of Physical Abuse significantly more. Regarding maternal emotional health, it is noteworthy that stress and... (Complete abstract click electronic access below) / Doutor

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Mes études doctorales ont permis de démontrer que les souris déficientes en VIP présentent une microcéphalie ayant principalement une origine maternelle qui affecte secondairement le développement de la substance blanche. Cette production placentaire par les lymphocytes T pourrait être affectée dans des pathologies du système immunitaire. De plus, nos données indiquent qu’une déficience en VIP prédispose à l'apparition de troubles sensoriels, en particulier de la nociception. Il est donc possible que les déficits précoces de développement du cerveau murin et l'apparition de l'hypersensibilité cutanée mécanique et thermique froide soient deux facettes d'une même pathologie. Des mesures d'activité de décharge spontanée des neurones dans le thalamus sensoriel chez des mâles adultes anesthésiés ont montré que les neurones des animaux KO sont hyper-excités, ce qui suggère un traitement aberrant des informations, notamment nociceptives, ou que l'activité inhibitrice des interneurones des réseaux locaux est réduite. / The studies carried out during my PhD demonstrate that VIP-deficient mice suffer from microcephaly and as well as white matter deficits mainly due to the absence of maternal VIP during embryogenesis, Placental secretion of VIP is dependent on T lymphocytes and could be altered in pathologies of the immune system. Moreover, our data links VIP deficiency to sensory alterations, specifically, the nociceptive system. Thus, it is possible that early developmental defects and hypersensitivity to mechanical and cold stimuli are two manifestations of the same pathology. This hypothesis was reinforced following analysis of spontaneous firing patterns of neurons in the sensory thalamus of anesthetized adult males. Neurons from VIP-KO mice are hyperactive, which suggests aberrant local processing of nociceptive input or that the inhibitory inputs from local interneuron networks is reduced.